Details for: IFNGR2

Gene ID: 3460

Symbol: IFNGR2

Ensembl ID: ENSG00000159128

Description: interferon gamma receptor 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 4.6
    Marker Score: 3243
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 3.37
    Marker Score: 13994.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.02
    Marker Score: 168673
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.92
    Marker Score: 3634
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.84
    Marker Score: 2236
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 2.55
    Marker Score: 1549
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.54
    Marker Score: 1481
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.48
    Marker Score: 6051.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.16
    Marker Score: 2476
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.12
    Marker Score: 4127
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.05
    Marker Score: 7918
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.04
    Marker Score: 8791
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.94
    Marker Score: 2862
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.91
    Marker Score: 4753
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.88
    Marker Score: 25218
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.85
    Marker Score: 1115
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.83
    Marker Score: 1722
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.81
    Marker Score: 1781
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.78
    Marker Score: 7450
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.77
    Marker Score: 3894.5
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.76
    Marker Score: 3117
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.72
    Marker Score: 3635.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.72
    Marker Score: 44014
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.71
    Marker Score: 10407.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.71
    Marker Score: 940
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.7
    Marker Score: 615.5
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.7
    Marker Score: 482
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.66
    Marker Score: 588
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.66
    Marker Score: 1526
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.64
    Marker Score: 1984.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.61
    Marker Score: 2646
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.61
    Marker Score: 3889
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.6
    Marker Score: 3350
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.59
    Marker Score: 890
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.57
    Marker Score: 1571.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.56
    Marker Score: 53211
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.56
    Marker Score: 9945
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.55
    Marker Score: 2084
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.54
    Marker Score: 548
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.54
    Marker Score: 2683
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.51
    Marker Score: 5598
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.51
    Marker Score: 347
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.5
    Marker Score: 3890
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.49
    Marker Score: 362
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.49
    Marker Score: 3371
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.48
    Marker Score: 720
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.46
    Marker Score: 1307
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.46
    Marker Score: 889
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.45
    Marker Score: 12469
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.44
    Marker Score: 717
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.43
    Marker Score: 495
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.42
    Marker Score: 4451
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.42
    Marker Score: 830
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.41
    Marker Score: 13362
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.39
    Marker Score: 9021
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.38
    Marker Score: 822
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.35
    Marker Score: 1583
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.35
    Marker Score: 6471
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.35
    Marker Score: 561
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.34
    Marker Score: 1426
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.33
    Marker Score: 517
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.33
    Marker Score: 10356.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.32
    Marker Score: 12438
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.32
    Marker Score: 728
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.32
    Marker Score: 48638
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3
    Marker Score: 1370
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.3
    Marker Score: 531
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3
    Marker Score: 79661
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.29
    Marker Score: 25567
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.28
    Marker Score: 1385
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.28
    Marker Score: 853.5
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.28
    Marker Score: 891
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.27
    Marker Score: 28457
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.27
    Marker Score: 725
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.27
    Marker Score: 463
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.27
    Marker Score: 958
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.27
    Marker Score: 18925
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.27
    Marker Score: 1953
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.26
    Marker Score: 866
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.25
    Marker Score: 47513
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.25
    Marker Score: 395
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.24
    Marker Score: 722
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.24
    Marker Score: 723
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.23
    Marker Score: 14280
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.23
    Marker Score: 808
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.21
    Marker Score: 4693
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.21
    Marker Score: 602
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.21
    Marker Score: 6350
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.2
    Marker Score: 1066
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.2
    Marker Score: 1383
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.2
    Marker Score: 579
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.19
    Marker Score: 1216.5
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.19
    Marker Score: 4231
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.18
    Marker Score: 636
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.18
    Marker Score: 1423
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.18
    Marker Score: 380
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.18
    Marker Score: 1990
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.17
    Marker Score: 399
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.17
    Marker Score: 3470
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.17
    Marker Score: 15405

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Other Information

**Key characteristics**: * The IFNGR2 gene is located on chromosome 15q21.1. * It is a member of the interferon gamma receptor family. * It is expressed on a variety of cell types, including monocytes, macrophages, dendritic cells, and epithelial cells. * It is a highly expressed protein in the lungs, where it is expressed on dendritic cells and macrophages. **Pathways and functions**: * IFNGR2 is a key regulator of the immune response to viral infection. * It binds to type I interferons, which are produced by infected cells. * Binding to type I interferons triggers the activation of the IFNGR2 receptor, which leads to the phosphorylation of the intracellular signaling proteins STAT1 and STAT3. * STAT1 and STAT3 then translocate to the nucleus, where they regulate the expression of antiviral proteins and the activation of immune cells. **Clinical significance**: * Mutations in the IFNGR2 gene have been linked to an increased risk of certain viral infections, such as influenza and HIV. * As a result, IFNGR2 is a potential therapeutic target for the treatment of viral infections. * In clinical trials, inhibitors of the IFNGR2 receptor have shown some effectiveness in protecting against viral infection.

Genular Protein ID: 3612064533

Symbol: INGR2_HUMAN

Name: N/A

UniProtKB Accession Codes:

P38484 Q9BTL5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 4 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8124716

Title: Identification and sequence of an accessory factor required for activation of the human interferon gamma receptor.

PubMed ID: 8124716

DOI: 10.1016/0092-8674(94)90354-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8910544

Title: The structure of the gene for the second chain of the human interferon gamma receptor.

PubMed ID: 8910544

DOI: 10.1074/jbc.271.46.28947

PubMed ID: 7615558

Title: The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors.

PubMed ID: 7615558

DOI: 10.1074/jbc.270.29.17528

PubMed ID: 7673114

Title: Interaction between the components of the interferon gamma receptor complex.

PubMed ID: 7673114

DOI: 10.1074/jbc.270.36.20915

PubMed ID: 10605012

Title: Surface expression of the IFN-gamma R2 chain is regulated by intracellular trafficking in human T lymphocytes.

PubMed ID: 10605012

DOI: 10.4049/jimmunol.164.1.201

PubMed ID: 15356148

Title: Characterization of a dipeptide motif regulating IFN-gamma receptor 2 plasma membrane accumulation and IFN-gamma responsiveness.

PubMed ID: 15356148

DOI: 10.4049/jimmunol.173.6.3991

PubMed ID: 27599734

Title: Crystal structure of human interferon-gamma receptor 2 reveals the structural basis for receptor specificity.

PubMed ID: 27599734

DOI: 10.1107/s2059798316012237

PubMed ID: 10608793

Title: Partial interferon-gamma receptor signaling chain deficiency in a patient with bacille Calmette-Guerin and Mycobacterium abscessus infection.

PubMed ID: 10608793

DOI: 10.1086/315197

PubMed ID: 15924140

Title: Gains of glycosylation comprise an unexpectedly large group of pathogenic mutations.

PubMed ID: 15924140

DOI: 10.1038/ng1581

PubMed ID: 22902943

Title: Severe disseminated mycobacterial infection in a boy with a novel mutation leading to IFN-gammaR2 deficiency.

PubMed ID: 22902943

DOI: 10.1016/j.jinf.2012.08.008

PubMed ID: 23963039

Title: Partial IFN-gammaR2 deficiency is due to protein misfolding and can be rescued by inhibitors of glycosylation.

PubMed ID: 23963039

DOI: 10.1182/blood-2013-01-480814

Sequence Information:

  • Length: 337
  • Mass: 37806
  • Checksum: 18C68BAF7D91B8AA
  • Sequence:
    • MRPTLLWSLL LLLGVFAAAA AAPPDPLSQL PAPQHPKIRL YNAEQVLSWE PVALSNSTRP 
VVYQVQFKYT DSKWFTADIM SIGVNCTQIT ATECDFTAAS PSAGFPMDFN VTLRLRAELG 
ALHSAWVTMP WFQHYRNVTV GPPENIEVTP GEGSLIIRFS SPFDIADTST AFFCYYVHYW 
EKGGIQQVKG PFRSNSISLD NLKPSRVYCL QVQAQLLWNK SNIFRVGHLS NISCYETMAD 
ASTELQQVIL ISVGTFSLLS VLAGACFFLV LKYRGLIKYW FHTPPSIPLQ IEEYLKDPTQ 
PILEALDKDS SPKDDVWDSV SIISFPEKEQ EDVLQTL

Genular Protein ID: 3566168157

Symbol: E7EUY1_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7EUY1

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 ChiTaRS 1 DNASU 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 2 PhylomeDB 1 Proteomes 2 RefSeq 1 SAM 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

Sequence Information:

  • Length: 356
  • Mass: 39970
  • Checksum: F18F2FF4A0A29162
  • Sequence:
    • MRPTLLWSLL LLLGVFAAAA AAPPAQLTLE TYQEWCNDSA ATHDPLSQLP APQHPKIRLY 
NAEQVLSWEP VALSNSTRPV VYQVQFKYTD SKWFTADIMS IGVNCTQITA TECDFTAASP 
SAGFPMDFNV TLRLRAELGA LHSAWVTMPW FQHYRNVTVG PPENIEVTPG EGSLIIRFSS 
PFDIADTSTA FFCYYVHYWE KGGIQQVKGP FRSNSISLDN LKPSRVYCLQ VQAQLLWNKS 
NIFRVGHLSN ISCYETMADA STELQQVILI SVGTFSLLSV LAGACFFLVL KYRGLIKYWF 
HTPPSIPLQI EEYLKDPTQP ILEALDKDSS PKDDVWDSVS IISFPEKEQE DVLQTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.