Details for: TRNS1

Gene ID: 4574

Symbol: TRNS1

Ensembl ID: ENSG00000210151

Description: tRNA-Ser

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.4492
    Cell Significance Index: -9.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5521
    Cell Significance Index: 70.3500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.3309
    Cell Significance Index: 18.9500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.2460
    Cell Significance Index: 31.1200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.3723
    Cell Significance Index: 3.2800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3550
    Cell Significance Index: 5.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2346
    Cell Significance Index: 12.1900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.2198
    Cell Significance Index: 2.9300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1967
    Cell Significance Index: 3.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1818
    Cell Significance Index: 8.4800
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.1209
    Cell Significance Index: 1.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0944
    Cell Significance Index: 2.7200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0719
    Cell Significance Index: 4.5300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0438
    Cell Significance Index: 0.5200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0336
    Cell Significance Index: 0.5800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0074
    Cell Significance Index: 0.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0220
    Cell Significance Index: -2.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0275
    Cell Significance Index: -4.7000
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0341
    Cell Significance Index: -0.4400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0437
    Cell Significance Index: -0.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0511
    Cell Significance Index: -10.2600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0537
    Cell Significance Index: -1.0500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0921
    Cell Significance Index: -1.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1047
    Cell Significance Index: -2.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1250
    Cell Significance Index: -7.6700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1252
    Cell Significance Index: -1.6400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1253
    Cell Significance Index: -1.2800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1687
    Cell Significance Index: -4.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1801
    Cell Significance Index: -6.3300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.2083
    Cell Significance Index: -2.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2254
    Cell Significance Index: -7.2200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2360
    Cell Significance Index: -3.2200
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.2620
    Cell Significance Index: -2.8400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2738
    Cell Significance Index: -4.6800
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2875
    Cell Significance Index: -3.3400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2876
    Cell Significance Index: -9.1600
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.2958
    Cell Significance Index: -2.8300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3028
    Cell Significance Index: -7.7200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3073
    Cell Significance Index: -4.4200
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.3079
    Cell Significance Index: -3.2700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3169
    Cell Significance Index: -4.4000
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.3471
    Cell Significance Index: -4.3100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.3568
    Cell Significance Index: -3.7300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3577
    Cell Significance Index: -7.4200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.3622
    Cell Significance Index: -3.4000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.3632
    Cell Significance Index: -4.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3896
    Cell Significance Index: -8.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3944
    Cell Significance Index: -8.4000
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.3954
    Cell Significance Index: -4.3300
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.3992
    Cell Significance Index: -3.4900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.4287
    Cell Significance Index: -4.3500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.4297
    Cell Significance Index: -5.5200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.4312
    Cell Significance Index: -5.7300
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.4368
    Cell Significance Index: -5.3100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.4389
    Cell Significance Index: -4.6300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.4449
    Cell Significance Index: -5.8600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.4451
    Cell Significance Index: -4.9300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.4496
    Cell Significance Index: -4.5900
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.4516
    Cell Significance Index: -5.0000
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.4518
    Cell Significance Index: -4.6800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4598
    Cell Significance Index: -9.2300
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.4607
    Cell Significance Index: -5.0100
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.4639
    Cell Significance Index: -4.8500
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.4687
    Cell Significance Index: -4.8600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.4711
    Cell Significance Index: -6.1500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.4728
    Cell Significance Index: -9.3000
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.4783
    Cell Significance Index: -5.2500
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.4797
    Cell Significance Index: -5.3400
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.4835
    Cell Significance Index: -5.3700
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.4860
    Cell Significance Index: -4.0200
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.4897
    Cell Significance Index: -4.5000
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.4946
    Cell Significance Index: -3.6000
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.4989
    Cell Significance Index: -5.4400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.4993
    Cell Significance Index: -5.1500
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.5016
    Cell Significance Index: -5.4300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.5080
    Cell Significance Index: -4.7300
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.5082
    Cell Significance Index: -5.4300
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.5084
    Cell Significance Index: -5.3800
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: -0.5094
    Cell Significance Index: -4.0200
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.5133
    Cell Significance Index: -6.2500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.5141
    Cell Significance Index: -7.0600
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.5170
    Cell Significance Index: -4.5200
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.5174
    Cell Significance Index: -5.6100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.5186
    Cell Significance Index: -5.2900
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.5238
    Cell Significance Index: -5.4900
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.5246
    Cell Significance Index: -5.7300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.5285
    Cell Significance Index: -6.1300
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.5305
    Cell Significance Index: -4.9100
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.5339
    Cell Significance Index: -7.2600
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.5369
    Cell Significance Index: -5.7300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.5391
    Cell Significance Index: -6.3700
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.5393
    Cell Significance Index: -5.3200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.5479
    Cell Significance Index: -5.6700
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -0.5486
    Cell Significance Index: -5.4100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.5505
    Cell Significance Index: -6.1500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.5531
    Cell Significance Index: -6.9100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.5552
    Cell Significance Index: -7.1500
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: -0.5566
    Cell Significance Index: -5.7300
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.5687
    Cell Significance Index: -6.4600
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.5719
    Cell Significance Index: -5.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine tRNA**: TRNS1 encodes a serine tRNA molecule, which is a crucial component of the tRNA family involved in protein synthesis. 2. **Multifunctional expression**: TRNS1 is expressed in various cell types, including immune cells, epithelial cells, and stem cells, indicating its role in multiple cellular processes. 3. **High expression levels**: The significantly expressed cells listed in the description suggest that TRNS1 plays a significant role in these cell types, possibly influencing their function and behavior. 4. **Abnormal expression in disease states**: The inclusion of "abnormal cell", "neoplastic cell", and "neoplastic cell" in the list of cells expressing TRNS1 indicates its potential involvement in disease states, such as cancer. **Pathways and Functions:** 1. **Protein synthesis**: As a serine tRNA molecule, TRNS1 plays a crucial role in protein synthesis, ensuring the accurate translation of genetic information into proteins. 2. **Immune response**: The expression of TRNS1 in immune cells, such as plasma cells and T cells, suggests its involvement in the immune response, possibly influencing the production of antibodies or cytokines. 3. **Cellular homeostasis**: TRNS1 may contribute to the maintenance of cellular homeostasis by regulating protein synthesis and cell growth. 4. **Intestinal epithelial barrier function**: The expression of TRNS1 in intestinal epithelial cells may play a role in maintaining the integrity of the intestinal barrier, preventing the passage of toxins and pathogens. **Clinical Significance:** 1. **Cancer research**: The abnormal expression of TRNS1 in neoplastic cells suggests its potential role in cancer development and progression. 2. **Immunological disorders**: The involvement of TRNS1 in immune response and cellular homeostasis may contribute to the pathogenesis of immunological disorders, such as autoimmune diseases or immune-mediated cancers. 3. **Intestinal diseases**: The expression of TRNS1 in intestinal epithelial cells may play a role in maintaining the integrity of the intestinal barrier, potentially influencing the development of intestinal diseases, such as inflammatory bowel disease (IBD). 4. **Diagnostic and therapeutic applications**: Further research on TRNS1 may lead to the development of diagnostic biomarkers or therapeutic targets for diseases involving abnormal TRNS1 expression. In conclusion, the tRNA-Ser (TRNS1) gene plays a multifaceted role in various cellular processes, including protein synthesis, immune response, and cellular homeostasis. Its significant expression in multiple cell types and potential involvement in disease states make it an important area of research for understanding the underlying mechanisms of immune disorders and cancer.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.