Details for: TRAV20

Gene ID: 28663

Symbol: TRAV20

Ensembl ID: ENSG00000211800

Description: T cell receptor alpha variable 20

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 9.3045
    Cell Significance Index: -3.7800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.5636
    Cell Significance Index: 8.7200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0367
    Cell Significance Index: 0.2000
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0125
    Cell Significance Index: -0.1400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0296
    Cell Significance Index: -0.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0468
    Cell Significance Index: -1.2500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0881
    Cell Significance Index: -2.1400
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.1134
    Cell Significance Index: -1.3500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1241
    Cell Significance Index: -3.3200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1601
    Cell Significance Index: -3.1300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1616
    Cell Significance Index: -1.6200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1764
    Cell Significance Index: -2.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1917
    Cell Significance Index: -4.4300
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.2071
    Cell Significance Index: -1.4900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2137
    Cell Significance Index: -2.9300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2146
    Cell Significance Index: -3.6100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2289
    Cell Significance Index: -4.2300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2477
    Cell Significance Index: -6.3100
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.2527
    Cell Significance Index: -2.6200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2575
    Cell Significance Index: -4.1700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2595
    Cell Significance Index: -3.2100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2618
    Cell Significance Index: -3.3100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2648
    Cell Significance Index: -3.1200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2720
    Cell Significance Index: -4.6500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2842
    Cell Significance Index: -3.2700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.2856
    Cell Significance Index: -3.7400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2970
    Cell Significance Index: -3.7100
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.2989
    Cell Significance Index: -2.5700
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2996
    Cell Significance Index: -3.6500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3035
    Cell Significance Index: -3.8300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3043
    Cell Significance Index: -3.7400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.3135
    Cell Significance Index: -4.5700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.3236
    Cell Significance Index: -3.7600
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.3239
    Cell Significance Index: -3.8500
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.3241
    Cell Significance Index: -3.6900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.3246
    Cell Significance Index: -4.1700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3266
    Cell Significance Index: -3.8400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3300
    Cell Significance Index: -4.2700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.3327
    Cell Significance Index: -3.7800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3349
    Cell Significance Index: -4.4500
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.3478
    Cell Significance Index: -3.7500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.3485
    Cell Significance Index: -3.2600
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.3520
    Cell Significance Index: -3.9100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.3526
    Cell Significance Index: -3.3100
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.3543
    Cell Significance Index: -3.8700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3543
    Cell Significance Index: -4.6500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3564
    Cell Significance Index: -3.7600
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.3573
    Cell Significance Index: -3.4300
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.3578
    Cell Significance Index: -3.7600
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.3598
    Cell Significance Index: -3.9200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.3631
    Cell Significance Index: -4.3100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.3641
    Cell Significance Index: -3.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3645
    Cell Significance Index: -17.1300
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.3660
    Cell Significance Index: -3.7400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.3664
    Cell Significance Index: -3.9500
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.3673
    Cell Significance Index: -4.4300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.3688
    Cell Significance Index: -4.1200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3742
    Cell Significance Index: -4.3400
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.3764
    Cell Significance Index: -4.1500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3774
    Cell Significance Index: -4.4600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.3781
    Cell Significance Index: -3.8100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.3789
    Cell Significance Index: -4.3600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.3807
    Cell Significance Index: -4.2900
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.3825
    Cell Significance Index: -4.5200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.3842
    Cell Significance Index: -3.3600
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.3858
    Cell Significance Index: -3.9400
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.3860
    Cell Significance Index: -4.1200
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.3863
    Cell Significance Index: -3.4800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.3924
    Cell Significance Index: -3.7200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3947
    Cell Significance Index: -4.3700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.3952
    Cell Significance Index: -4.0100
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.3953
    Cell Significance Index: -3.9000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.3962
    Cell Significance Index: -4.2600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3967
    Cell Significance Index: -5.2200
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.4026
    Cell Significance Index: -4.1700
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.4041
    Cell Significance Index: -4.2900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.4068
    Cell Significance Index: -4.1100
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.4073
    Cell Significance Index: -3.9700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.4092
    Cell Significance Index: -4.4300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.4099
    Cell Significance Index: -4.5400
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.4103
    Cell Significance Index: -3.8600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.4111
    Cell Significance Index: -4.9300
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.4124
    Cell Significance Index: -4.4800
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.4125
    Cell Significance Index: -3.3400
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.4126
    Cell Significance Index: -4.3900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.4129
    Cell Significance Index: -5.3900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.4145
    Cell Significance Index: -5.8900
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.4149
    Cell Significance Index: -3.8500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.4161
    Cell Significance Index: -3.7500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.4171
    Cell Significance Index: -3.5200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.4213
    Cell Significance Index: -3.6400
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.4267
    Cell Significance Index: -4.3900
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.4277
    Cell Significance Index: -3.8900
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.4296
    Cell Significance Index: -4.6500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.4332
    Cell Significance Index: -5.6700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.4339
    Cell Significance Index: -4.4300
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.4344
    Cell Significance Index: -4.5200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.4359
    Cell Significance Index: -4.5900
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.4363
    Cell Significance Index: -3.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV20 is a member of the TCR alpha variable region family, which consists of approximately 30-40 genes. These genes are responsible for encoding the variable region of the TCR alpha chain, a crucial component of the T cell receptor complex. TRAV20 is characterized by its unique sequence and structure, which enables it to interact with the TCR beta chain and other co-receptors to recognize specific antigens. The expression of TRAV20 is restricted to certain cell types, suggesting a specialized function in the immune response. **Pathways and Functions:** TRAV20 is involved in the adaptive immune response, specifically in the recognition and response to bacterial pathogens. The TCR complex, comprising TRAV20, TRAV17, and TRAV6, is a key player in the activation of T cells in response to antigen presentation. Upon antigen recognition, the TCR complex undergoes clonal expansion, allowing for the proliferation of T cells that recognize specific antigens. This process is crucial for the development of immune memory and the long-term protection against pathogens. TRAV20 is also implicated in the regulation of T cell activation and tolerance. The expression of TRAV20 is downregulated in regulatory T cells (Tregs), which are essential for maintaining immune homeostasis and preventing autoimmune diseases. Conversely, the upregulation of TRAV20 has been linked to the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where T cell activation and dysregulation play a key role. **Clinical Significance:** The dysregulation of TRAV20 has significant clinical implications, particularly in the context of autoimmune diseases and cancer. The aberrant expression of TRAV20 has been linked to the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where T cell activation and dysregulation play a key role. Additionally, the overexpression of TRAV20 has been observed in various types of cancer, including leukemia and lymphoma, where T cell dysregulation contributes to tumor progression. Furthermore, TRAV20 has been identified as a potential biomarker for cancer diagnosis and prognosis. The expression of TRAV20 in tumor cells can serve as a surrogate marker for T cell activation and dysregulation, which is often associated with poor prognosis. Therefore, the analysis of TRAV20 expression in tumor cells may provide valuable insights into the underlying immunological mechanisms driving cancer progression. In conclusion, TRAV20 is a critical component of the T cell receptor complex, playing a pivotal role in the adaptive immune response and the regulation of T cell activation and tolerance. The dysregulation of TRAV20 has significant clinical implications, particularly in the context of autoimmune diseases and cancer. Further research into the mechanisms and functions of TRAV20 is essential for developing novel therapeutic strategies and improving our understanding of the complex interactions between the immune system and disease states.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.