Details for: ITPR2

Gene ID: 3709

Symbol: ITPR2

Ensembl ID: ENSG00000123104

Description: inositol 1,4,5-trisphosphate receptor type 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 5.56
    Marker Score: 2011
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 5.12
    Marker Score: 16769
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 3.84
    Marker Score: 2526
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.64
    Marker Score: 4124
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3.57
    Marker Score: 1777
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.43
    Marker Score: 60937
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 3.25
    Marker Score: 1712
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 3.24
    Marker Score: 2493
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.2
    Marker Score: 5829
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.16
    Marker Score: 67405
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 3.14
    Marker Score: 2183
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 3.01
    Marker Score: 1101
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.94
    Marker Score: 5664
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.74
    Marker Score: 3159
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.64
    Marker Score: 1474
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.63
    Marker Score: 2335
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.48
    Marker Score: 2150
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.44
    Marker Score: 714
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.44
    Marker Score: 2003
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.22
    Marker Score: 5948
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.2
    Marker Score: 2721
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.1
    Marker Score: 7458.5
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.04
    Marker Score: 2139
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.04
    Marker Score: 4639
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.03
    Marker Score: 1940
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.03
    Marker Score: 2244
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2
    Marker Score: 1164
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.89
    Marker Score: 30330
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.86
    Marker Score: 10015
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.83
    Marker Score: 799
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.82
    Marker Score: 4561
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.8
    Marker Score: 614
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.8
    Marker Score: 1273
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.8
    Marker Score: 756
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.78
    Marker Score: 671
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.77
    Marker Score: 2377
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.76
    Marker Score: 11317
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.74
    Marker Score: 6186
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.74
    Marker Score: 649.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.73
    Marker Score: 806
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.7
    Marker Score: 38088
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.67
    Marker Score: 2763
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.67
    Marker Score: 15666
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.66
    Marker Score: 2008
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.65
    Marker Score: 523
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.64
    Marker Score: 7072
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.61
    Marker Score: 6720
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.6
    Marker Score: 515
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.59
    Marker Score: 2310
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.59
    Marker Score: 3742
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.58
    Marker Score: 1037
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.57
    Marker Score: 761
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.55
    Marker Score: 1670
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.53
    Marker Score: 2161
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.51
    Marker Score: 3626
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.51
    Marker Score: 1616
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.5
    Marker Score: 898
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.5
    Marker Score: 410
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.47
    Marker Score: 820
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.45
    Marker Score: 6012
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.44
    Marker Score: 2558
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.44
    Marker Score: 1439.5
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.44
    Marker Score: 378.5
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.43
    Marker Score: 877
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.43
    Marker Score: 12273
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.43
    Marker Score: 1447
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.42
    Marker Score: 516
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.41
    Marker Score: 576
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.39
    Marker Score: 1681
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.37
    Marker Score: 1656
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.37
    Marker Score: 50418
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.36
    Marker Score: 2104
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.36
    Marker Score: 2989
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.35
    Marker Score: 809
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.34
    Marker Score: 420
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.34
    Marker Score: 2724
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.33
    Marker Score: 50577
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.32
    Marker Score: 20602
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.31
    Marker Score: 14755
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.31
    Marker Score: 12424
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.29
    Marker Score: 12976
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.27
    Marker Score: 13161
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.27
    Marker Score: 409
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.27
    Marker Score: 1346
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.26
    Marker Score: 1307
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.25
    Marker Score: 414
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.25
    Marker Score: 1433
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.25
    Marker Score: 6690
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.24
    Marker Score: 3133
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.24
    Marker Score: 1316
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.24
    Marker Score: 1752
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.23
    Marker Score: 313
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.23
    Marker Score: 318
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.21
    Marker Score: 656
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.2
    Marker Score: 679
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.2
    Marker Score: 818
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.19
    Marker Score: 495
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.18
    Marker Score: 3222
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.18
    Marker Score: 1307
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.16
    Marker Score: 346

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Other Information

**Key characteristics:** * ITPR2 is a transmembrane protein with a molecular weight of approximately 140 kDa. * It is a type I transmembrane receptor, meaning that it has a single extracellular domain and a single transmembrane domain. * ITPR2 is expressed on a variety of cell types, including immune cells, endothelial cells, and cancer cells. * It is a highly conserved protein, with a similar sequence in mammals, birds, and reptiles. * ITPR2 is a ligand-gated ion channel, which means that it opens or closes in response to the binding of a specific ligand. **Pathways and functions:** * ITPR2 is a key receptor for sphingosine-1-phosphate (S1P), a lipid molecule that is involved in various cellular processes, including immune responses. * S1P is produced by activated platelets and macrophages, and it binds to ITPR2 on endothelial cells and immune cells. * This binding activates ITPR2, which leads to the opening of the ion channel and the influx of calcium ions. * Calcium ions activate a variety of intracellular signaling pathways, including the phospholipase C (PLC)/inositol 1,4,5-trisphosphate (IP3) pathway, the JAK/STAT signaling pathway, and the MAPK pathway. * These pathways regulate a wide range of cellular processes, including cell migration, differentiation, and proliferation. **Clinical significance:** ITPR2 mutations have been linked to several human diseases, including asthma, rheumatoid arthritis, and cancer. In asthma, ITPR2 mutations can lead to the production of a mutated form of S1P that is unable to bind to ITPR2 on endothelial cells. This leads to the formation of blood clots and the development of asthma symptoms. In rheumatoid arthritis, ITPR2 mutations can lead to the activation of the JAK/STAT signaling pathway, which is involved in the pathogenesis of rheumatoid arthritis. This leads to the production of inflammatory cytokines and the destruction of joint tissue. In cancer, ITPR2 mutations can promote tumor growth and metastasis. This is because ITPR2 is expressed on cancer cells, and its activation by S1P promotes cell migration, invasion, and angiogenesis.

Genular Protein ID: 3183447471

Symbol: ITPR2_HUMAN

Name: Inositol 1,4,5-trisphosphate receptor type 2

UniProtKB Accession Codes:

Q14571 O94773

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 7 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 23 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 14 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8081734

Title: Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors.

PubMed ID: 8081734

PubMed ID: 9729462

Title: Muscle-specific mRNA isoform encodes a protein composed mainly of the N-terminal 175 residues of type 2 Ins(1,4,5)P3 receptor.

PubMed ID: 9729462

DOI: 10.1042/bj3340559

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 12032348

Title: Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels.

PubMed ID: 12032348

DOI: 10.1073/pnas.102006299

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25329695

Title: Abolished InsP3R2 function inhibits sweat secretion in both humans and mice.

PubMed ID: 25329695

DOI: 10.1172/jci70720

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27995898

Title: IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact.

PubMed ID: 27995898

DOI: 10.7554/elife.19896

Sequence Information:

  • Length: 2701
  • Mass: 308064
  • Checksum: 373BA20228A159BC
  • Sequence:
    • MTEKMSSFLY IGDIVSLYAE GSVNGFISTL GLVDDRCVVH PEAGDLANPP KKFRDCLFKV 
CPMNRYSAQK QYWKAKQAKQ GNHTEAALLK KLQHAAELEQ KQNESENKKL LGEIVKYSNV 
IQLLHIKSNK YLTVNKRLPA LLEKNAMRVS LDAAGNEGSW FYIHPFWKLR SEGDNIVVGD 
KVVLMPVNAG QPLHASNIEL LDNPGCKEVN AVNCNTSWKI TLFMKYSSYR EDVLKGGDVV 
RLFHAEQEKF LTCDEYEKKQ HIFLRTTLRQ SATSATSSKA LWEIEVVHHD PCRGGAGQWN 
SLFRFKHLAT GNYLAAELNP DYRDAQNEGK NVRDGVPPTS KKKRQAGEKI MYTLVSVPHG 
NDIASLFELD ATTLQRADCL VPRNSYVRLR HLCTNTWVTS TSIPIDTDEE RPVMLKIGTC 
QTKEDKEAFA IVSVPLSEVR DLDFANDANK VLATTVKKLE NGTITQNERR FVTKLLEDLI 
FFVADVPNNG QEVLDVVITK PNRERQKLMR EQNILAQVFG ILKAPFKEKA GEGSMLRLED 
LGDQRYAPYK YMLRLCYRVL RHSQQDYRKN QEYIAKNFCV MQSQIGYDIL AEDTITALLH 
NNRKLLEKHI TAKEIETFVS LLRRNREPRF LDYLSDLCVS NTTAIPVTQE LICKFMLSPG 
NADILIQTKV VSMQADNPME SSILSDDIDD EEVWLYWIDS NKEPHGKAIR HLAQEAKEGT 
KADLEVLTYY RYQLNLFARM CLDRQYLAIN QISTQLSVDL ILRCVSDESL PFDLRASFCR 
LMLHMHVDRD PQESVVPVRY ARLWTEIPTK ITIHEYDSIT DSSRNDMKRK FALTMEFVEE 
YLKEVVNQPF PFGDKEKNKL TFEVVHLARN LIYFGFYSFS ELLRLTRTLL AILDIVQAPM 
SSYFERLSKF QDGGNNVMRT IHGVGEMMTQ MVLSRGSIFP MSVPDVPPSI HPSKQGSPTE 
HEDVTVMDTK LKIIEILQFI LSVRLDYRIS YMLSIYKKEF GEDNDNAETS ASGSPDTLLP 
SAIVPDIDEI AAQAETMFAG RKEKNPVQLD DEGGRTFLRV LIHLIMHDYP PLLSGALQLL 
FKHFSQRAEV LQAFKQVQLL VSNQDVDNYK QIKADLDQLR LTVEKSELWV EKSSNYENGE 
IGESQVKGGE EPIEESNILS PVQDGTKKPQ IDSNKSNNYR IVKEILIRLS KLCVQNKKCR 
NQHQRLLKNM GAHSVVLDLL QIPYEKNDEK MNEVMNLAHT FLQNFCRGNP QNQVLLHKHL 
NLFLTPGLLE AETMRHIFMN NYHLCNEISE RVVQHFVHCI ETHGRHVEYL RFLQTIVKAD 
GKYVKKCQDM VMTELINGGE DVLIFYNDRA SFPILLHMMC SERDRGDESG PLAYHITLVE 
LLAACTEGKN VYTEIKCNSL LPLDDIVRVV THDDCIPEVK IAYVNFVNHC YVDTEVEMKE 
IYTSNHIWKL FENFLVDMAR VCNTTTDRKH ADIFLEKCVT ESIMNIVSGF FNSPFSDNST 
SLQTHQPVFI QLLQSAFRIY NCTWPNPAQK ASVESCIRTL AEVAKNRGIA IPVDLDSQVN 
TLFMKSHSNM VQRAAMGWRL SARSGPRFKE ALGGPAWDYR NIIEKLQDVV ASLEHQFSPM 
MQAEFSVLVD VLYSPELLFP EGSDARIRCG AFMSKLINHT KKLMEKEEKL CIKILQTLRE 
MLEKKDSFVE EGNTLRKILL NRYFKGDYSI GVNGHLSGAY SKTAQVGGSF SGQDSDKMGI 
SMSDIQCLLD KEGASELVID VIVNTKNDRI FSEGIFLGIA LLEGGNTQTQ YSFYQQLHEQ 
KKSEKFFKVL YDRMKAAQKE IRSTVTVNTI DLGNKKRDDD NELMTSGPRM RVRDSTLHLK 
EGMKGQLTEA SSATSKAYCV YRREMDPEID IMCTGPEAGN TEEKSAEEVT MSPAIAIMQP 
ILRFLQLLCE NHNRELQNFL RNQNNKTNYN LVCETLQFLD CICGSTTGGL GLLGLYINEK 
NVALVNQNLE SLTEYCQGPC HENQTCIATH ESNGIDIIIA LILNDINPLG KYRMDLVLQL 
KNNASKLLLA IMESRHDSEN AERILFNMRP RELVDVMKNA YNQGLECDHG DDEGGDDGVS 
PKDVGHNIYI LAHQLARHNK LLQQMLKPGS DPDEGDEALK YYANHTAQIE IVRHDRTMEQ 
IVFPVPNICE YLTRESKCRV FNTTERDEQG SKVNDFFQQT EDLYNEMKWQ KKIRNNPALF 
WFSRHISLWG SISFNLAVFI NLAVALFYPF GDDGDEGTLS PLFSVLLWIA VAICTSMLFF 
FSKPVGIRPF LVSIMLRSIY TIGLGPTLIL LGAANLCNKI VFLVSFVGNR GTFTRGYRAV 
ILDMAFLYHV AYVLVCMLGL FVHEFFYSFL LFDLVYREET LLNVIKSVTR NGRSIILTAV 
LALILVYLFS IIGFLFLKDD FTMEVDRLKN RTPVTGSHQV PTMTLTTMME ACAKENCSPT 
IPASNTADEE YEDGIERTCD TLLMCIVTVL NQGLRNGGGV GDVLRRPSKD EPLFAARVVY 
DLLFYFIVII IVLNLIFGVI IDTFADLRSE KQKKEEILKT TCFICGLERD KFDNKTVSFE 
EHIKSEHNMW HYLYFIVLVK VKDPTEYTGP ESYVAQMIVE KNLDWFPRMR AMSLVSNEGD 
SEQNEIRSLQ EKLESTMSLV KQLSGQLAEL KEQMTEQRKN KQRLGFLGSN TPHVNHHMPP 
H

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.