Details for: HSP90AB3P

Gene ID: 3327

Symbol: HSP90AB3P

Ensembl ID: ENSG00000183199

Description: heat shock protein 90 alpha family class B member 3, pseudogene

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 6.1364
    Cell Significance Index: 72.9400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.6051
    Cell Significance Index: 20.6700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.0114
    Cell Significance Index: 10.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4871
    Cell Significance Index: 30.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3994
    Cell Significance Index: 10.8700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.2508
    Cell Significance Index: 3.1500
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.1622
    Cell Significance Index: 1.8700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1575
    Cell Significance Index: 4.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1093
    Cell Significance Index: 5.6800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.1054
    Cell Significance Index: 1.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0483
    Cell Significance Index: 2.2500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0424
    Cell Significance Index: 0.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0331
    Cell Significance Index: 6.6400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0052
    Cell Significance Index: 0.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0007
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0056
    Cell Significance Index: -10.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0090
    Cell Significance Index: -5.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0116
    Cell Significance Index: -7.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0161
    Cell Significance Index: -11.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0231
    Cell Significance Index: -10.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0250
    Cell Significance Index: -2.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0268
    Cell Significance Index: -5.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0336
    Cell Significance Index: -5.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0499
    Cell Significance Index: -7.2500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0741
    Cell Significance Index: -1.2700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0777
    Cell Significance Index: -0.9000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0822
    Cell Significance Index: -1.1700
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0843
    Cell Significance Index: -0.5300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1011
    Cell Significance Index: -1.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1015
    Cell Significance Index: -4.6000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1146
    Cell Significance Index: -1.5900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1463
    Cell Significance Index: -2.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1593
    Cell Significance Index: -5.5800
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1664
    Cell Significance Index: -2.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1708
    Cell Significance Index: -5.4400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1750
    Cell Significance Index: -5.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2138
    Cell Significance Index: -13.1100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2153
    Cell Significance Index: -5.3700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2158
    Cell Significance Index: -4.5800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2259
    Cell Significance Index: -4.8800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2281
    Cell Significance Index: -4.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2354
    Cell Significance Index: -7.5400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2364
    Cell Significance Index: -4.6800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.2567
    Cell Significance Index: -3.4200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2713
    Cell Significance Index: -5.4100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2733
    Cell Significance Index: -5.3800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2737
    Cell Significance Index: -5.5700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2762
    Cell Significance Index: -10.1400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2779
    Cell Significance Index: -5.8000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2877
    Cell Significance Index: -6.3000
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.3114
    Cell Significance Index: -2.9600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3193
    Cell Significance Index: -5.5200
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.3248
    Cell Significance Index: -4.0900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3466
    Cell Significance Index: -4.3800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3607
    Cell Significance Index: -9.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4148
    Cell Significance Index: -11.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4477
    Cell Significance Index: -9.7000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.4583
    Cell Significance Index: -5.5800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4614
    Cell Significance Index: -7.7600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.4671
    Cell Significance Index: -5.4300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.4690
    Cell Significance Index: -6.0600
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.4694
    Cell Significance Index: -4.9200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.5068
    Cell Significance Index: -8.0400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.5075
    Cell Significance Index: -6.5200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5100
    Cell Significance Index: -7.5300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5186
    Cell Significance Index: -7.7700
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.5269
    Cell Significance Index: -5.0400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5296
    Cell Significance Index: -9.1300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.5364
    Cell Significance Index: -9.1700
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.5383
    Cell Significance Index: -5.8200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.5491
    Cell Significance Index: -7.5400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5637
    Cell Significance Index: -6.7200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.5709
    Cell Significance Index: -5.0300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.5924
    Cell Significance Index: -6.9700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.5975
    Cell Significance Index: -7.1100
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.6054
    Cell Significance Index: -5.6400
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.6076
    Cell Significance Index: -6.6700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.6170
    Cell Significance Index: -10.4800
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.6222
    Cell Significance Index: -7.8800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6248
    Cell Significance Index: -12.9600
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.6294
    Cell Significance Index: -7.8200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.6307
    Cell Significance Index: -7.6500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.6331
    Cell Significance Index: -9.2600
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.6509
    Cell Significance Index: -7.4100
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.6516
    Cell Significance Index: -9.0100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.6649
    Cell Significance Index: -8.7300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.6693
    Cell Significance Index: -7.0600
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.6698
    Cell Significance Index: -8.0800
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.6727
    Cell Significance Index: -8.1300
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.6737
    Cell Significance Index: -8.3000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.6755
    Cell Significance Index: -8.3000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.6797
    Cell Significance Index: -5.6100
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.6812
    Cell Significance Index: -6.8300
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.6837
    Cell Significance Index: -7.5900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.6842
    Cell Significance Index: -7.0800
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.6868
    Cell Significance Index: -7.8000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.6916
    Cell Significance Index: -9.1900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.6939
    Cell Significance Index: -7.0100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.6949
    Cell Significance Index: -7.3800
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.6957
    Cell Significance Index: -8.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene**: HSP90AB3P is a pseudogene, which means it is a non-functional copy of a gene that has evolved to be non-coding. Despite its pseudogenic nature, it exhibits significant expression in various cell types. 2. **Highly expressed cells**: HSP90AB3P is significantly expressed in type A enteroendocrine cells, adventitial cells, mesenchymal stem cells, CD4-positive T cells, alpha-beta thymocytes, skeletal muscle satellite stem cells, lung ciliated cells, leukocytes, malignant cells, and hematopoietic stem cells. 3. **Cellular localization**: HSP90AB3P is localized to the cytosol and perinuclear region of the cytoplasm, suggesting its involvement in protein folding and cellular stress response. **Pathways and Functions:** 1. **ATP-dependent protein folding chaperone**: HSP90AB3P is involved in ATP-dependent protein folding chaperone pathways, which are essential for maintaining protein homeostasis and preventing protein misfolding. 2. **Protein stabilization**: HSP90AB3P plays a role in protein stabilization, which is critical for maintaining the function and structure of proteins. 3. **Unfolded protein binding**: HSP90AB3P binds to unfolded proteins, which is essential for preventing protein aggregation and maintaining cellular homeostasis. 4. **Cytosol and perinuclear region of cytoplasm**: HSP90AB3P is localized to the cytosol and perinuclear region of the cytoplasm, suggesting its involvement in protein folding and cellular stress response. **Clinical Significance:** 1. **Cancer**: HSP90AB3P expression has been identified in various types of cancer, including leukemia, lymphoma, and breast cancer. Its overexpression may contribute to cancer progression and metastasis. 2. **Neurological disorders**: HSP90AB3P expression has been identified in neurological disorders such as Alzheimer's disease and Parkinson's disease. Its involvement in protein folding and cellular stress response may contribute to disease progression. 3. **Infectious diseases**: HSP90AB3P expression has been identified in infectious diseases such as HIV and tuberculosis. Its involvement in protein folding and cellular stress response may contribute to disease progression. 4. **Regenerative medicine**: HSP90AB3P expression has been identified in regenerative medicine applications, including stem cell therapy and tissue engineering. Its involvement in protein folding and cellular stress response may contribute to tissue regeneration and repair. In conclusion, HSP90AB3P, a pseudogene involved in protein folding and cellular stress response, exhibits significant expression in various cell types and plays a crucial role in maintaining cellular homeostasis. Its clinical significance is evident in its involvement in cancer, neurological disorders, infectious diseases, and regenerative medicine applications. Further research is needed to fully understand the functions and significance of HSP90AB3P.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.