Details for: TRBV10 3

Gene ID: 28583

Symbol: TRBV10 3

Ensembl ID: ENSG00000275791

Description: T cell receptor beta variable 10-3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.3668
    Cell Significance Index: 2.0000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.3373
    Cell Significance Index: 3.7700
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.1388
    Cell Significance Index: 1.1500
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.0945
    Cell Significance Index: 0.8500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0093
    Cell Significance Index: -0.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0179
    Cell Significance Index: -3.5900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0394
    Cell Significance Index: -0.6700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0508
    Cell Significance Index: -1.2300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0569
    Cell Significance Index: -0.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0646
    Cell Significance Index: -2.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0834
    Cell Significance Index: -2.2300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0954
    Cell Significance Index: -1.2400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1209
    Cell Significance Index: -1.0200
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1247
    Cell Significance Index: -1.0100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1287
    Cell Significance Index: -1.3000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1323
    Cell Significance Index: -3.3700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1678
    Cell Significance Index: -2.1200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1682
    Cell Significance Index: -2.0800
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1686
    Cell Significance Index: -1.4500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1760
    Cell Significance Index: -2.0800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1763
    Cell Significance Index: -1.4900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1767
    Cell Significance Index: -1.9000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1799
    Cell Significance Index: -2.3900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1807
    Cell Significance Index: -1.6900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1838
    Cell Significance Index: -2.1700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1851
    Cell Significance Index: -2.1300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1872
    Cell Significance Index: -3.6600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1883
    Cell Significance Index: -2.8600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1959
    Cell Significance Index: -3.6200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1976
    Cell Significance Index: -2.5800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1995
    Cell Significance Index: -2.6300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2056
    Cell Significance Index: -2.8200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2105
    Cell Significance Index: -3.5500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2161
    Cell Significance Index: -3.5000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2264
    Cell Significance Index: -3.6400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2268
    Cell Significance Index: -2.1500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2293
    Cell Significance Index: -3.9200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2301
    Cell Significance Index: -3.0200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2305
    Cell Significance Index: -2.8800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2308
    Cell Significance Index: -2.9600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2319
    Cell Significance Index: -2.7600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.2329
    Cell Significance Index: -2.0100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2400
    Cell Significance Index: -2.4500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2402
    Cell Significance Index: -4.1400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2403
    Cell Significance Index: -3.4200
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2425
    Cell Significance Index: -2.9500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2426
    Cell Significance Index: -3.4000
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.2428
    Cell Significance Index: -1.6700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2491
    Cell Significance Index: -3.6300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2493
    Cell Significance Index: -2.5000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.2497
    Cell Significance Index: -2.4000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2500
    Cell Significance Index: -2.9000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2555
    Cell Significance Index: -2.6500
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.2575
    Cell Significance Index: -2.7300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.2705
    Cell Significance Index: -2.7500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2735
    Cell Significance Index: -3.2200
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.2747
    Cell Significance Index: -2.3400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2760
    Cell Significance Index: -2.6900
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.2770
    Cell Significance Index: -3.0300
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.2802
    Cell Significance Index: -2.0900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2802
    Cell Significance Index: -3.6000
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2809
    Cell Significance Index: -3.0600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2827
    Cell Significance Index: -3.3900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2833
    Cell Significance Index: -3.9300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.2834
    Cell Significance Index: -3.0100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.2870
    Cell Significance Index: -2.9100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2875
    Cell Significance Index: -3.1000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.2889
    Cell Significance Index: -3.4300
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.2901
    Cell Significance Index: -3.1000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.2908
    Cell Significance Index: -2.9300
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2911
    Cell Significance Index: -3.4600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2913
    Cell Significance Index: -4.0000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2943
    Cell Significance Index: -3.5800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.2951
    Cell Significance Index: -3.0100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3004
    Cell Significance Index: -3.5500
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.3004
    Cell Significance Index: -2.5600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3010
    Cell Significance Index: -3.7000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3010
    Cell Significance Index: -3.6000
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.3066
    Cell Significance Index: -3.0600
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.3071
    Cell Significance Index: -3.5400
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.3076
    Cell Significance Index: -3.5400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.3101
    Cell Significance Index: -2.8700
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.3112
    Cell Significance Index: -3.0700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.3115
    Cell Significance Index: -3.5100
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.3171
    Cell Significance Index: -2.6500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.3201
    Cell Significance Index: -2.4900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.3240
    Cell Significance Index: -3.6200
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.3280
    Cell Significance Index: -3.6000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.3296
    Cell Significance Index: -3.6500
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.3335
    Cell Significance Index: -3.3900
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3360
    Cell Significance Index: -3.7200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.3374
    Cell Significance Index: -3.5900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.3386
    Cell Significance Index: -3.4600
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.3416
    Cell Significance Index: -3.1600
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.3431
    Cell Significance Index: -3.6500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.3436
    Cell Significance Index: -3.6500
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.3460
    Cell Significance Index: -3.5600
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.3468
    Cell Significance Index: -3.1500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3479
    Cell Significance Index: -3.6700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.3486
    Cell Significance Index: -3.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV10-3 is characterized by its unique structure and function, which enable it to recognize and bind to specific antigens. The gene encodes a variable region of the TCR beta chain, which is crucial for the specificity and affinity of the TCR for antigen-MHC complexes. TRBV10-3 is also notable for its high degree of polymorphism, allowing for the generation of a diverse repertoire of TCRs that can recognize a wide range of pathogens. Furthermore, the gene's expression is tightly regulated, with its expression levels influenced by various transcriptional and post-transcriptional mechanisms. **Pathways and Functions:** The TRBV10-3 gene is integrated into several key signaling pathways that govern T cell development, function, and responses. These include: 1. **Adaptive Immune Response:** TRBV10-3 plays a critical role in the adaptive immune response by enabling alpha-beta T cells to recognize and respond to specific antigens. 2. **Cell Surface Receptor Signaling Pathway:** The TCR beta chain, encoded by TRBV10-3, is a key component of the cell surface receptor signaling pathway, which transduces signals from the TCR to downstream effectors, influencing T cell activation, proliferation, and differentiation. 3. **Plasma Membrane:** TRBV10-3 is a transmembrane protein, anchored to the plasma membrane, where it interacts with MHC molecules and other co-receptors to facilitate antigen recognition. 4. **T Cell Receptor Complex:** TRBV10-3 is part of the TCR complex, a heterodimeric structure composed of alpha and beta chains, which recognizes and binds to antigen-MHC complexes. **Clinical Significance:** Dysregulation of TRBV10-3 expression has been implicated in various immune-related disorders, including: 1. **Autoimmune Diseases:** Altered TCR repertoire and function have been linked to autoimmune diseases, such as multiple sclerosis and type 1 diabetes. 2. **Cancer Immunotherapy:** TRBV10-3 has been identified as a potential target for cancer immunotherapy, as its expression is often downregulated in cancer cells. 3. **Vaccine Efficacy:** TRBV10-3 has been shown to play a role in vaccine-induced immune responses, highlighting its importance in vaccine design and development. In conclusion, TRBV10-3 is a critical component of the adaptive immune system, with a complex and multifaceted role in T cell development, function, and responses. Further research into the molecular mechanisms and clinical implications of TRBV10-3 is essential for understanding the intricacies of immune regulation and developing novel therapeutic strategies for immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.