Details for: GPR25

Gene ID: 2848

Symbol: GPR25

Ensembl ID: ENSG00000170128

Description: G protein-coupled receptor 25

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 2.1546
    Cell Significance Index: 24.0800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.6331
    Cell Significance Index: 17.5600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.6823
    Cell Significance Index: 9.9500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.4035
    Cell Significance Index: 2.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3194
    Cell Significance Index: 9.3800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1229
    Cell Significance Index: 1.7600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0301
    Cell Significance Index: 0.8100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.0119
    Cell Significance Index: 0.1400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0089
    Cell Significance Index: -0.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0109
    Cell Significance Index: -2.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0115
    Cell Significance Index: -1.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0125
    Cell Significance Index: -2.2500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0130
    Cell Significance Index: -0.1700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0155
    Cell Significance Index: -1.8300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0201
    Cell Significance Index: -0.5000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0213
    Cell Significance Index: -0.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0227
    Cell Significance Index: -2.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0317
    Cell Significance Index: -1.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0343
    Cell Significance Index: -1.6100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0400
    Cell Significance Index: -0.9700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0445
    Cell Significance Index: -1.5600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0459
    Cell Significance Index: -0.7800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0485
    Cell Significance Index: -0.6600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0499
    Cell Significance Index: -0.7300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0604
    Cell Significance Index: -0.6100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0653
    Cell Significance Index: -1.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0681
    Cell Significance Index: -2.2300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0686
    Cell Significance Index: -2.1900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0698
    Cell Significance Index: -1.4600
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0702
    Cell Significance Index: -0.6300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0719
    Cell Significance Index: -0.8500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0722
    Cell Significance Index: -0.8500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0723
    Cell Significance Index: -2.1300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0740
    Cell Significance Index: -1.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0745
    Cell Significance Index: -1.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0862
    Cell Significance Index: -2.4700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0873
    Cell Significance Index: -1.1300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0878
    Cell Significance Index: -2.1900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0903
    Cell Significance Index: -1.8000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0940
    Cell Significance Index: -2.4000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0956
    Cell Significance Index: -1.8900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0986
    Cell Significance Index: -2.1300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1022
    Cell Significance Index: -2.1700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1057
    Cell Significance Index: -1.3200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1057
    Cell Significance Index: -2.0800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1069
    Cell Significance Index: -2.4700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1081
    Cell Significance Index: -2.1700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1083
    Cell Significance Index: -1.3400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1097
    Cell Significance Index: -1.3000
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1249
    Cell Significance Index: -1.4400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1262
    Cell Significance Index: -1.7300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1294
    Cell Significance Index: -2.5300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1297
    Cell Significance Index: -2.1000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1363
    Cell Significance Index: -2.5200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1380
    Cell Significance Index: -2.3100
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1386
    Cell Significance Index: -1.4300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1399
    Cell Significance Index: -1.4200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1433
    Cell Significance Index: -2.4500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1459
    Cell Significance Index: -1.6700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1493
    Cell Significance Index: -1.9900
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1505
    Cell Significance Index: -1.3400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1535
    Cell Significance Index: -2.0200
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.1535
    Cell Significance Index: -1.8300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1539
    Cell Significance Index: -1.4400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1540
    Cell Significance Index: -2.4700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1543
    Cell Significance Index: -2.0300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1550
    Cell Significance Index: -2.1500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1567
    Cell Significance Index: -1.8700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1569
    Cell Significance Index: -2.1600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1577
    Cell Significance Index: -2.0200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1584
    Cell Significance Index: -2.4500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1616
    Cell Significance Index: -1.7900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1625
    Cell Significance Index: -1.8700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1633
    Cell Significance Index: -2.3200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1645
    Cell Significance Index: -1.5600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1651
    Cell Significance Index: -1.8000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1660
    Cell Significance Index: -1.7600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1676
    Cell Significance Index: -1.9800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1679
    Cell Significance Index: -2.5500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1681
    Cell Significance Index: -1.9500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1683
    Cell Significance Index: -1.8800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1688
    Cell Significance Index: -1.8100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1688
    Cell Significance Index: -2.1300
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1694
    Cell Significance Index: -1.5500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1708
    Cell Significance Index: -1.9300
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1725
    Cell Significance Index: -1.9900
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1739
    Cell Significance Index: -1.8500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1761
    Cell Significance Index: -1.3900
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1781
    Cell Significance Index: -1.7300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1797
    Cell Significance Index: -2.3500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1799
    Cell Significance Index: -1.9600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1806
    Cell Significance Index: -2.3200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1806
    Cell Significance Index: -1.8700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1811
    Cell Significance Index: -2.1400
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1828
    Cell Significance Index: -1.7900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1831
    Cell Significance Index: -2.1900
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1832
    Cell Significance Index: -1.7900
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1852
    Cell Significance Index: -2.3500
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.1854
    Cell Significance Index: -2.3300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1873
    Cell Significance Index: -1.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GPR25 is a member of the GPCR family, characterized by its ability to bind to G-proteins, which trigger a cascade of downstream signaling events. The receptor is composed of seven transmembrane domains and exhibits a high degree of sequence homology with other GPCRs. Notably, GPR25 is specifically expressed in a wide range of cell types, including progenitor cells, microglial cells, and neoplastic cells, suggesting its involvement in various cellular processes. **Pathways and Functions:** GPR25 is activated by a variety of ligands, including prostaglandin E2 (PGE2) and prostaglandin D2 (PGD2), which are known to modulate immune responses. Upon activation, GPR25 triggers a signaling cascade involving Gαs proteins, leading to the activation of downstream effectors, such as adenylyl cyclase and protein kinase A (PKA). This pathway is involved in various cellular processes, including: 1. Immune regulation: GPR25 has been shown to modulate immune responses by promoting the production of anti-inflammatory cytokines and suppressing the expression of pro-inflammatory genes. 2. Cell proliferation: GPR25 has been implicated in the regulation of cell proliferation, particularly in neoplastic cells, where it may contribute to tumor development and progression. 3. Developmental processes: GPR25 is expressed in progenitor cells and early T lineage precursors, suggesting its involvement in embryonic development and immune system maturation. **Clinical Significance:** The discovery of GPR25 has significant implications for our understanding of various diseases, including: 1. Immune-related disorders: GPR25's role in modulating immune responses makes it a potential therapeutic target for the treatment of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. Cancer: The involvement of GPR25 in cell proliferation and tumor development highlights its potential as a biomarker for cancer diagnosis and treatment. 3. Neurological disorders: GPR25's expression in cerebral cortex GABAergic interneurons suggests its potential involvement in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, GPR25 is a multifunctional GPCR that plays a critical role in various cellular processes, including immune regulation, cell signaling, and development. Further research is necessary to fully elucidate the mechanisms underlying GPR25's functions and to explore its therapeutic potential in various diseases. As an expert immunologist, I am excited to contribute to the ongoing research on GPR25 and its far-reaching implications for human health.

Genular Protein ID: 3808292474

Symbol: GPR25_HUMAN

Name: Probable G-protein coupled receptor 25

UniProtKB Accession Codes:

O00155 A0AVJ5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9020062

Title: Discovery of a novel human G protein-coupled receptor gene (GPR25) located on chromosome 1.

PubMed ID: 9020062

DOI: 10.1006/bbrc.1996.5828

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 361
  • Mass: 38779
  • Checksum: C9C155A415B1DE9F
  • Sequence:
    • MAPTEPWSPS PGSAPWDYSG LDGLEELELC PAGDLPYGYV YIPALYLAAF AVGLLGNAFV 
VWLLAGRRGP RRLVDTFVLH LAAADLGFVL TLPLWAAAAA LGGRWPFGDG LCKLSSFALA 
GTRCAGALLL AGMSVDRYLA VVKLLEARPL RTPRCALASC CGVWAVALLA GLPSLVYRGL 
QPLPGGQDSQ CGEEPSHAFQ GLSLLLLLLT FVLPLVVTLF CYCRISRRLR RPPHVGRARR 
NSLRIIFAIE STFVGSWLPF SALRAVFHLA RLGALPLPCP LLLALRWGLT IATCLAFVNS 
CANPLIYLLL DRSFRARALD GACGRTGRLA RRISSASSLS RDDSSVFRCR AQAANTASAS 
W

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.