Details for: TRNL1

Gene ID: 4567

Symbol: TRNL1

Ensembl ID: ENSG00000209082

Description: tRNA-Leu

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.6545
    Cell Significance Index: -9.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.6354
    Cell Significance Index: 164.7800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.8467
    Cell Significance Index: 71.1000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.5133
    Cell Significance Index: 37.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.0964
    Cell Significance Index: 60.4000
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.1381
    Cell Significance Index: 11.0100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.6524
    Cell Significance Index: 7.0700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.5374
    Cell Significance Index: 6.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5279
    Cell Significance Index: 14.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3597
    Cell Significance Index: 16.7700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.3208
    Cell Significance Index: 3.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2777
    Cell Significance Index: 14.4300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.2523
    Cell Significance Index: 7.4300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.2156
    Cell Significance Index: 1.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1870
    Cell Significance Index: 53.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1759
    Cell Significance Index: 3.8100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.1638
    Cell Significance Index: 1.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0416
    Cell Significance Index: 7.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0234
    Cell Significance Index: 2.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0056
    Cell Significance Index: -10.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0070
    Cell Significance Index: -12.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0084
    Cell Significance Index: -12.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0094
    Cell Significance Index: -12.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0130
    Cell Significance Index: -0.8200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0134
    Cell Significance Index: -0.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0135
    Cell Significance Index: -7.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0157
    Cell Significance Index: -9.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0251
    Cell Significance Index: -11.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0494
    Cell Significance Index: -9.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0563
    Cell Significance Index: -1.9800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0690
    Cell Significance Index: -0.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0741
    Cell Significance Index: -10.7700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0818
    Cell Significance Index: -1.6000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0938
    Cell Significance Index: -1.9500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1161
    Cell Significance Index: -3.8000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1256
    Cell Significance Index: -4.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1285
    Cell Significance Index: -7.8800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1513
    Cell Significance Index: -1.7800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1920
    Cell Significance Index: -2.4800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2067
    Cell Significance Index: -4.3200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2198
    Cell Significance Index: -3.8000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2212
    Cell Significance Index: -4.4100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2302
    Cell Significance Index: -4.5300
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.2396
    Cell Significance Index: -2.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2467
    Cell Significance Index: -7.9000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2694
    Cell Significance Index: -3.7000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.2826
    Cell Significance Index: -3.5500
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.2864
    Cell Significance Index: -2.5200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2975
    Cell Significance Index: -7.5800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.3023
    Cell Significance Index: -4.1800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3148
    Cell Significance Index: -3.4300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3166
    Cell Significance Index: -4.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3489
    Cell Significance Index: -7.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3554
    Cell Significance Index: -11.3200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.3596
    Cell Significance Index: -5.3800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.3670
    Cell Significance Index: -3.6800
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.3729
    Cell Significance Index: -3.2600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3870
    Cell Significance Index: -4.5500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3870
    Cell Significance Index: -6.1400
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.4019
    Cell Significance Index: -4.9900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.4031
    Cell Significance Index: -5.5900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.4171
    Cell Significance Index: -4.4000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4404
    Cell Significance Index: -5.2500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4418
    Cell Significance Index: -11.0200
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.4456
    Cell Significance Index: -4.6200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.4478
    Cell Significance Index: -5.3600
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.4486
    Cell Significance Index: -5.6500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.4546
    Cell Significance Index: -6.8000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4604
    Cell Significance Index: -11.4800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4605
    Cell Significance Index: -9.9500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.4613
    Cell Significance Index: -5.6700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4721
    Cell Significance Index: -6.7200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4754
    Cell Significance Index: -10.0900
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.4840
    Cell Significance Index: -5.0600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.4861
    Cell Significance Index: -8.3100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.4911
    Cell Significance Index: -5.2200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4918
    Cell Significance Index: -7.2600
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: -0.4950
    Cell Significance Index: -3.7500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4981
    Cell Significance Index: -10.0000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5028
    Cell Significance Index: -7.2200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.5048
    Cell Significance Index: -6.3700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5057
    Cell Significance Index: -10.0000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.5110
    Cell Significance Index: -6.5700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5195
    Cell Significance Index: -8.9600
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.5248
    Cell Significance Index: -5.0200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.5321
    Cell Significance Index: -6.4500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.5345
    Cell Significance Index: -6.9900
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.5440
    Cell Significance Index: -5.9500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.5662
    Cell Significance Index: -3.3600
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.5673
    Cell Significance Index: -7.4300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.5764
    Cell Significance Index: -7.2000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5781
    Cell Significance Index: -5.4800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.5945
    Cell Significance Index: -5.9900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.6034
    Cell Significance Index: -7.8800
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.6057
    Cell Significance Index: -7.6000
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.6079
    Cell Significance Index: -6.2100
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.6115
    Cell Significance Index: -7.5300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.6135
    Cell Significance Index: -7.3000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.6188
    Cell Significance Index: -7.1200
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.6292
    Cell Significance Index: -7.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRNL1 is a mitochondrial gene, specifically located on the tRNA-Leu gene cluster (tRNA-Leu1). It is highly expressed in various cell types, including goblet cells, absorptive cells, intestinal crypt stem cells, transit amplifying cells, and neoplastic cells. These cells are all integral components of the intestinal epithelium, which plays a vital role in maintaining gut homeostasis and preventing cancer. Notably, TRNL1 expression is significantly reduced in abnormal cells, suggesting its potential role in cancer suppression. **Pathways and Functions:** TRNL1 is involved in the translation of leucine into proteins, which are essential for various cellular processes, including cell proliferation, differentiation, and survival. The tRNA-Leu molecule, encoded by TRNL1, binds to the ribosome and delivers the leucine amino acid to the growing protein chain. This process is critical for maintaining the structural integrity and function of the intestinal epithelium. Additionally, TRNL1 has been implicated in the regulation of the mTOR (mechanistic target of rapamycin) pathway, which is a key regulator of cell growth and proliferation. **Clinical Significance:** The dysregulation of TRNL1 has been linked to various gastrointestinal disorders, including cancer. Studies have shown that reduced expression of TRNL1 is associated with an increased risk of colon cancer, suggesting its potential as a biomarker for early detection and prevention. Furthermore, TRNL1 has been implicated in the regulation of immune responses, particularly in the context of inflammatory bowel disease (IBD). Abnormal expression of TRNL1 has been observed in patients with Crohn's disease and ulcerative colitis, highlighting its potential role in modulating the immune response and preventing disease progression. In conclusion, TRNL1 is a critical gene involved in maintaining intestinal homeostasis and suppressing cancer development. Its dysregulation has significant clinical implications, particularly in the context of gastrointestinal disorders. Further research is needed to fully elucidate the mechanisms by which TRNL1 regulates cellular processes and to explore its potential as a therapeutic target for cancer prevention and treatment. **Recommendations:** * Further studies are needed to investigate the mechanisms by which TRNL1 regulates the mTOR pathway and immune responses. * The development of TRNL1 as a biomarker for early detection and prevention of colon cancer is warranted. * The exploration of TRNL1 as a therapeutic target for cancer treatment is a promising area of research. **Limitations:** This review highlights the critical role of TRNL1 in maintaining intestinal homeostasis and suppressing cancer development. However, further research is needed to fully elucidate the mechanisms by which TRNL1 regulates cellular processes and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.