Details for: LINC00442

Gene ID: 348021

Symbol: LINC00442

Ensembl ID: ENSG00000232685

Description: long intergenic non-protein coding RNA 442

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7311
    Cell Significance Index: 17.7100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2744
    Cell Significance Index: 4.0000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.0783
    Cell Significance Index: 0.8000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.0728
    Cell Significance Index: 0.9500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0545
    Cell Significance Index: 0.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0344
    Cell Significance Index: 0.9400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0321
    Cell Significance Index: 0.3900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0227
    Cell Significance Index: 0.2200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0099
    Cell Significance Index: 0.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0090
    Cell Significance Index: 0.2400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0080
    Cell Significance Index: 0.3300
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.0042
    Cell Significance Index: 0.0500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0037
    Cell Significance Index: 0.0800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: -0.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0000
    Cell Significance Index: -0.0500
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0002
    Cell Significance Index: -0.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0004
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0006
    Cell Significance Index: -0.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0008
    Cell Significance Index: -0.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0012
    Cell Significance Index: -0.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0012
    Cell Significance Index: -0.1800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0033
    Cell Significance Index: -0.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0037
    Cell Significance Index: -0.2100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0041
    Cell Significance Index: -0.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0045
    Cell Significance Index: -0.2000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0047
    Cell Significance Index: -0.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0053
    Cell Significance Index: -0.1700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0056
    Cell Significance Index: -0.1400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0057
    Cell Significance Index: -0.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0075
    Cell Significance Index: -0.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0088
    Cell Significance Index: -0.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0099
    Cell Significance Index: -0.2100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0100
    Cell Significance Index: -0.2000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0109
    Cell Significance Index: -0.1000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0111
    Cell Significance Index: -0.2200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0116
    Cell Significance Index: -0.2000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0119
    Cell Significance Index: -0.1600
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0122
    Cell Significance Index: -0.1200
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0126
    Cell Significance Index: -0.1200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0129
    Cell Significance Index: -0.1800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0133
    Cell Significance Index: -0.1900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0136
    Cell Significance Index: -0.1700
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0138
    Cell Significance Index: -0.1600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0139
    Cell Significance Index: -0.2000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0144
    Cell Significance Index: -0.1700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0144
    Cell Significance Index: -0.1900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0148
    Cell Significance Index: -0.1900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0149
    Cell Significance Index: -0.1300
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0150
    Cell Significance Index: -0.2000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0151
    Cell Significance Index: -0.2000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0152
    Cell Significance Index: -0.1800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0152
    Cell Significance Index: -0.2000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0153
    Cell Significance Index: -0.1700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0156
    Cell Significance Index: -0.1900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0159
    Cell Significance Index: -0.1900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0161
    Cell Significance Index: -0.2000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0163
    Cell Significance Index: -0.2000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0163
    Cell Significance Index: -0.1900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0164
    Cell Significance Index: -0.1900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0164
    Cell Significance Index: -0.2000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0167
    Cell Significance Index: -0.1900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0168
    Cell Significance Index: -0.1700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0170
    Cell Significance Index: -0.2000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0170
    Cell Significance Index: -0.1900
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0172
    Cell Significance Index: -0.2000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0176
    Cell Significance Index: -0.2100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0182
    Cell Significance Index: -0.2100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0185
    Cell Significance Index: -0.2200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0189
    Cell Significance Index: -0.1900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0190
    Cell Significance Index: -0.2000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0190
    Cell Significance Index: -0.2100
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0191
    Cell Significance Index: -0.2300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0192
    Cell Significance Index: -0.2200
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0192
    Cell Significance Index: -0.1800
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0193
    Cell Significance Index: -0.2100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0196
    Cell Significance Index: -0.2100
  • Cell Name: kidney interstitial alternatively activated macrophage (CL1000695)
    Fold Change: -0.0196
    Cell Significance Index: -0.2000
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: -0.0201
    Cell Significance Index: -0.2200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0202
    Cell Significance Index: -0.2100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0202
    Cell Significance Index: -0.1900
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0202
    Cell Significance Index: -0.2400
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0203
    Cell Significance Index: -0.2100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0206
    Cell Significance Index: -0.2100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0208
    Cell Significance Index: -0.1700
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0209
    Cell Significance Index: -0.2200
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0209
    Cell Significance Index: -0.1900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0211
    Cell Significance Index: -0.2000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0211
    Cell Significance Index: -0.2000
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0212
    Cell Significance Index: -0.2300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0214
    Cell Significance Index: -0.2000
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.0215
    Cell Significance Index: -0.2200
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0222
    Cell Significance Index: -0.2000
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0230
    Cell Significance Index: -0.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell type specificity**: LINC00442 is predominantly expressed in cells of the immune system, including neutrophils, lymphoid lineage-restricted progenitor cells, and B cells, highlighting its role in immune cell development and function. 2. **Non-coding nature**: Despite its significant expression, LINC00442 lacks a coding potential, suggesting its involvement in regulating gene expression through RNA-mediated mechanisms. 3. **Interactions with chromatin**: LINC00442 has been shown to interact with chromatin, influencing the accessibility of transcription factors to target gene promoters, thereby modulating gene expression. 4. **Regulation of cellular differentiation**: LINC00442 has been implicated in regulating the differentiation of immune cells, including the development of neutrophils and B cells. **Pathways and Functions:** 1. **Immune cell development and function**: LINC00442 regulates the expression of genes involved in immune cell development, proliferation, and differentiation, including the Notch signaling pathway. 2. **Chromatin remodeling**: LINC00442 interacts with chromatin to modulate the accessibility of transcription factors, influencing the expression of target genes involved in immune responses and tissue homeostasis. 3. **Cellular differentiation**: LINC00442 regulates the expression of genes involved in cellular differentiation, including the development of immune cells and the maintenance of tissue homeostasis. 4. **Regulation of gene expression**: LINC00442 modulates the expression of target genes through RNA-mediated mechanisms, influencing the transcriptional landscape of immune cells and tissues. **Clinical Significance:** 1. **Immunological diseases**: Dysregulation of LINC00442 has been implicated in various immunological diseases, including autoimmune disorders, such as rheumatoid arthritis and lupus, as well as inflammatory conditions, such as atherosclerosis and asthma. 2. **Cancer**: LINC00442 has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma, suggesting its potential as a biomarker for cancer diagnosis and prognosis. 3. **Tissue repair and regeneration**: LINC00442 has been implicated in the regulation of tissue repair and regeneration, highlighting its potential as a therapeutic target for tissue repair and regeneration disorders. 4. **Infectious diseases**: LINC00442 has been shown to play a role in the regulation of the immune response to infectious diseases, including the development of vaccines and the treatment of infectious diseases. In conclusion, LINC00442 is a multifaceted lincRNA that plays a critical role in regulating immune responses, tissue homeostasis, and cellular differentiation. Further research is needed to fully elucidate the mechanisms by which LINC00442 modulates gene expression and to explore its potential as a therapeutic target for various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.