Details for: NPY4R

Gene ID: 5540

Symbol: NPY4R

Ensembl ID: ENSG00000204174

Description: neuropeptide Y receptor Y4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 7.9355
    Cell Significance Index: 202.1800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 5.2308
    Cell Significance Index: 84.7200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.0994
    Cell Significance Index: 52.9800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.0520
    Cell Significance Index: 28.1400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.8976
    Cell Significance Index: 24.5600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 1.0487
    Cell Significance Index: 11.1400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1550
    Cell Significance Index: 2.2500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.0804
    Cell Significance Index: 1.0600
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.0292
    Cell Significance Index: 0.3000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0280
    Cell Significance Index: 0.2900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0271
    Cell Significance Index: 0.3300
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.0213
    Cell Significance Index: 0.1500
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.0156
    Cell Significance Index: 0.1600
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.0134
    Cell Significance Index: 0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0016
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0028
    Cell Significance Index: -0.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0038
    Cell Significance Index: -0.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0052
    Cell Significance Index: -0.1500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0068
    Cell Significance Index: -0.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0068
    Cell Significance Index: -0.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0073
    Cell Significance Index: -0.4900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0085
    Cell Significance Index: -0.0900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0086
    Cell Significance Index: -0.1100
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0087
    Cell Significance Index: -0.1300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0112
    Cell Significance Index: -0.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0128
    Cell Significance Index: -0.4200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0128
    Cell Significance Index: -0.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0129
    Cell Significance Index: -0.4100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0160
    Cell Significance Index: -0.1900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0175
    Cell Significance Index: -0.2300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0179
    Cell Significance Index: -0.5100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0185
    Cell Significance Index: -0.4000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0192
    Cell Significance Index: -0.4000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0201
    Cell Significance Index: -0.4000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0203
    Cell Significance Index: -0.4000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0203
    Cell Significance Index: -0.4100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0205
    Cell Significance Index: -0.4400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0207
    Cell Significance Index: -0.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0208
    Cell Significance Index: -0.3500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0211
    Cell Significance Index: -0.2300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0212
    Cell Significance Index: -0.4300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0215
    Cell Significance Index: -0.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0240
    Cell Significance Index: -0.6000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0246
    Cell Significance Index: -0.5100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0251
    Cell Significance Index: -0.2700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0254
    Cell Significance Index: -0.4400
  • Cell Name: obsolete somatic cell (CL0002371)
    Fold Change: -0.0272
    Cell Significance Index: -0.2100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0291
    Cell Significance Index: -0.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0295
    Cell Significance Index: -0.6400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0300
    Cell Significance Index: -0.4300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0302
    Cell Significance Index: -0.5900
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0310
    Cell Significance Index: -0.3300
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.0313
    Cell Significance Index: -0.2700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0318
    Cell Significance Index: -0.4100
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0321
    Cell Significance Index: -0.3900
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0337
    Cell Significance Index: -0.4000
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.0342
    Cell Significance Index: -0.1700
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0346
    Cell Significance Index: -0.3300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0357
    Cell Significance Index: -0.4200
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0364
    Cell Significance Index: -0.4000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0397
    Cell Significance Index: -0.4300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0402
    Cell Significance Index: -0.4600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0415
    Cell Significance Index: -0.5100
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.0422
    Cell Significance Index: -0.2000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0424
    Cell Significance Index: -0.4700
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0429
    Cell Significance Index: -0.4200
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0433
    Cell Significance Index: -0.3900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0435
    Cell Significance Index: -0.2700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0437
    Cell Significance Index: -0.4100
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0448
    Cell Significance Index: -0.2400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0455
    Cell Significance Index: -0.5400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0461
    Cell Significance Index: -0.5300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0463
    Cell Significance Index: -0.5800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0465
    Cell Significance Index: -0.5800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0467
    Cell Significance Index: -0.5600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0470
    Cell Significance Index: -0.5600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0472
    Cell Significance Index: -0.5900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0480
    Cell Significance Index: -0.3700
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0496
    Cell Significance Index: -0.4100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0500
    Cell Significance Index: -0.6200
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0505
    Cell Significance Index: -0.5200
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0508
    Cell Significance Index: -0.4200
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0512
    Cell Significance Index: -0.4800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0513
    Cell Significance Index: -0.6400
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0520
    Cell Significance Index: -0.4600
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0531
    Cell Significance Index: -0.4800
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0533
    Cell Significance Index: -0.4900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0533
    Cell Significance Index: -0.4700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0565
    Cell Significance Index: -0.5900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0570
    Cell Significance Index: -0.5400
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.0579
    Cell Significance Index: -0.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0583
    Cell Significance Index: -0.5600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0583
    Cell Significance Index: -0.6800
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0594
    Cell Significance Index: -0.5400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0598
    Cell Significance Index: -0.3500
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0702
    Cell Significance Index: -0.5100
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.0791
    Cell Significance Index: -0.6200
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0819
    Cell Significance Index: -0.8700
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0990
    Cell Significance Index: -0.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NPY4R is a rhodopsin-like receptor belonging to the class A/1 GPCR family. It is characterized by its high sequence similarity to other NPY receptors, which suggests conserved functional properties. NPY4R is expressed in a wide range of cell types, including hematopoietic stem cells, T cells, B cells, and neuroendocrine cells, underscoring its potential involvement in immune system development and function. **Pathways and Functions:** NPY4R is activated by the neuropeptide Y4 (NPY4), which is released by various cell types, including neurons and immune cells. Upon activation, NPY4R triggers a signaling cascade involving Gαi proteins, which modulate downstream effectors, such as adenylyl cyclase and phospholipase C. This leads to the regulation of various cellular processes, including: 1. **Immune cell function**: NPY4R modulates T cell proliferation, differentiation, and cytokine production, influencing the adaptive immune response. 2. **Inflammation**: NPY4R has anti-inflammatory properties, reducing the production of pro-inflammatory cytokines and promoting resolution of inflammation. 3. **Cell survival and death**: NPY4R regulates apoptosis and cell survival pathways, impacting the fate of immune cells and other cell types. 4. **Neuroendocrine function**: NPY4R may influence the release of hormones and neurotransmitters, modulating neuroendocrine responses. **Clinical Significance:** NPY4R's role in immune regulation and inflammation has significant implications for various clinical conditions, including: 1. **Autoimmune diseases**: NPY4R's modulatory effects on T cell function and cytokine production may be exploited to develop novel therapeutic strategies for autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Inflammatory disorders**: NPY4R's anti-inflammatory properties may be leveraged to treat conditions characterized by chronic inflammation, such as asthma, chronic obstructive pulmonary disease (COPD), and inflammatory bowel disease. 3. **Cancer**: NPY4R's impact on cell survival and death pathways may influence cancer progression and metastasis, highlighting its potential as a therapeutic target in oncology. 4. **Neurological disorders**: NPY4R's involvement in neuroendocrine function and inflammation may contribute to the pathogenesis of neurological disorders, such as Parkinson's disease and multiple sclerosis. In conclusion, the Neuropeptide Y4 Receptor (NPY4R) is a complex GPCR with far-reaching implications for immune regulation, inflammation, and cellular signaling. Further research is necessary to fully elucidate the mechanisms underlying NPY4R's functions and to explore its therapeutic potential in various clinical contexts.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.