Details for: GYPB

Gene ID: 2994

Symbol: GYPB

Ensembl ID: ENSG00000250361

Description: glycophorin B (MNS blood group)

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroblast (CL0000765)
    Fold Change: 5.57
    Marker Score: 3474.5
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.86
    Marker Score: 11068
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.16
    Marker Score: 2173
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.74
    Marker Score: 1179
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.62
    Marker Score: 10799
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.54
    Marker Score: 763
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 1.52
    Marker Score: 4447
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.52
    Marker Score: 1590
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.24
    Marker Score: 7544
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3644
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32726
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71833
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48058
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2399
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5315
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.82
    Marker Score: 613.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 615.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.8
    Marker Score: 733
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.73
    Marker Score: 1190
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.64
    Marker Score: 1218
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: 0.62
    Marker Score: 263
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.58
    Marker Score: 1903
  • Cell Name: enucleated reticulocyte (CL0002422)
    Fold Change: 0.57
    Marker Score: 212
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.52
    Marker Score: 1050
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.5
    Marker Score: 4208.5
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.49
    Marker Score: 274
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.41
    Marker Score: 6387
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.4
    Marker Score: 239
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.36
    Marker Score: 178
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.34
    Marker Score: 451
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.27
    Marker Score: 159
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.27
    Marker Score: 329
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.26
    Marker Score: 72
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.25
    Marker Score: 154
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.24
    Marker Score: 118
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.23
    Marker Score: 2008
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.23
    Marker Score: 95
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.22
    Marker Score: 104
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.21
    Marker Score: 86
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.21
    Marker Score: 140
  • Cell Name: enucleate erythrocyte (CL0000595)
    Fold Change: 0.2
    Marker Score: 80
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.2
    Marker Score: 243
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.2
    Marker Score: 63
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.19
    Marker Score: 88
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.19
    Marker Score: 65
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.17
    Marker Score: 696
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.16
    Marker Score: 1562
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.16
    Marker Score: 42
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.15
    Marker Score: 48
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.15
    Marker Score: 94
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.14
    Marker Score: 82
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.14
    Marker Score: 66
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.14
    Marker Score: 74
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.14
    Marker Score: 56
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.14
    Marker Score: 118
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.13
    Marker Score: 1391
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.13
    Marker Score: 89
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.13
    Marker Score: 199
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.13
    Marker Score: 57
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.12
    Marker Score: 43
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.11
    Marker Score: 56
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.1
    Marker Score: 47
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1
    Marker Score: 6409
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1
    Marker Score: 275
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.09
    Marker Score: 54
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.09
    Marker Score: 42.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.09
    Marker Score: 88
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.09
    Marker Score: 109
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.09
    Marker Score: 77
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.09
    Marker Score: 351
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.08
    Marker Score: 17
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.08
    Marker Score: 41.5
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.07
    Marker Score: 70
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.07
    Marker Score: 288
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.06
    Marker Score: 380
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.06
    Marker Score: 31
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.06
    Marker Score: 41
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.06
    Marker Score: 55
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.06
    Marker Score: 123
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.06
    Marker Score: 58
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.06
    Marker Score: 915
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.06
    Marker Score: 16

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Other Information

**Key characteristics:** * Gene name: GYPB * Ensembl ID: ENSG00000250361 * Protein: GLPB_HUMAN (PAS-3) * Protein function: Glycophorin B is a glycoprotein that is expressed on the surface of red blood cells. It is involved in blood group determination and plays a crucial role in the immune response. **Pathways and functions:** * **Ankyrin-1 complex pathway:** Glycophorin B is a glycoprotein that is involved in the formation of the ankyrin-1 complex, a signaling pathway that is important for the regulation of immune responses. The ankyrin-1 complex is composed of ankyrin-1 protein and two other glycoproteins, GP-1 and GP-4. The ankyrin-1 complex is expressed on the surface of endothelial cells and immune cells, and it mediates the binding of immune complexes to the vascular wall. * **Cell surface interactions at the vascular wall:** Glycophorin B is also expressed on the surface of red blood cells, where it helps to maintain the integrity of the blood-vessel barrier. * **Hemostasis:** Glycophorin B is also involved in the regulation of blood clotting. It is a cofactor for factor VIII, which is an enzyme that is involved in the coagulation cascade. * **Plasma membrane:** Glycophorin B is also expressed on the surface of red blood cells, where it helps to regulate the passage of ions and molecules between the blood and the extracellular environment. **Clinical significance:** Mutations in the GYPB gene have been linked to several blood disorders, including sickle cell disease, thalassemia, and immune disorders. These disorders are caused by mutations in the genes that encode glycophorin B, which can lead to the production of abnormal glycoproteins that can interfere with blood cell function.

Genular Protein ID: 323767077

Symbol: GLPB_HUMAN

Name: PAS-3

UniProtKB Accession Codes:

P06028 B8Q174 E2QBW7 Q0VAF4 Q58HE9 Q58HF0 Q58HF1 Q9UCH7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 19 EMDB 3 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 2 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 PANTHER 2 PDB 7 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3477806

Title: Molecular cloning of a human glycophorin B cDNA: nucleotide sequence and genomic relationship to glycophorin A.

PubMed ID: 3477806

DOI: 10.1073/pnas.84.19.6735

PubMed ID: 3196288

Title: Isolation of cDNA clones for human erythrocyte membrane sialoglycoproteins alpha and delta.

PubMed ID: 3196288

DOI: 10.1042/bj2540743

PubMed ID: 2734312

Title: Structural organization of glycophorin A and B genes: glycophorin B gene evolved by homologous recombination at Alu repeat sequences.

PubMed ID: 2734312

DOI: 10.1073/pnas.86.12.4619

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 11239234

Title: The low-incidence MNS antigens M(v), s(D), and Mit arise from single amino acid substitutions on GPB.

PubMed ID: 11239234

DOI: 10.1046/j.1537-2995.2001.41020269.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2016325

Title: Molecular genetics of human erythrocyte MiIII and MiVI glycophorins. Use of a pseudoexon in construction of two delta-alpha-delta hybrid genes resulting in antigenic diversification.

PubMed ID: 2016325

DOI: 10.1016/s0021-9258(20)89637-9

PubMed ID: 3595615

Title: Hybrid glycophorins from human erythrocyte membranes. I. Isolation and complete structural analysis of the hybrid sialoglycoprotein from Dantu-positive red cells of the N.E. variety.

PubMed ID: 3595615

DOI: 10.1111/j.1432-1033.1987.tb13479.x

PubMed ID: 3571235

Title: Glycophorins B and C from human erythrocyte membranes. Purification and sequence analysis.

PubMed ID: 3571235

DOI: 10.1016/s0021-9258(18)45646-3

PubMed ID: 1611092

Title: Molecular basis for the human erythrocyte glycophorin specifying the Miltenberger class I (MiI) phenotype.

PubMed ID: 1611092

PubMed ID: 7681597

Title: Epitopic structure of Tn glycophorin A for an anti-Tn antibody (MLS 128).

PubMed ID: 7681597

DOI: 10.1073/pnas.90.6.2495

PubMed ID: 35835865

Title: Architecture of the human erythrocyte ankyrin-1 complex.

PubMed ID: 35835865

DOI: 10.1038/s41594-022-00792-w

Sequence Information:

  • Length: 91
  • Mass: 9782
  • Checksum: EF15A64BAA929B7B
  • Sequence:
    • MYGKIIFVLL LSEIVSISAL STTEVAMHTS TSSSVTKSYI SSQTNGETGQ LVHRFTVPAP 
VVIILIILCV MAGIIGTILL ISYSIRRLIK A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.