Details for: IGKV1 37

Gene ID: 28931

Symbol: IGKV1 37

Ensembl ID: ENSG00000239862

Description: immunoglobulin kappa variable 1-37 (non-functional)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.2893
    Cell Significance Index: 4.2000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0610
    Cell Significance Index: 0.7600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0310
    Cell Significance Index: 0.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0136
    Cell Significance Index: 0.3700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0102
    Cell Significance Index: 0.2600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0093
    Cell Significance Index: 0.1100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0022
    Cell Significance Index: 0.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0027
    Cell Significance Index: -0.1300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0163
    Cell Significance Index: -0.2200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0241
    Cell Significance Index: -0.3900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0259
    Cell Significance Index: -0.2900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0332
    Cell Significance Index: -0.4300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0334
    Cell Significance Index: -0.4600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0347
    Cell Significance Index: -0.4100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0405
    Cell Significance Index: -0.4300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0421
    Cell Significance Index: -0.4700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0436
    Cell Significance Index: -0.6200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0460
    Cell Significance Index: -0.4700
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.0470
    Cell Significance Index: -0.4100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0494
    Cell Significance Index: -0.7500
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0510
    Cell Significance Index: -0.8200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0515
    Cell Significance Index: -0.7500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0575
    Cell Significance Index: -0.6900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0599
    Cell Significance Index: -0.7700
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0610
    Cell Significance Index: -0.6900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0612
    Cell Significance Index: -0.8400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0639
    Cell Significance Index: -0.7600
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0660
    Cell Significance Index: -0.5900
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0685
    Cell Significance Index: -0.7900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0687
    Cell Significance Index: -0.8500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0689
    Cell Significance Index: -1.6700
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0693
    Cell Significance Index: -0.7400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0701
    Cell Significance Index: -0.9200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0704
    Cell Significance Index: -0.8100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0704
    Cell Significance Index: -0.8800
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0719
    Cell Significance Index: -0.7300
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0752
    Cell Significance Index: -0.6800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0756
    Cell Significance Index: -0.7100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0781
    Cell Significance Index: -0.8100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0793
    Cell Significance Index: -1.5500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0809
    Cell Significance Index: -0.8700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0845
    Cell Significance Index: -0.8900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0852
    Cell Significance Index: -0.8700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0855
    Cell Significance Index: -0.9100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0861
    Cell Significance Index: -0.8700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0905
    Cell Significance Index: -1.6700
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0925
    Cell Significance Index: -0.8700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0944
    Cell Significance Index: -1.0500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0956
    Cell Significance Index: -1.1300
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0958
    Cell Significance Index: -0.7700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0960
    Cell Significance Index: -1.1400
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.0980
    Cell Significance Index: -0.8500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1009
    Cell Significance Index: -1.1700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1025
    Cell Significance Index: -1.2100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1040
    Cell Significance Index: -0.8600
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1115
    Cell Significance Index: -1.0600
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1126
    Cell Significance Index: -1.2300
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: -0.1127
    Cell Significance Index: -0.8700
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1154
    Cell Significance Index: -1.1700
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1161
    Cell Significance Index: -0.7200
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1171
    Cell Significance Index: -0.7800
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: -0.1199
    Cell Significance Index: -0.8800
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.1214
    Cell Significance Index: -1.1100
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.1217
    Cell Significance Index: -0.8600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1224
    Cell Significance Index: -1.3600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1231
    Cell Significance Index: -1.6100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1239
    Cell Significance Index: -1.4700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1263
    Cell Significance Index: -1.4300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1311
    Cell Significance Index: -1.3300
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1336
    Cell Significance Index: -1.2400
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1338
    Cell Significance Index: -1.1400
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1385
    Cell Significance Index: -1.2400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1396
    Cell Significance Index: -1.3000
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1429
    Cell Significance Index: -0.9300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1451
    Cell Significance Index: -1.6400
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1464
    Cell Significance Index: -1.4100
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.1476
    Cell Significance Index: -1.3800
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.1542
    Cell Significance Index: -1.6300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1559
    Cell Significance Index: -1.5200
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.1567
    Cell Significance Index: -1.4000
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.1568
    Cell Significance Index: -1.3800
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1572
    Cell Significance Index: -1.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1592
    Cell Significance Index: -1.5300
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1612
    Cell Significance Index: -1.6700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1619
    Cell Significance Index: -1.5400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1623
    Cell Significance Index: -1.6400
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.1623
    Cell Significance Index: -1.6700
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.1630
    Cell Significance Index: -1.3100
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1638
    Cell Significance Index: -1.6400
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1645
    Cell Significance Index: -1.3900
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1657
    Cell Significance Index: -1.4300
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1663
    Cell Significance Index: -1.3900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1673
    Cell Significance Index: -1.5700
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.1680
    Cell Significance Index: -1.2900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1698
    Cell Significance Index: -1.5000
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.1708
    Cell Significance Index: -1.4100
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: -0.1793
    Cell Significance Index: -0.9500
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1808
    Cell Significance Index: -1.6100
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.1822
    Cell Significance Index: -1.6600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1869
    Cell Significance Index: -1.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IGKV1-37 gene is a member of the immunoglobulin kappa (IgK) family, which consists of four variable regions (V, D, J, and C) that are responsible for generating the diversity of antibodies. The IGKV1-37 gene is unique in that it lacks a functional variable region, which is essential for antibody production. This non-functional gene is also characterized by its broad expression in various immune cells, including myeloid and lymphoid progenitor cells, suggesting a role in the development and maturation of these cells. **Pathways and Functions:** The IGKV1-37 gene is involved in several key pathways and functions, including: 1. **Adaptive Immune Response:** The IGKV1-37 gene is expressed in cells that participate in the adaptive immune response, including T cells and B cells. Although the gene is non-functional, it may still contribute to the development and maturation of these cells. 2. **Extracellular Space:** The IGKV1-37 gene is expressed in cells that interact with the extracellular space, including neutrophils and mast cells. This suggests a potential role in the regulation of immune responses at the cell surface. 3. **Immunoglobulin Complex:** The IGKV1-37 gene is part of the immunoglobulin complex, which is a network of antibodies that recognize and bind to specific antigens. Although the gene is non-functional, it may still contribute to the regulation of this complex. 4. **Immunoglobulin Production:** The IGKV1-37 gene is involved in the production of immunoglobulins, which are essential for the recognition and elimination of pathogens. Although the gene is non-functional, it may still contribute to the regulation of immunoglobulin production. **Clinical Significance:** The IGKV1-37 gene has several clinical implications, including: 1. **Immune Deficiency:** The non-functional IGKV1-37 gene may contribute to immune deficiency disorders, such as immunoglobulin deficiencies, where the immune system is unable to produce functional antibodies. 2. **Cancer:** The IGKV1-37 gene is expressed in various types of cancer, including leukemia and lymphoma. This suggests a potential role in the development and progression of these diseases. 3. **Autoimmunity:** The IGKV1-37 gene is expressed in cells that participate in autoimmune responses, including neutrophils and mast cells. This suggests a potential role in the regulation of autoimmune responses. In conclusion, the IGKV1-37 gene is a non-functional gene that plays a crucial role in the adaptive immune response. Its broad expression in various immune cells suggests a potential role in the development and maturation of these cells. The clinical implications of this gene are significant, and further research is needed to fully understand its role in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.