Details for: KCNJ9

Gene ID: 3765

Symbol: KCNJ9

Ensembl ID: ENSG00000162728

Description: potassium inwardly rectifying channel subfamily J member 9

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.47
    Marker Score: 2481.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.63
    Marker Score: 1627
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1179
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.19
    Marker Score: 494
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.19
    Marker Score: 2455
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.16
    Marker Score: 787.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4822
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.12
    Marker Score: 10644
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.11
    Marker Score: 9568
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.11
    Marker Score: 509.5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.08
    Marker Score: 1208
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.05
    Marker Score: 1617
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.03
    Marker Score: 63357
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 515.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71830.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48054
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 469
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.95
    Marker Score: 380
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.93
    Marker Score: 8750
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 331
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2744
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 494
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 403
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 468.5
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.7
    Marker Score: 1116
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.65
    Marker Score: 520
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.63
    Marker Score: 2631
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.63
    Marker Score: 2446
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.62
    Marker Score: 22927
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.61
    Marker Score: 9138
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.6
    Marker Score: 2447
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.58
    Marker Score: 22024
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.57
    Marker Score: 537.5
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 177
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.55
    Marker Score: 4241
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.55
    Marker Score: 10932
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.54
    Marker Score: 315
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.53
    Marker Score: 5512
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.49
    Marker Score: 471
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.48
    Marker Score: 574
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.47
    Marker Score: 7410
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.46
    Marker Score: 243
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.46
    Marker Score: 146
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.4
    Marker Score: 823
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.38
    Marker Score: 247
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.35
    Marker Score: 705
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.33
    Marker Score: 407
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.33
    Marker Score: 770
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.32
    Marker Score: 193
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.31
    Marker Score: 595
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.3
    Marker Score: 155.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.28
    Marker Score: 217.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.26
    Marker Score: 95
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.25
    Marker Score: 604
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.23
    Marker Score: 235
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.23
    Marker Score: 950
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.22
    Marker Score: 192
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.22
    Marker Score: 65
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.21
    Marker Score: 611
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.2
    Marker Score: 340
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.19
    Marker Score: 86
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.18
    Marker Score: 121
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.17
    Marker Score: 55
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.17
    Marker Score: 101
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.17
    Marker Score: 208
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.16
    Marker Score: 75
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.16
    Marker Score: 89
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.15
    Marker Score: 38
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.15
    Marker Score: 130
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.14
    Marker Score: 59
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.14
    Marker Score: 49
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.14
    Marker Score: 72
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.13
    Marker Score: 1355
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.13
    Marker Score: 594
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.13
    Marker Score: 84
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.12
    Marker Score: 46
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.12
    Marker Score: 54
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.12
    Marker Score: 49
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.12
    Marker Score: 201
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.11
    Marker Score: 52
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1
    Marker Score: 51
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.1
    Marker Score: 99
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.1
    Marker Score: 179
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.1
    Marker Score: 39
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.09
    Marker Score: 1955
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.09
    Marker Score: 100
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.09
    Marker Score: 102
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.09
    Marker Score: 2880
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.09
    Marker Score: 21

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * KCNJ9 is a member of the potassium inwardly rectifying channel family, which is a large superfamily of ion channels that are involved in a variety of cellular processes, including potassium ion transport, membrane potential, and signal transduction. * KCNJ9 is a tetrameric protein, which means that it is composed of four subunits that come together to form a functional channel. * KCNJ9 is a G protein-activated inward rectifier potassium channel, which means that it opens when the binding of a G protein to its receptor activates it. * KCNJ9 is expressed in the plasma membrane of cells, where it is responsible for the movement of potassium ions across the cell membrane. **Pathways and functions:** * KCNJ9 is involved in a variety of cellular processes, including potassium ion transport, membrane potential, and signal transduction. * In the plasma membrane, KCNJ9 is localized to the basolateral surface of the cell, where it is responsible for the movement of potassium ions from the outside of the cell to the inside. * The movement of potassium ions down their concentration gradient through KCNJ9 is driven by the binding of a G protein to its receptor, Gbeta. * This binding activates KCNJ9, which opens, allowing potassium ions to flow into the cell. * The influx of potassium ions depolarizes the cell, which can lead to a variety of cellular responses, including contraction, proliferation, and differentiation. **Clinical significance:** Mutations in the KCNJ9 gene have been linked to a number of human diseases, including epilepsy, heart failure, and stroke. These diseases are characterized by abnormal potassium ion channel function, which can lead to a variety of symptoms, including seizures, heart arrhythmias, and cognitive impairment. **Additional information:** * KCNJ9 is a well-characterized gene, and there are a number of drugs that target it for the treatment of epilepsy and other diseases. * The development of these drugs is an active area of research, as there is a strong clinical need for new treatments for these diseases.

Genular Protein ID: 3821494177

Symbol: KCNJ9_HUMAN

Name: G protein-activated inward rectifier potassium channel 3

UniProtKB Accession Codes:

Q92806 Q5JW75

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 3 Ensembl 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIRSF 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10659995

Title: Co-expression of human Kir3 subunits can yield channels with different functional properties.

PubMed ID: 10659995

DOI: 10.1016/s0898-6568(99)00059-5

PubMed ID: 10913335

Title: Genomic structure and expression of human KCNJ9 (Kir3.3/GIRK3).

PubMed ID: 10913335

DOI: 10.1006/bbrc.2000.3136

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 393
  • Mass: 44020
  • Checksum: C6F79F80A37B01C9
  • Sequence:
    • MAQENAAFSP GQEEPPRRRG RQRYVEKDGR CNVQQGNVRE TYRYLTDLFT TLVDLQWRLS 
LLFFVLAYAL TWLFFGAIWW LIAYGRGDLE HLEDTAWTPC VNNLNGFVAA FLFSIETETT 
IGYGHRVITD QCPEGIVLLL LQAILGSMVN AFMVGCMFVK ISQPNKRAAT LVFSSHAVVS 
LRDGRLCLMF RVGDLRSSHI VEASIRAKLI RSRQTLEGEF IPLHQTDLSV GFDTGDDRLF 
LVSPLVISHE IDAASPFWEA SRRALERDDF EIVVILEGMV EATGMTCQAR SSYLVDEVLW 
GHRFTSVLTL EDGFYEVDYA SFHETFEVPT PSCSARELAE AAARLDAHLY WSIPSRLDEK 
VEEEGAGEGA GGEAGADKEQ NGCLPPPESE SKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.