Details for: IGLV9 49

Gene ID: 28773

Symbol: IGLV9 49

Ensembl ID: ENSG00000223350

Description: immunoglobulin lambda variable 9-49

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.5651
    Cell Significance Index: 8.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0348
    Cell Significance Index: -1.6200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0674
    Cell Significance Index: -1.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0890
    Cell Significance Index: -17.8600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1589
    Cell Significance Index: -1.9300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2333
    Cell Significance Index: -3.6100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3600
    Cell Significance Index: -8.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5133
    Cell Significance Index: -15.1200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5164
    Cell Significance Index: -5.8700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5617
    Cell Significance Index: -14.3100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6116
    Cell Significance Index: -16.3600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.6772
    Cell Significance Index: -13.2400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.8120
    Cell Significance Index: -13.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8267
    Cell Significance Index: -15.2800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.9319
    Cell Significance Index: -21.5300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.9626
    Cell Significance Index: -13.9800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.9971
    Cell Significance Index: -16.1500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -1.0533
    Cell Significance Index: -12.6300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -1.0710
    Cell Significance Index: -15.6100
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -1.0868
    Cell Significance Index: -13.1100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -1.0910
    Cell Significance Index: -11.3200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -1.1048
    Cell Significance Index: -15.1500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -1.1068
    Cell Significance Index: -13.1400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -1.1156
    Cell Significance Index: -12.9400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -1.1263
    Cell Significance Index: -14.7300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -1.1645
    Cell Significance Index: -13.4000
  • Cell Name: T cell (CL0000084)
    Fold Change: -1.1824
    Cell Significance Index: -13.9600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -1.1877
    Cell Significance Index: -11.1500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -1.1949
    Cell Significance Index: -14.1200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -1.1982
    Cell Significance Index: -20.3500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -1.2003
    Cell Significance Index: -15.4200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -1.2473
    Cell Significance Index: -16.1400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -1.2518
    Cell Significance Index: -17.1900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -1.2650
    Cell Significance Index: -20.3400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -1.2661
    Cell Significance Index: -13.4500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -1.2708
    Cell Significance Index: -19.3000
  • Cell Name: platelet (CL0000233)
    Fold Change: -1.2831
    Cell Significance Index: -13.2000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -1.2831
    Cell Significance Index: -14.3400
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -1.2912
    Cell Significance Index: -13.3800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -1.3141
    Cell Significance Index: -16.2600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.3185
    Cell Significance Index: -18.4800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -1.3205
    Cell Significance Index: -17.8200
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -1.3252
    Cell Significance Index: -14.1000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -1.3263
    Cell Significance Index: -17.3100
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -1.3342
    Cell Significance Index: -13.1600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -1.3360
    Cell Significance Index: -13.6500
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -1.3384
    Cell Significance Index: -14.4300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -1.3408
    Cell Significance Index: -14.8500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -1.3493
    Cell Significance Index: -15.8800
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -1.3508
    Cell Significance Index: -13.1900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -1.3597
    Cell Significance Index: -16.0700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -1.3666
    Cell Significance Index: -15.4000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -1.4071
    Cell Significance Index: -18.4700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.4082
    Cell Significance Index: -17.7700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -1.4141
    Cell Significance Index: -17.0700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -1.4225
    Cell Significance Index: -18.2400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -1.4252
    Cell Significance Index: -16.9600
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -1.4501
    Cell Significance Index: -11.9700
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -1.4505
    Cell Significance Index: -18.3700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -1.4565
    Cell Significance Index: -19.8200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -1.4678
    Cell Significance Index: -16.2500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.4789
    Cell Significance Index: -15.3100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -1.4870
    Cell Significance Index: -19.7600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -1.4885
    Cell Significance Index: -17.1300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -1.4886
    Cell Significance Index: -14.5100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -1.5035
    Cell Significance Index: -13.1500
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -1.5065
    Cell Significance Index: -14.0400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -1.5114
    Cell Significance Index: -17.1100
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: -1.5137
    Cell Significance Index: -13.9600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -1.5137
    Cell Significance Index: -19.9200
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -1.5155
    Cell Significance Index: -13.3200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -1.5167
    Cell Significance Index: -19.8000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -1.5176
    Cell Significance Index: -15.2900
  • Cell Name: blood cell (CL0000081)
    Fold Change: -1.5217
    Cell Significance Index: -12.9700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -1.5394
    Cell Significance Index: -19.2300
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -1.5429
    Cell Significance Index: -12.4000
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -1.5516
    Cell Significance Index: -13.8400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -1.5535
    Cell Significance Index: -17.7800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -1.5620
    Cell Significance Index: -19.2000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -1.5623
    Cell Significance Index: -15.9500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.5939
    Cell Significance Index: -26.8500
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -1.5992
    Cell Significance Index: -17.0800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -1.6038
    Cell Significance Index: -17.2500
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -1.6061
    Cell Significance Index: -13.1800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -1.6131
    Cell Significance Index: -17.3000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -1.6237
    Cell Significance Index: -18.1400
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -1.6246
    Cell Significance Index: -15.0100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -1.6260
    Cell Significance Index: -17.1200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.6311
    Cell Significance Index: -17.7700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -1.6324
    Cell Significance Index: -17.2200
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -1.6477
    Cell Significance Index: -14.7200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -1.6478
    Cell Significance Index: -17.5300
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -1.6483
    Cell Significance Index: -13.9100
  • Cell Name: B cell (CL0000236)
    Fold Change: -1.6523
    Cell Significance Index: -19.5300
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -1.6538
    Cell Significance Index: -16.1600
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -1.6557
    Cell Significance Index: -18.3900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -1.6571
    Cell Significance Index: -20.1600
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -1.6769
    Cell Significance Index: -17.7800
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -1.6841
    Cell Significance Index: -12.5300
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -1.6885
    Cell Significance Index: -15.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Location:** IGLV9-49 is located on chromosome 22, a region rich in immunoglobulin genes. 2. **Gene Structure:** The IGLV9-49 gene consists of three exons that encode a lambda variable region (V9) and a constant region (C49). 3. **Expression Pattern:** IGLV9-49 is expressed in various cell types, including T cells, granulocyte-monocyte progenitor cells, intestinal crypt stem cells, goblet cells, and intestinal epithelial cells. 4. **Signaling Pathways:** IGLV9-49 is involved in adaptive immune responses, including the activation of T cells and the production of antibodies. **Pathways and Functions:** 1. **Adaptive Immune Response:** IGLV9-49 is a key component of the adaptive immune response, enabling the recognition and neutralization of pathogens. 2. **Immunoglobulin Production:** IGLV9-49 is involved in the production of antibodies, which are essential for preventing infections and autoimmune diseases. 3. **T Cell Activation:** IGLV9-49 is expressed on T cells and is involved in their activation, proliferation, and differentiation. 4. **Immune Homeostasis:** IGLV9-49 plays a critical role in maintaining immune homeostasis by regulating the expression of other immune genes. **Clinical Significance:** 1. **Autoimmune Diseases:** Abnormal expression of IGLV9-49 has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** IGLV9-49 is overexpressed in certain types of cancer, including breast and lung cancer, where it contributes to tumor progression and metastasis. 3. **Infectious Diseases:** IGLV9-49 is involved in the immune response to infections, such as HIV and influenza, where it plays a critical role in the production of antibodies. 4. **Vaccine Development:** IGLV9-49 is a promising target for vaccine development, as it can be used to generate antibodies against specific pathogens. In conclusion, IGLV9-49 is a critical component of the adaptive immune response, playing a pivotal role in the production of antibodies and the activation of T cells. Its abnormal expression has been linked to various diseases, including autoimmune disorders and cancer. Further research is needed to fully understand the mechanisms of IGLV9-49 and its potential applications in immunotherapy and vaccine development.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.