Details for: TRNQ

Gene ID: 4572

Symbol: TRNQ

Ensembl ID: ENSG00000210107

Description: tRNA-Gln

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 4.6059
    Cell Significance Index: 208.7700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.1260
    Cell Significance Index: 46.8400
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.9623
    Cell Significance Index: 26.1000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.8526
    Cell Significance Index: 29.5200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.6724
    Cell Significance Index: 16.1800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 1.3381
    Cell Significance Index: 16.2200
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.1718
    Cell Significance Index: 12.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8148
    Cell Significance Index: 23.4800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.7251
    Cell Significance Index: 18.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5649
    Cell Significance Index: 26.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5446
    Cell Significance Index: 28.2900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.4327
    Cell Significance Index: 5.5900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.2966
    Cell Significance Index: 1.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2755
    Cell Significance Index: 7.5000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.2726
    Cell Significance Index: 8.0300
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.2471
    Cell Significance Index: 2.1600
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.2093
    Cell Significance Index: 1.8300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1774
    Cell Significance Index: 2.4200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0891
    Cell Significance Index: 0.9300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0318
    Cell Significance Index: 0.4700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.0108
    Cell Significance Index: 0.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0055
    Cell Significance Index: -4.0600
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0139
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0223
    Cell Significance Index: -3.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0270
    Cell Significance Index: -3.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0583
    Cell Significance Index: -6.6800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0611
    Cell Significance Index: -3.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0897
    Cell Significance Index: -18.0000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1135
    Cell Significance Index: -1.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1186
    Cell Significance Index: -3.8000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1200
    Cell Significance Index: -1.6700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1502
    Cell Significance Index: -2.9700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1546
    Cell Significance Index: -5.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1558
    Cell Significance Index: -9.5500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1564
    Cell Significance Index: -2.2500
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.1569
    Cell Significance Index: -1.7300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1635
    Cell Significance Index: -2.1000
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1890
    Cell Significance Index: -2.5200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1925
    Cell Significance Index: -4.1600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2015
    Cell Significance Index: -2.0200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2156
    Cell Significance Index: -5.3800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2332
    Cell Significance Index: -3.3200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2450
    Cell Significance Index: -6.1100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2757
    Cell Significance Index: -5.4300
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.2793
    Cell Significance Index: -2.6600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2819
    Cell Significance Index: -3.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2853
    Cell Significance Index: -6.1800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.3016
    Cell Significance Index: -4.1700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.3125
    Cell Significance Index: -3.2400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.3131
    Cell Significance Index: -2.9200
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.3185
    Cell Significance Index: -2.9300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3389
    Cell Significance Index: -7.0300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.3430
    Cell Significance Index: -4.7100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3438
    Cell Significance Index: -6.8600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3504
    Cell Significance Index: -4.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3569
    Cell Significance Index: -12.5400
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.3574
    Cell Significance Index: -3.3300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.3648
    Cell Significance Index: -3.9900
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.3789
    Cell Significance Index: -3.9300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.3833
    Cell Significance Index: -4.1100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.3914
    Cell Significance Index: -5.1100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.4168
    Cell Significance Index: -5.7800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4275
    Cell Significance Index: -7.3700
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.4352
    Cell Significance Index: -3.6000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.4416
    Cell Significance Index: -3.7300
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.4782
    Cell Significance Index: -5.2100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.4911
    Cell Significance Index: -5.1800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.5023
    Cell Significance Index: -5.9100
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.5062
    Cell Significance Index: -5.6300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.5181
    Cell Significance Index: -6.1700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.5199
    Cell Significance Index: -6.0400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.5226
    Cell Significance Index: -5.3300
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.5348
    Cell Significance Index: -5.9400
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.5394
    Cell Significance Index: -5.8600
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.5453
    Cell Significance Index: -5.1100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5467
    Cell Significance Index: -13.9300
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.5560
    Cell Significance Index: -6.0700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.5609
    Cell Significance Index: -4.6300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.5613
    Cell Significance Index: -5.2700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.5630
    Cell Significance Index: -6.1800
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.5668
    Cell Significance Index: -6.0500
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.5672
    Cell Significance Index: -6.1400
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.5738
    Cell Significance Index: -6.8200
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.5861
    Cell Significance Index: -7.1300
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: -0.5930
    Cell Significance Index: -6.1100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.6005
    Cell Significance Index: -7.9800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.6013
    Cell Significance Index: -6.5100
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.6018
    Cell Significance Index: -6.4300
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.6052
    Cell Significance Index: -6.4100
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.6122
    Cell Significance Index: -6.0400
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -0.6155
    Cell Significance Index: -6.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6165
    Cell Significance Index: -13.1300
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: -0.6190
    Cell Significance Index: -6.1400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.6220
    Cell Significance Index: -6.3500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.6246
    Cell Significance Index: -8.9700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.6338
    Cell Significance Index: -7.6000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.6452
    Cell Significance Index: -7.9300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.6505
    Cell Significance Index: -11.1200
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.6632
    Cell Significance Index: -4.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The tRNA-Gln gene encodes for a transfer RNA molecule that recognizes glutamine, a critical amino acid for immune cell function. This gene is highly expressed in cells involved in immune responses, such as plasma cells, B cells, and mast cells. tRNA-Gln is also expressed in epithelial cells, including those in the intestinal crypts, where it plays a role in maintaining the integrity of the epithelial barrier. Notably, tRNA-Gln expression is often downregulated in cancerous cells, suggesting a potential role in tumor suppression. **Pathways and Functions:** The tRNA-Gln gene is involved in several key pathways that regulate immune cell function and epithelial integrity. These include: 1. **Glutamine synthesis**: tRNA-Gln is responsible for the synthesis of glutamine, a critical amino acid for immune cell proliferation, differentiation, and survival. 2. **Immune cell function**: tRNA-Gln is involved in the regulation of immune cell function, including the activation and suppression of immune responses. 3. **Epithelial integrity**: tRNA-Gln plays a role in maintaining the integrity of the epithelial barrier, particularly in the intestinal crypts. 4. **Cell cycle regulation**: tRNA-Gln has been shown to regulate cell cycle progression, particularly in cancer cells. **Clinical Significance:** The dysregulation of tRNA-Gln expression has been implicated in various diseases, including: 1. **Cancer**: Abnormal tRNA-Gln expression has been linked to cancer development and progression, particularly in colon cancer. 2. **Inflammatory disorders**: tRNA-Gln expression is often downregulated in inflammatory disorders, such as Crohn's disease and ulcerative colitis. 3. **Immunodeficiency**: tRNA-Gln expression is critical for the development and function of immune cells, particularly in individuals with immunodeficiency disorders. 4. **Neoplastic transformation**: tRNA-Gln expression is often downregulated in neoplastic cells, suggesting a potential role in tumor suppression. In conclusion, the tRNA-Gln gene plays a critical role in regulating immune cell function, epithelial integrity, and cell cycle progression. Its dysregulation has been implicated in various diseases, highlighting its importance in immune homeostasis and tissue repair. Further research is needed to fully elucidate the mechanisms by which tRNA-Gln regulates immune responses and epithelial integrity, and to explore its potential as a therapeutic target for various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.