Details for: IGLV1 41

Gene ID: 28824

Symbol: IGLV1 41

Ensembl ID: ENSG00000253818

Description: immunoglobulin lambda variable 1-41 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.0117
    Cell Significance Index: 0.1000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0110
    Cell Significance Index: 0.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0055
    Cell Significance Index: -1.1000
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0071
    Cell Significance Index: -0.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0180
    Cell Significance Index: -0.8400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0206
    Cell Significance Index: -0.2100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0224
    Cell Significance Index: -0.6000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0250
    Cell Significance Index: -0.3400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0259
    Cell Significance Index: -0.4400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0294
    Cell Significance Index: -0.7500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0301
    Cell Significance Index: -0.4400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0333
    Cell Significance Index: -0.8300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0367
    Cell Significance Index: -0.4100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0375
    Cell Significance Index: -0.8100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0380
    Cell Significance Index: -0.4800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0381
    Cell Significance Index: -0.4500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0403
    Cell Significance Index: -0.4500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0405
    Cell Significance Index: -0.9800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0410
    Cell Significance Index: -0.8700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0441
    Cell Significance Index: -0.5500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0445
    Cell Significance Index: -0.8700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0451
    Cell Significance Index: -0.7300
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0466
    Cell Significance Index: -0.3100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0491
    Cell Significance Index: -0.8400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0498
    Cell Significance Index: -0.9200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0550
    Cell Significance Index: -0.6500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0578
    Cell Significance Index: -0.6800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0587
    Cell Significance Index: -0.7600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0613
    Cell Significance Index: -0.7400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0639
    Cell Significance Index: -0.6800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0642
    Cell Significance Index: -0.7700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0649
    Cell Significance Index: -0.8900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0653
    Cell Significance Index: -0.8600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0663
    Cell Significance Index: -0.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0667
    Cell Significance Index: -0.9100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0669
    Cell Significance Index: -0.8400
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0674
    Cell Significance Index: -0.5700
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0683
    Cell Significance Index: -0.7300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0693
    Cell Significance Index: -0.8600
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0698
    Cell Significance Index: -0.6700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0698
    Cell Significance Index: -0.7500
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0702
    Cell Significance Index: -0.7800
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0702
    Cell Significance Index: -0.7500
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0711
    Cell Significance Index: -0.8900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0720
    Cell Significance Index: -0.9400
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0733
    Cell Significance Index: -0.6800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0742
    Cell Significance Index: -0.9000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0755
    Cell Significance Index: -1.1000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0770
    Cell Significance Index: -0.9100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0773
    Cell Significance Index: -0.8900
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0774
    Cell Significance Index: -0.7900
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0776
    Cell Significance Index: -0.7100
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.0776
    Cell Significance Index: -0.8900
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0779
    Cell Significance Index: -0.8800
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0788
    Cell Significance Index: -0.8000
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.0791
    Cell Significance Index: -0.5200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0795
    Cell Significance Index: -0.9200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0806
    Cell Significance Index: -0.7500
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0812
    Cell Significance Index: -0.8800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0817
    Cell Significance Index: -0.8600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0825
    Cell Significance Index: -0.8700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0830
    Cell Significance Index: -1.1800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0849
    Cell Significance Index: -1.0100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0858
    Cell Significance Index: -0.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0858
    Cell Significance Index: -2.2900
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.0859
    Cell Significance Index: -0.9600
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0859
    Cell Significance Index: -0.8900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0864
    Cell Significance Index: -1.3900
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0869
    Cell Significance Index: -0.7400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0873
    Cell Significance Index: -0.8900
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0876
    Cell Significance Index: -1.0500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0877
    Cell Significance Index: -0.8200
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0885
    Cell Significance Index: -0.9700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0885
    Cell Significance Index: -0.9400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0886
    Cell Significance Index: -0.9100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0886
    Cell Significance Index: -0.9500
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0890
    Cell Significance Index: -0.9600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0895
    Cell Significance Index: -1.1000
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0897
    Cell Significance Index: -0.8100
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0898
    Cell Significance Index: -0.8500
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0912
    Cell Significance Index: -0.9100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0915
    Cell Significance Index: -0.9700
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0916
    Cell Significance Index: -0.9600
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0920
    Cell Significance Index: -0.9700
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0925
    Cell Significance Index: -0.8200
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0928
    Cell Significance Index: -0.9600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0933
    Cell Significance Index: -1.2400
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0937
    Cell Significance Index: -0.8700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0949
    Cell Significance Index: -0.9000
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0965
    Cell Significance Index: -1.0000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0966
    Cell Significance Index: -0.9800
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0969
    Cell Significance Index: -0.9600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0970
    Cell Significance Index: -1.1800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0973
    Cell Significance Index: -0.9800
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.0975
    Cell Significance Index: -0.8400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0976
    Cell Significance Index: -1.3400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0987
    Cell Significance Index: -0.8200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1000
    Cell Significance Index: -1.0100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1000
    Cell Significance Index: -1.1600
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.1010
    Cell Significance Index: -0.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGLV1-41 is a member of the immunoglobulin lambda variable region gene family, which is typically involved in the generation of antibody diversity. However, unlike its functional counterparts, IGLV1-41 lacks the typical immunoglobulin gene structure and is considered a pseudogene. Its expression is widespread, with notable presence in: 1. Immune cells: Conventional dendritic cells, granulocyte monocyte progenitor cells, CD4-positive T cells, and alpha-beta T cells. 2. Non-immune cells: Glutamatergic neurons, progenitor cells, oligodendrocyte precursor cells, microglial cells, blood vessel endothelial cells, and cerebral cortex GABAergic interneurons. **Pathways and Functions:** The functions of IGLV1-41 remain unclear, but several hypotheses have been proposed: 1. **Regulation of gene expression**: IGLV1-41 may act as a transcriptional regulator, influencing the expression of other genes in specific cell types. 2. **Cellular differentiation**: The presence of IGLV1-41 in progenitor cells and neuronal cells suggests a potential role in cell differentiation and development. 3. **Immune modulation**: IGLV1-41's expression in immune cells may contribute to the regulation of immune responses and the maintenance of immune homeostasis. 4. **Non-immune cell functions**: IGLV1-41's expression in non-immune cells, such as neurons and endothelial cells, may indicate a broader role in cellular homeostasis and tissue development. **Clinical Significance:** The clinical significance of IGLV1-41 is still an area of active research. However, potential implications include: 1. **Immunological disorders**: Alterations in IGLV1-41 expression may contribute to the development of autoimmune diseases or immune-related disorders. 2. **Neurological disorders**: The expression of IGLV1-41 in neuronal cells raises questions about its potential involvement in neurological diseases, such as Alzheimer's or Parkinson's disease. 3. **Cancer**: IGLV1-41's expression in some cancer cells has been reported, suggesting a possible role in cancer development or progression. In conclusion, the IGLV1-41 gene, despite being a pseudogene, exhibits a complex and widespread expression pattern, raising questions about its potential functions and clinical significance. Further research is necessary to unravel the mysteries of this enigmatic gene and its implications in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.