Details for: EIF3EP1

Gene ID: 3647

Symbol: EIF3EP1

Ensembl ID: ENSG00000234882

Description: EIF3E pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2083
    Cell Significance Index: 4.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1917
    Cell Significance Index: 2.6200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.1781
    Cell Significance Index: 1.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1234
    Cell Significance Index: 3.3600
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.1199
    Cell Significance Index: 1.4300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0278
    Cell Significance Index: 0.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0205
    Cell Significance Index: 1.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0073
    Cell Significance Index: -1.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0209
    Cell Significance Index: -3.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0272
    Cell Significance Index: -3.1200
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0378
    Cell Significance Index: -0.4200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0387
    Cell Significance Index: -0.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0506
    Cell Significance Index: -2.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0637
    Cell Significance Index: -1.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1310
    Cell Significance Index: -3.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1501
    Cell Significance Index: -9.2000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1526
    Cell Significance Index: -1.5800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1610
    Cell Significance Index: -4.1000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1685
    Cell Significance Index: -5.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1733
    Cell Significance Index: -7.8600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1749
    Cell Significance Index: -6.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1750
    Cell Significance Index: -8.1600
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.2115
    Cell Significance Index: -2.9700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.2181
    Cell Significance Index: -2.7600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2237
    Cell Significance Index: -2.6800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2273
    Cell Significance Index: -3.2400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2367
    Cell Significance Index: -4.0800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2411
    Cell Significance Index: -3.8300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2528
    Cell Significance Index: -3.1900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2658
    Cell Significance Index: -4.4700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2857
    Cell Significance Index: -7.1400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3007
    Cell Significance Index: -4.1700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3065
    Cell Significance Index: -5.2400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.3161
    Cell Significance Index: -4.2100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3417
    Cell Significance Index: -4.4800
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.3487
    Cell Significance Index: -3.9700
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.3496
    Cell Significance Index: -3.9700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3511
    Cell Significance Index: -5.0500
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.3518
    Cell Significance Index: -4.5100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3562
    Cell Significance Index: -6.0500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.3597
    Cell Significance Index: -4.2800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.3630
    Cell Significance Index: -4.5600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.3663
    Cell Significance Index: -3.0300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.3747
    Cell Significance Index: -5.4800
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3761
    Cell Significance Index: -4.1600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.3781
    Cell Significance Index: -2.2400
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.3792
    Cell Significance Index: -4.2100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.3890
    Cell Significance Index: -5.0100
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.3918
    Cell Significance Index: -5.3800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.3920
    Cell Significance Index: -4.7000
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.3923
    Cell Significance Index: -4.5600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.3993
    Cell Significance Index: -4.8400
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.4008
    Cell Significance Index: -4.3500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.4024
    Cell Significance Index: -5.1700
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.4024
    Cell Significance Index: -5.0700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.4060
    Cell Significance Index: -5.1300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.4098
    Cell Significance Index: -4.3600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.4116
    Cell Significance Index: -5.4700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.4127
    Cell Significance Index: -5.0200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.4148
    Cell Significance Index: -4.1900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.4149
    Cell Significance Index: -5.4600
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.4154
    Cell Significance Index: -4.8100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.4193
    Cell Significance Index: -4.9300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.4208
    Cell Significance Index: -5.2700
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.4260
    Cell Significance Index: -5.4000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.4264
    Cell Significance Index: -4.8800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4270
    Cell Significance Index: -5.0900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.4274
    Cell Significance Index: -5.5900
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.4315
    Cell Significance Index: -4.9500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.4365
    Cell Significance Index: -4.7800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.4366
    Cell Significance Index: -5.7000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.4397
    Cell Significance Index: -4.6700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.4423
    Cell Significance Index: -5.1300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.4442
    Cell Significance Index: -5.4600
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.4445
    Cell Significance Index: -4.8700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.4462
    Cell Significance Index: -5.3200
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.4480
    Cell Significance Index: -5.4500
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: -0.4484
    Cell Significance Index: -4.9000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.4484
    Cell Significance Index: -5.0100
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.4487
    Cell Significance Index: -5.6300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.4490
    Cell Significance Index: -5.0600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.4500
    Cell Significance Index: -5.4700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.4502
    Cell Significance Index: -5.2300
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.4517
    Cell Significance Index: -4.2900
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.4519
    Cell Significance Index: -5.2800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.4527
    Cell Significance Index: -5.3500
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.4555
    Cell Significance Index: -4.1200
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.4572
    Cell Significance Index: -4.9300
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.4584
    Cell Significance Index: -4.9700
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.4590
    Cell Significance Index: -5.7300
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.4609
    Cell Significance Index: -5.5600
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.4627
    Cell Significance Index: -4.8500
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.4635
    Cell Significance Index: -4.8700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.4644
    Cell Significance Index: -5.0600
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.4651
    Cell Significance Index: -4.2000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.4654
    Cell Significance Index: -4.9900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.4671
    Cell Significance Index: -4.7400
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.4710
    Cell Significance Index: -5.1700
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.4716
    Cell Significance Index: -4.6800
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.4751
    Cell Significance Index: -4.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EIF3EP1 is a pseudogene, meaning it lacks the ability to encode a functional protein. However, its expression is not limited to its typical pseudogene expression patterns, as it is significantly expressed in a range of cell types, including astrocytes, T cells, and stem cells. This widespread expression suggests that EIF3EP1 may play a role in regulating cellular processes beyond its pseudogene status. **Pathways and Functions:** The exact mechanisms by which EIF3EP1 influences cellular processes remain unclear. However, its expression in immune cells, such as T cells and hematopoietic stem cells, suggests that it may be involved in the regulation of immune responses. Additionally, EIF3EP1's expression in neural cells, including GABAergic neurons and inhibitory interneurons, implies that it may also play a role in the development and function of the nervous system. Several potential pathways have been proposed to explain EIF3EP1's functions, including: 1. **Regulation of gene expression**: EIF3EP1 may act as a transcriptional regulator, influencing the expression of other genes involved in immune response and development. 2. **Modulation of cell signaling**: EIF3EP1 may interact with signaling pathways, such as the PI3K/AKT pathway, to regulate cell survival, proliferation, and differentiation. 3. **Influence on epigenetic marks**: EIF3EP1 may contribute to the establishment and maintenance of epigenetic marks, which are crucial for gene expression regulation. **Clinical Significance:** The clinical significance of EIF3EP1 is still being explored, but its expression in various cell types suggests that it may be involved in the development and progression of diseases. Some potential clinical implications of EIF3EP1 include: 1. **Autoimmune diseases**: EIF3EP1's expression in immune cells may contribute to the development of autoimmune diseases, such as multiple sclerosis and type 1 diabetes. 2. **Cancer**: EIF3EP1's expression in stem cells and cancer cells may contribute to cancer progression and metastasis. 3. **Neurological disorders**: EIF3EP1's expression in neural cells may contribute to the development and progression of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, EIF3EP1 is a complex gene with widespread expression across various cell types. While its exact functions and mechanisms are still unclear, its clinical significance suggests that it may play a role in regulating immune responses, cell signaling, and epigenetic marks. Further research is necessary to fully elucidate the role of EIF3EP1 in human disease and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.