Details for: IFNB1

Gene ID: 3456

Symbol: IFNB1

Ensembl ID: ENSG00000171855

Description: interferon beta 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: plasma cell (CL0000786)
    Fold Change: 18.74
    Marker Score: 20931
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 4.76
    Marker Score: 5881
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.66
    Marker Score: 4846
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.43
    Marker Score: 2446
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10817
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.53
    Marker Score: 805
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.41
    Marker Score: 821.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.32
    Marker Score: 838.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7582
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3661
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32733
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.05
    Marker Score: 1000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.02
    Marker Score: 1938
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1
    Marker Score: 766
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71840
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48065
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.96
    Marker Score: 1954
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.87
    Marker Score: 363
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 741
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 404
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 183
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.65
    Marker Score: 394
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.64
    Marker Score: 10048
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.63
    Marker Score: 380
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 483
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 283
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.46
    Marker Score: 121
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.45
    Marker Score: 254
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.4
    Marker Score: 2388
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 217
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 364
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.29
    Marker Score: 137
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.27
    Marker Score: 178
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.17
    Marker Score: 94
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.15
    Marker Score: 66
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.13
    Marker Score: 320
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.12
    Marker Score: 125
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.08
    Marker Score: 238
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.08
    Marker Score: 53
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.06
    Marker Score: 56
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.06
    Marker Score: 49.5
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.05
    Marker Score: 28
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.05
    Marker Score: 98
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.04
    Marker Score: 226
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.03
    Marker Score: 35.5
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.01
    Marker Score: 59
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 22
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.01
    Marker Score: 29
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.01
    Marker Score: 26
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0
    Marker Score: 11
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0
    Marker Score: 12

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Other Information

**Key characteristics:** - IFNB1 is a type I interferon, which are cytokines that are produced by cells of the innate immune system. - It is a highly conserved protein, with a sequence that is found in mammals, birds, and fish. - It is a large protein, with a molecular weight of approximately 140 kDa. - It is a potent activator of the innate immune response. **Pathways and functions:** - IFNB1 binds to receptors on immune cells, including macrophages, dendritic cells, and B cells. - Upon binding, it triggers the activation of the innate immune response pathway. - This pathway leads to the production of other cytokines and chemokines, which attract immune cells to the site of infection. - IFNB1 also has anti-apoptotic properties and can protect cells from death. - It is involved in the regulation of inflammation, tissue repair, and immune responses. **Clinical significance:** - Mutations in the IFNB1 gene have been linked to several human diseases, including cancer, autoimmune disorders, and respiratory infections. - IFNB1 is a potential therapeutic target for these diseases. - Low levels of IFNB1 have been linked to an increased risk of infection and inflammation. **Additional notes:** - IFNB1 is a key regulator of the innate immune response. - It is produced in response to a variety of stimuli, including infection, stress, and tissue damage. - It is a potent activator of the innate immune response pathway. - It is involved in the regulation of inflammation, tissue repair, and immune responses.

Genular Protein ID: 553573350

Symbol: IFNB_HUMAN

Name: N/A

UniProtKB Accession Codes:

P01574 Q5VWC9

Database IDs:

AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 14 Ensembl 1 EvolutionaryTrace 1 GO 36 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 7 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 6157601

Title: The nucleotide sequence of human fibroblast interferon cDNA.

PubMed ID: 6157601

DOI: 10.1016/0378-1119(80)90138-9

PubMed ID: 6157094

Title: Isolation and structure of a human fibroblast interferon gene.

PubMed ID: 6157094

DOI: 10.1038/285542a0

PubMed ID: 6159584

Title: Synthesis of human fibroblast interferon by E. coli.

PubMed ID: 6159584

DOI: 10.1093/nar/8.18.4057

PubMed ID: 6164984

Title: Human fibroblast interferon gene lacks introns.

PubMed ID: 6164984

DOI: 10.1093/nar/9.5.1045

PubMed ID: 16593086

Title: Structure of a chromosomal gene for human interferon beta.

PubMed ID: 16593086

DOI: 10.1073/pnas.78.9.5305

PubMed ID: 6159580

Title: The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase.

PubMed ID: 6159580

DOI: 10.1093/nar/8.13.2885

PubMed ID: 2414376

Title: On the relationship between human interferon alpha 1 and beta 1 genes.

PubMed ID: 2414376

DOI: 10.1089/jir.1985.5.521

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6159597

Title: The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers.

PubMed ID: 6159597

DOI: 10.1093/nar/8.9.1913

PubMed ID: 6171735

Title: A single amino acid change in IFN-beta1 abolishes its antiviral activity.

PubMed ID: 6171735

DOI: 10.1038/294563a0

PubMed ID: 6162107

Title: Assignment of the disulphide bonds of leukocyte interferon.

PubMed ID: 6162107

DOI: 10.1038/289606a0

PubMed ID: 8469318

Title: Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial.

PubMed ID: 8469318

DOI: 10.1212/wnl.43.4.655

PubMed ID: 8469319

Title: Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group.

PubMed ID: 8469319

DOI: 10.1212/wnl.43.4.662

PubMed ID: 7813427

Title: Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN-alpha and IFN-beta.

PubMed ID: 7813427

DOI: 10.1002/j.1460-2075.1994.tb06932.x

PubMed ID: 8027027

Title: Tyrosine phosphorylation of the alpha and beta subunits of the type I interferon receptor. Interferon-beta selectively induces tyrosine phosphorylation of an alpha subunit-associated protein.

PubMed ID: 8027027

DOI: 10.1016/s0021-9258(17)32371-2

PubMed ID: 7665574

Title: Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling.

PubMed ID: 7665574

DOI: 10.1074/jbc.270.37.21606

PubMed ID: 8798579

Title: Differences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptor.

PubMed ID: 8798579

DOI: 10.1074/jbc.271.39.23630

PubMed ID: 8969169

Title: The human type I interferon receptor. Identification of the interferon beta-specific receptor-associated phosphoprotein.

PubMed ID: 8969169

DOI: 10.1074/jbc.271.52.33165

PubMed ID: 9345408

Title: Interferon beta treatment for multiple sclerosis: persisting questions.

PubMed ID: 9345408

DOI: 10.1177/135245859600100605

PubMed ID: 10049744

Title: Formation of a uniquely stable type I interferon receptor complex by interferon beta is dependent upon particular interactions between interferon beta and its receptor and independent of tyrosine phosphorylation.

PubMed ID: 10049744

DOI: 10.1006/bbrc.1998.0105

PubMed ID: 10556041

Title: Mutational and structural analysis of the binding interface between type I interferons and their receptor Ifnar2.

PubMed ID: 10556041

DOI: 10.1006/jmbi.1999.3230

PubMed ID: 9342320

Title: The crystal structure of human interferon beta at 2.2-A resolution.

PubMed ID: 9342320

DOI: 10.1073/pnas.94.22.11813

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 187
  • Mass: 22294
  • Checksum: 0B013D4087723CEC
  • Sequence:
    • MTNKCLLQIA LLLCFSTTAL SMSYNLLGFL QRSSNFQCQK LLWQLNGRLE YCLKDRMNFD 
IPEEIKQLQQ FQKEDAALTI YEMLQNIFAI FRQDSSSTGW NETIVENLLA NVYHQINHLK 
TVLEEKLEKE DFTRGKLMSS LHLKRYYGRI LHYLKAKEYS HCAWTIVRVE ILRNFYFINR 
LTGYLRN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.