Details for: TRAV20

Gene ID: 28663

Symbol: TRAV20

Ensembl ID: ENSG00000211800

Description: T cell receptor alpha variable 20

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast (CL0000057)
    Fold Change: 133.9
    Marker Score: 129,331
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 20.65
    Marker Score: 18,510
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10,810
  • Cell Name: mast cell (CL0000097)
    Fold Change: 1.4
    Marker Score: 809
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,574
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,651
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.06
    Marker Score: 704
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,726
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 801
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,815
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,401
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,328
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 736
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,259
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 503
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.65
    Marker Score: 372
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 390
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 234
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 436
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.5
    Marker Score: 437
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 478
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.26
    Marker Score: 218
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.25
    Marker Score: 423
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.24
    Marker Score: 198
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.22
    Marker Score: 687
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.2
    Marker Score: 125
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.19
    Marker Score: 87
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.18
    Marker Score: 142
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.18
    Marker Score: 102
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.15
    Marker Score: 166
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.15
    Marker Score: 168
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.14
    Marker Score: 248
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.14
    Marker Score: 149
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.11
    Marker Score: 252
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.11
    Marker Score: 216
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.11
    Marker Score: 456
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.11
    Marker Score: 49
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.1
    Marker Score: 77
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1
    Marker Score: 5,426
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.1
    Marker Score: 53
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.1
    Marker Score: 238
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.1
    Marker Score: 75
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.09
    Marker Score: 91
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.09
    Marker Score: 133
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.09
    Marker Score: 84
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.09
    Marker Score: 64
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.09
    Marker Score: 139
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.07
    Marker Score: 51
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.07
    Marker Score: 697
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 134
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.06
    Marker Score: 44
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.06
    Marker Score: 35
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.06
    Marker Score: 684
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.06
    Marker Score: 61
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.06
    Marker Score: 44
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.06
    Marker Score: 158
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.06
    Marker Score: 72
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.05
    Marker Score: 44
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.05
    Marker Score: 47
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.05
    Marker Score: 82
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.04
    Marker Score: 55
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.04
    Marker Score: 52
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.03
    Marker Score: 29
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.03
    Marker Score: 122
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.02
    Marker Score: 61
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.02
    Marker Score: 15

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV20 is a member of the TCR alpha variable region family, which consists of approximately 30-40 genes. These genes are responsible for encoding the variable region of the TCR alpha chain, a crucial component of the T cell receptor complex. TRAV20 is characterized by its unique sequence and structure, which enables it to interact with the TCR beta chain and other co-receptors to recognize specific antigens. The expression of TRAV20 is restricted to certain cell types, suggesting a specialized function in the immune response. **Pathways and Functions:** TRAV20 is involved in the adaptive immune response, specifically in the recognition and response to bacterial pathogens. The TCR complex, comprising TRAV20, TRAV17, and TRAV6, is a key player in the activation of T cells in response to antigen presentation. Upon antigen recognition, the TCR complex undergoes clonal expansion, allowing for the proliferation of T cells that recognize specific antigens. This process is crucial for the development of immune memory and the long-term protection against pathogens. TRAV20 is also implicated in the regulation of T cell activation and tolerance. The expression of TRAV20 is downregulated in regulatory T cells (Tregs), which are essential for maintaining immune homeostasis and preventing autoimmune diseases. Conversely, the upregulation of TRAV20 has been linked to the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where T cell activation and dysregulation play a key role. **Clinical Significance:** The dysregulation of TRAV20 has significant clinical implications, particularly in the context of autoimmune diseases and cancer. The aberrant expression of TRAV20 has been linked to the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where T cell activation and dysregulation play a key role. Additionally, the overexpression of TRAV20 has been observed in various types of cancer, including leukemia and lymphoma, where T cell dysregulation contributes to tumor progression. Furthermore, TRAV20 has been identified as a potential biomarker for cancer diagnosis and prognosis. The expression of TRAV20 in tumor cells can serve as a surrogate marker for T cell activation and dysregulation, which is often associated with poor prognosis. Therefore, the analysis of TRAV20 expression in tumor cells may provide valuable insights into the underlying immunological mechanisms driving cancer progression. In conclusion, TRAV20 is a critical component of the T cell receptor complex, playing a pivotal role in the adaptive immune response and the regulation of T cell activation and tolerance. The dysregulation of TRAV20 has significant clinical implications, particularly in the context of autoimmune diseases and cancer. Further research into the mechanisms and functions of TRAV20 is essential for developing novel therapeutic strategies and improving our understanding of the complex interactions between the immune system and disease states.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.