Details for: TRNF

Gene ID: 4558

Symbol: TRNF

Ensembl ID: ENSG00000210049

Description: tRNA-Phe

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.2788
    Cell Significance Index: 31.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1190
    Cell Significance Index: 32.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9599
    Cell Significance Index: 43.5100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.8001
    Cell Significance Index: 11.3900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7161
    Cell Significance Index: 10.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.6196
    Cell Significance Index: 18.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1719
    Cell Significance Index: 8.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1531
    Cell Significance Index: 7.1400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1422
    Cell Significance Index: 2.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0932
    Cell Significance Index: 15.9100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0483
    Cell Significance Index: 0.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0463
    Cell Significance Index: 1.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0393
    Cell Significance Index: 2.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0312
    Cell Significance Index: 3.5700
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.0304
    Cell Significance Index: 0.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0136
    Cell Significance Index: 3.9000
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0132
    Cell Significance Index: 0.1700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0099
    Cell Significance Index: 0.1700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0025
    Cell Significance Index: -1.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0028
    Cell Significance Index: -1.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0088
    Cell Significance Index: -0.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0091
    Cell Significance Index: -4.1300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0093
    Cell Significance Index: -0.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0227
    Cell Significance Index: -4.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0278
    Cell Significance Index: -4.0400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0310
    Cell Significance Index: -0.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0435
    Cell Significance Index: -1.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0457
    Cell Significance Index: -0.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0804
    Cell Significance Index: -4.9300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0808
    Cell Significance Index: -0.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0827
    Cell Significance Index: -2.6500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0908
    Cell Significance Index: -1.0800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1185
    Cell Significance Index: -1.2500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1193
    Cell Significance Index: -1.6500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1239
    Cell Significance Index: -1.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1310
    Cell Significance Index: -4.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1332
    Cell Significance Index: -4.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1436
    Cell Significance Index: -3.6900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1483
    Cell Significance Index: -3.7000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1519
    Cell Significance Index: -3.8700
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1527
    Cell Significance Index: -1.6700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1586
    Cell Significance Index: -3.1000
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1637
    Cell Significance Index: -1.9900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1732
    Cell Significance Index: -5.5200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1749
    Cell Significance Index: -3.6500
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1765
    Cell Significance Index: -1.8300
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: -0.1787
    Cell Significance Index: -1.4100
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1804
    Cell Significance Index: -1.6700
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.1811
    Cell Significance Index: -2.2300
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1868
    Cell Significance Index: -2.4900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1929
    Cell Significance Index: -2.3000
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.1944
    Cell Significance Index: -1.7000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1946
    Cell Significance Index: -3.8800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1952
    Cell Significance Index: -1.7200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1971
    Cell Significance Index: -3.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2024
    Cell Significance Index: -4.3100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2065
    Cell Significance Index: -2.7000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2120
    Cell Significance Index: -2.7300
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.2135
    Cell Significance Index: -2.0300
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2163
    Cell Significance Index: -2.2100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2199
    Cell Significance Index: -4.7500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2225
    Cell Significance Index: -2.5600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2294
    Cell Significance Index: -3.1500
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.2296
    Cell Significance Index: -2.7700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2359
    Cell Significance Index: -2.8600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2384
    Cell Significance Index: -2.9300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2456
    Cell Significance Index: -4.9300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2459
    Cell Significance Index: -5.2200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2480
    Cell Significance Index: -3.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2527
    Cell Significance Index: -4.3300
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.2553
    Cell Significance Index: -3.8200
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.2558
    Cell Significance Index: -2.7700
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.2563
    Cell Significance Index: -2.0100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2589
    Cell Significance Index: -5.1200
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.2625
    Cell Significance Index: -3.2600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2627
    Cell Significance Index: -3.4300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2639
    Cell Significance Index: -3.3900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2642
    Cell Significance Index: -3.9000
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2653
    Cell Significance Index: -2.7700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2702
    Cell Significance Index: -3.1900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2703
    Cell Significance Index: -2.7600
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.2717
    Cell Significance Index: -3.7000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2726
    Cell Significance Index: -3.4400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2747
    Cell Significance Index: -3.2300
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.2756
    Cell Significance Index: -1.7100
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.2760
    Cell Significance Index: -3.3600
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.2771
    Cell Significance Index: -3.1300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2774
    Cell Significance Index: -3.6500
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.2787
    Cell Significance Index: -3.6500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2801
    Cell Significance Index: -3.3500
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2823
    Cell Significance Index: -3.2800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2827
    Cell Significance Index: -2.6800
  • Cell Name: DN4 thymocyte (CL0000808)
    Fold Change: -0.2840
    Cell Significance Index: -2.1400
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.2906
    Cell Significance Index: -3.6500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2946
    Cell Significance Index: -3.6800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2981
    Cell Significance Index: -3.3300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.3003
    Cell Significance Index: -2.3100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.3011
    Cell Significance Index: -3.6100
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.3034
    Cell Significance Index: -3.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The tRNA-Phe gene is a type of transfer RNA (tRNA) molecule, specifically designed to bind to the amino acid phenylalanine (Phe). tRNAs are essential components of the ribosome, where they facilitate the translation of genetic information into proteins. The TRNF gene is expressed in various cell types, including T cells, plasma cells, goblet cells, B cells, absorptive cells, intestinal crypt stem cells, transit amplifying cells, and neoplastic cells. This widespread expression suggests that tRNA-Phe plays a vital role in maintaining the integrity of these cells and tissues. **Pathways and Functions:** The tRNA-Phe gene is involved in several key pathways, including the regulation of protein synthesis, cell differentiation, and immune responses. As a tRNA molecule, it binds to the ribosome, where it facilitates the incorporation of phenylalanine into proteins. This process is essential for the production of various proteins, including those involved in immune responses, such as cytokines and chemokines. Additionally, tRNA-Phe has been implicated in the regulation of cell differentiation, particularly in the development of immune cells, such as T cells and B cells. In the context of immune responses, tRNA-Phe has been shown to play a crucial role in the regulation of cytokine production and the activation of immune cells. For example, studies have demonstrated that tRNA-Phe is involved in the regulation of interferon-gamma (IFN-γ) production, a key cytokine involved in the activation of immune responses against viral infections and tumor cells. **Clinical Significance:** Dysregulation of the tRNA-Phe gene has been implicated in various diseases, including autoimmune disorders, cancer, and infectious diseases. For instance, studies have shown that alterations in tRNA-Phe expression can contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus. Additionally, tRNA-Phe has been implicated in the progression of cancer, particularly in the development of tumor cells and the regulation of immune responses against cancer. Furthermore, tRNA-Phe has been shown to play a crucial role in the regulation of immune responses against infectious diseases, such as HIV and tuberculosis. In these contexts, dysregulation of tRNA-Phe expression can contribute to the failure of immune responses, leading to the progression of disease. **Conclusion:** In conclusion, the tRNA-Phe gene, also known as TRNF, is a complex molecule that plays a vital role in the regulation of cellular processes and immune responses. Through its involvement in protein synthesis, cell differentiation, and immune responses, tRNA-Phe has significant implications for our understanding of various diseases, including autoimmune disorders, cancer, and infectious diseases. Further research is necessary to fully elucidate the mechanisms by which tRNA-Phe regulates immune responses and to explore its potential as a therapeutic target for the treatment of these diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.