Details for: IGLV1 41

Gene ID: 28824

Symbol: IGLV1 41

Ensembl ID: ENSG00000253818

Description: immunoglobulin lambda variable 1-41 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162,088
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.24
    Marker Score: 53,072
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.7
    Marker Score: 8,281
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6,847
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3,178
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.2
    Marker Score: 1,517
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.34
    Marker Score: 3,008
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 800
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,836
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,062
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.75
    Marker Score: 1,215
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 388
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.57
    Marker Score: 2,367
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.54
    Marker Score: 704
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.43
    Marker Score: 246
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4
    Marker Score: 383
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.3
    Marker Score: 172
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.24
    Marker Score: 323
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 117
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.16
    Marker Score: 108
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.15
    Marker Score: 355
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.14
    Marker Score: 418
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.12
    Marker Score: 145
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.11
    Marker Score: 77
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.1
    Marker Score: 42
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.08
    Marker Score: 76
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.08
    Marker Score: 50
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 81
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.07
    Marker Score: 807
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 135
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.05
    Marker Score: 45
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.05
    Marker Score: 66
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.05
    Marker Score: 49
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.05
    Marker Score: 38
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.05
    Marker Score: 43
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.05
    Marker Score: 51
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.04
    Marker Score: 55
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.04
    Marker Score: 46
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.04
    Marker Score: 9
  • Cell Name: enucleated reticulocyte (CL0002422)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.03
    Marker Score: 29
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.03
    Marker Score: 58
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.02
    Marker Score: 52
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.02
    Marker Score: 29
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0
    Marker Score: 13
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0
    Marker Score: 21
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0
    Marker Score: 10
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: neuron (CL0000540)
    Fold Change: 0
    Marker Score: 13
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0
    Marker Score: 14
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 72
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0
    Marker Score: 13
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0
    Marker Score: 14
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0
    Marker Score: 14

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGLV1-41 is a member of the immunoglobulin lambda variable region gene family, which is typically involved in the generation of antibody diversity. However, unlike its functional counterparts, IGLV1-41 lacks the typical immunoglobulin gene structure and is considered a pseudogene. Its expression is widespread, with notable presence in: 1. Immune cells: Conventional dendritic cells, granulocyte monocyte progenitor cells, CD4-positive T cells, and alpha-beta T cells. 2. Non-immune cells: Glutamatergic neurons, progenitor cells, oligodendrocyte precursor cells, microglial cells, blood vessel endothelial cells, and cerebral cortex GABAergic interneurons. **Pathways and Functions:** The functions of IGLV1-41 remain unclear, but several hypotheses have been proposed: 1. **Regulation of gene expression**: IGLV1-41 may act as a transcriptional regulator, influencing the expression of other genes in specific cell types. 2. **Cellular differentiation**: The presence of IGLV1-41 in progenitor cells and neuronal cells suggests a potential role in cell differentiation and development. 3. **Immune modulation**: IGLV1-41's expression in immune cells may contribute to the regulation of immune responses and the maintenance of immune homeostasis. 4. **Non-immune cell functions**: IGLV1-41's expression in non-immune cells, such as neurons and endothelial cells, may indicate a broader role in cellular homeostasis and tissue development. **Clinical Significance:** The clinical significance of IGLV1-41 is still an area of active research. However, potential implications include: 1. **Immunological disorders**: Alterations in IGLV1-41 expression may contribute to the development of autoimmune diseases or immune-related disorders. 2. **Neurological disorders**: The expression of IGLV1-41 in neuronal cells raises questions about its potential involvement in neurological diseases, such as Alzheimer's or Parkinson's disease. 3. **Cancer**: IGLV1-41's expression in some cancer cells has been reported, suggesting a possible role in cancer development or progression. In conclusion, the IGLV1-41 gene, despite being a pseudogene, exhibits a complex and widespread expression pattern, raising questions about its potential functions and clinical significance. Further research is necessary to unravel the mysteries of this enigmatic gene and its implications in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.