Details for: KRT31

Gene ID: 3881

Symbol: KRT31

Ensembl ID: ENSG00000094796

Description: keratin 31

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.44
    Marker Score: 2454
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10815
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 1.46
    Marker Score: 2094.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7563
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3657
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32732
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71839
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48064
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2404
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5347
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 739
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 401.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.75
    Marker Score: 1235
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.58
    Marker Score: 4565
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 438.5
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.55
    Marker Score: 186
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.46
    Marker Score: 386
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.41
    Marker Score: 277
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.34
    Marker Score: 2892
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.31
    Marker Score: 486
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.23
    Marker Score: 246.5
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.22
    Marker Score: 72
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.16
    Marker Score: 577.5
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.13
    Marker Score: 237
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.13
    Marker Score: 151
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.13
    Marker Score: 1684
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.11
    Marker Score: 78
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.1
    Marker Score: 88
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.1
    Marker Score: 520.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.08
    Marker Score: 723
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.08
    Marker Score: 30
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.08
    Marker Score: 89
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.08
    Marker Score: 165
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.08
    Marker Score: 88
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.06
    Marker Score: 596.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.06
    Marker Score: 64
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.06
    Marker Score: 42
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.05
    Marker Score: 222
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.05
    Marker Score: 361
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.05
    Marker Score: 11
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.04
    Marker Score: 109
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.04
    Marker Score: 241
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.03
    Marker Score: 45
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.03
    Marker Score: 45
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.02
    Marker Score: 6
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.02
    Marker Score: 26
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.02
    Marker Score: 6
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.01
    Marker Score: 40
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.01
    Marker Score: 46
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.01
    Marker Score: 30
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.01
    Marker Score: 32.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.01
    Marker Score: 643
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.01
    Marker Score: 341
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.01
    Marker Score: 30
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.01
    Marker Score: 30
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.01
    Marker Score: 12

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Other Information

**Key characteristics:** * KRT31 is a transmembrane protein with a predicted molecular weight of approximately 130 kDa. * It is a cytoskeletal protein that is expressed in both epithelial and mesenchymal cells. * It is a key component of the intermediate filament, a cytoskeletal network that provides structural support and elasticity to epithelial cells. * It is also involved in cell adhesion, migration, and differentiation. **Pathways and functions:** * KRT31 is involved in the formation of the cornified envelope, a specialized layer of cell membrane that surrounds and protects epithelial cells. * It is also involved in the maintenance of epithelial cell integrity and function. * It is involved in cell adhesion and migration by interacting with other cytoskeletal proteins. * It is also involved in cell differentiation and tissue morphogenesis. **Clinical significance:** Mutations in the KRT31 gene have been linked to several human diseases, including cancer, skin disorders, and developmental abnormalities. These diseases are characterized by abnormal cell growth, migration, and differentiation. Targeting KRT31 has emerged as a potential therapeutic strategy for these diseases.

Genular Protein ID: 2759448951

Symbol: K1H1_HUMAN

Name: Keratin, type I cuticular Ha1

UniProtKB Accession Codes:

Q15323 Q9UE12

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 3 GO 9 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7578244

Title: A cDNA encoding the human type I hair keratin hHal.

PubMed ID: 7578244

DOI: 10.1016/0167-4781(95)00122-w

PubMed ID: 9756910

Title: Characterization of a 190-kilobase pair domain of human type I hair keratin genes.

PubMed ID: 9756910

DOI: 10.1074/jbc.273.41.26683

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9457912

Title: Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle.

PubMed ID: 9457912

DOI: 10.1046/j.1523-1747.1998.00097.x

Sequence Information:

  • Length: 416
  • Mass: 47237
  • Checksum: C284DD33A4896009
  • Sequence:
    • MPYNFCLPSL SCRTSCSSRP CVPPSCHSCT LPGACNIPAN VSNCNWFCEG SFNGSEKETM 
QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLLC PSYQSYFKTI EELQQKILCT 
KSENARLVVQ IDNAKLAADD FRTKYQTELS LRQLVESDIN GLRRILDELT LCKSDLEAQV 
ESLKEELLCL KSNHEQEVNT LRCQLGDRLN VEVDAAPTVD LNRVLNETRS QYEALVETNR 
REVEQWFTTQ TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRDSLENTL 
TESEARYSSQ LSQVQSLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE CEINTYRSLL 
ESEDCNLPSN PCATTNACSK PIGPCLSNPC TSCVPPAPCT PCAPRPRCGP CNSFVR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.