Details for: IGLV9 49

Gene ID: 28773

Symbol: IGLV9 49

Ensembl ID: ENSG00000223350

Description: immunoglobulin lambda variable 9-49

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T cell (CL0000084)
    Fold Change: 2.54
    Marker Score: 4,378
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 876
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.17
    Marker Score: 2,968
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7,671
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 802
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,818
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.98
    Marker Score: 5,598
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,395
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.96
    Marker Score: 1,558
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,732
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,282
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 498
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1,185
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.72
    Marker Score: 699
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 182
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.69
    Marker Score: 549
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.59
    Marker Score: 362
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 237
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.46
    Marker Score: 440
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 384
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 377
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.31
    Marker Score: 948
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.27
    Marker Score: 350
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.24
    Marker Score: 264
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2
    Marker Score: 116
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.19
    Marker Score: 251
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.18
    Marker Score: 171
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.16
    Marker Score: 108
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.16
    Marker Score: 126
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.13
    Marker Score: 163
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.09
    Marker Score: 150
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.09
    Marker Score: 105
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.08
    Marker Score: 185
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.08
    Marker Score: 45
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.07
    Marker Score: 48
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.07
    Marker Score: 64
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.07
    Marker Score: 60
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 138
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.07
    Marker Score: 85
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.06
    Marker Score: 151
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.06
    Marker Score: 41
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.05
    Marker Score: 96
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.04
    Marker Score: 32
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.04
    Marker Score: 73
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.04
    Marker Score: 171
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.04
    Marker Score: 471
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.04
    Marker Score: 95
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.03
    Marker Score: 29
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.02
    Marker Score: 28
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.01
    Marker Score: 25
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.01
    Marker Score: 10

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Location:** IGLV9-49 is located on chromosome 22, a region rich in immunoglobulin genes. 2. **Gene Structure:** The IGLV9-49 gene consists of three exons that encode a lambda variable region (V9) and a constant region (C49). 3. **Expression Pattern:** IGLV9-49 is expressed in various cell types, including T cells, granulocyte-monocyte progenitor cells, intestinal crypt stem cells, goblet cells, and intestinal epithelial cells. 4. **Signaling Pathways:** IGLV9-49 is involved in adaptive immune responses, including the activation of T cells and the production of antibodies. **Pathways and Functions:** 1. **Adaptive Immune Response:** IGLV9-49 is a key component of the adaptive immune response, enabling the recognition and neutralization of pathogens. 2. **Immunoglobulin Production:** IGLV9-49 is involved in the production of antibodies, which are essential for preventing infections and autoimmune diseases. 3. **T Cell Activation:** IGLV9-49 is expressed on T cells and is involved in their activation, proliferation, and differentiation. 4. **Immune Homeostasis:** IGLV9-49 plays a critical role in maintaining immune homeostasis by regulating the expression of other immune genes. **Clinical Significance:** 1. **Autoimmune Diseases:** Abnormal expression of IGLV9-49 has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** IGLV9-49 is overexpressed in certain types of cancer, including breast and lung cancer, where it contributes to tumor progression and metastasis. 3. **Infectious Diseases:** IGLV9-49 is involved in the immune response to infections, such as HIV and influenza, where it plays a critical role in the production of antibodies. 4. **Vaccine Development:** IGLV9-49 is a promising target for vaccine development, as it can be used to generate antibodies against specific pathogens. In conclusion, IGLV9-49 is a critical component of the adaptive immune response, playing a pivotal role in the production of antibodies and the activation of T cells. Its abnormal expression has been linked to various diseases, including autoimmune disorders and cancer. Further research is needed to fully understand the mechanisms of IGLV9-49 and its potential applications in immunotherapy and vaccine development.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.