Details for: IGKV1D 43

Gene ID: 28891

Symbol: IGKV1D 43

Ensembl ID: ENSG00000242580

Description: immunoglobulin kappa variable 1D-43

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0962
    Cell Significance Index: 1.0800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0245
    Cell Significance Index: 0.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0015
    Cell Significance Index: -1.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0064
    Cell Significance Index: -1.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0087
    Cell Significance Index: -0.8900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0213
    Cell Significance Index: -0.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0234
    Cell Significance Index: -1.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0246
    Cell Significance Index: -1.0900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0271
    Cell Significance Index: -0.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0290
    Cell Significance Index: -1.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0295
    Cell Significance Index: -0.7900
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0365
    Cell Significance Index: -0.4400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0371
    Cell Significance Index: -0.5200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0410
    Cell Significance Index: -1.0500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0412
    Cell Significance Index: -0.4600
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.0455
    Cell Significance Index: -0.4500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0487
    Cell Significance Index: -0.6300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0505
    Cell Significance Index: -0.6600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0507
    Cell Significance Index: -0.7000
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0526
    Cell Significance Index: -0.3500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0590
    Cell Significance Index: -0.7300
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0636
    Cell Significance Index: -0.6500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0667
    Cell Significance Index: -0.7100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0674
    Cell Significance Index: -1.6800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0683
    Cell Significance Index: -1.3400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0685
    Cell Significance Index: -1.1100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0688
    Cell Significance Index: -0.8600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0690
    Cell Significance Index: -0.9100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0697
    Cell Significance Index: -0.8200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0730
    Cell Significance Index: -1.3500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0790
    Cell Significance Index: -1.3500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0801
    Cell Significance Index: -0.9100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0826
    Cell Significance Index: -1.0100
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0831
    Cell Significance Index: -0.7600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0835
    Cell Significance Index: -0.9500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0837
    Cell Significance Index: -0.9000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0838
    Cell Significance Index: -0.9900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0838
    Cell Significance Index: -1.1300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0840
    Cell Significance Index: -1.1100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0845
    Cell Significance Index: -0.8900
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0914
    Cell Significance Index: -1.0800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0914
    Cell Significance Index: -1.0600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0921
    Cell Significance Index: -1.0600
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0933
    Cell Significance Index: -0.7700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0942
    Cell Significance Index: -1.2300
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0946
    Cell Significance Index: -1.0100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0963
    Cell Significance Index: -1.2800
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0970
    Cell Significance Index: -0.8600
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.0981
    Cell Significance Index: -0.8500
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0983
    Cell Significance Index: -1.0500
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0983
    Cell Significance Index: -0.9700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0984
    Cell Significance Index: -1.2100
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0985
    Cell Significance Index: -1.0000
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0989
    Cell Significance Index: -1.0100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0991
    Cell Significance Index: -1.1400
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.0999
    Cell Significance Index: -0.6500
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1009
    Cell Significance Index: -1.0700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1020
    Cell Significance Index: -1.1300
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.1022
    Cell Significance Index: -1.1200
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1024
    Cell Significance Index: -0.9500
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1025
    Cell Significance Index: -1.0800
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1025
    Cell Significance Index: -0.9700
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.1027
    Cell Significance Index: -1.1500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1048
    Cell Significance Index: -1.0700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1066
    Cell Significance Index: -1.3700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1075
    Cell Significance Index: -1.1900
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1077
    Cell Significance Index: -0.8500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1100
    Cell Significance Index: -1.2400
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1102
    Cell Significance Index: -1.1700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1109
    Cell Significance Index: -1.1200
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.1111
    Cell Significance Index: -1.2900
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1114
    Cell Significance Index: -1.1300
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1125
    Cell Significance Index: -1.0800
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1130
    Cell Significance Index: -0.9800
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1132
    Cell Significance Index: -1.1300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1147
    Cell Significance Index: -1.1900
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1168
    Cell Significance Index: -1.4000
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1171
    Cell Significance Index: -1.2700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1180
    Cell Significance Index: -1.6200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1182
    Cell Significance Index: -1.6800
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.1187
    Cell Significance Index: -1.2900
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.1193
    Cell Significance Index: -1.0400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1198
    Cell Significance Index: -1.8200
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1211
    Cell Significance Index: -1.1200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1232
    Cell Significance Index: -1.3000
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.1238
    Cell Significance Index: -1.1000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1241
    Cell Significance Index: -1.4700
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1245
    Cell Significance Index: -1.2900
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1245
    Cell Significance Index: -1.2700
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1252
    Cell Significance Index: -1.3500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1252
    Cell Significance Index: -1.3300
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.1260
    Cell Significance Index: -1.1400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1262
    Cell Significance Index: -1.2300
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.1282
    Cell Significance Index: -1.0300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1289
    Cell Significance Index: -1.2000
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.1294
    Cell Significance Index: -1.0400
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1309
    Cell Significance Index: -1.1700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1310
    Cell Significance Index: -1.3200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1311
    Cell Significance Index: -1.3300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1321
    Cell Significance Index: -1.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IGKV1D 43 gene is a member of the immunoglobulin kappa (IgK) variable region family, which is responsible for encoding the unique variable regions of IgK antibodies. The IGKV1D 43 gene is specifically designated as IgKV1D-43, indicating its unique identity within the IgK family. This gene exhibits a high degree of polymorphism, which is essential for its role in generating a diverse repertoire of antibodies. The IGKV1D 43 gene is also characterized by its expression in various cell types, including those involved in the intestinal epithelium, such as goblet cells and intestinal epithelial cells. **Pathways and Functions:** The IGKV1D 43 gene is involved in several key immune response pathways, including: 1. **Adaptive Immune Response:** The IGKV1D 43 gene plays a crucial role in the adaptive immune response by contributing to the production of antibodies against pathogens and other foreign substances. 2. **Extracellular Space:** The gene's expression in goblet cells and other epithelial cells allows it to participate in the regulation of the extracellular space, including the maintenance of mucosal homeostasis. 3. **Immune Response:** IGKV1D 43 is involved in the regulation of immune cell function, including the activation and regulation of immune responses. 4. **Immunoglobulin Complex:** The gene's role in the production of IgK antibodies positions it as a critical component of the immunoglobulin complex, which is essential for the recognition and elimination of pathogens. 5. **Immunoglobulin Production:** IGKV1D 43 contributes to the production of IgK antibodies, which are essential for the protection against infections and the maintenance of immune homeostasis. **Clinical Significance:** The IGKV1D 43 gene's involvement in various immune response pathways and its expression in multiple cell types make it a critical component of the immune system. Dysregulation or aberrant expression of this gene has been implicated in various diseases, including: 1. **Immune-related disorders:** The IGKV1D 43 gene's role in immune regulation makes it a potential target for the treatment of immune-related disorders, such as autoimmune diseases and immunodeficiency disorders. 2. **Cancer:** The gene's expression in neoplastic cells and its potential role in cancer progression make it a potential biomarker for cancer diagnosis and treatment. 3. **Infectious diseases:** The IGKV1D 43 gene's involvement in the adaptive immune response makes it a potential target for the development of vaccines and therapies against infectious diseases. In conclusion, the IGKV1D 43 gene is a critical component of the immune system, playing a pivotal role in the production of antibodies and the regulation of immune cell function. Its involvement in various immune response pathways and its significance in clinical contexts make it an important area of research, with potential applications in the treatment of immune-related disorders and infectious diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.