Details for: PWAR5

Gene ID: 8123

Symbol: PWAR5

Ensembl ID: ENSG00000279192

Description: Prader Willi/Angelman region RNA 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.2952
    Cell Significance Index: 2.9100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.2854
    Cell Significance Index: 3.4600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.2714
    Cell Significance Index: 2.2400
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.1465
    Cell Significance Index: 1.3200
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.1207
    Cell Significance Index: 1.1000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.1170
    Cell Significance Index: 0.9000
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.0639
    Cell Significance Index: 0.6700
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.0375
    Cell Significance Index: 0.4700
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.0366
    Cell Significance Index: 0.4200
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.0229
    Cell Significance Index: 0.2700
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0186
    Cell Significance Index: 0.2100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0170
    Cell Significance Index: 0.1800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0126
    Cell Significance Index: 0.1500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0070
    Cell Significance Index: -0.1200
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0116
    Cell Significance Index: -0.1500
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0128
    Cell Significance Index: -0.1600
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0205
    Cell Significance Index: -0.2200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0298
    Cell Significance Index: -0.2300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0333
    Cell Significance Index: -0.3100
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0386
    Cell Significance Index: -0.3400
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0492
    Cell Significance Index: -0.4900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0507
    Cell Significance Index: -0.8500
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0516
    Cell Significance Index: -0.6000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0576
    Cell Significance Index: -0.6800
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0577
    Cell Significance Index: -0.5300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0608
    Cell Significance Index: -0.8000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0612
    Cell Significance Index: -0.5800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0619
    Cell Significance Index: -0.8500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0664
    Cell Significance Index: -0.9000
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0669
    Cell Significance Index: -0.5300
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0678
    Cell Significance Index: -0.7700
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0726
    Cell Significance Index: -0.6800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0730
    Cell Significance Index: -0.7700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0751
    Cell Significance Index: -0.9000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0751
    Cell Significance Index: -0.9800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0762
    Cell Significance Index: -0.9000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0762
    Cell Significance Index: -0.6400
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0780
    Cell Significance Index: -0.9800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0799
    Cell Significance Index: -0.7500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0804
    Cell Significance Index: -0.8700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0831
    Cell Significance Index: -0.9200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0834
    Cell Significance Index: -0.9600
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0835
    Cell Significance Index: -0.9100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0851
    Cell Significance Index: -0.7500
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0855
    Cell Significance Index: -1.0400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0867
    Cell Significance Index: -1.0800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0882
    Cell Significance Index: -1.0500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0901
    Cell Significance Index: -0.8500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0905
    Cell Significance Index: -1.0200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0909
    Cell Significance Index: -0.9300
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.0910
    Cell Significance Index: -0.9300
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0911
    Cell Significance Index: -1.0000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0912
    Cell Significance Index: -1.0100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0913
    Cell Significance Index: -0.9700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0940
    Cell Significance Index: -1.0500
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0940
    Cell Significance Index: -0.9200
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0945
    Cell Significance Index: -1.0300
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.0953
    Cell Significance Index: -1.0100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0956
    Cell Significance Index: -1.2700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0968
    Cell Significance Index: -1.1900
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0973
    Cell Significance Index: -0.9000
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0974
    Cell Significance Index: -1.0500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0979
    Cell Significance Index: -1.0000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0983
    Cell Significance Index: -0.9900
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0995
    Cell Significance Index: -1.0500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0996
    Cell Significance Index: -1.1400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0999
    Cell Significance Index: -1.0200
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1011
    Cell Significance Index: -0.9400
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1015
    Cell Significance Index: -1.0700
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.1038
    Cell Significance Index: -1.0300
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: -0.1069
    Cell Significance Index: -0.6600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1074
    Cell Significance Index: -1.0000
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1075
    Cell Significance Index: -1.0400
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.1075
    Cell Significance Index: -1.0600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1076
    Cell Significance Index: -0.8900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1101
    Cell Significance Index: -1.3000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1136
    Cell Significance Index: -0.9800
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: -0.1151
    Cell Significance Index: -1.1300
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.1166
    Cell Significance Index: -1.1100
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1247
    Cell Significance Index: -1.0100
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.1286
    Cell Significance Index: -0.9600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1313
    Cell Significance Index: -2.2300
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1338
    Cell Significance Index: -0.8300
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.1350
    Cell Significance Index: -1.2200
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.1373
    Cell Significance Index: -1.5800
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1396
    Cell Significance Index: -0.7500
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.1397
    Cell Significance Index: -1.2400
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.1417
    Cell Significance Index: -1.5300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1452
    Cell Significance Index: -1.1100
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: -0.1510
    Cell Significance Index: -1.6500
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: -0.1518
    Cell Significance Index: -1.1500
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: -0.1524
    Cell Significance Index: -1.4200
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: -0.1631
    Cell Significance Index: -1.0900
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: -0.1655
    Cell Significance Index: -0.7300
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: -0.1723
    Cell Significance Index: -1.2900
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: -0.1804
    Cell Significance Index: -1.4400
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.1822
    Cell Significance Index: -1.0500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1999
    Cell Significance Index: -1.0900
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.3210
    Cell Significance Index: -1.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The PWAR5 gene is a non-coding RNA, specifically a long non-coding RNA (lncRNA), which plays a crucial role in regulating gene expression at the post-transcriptional level. Its expression is widespread, with notable presence in various immune cells, including T cells, plasma cells, B cells, and mast cells. Additionally, PWAR5 has been detected in goblet cells, absorptive cells, intestinal crypt stem cells of the colon, transit amplifying cells, and even in abnormal and neoplastic cells. This suggests that PWAR5 may have a broad impact on cellular homeostasis and disease progression. **Pathways and Functions:** PWAR5 has been associated with the nucleolus, a key organelle involved in ribosome biogenesis and RNA processing. The gene's involvement in RNA processing pathways is thought to be mediated through its interaction with other regulatory elements, such as microRNAs and chromatin-modifying enzymes. The precise mechanisms by which PWAR5 regulates gene expression are not yet fully understood, but its presence in various cellular compartments suggests that it may influence multiple aspects of cellular behavior, including proliferation, differentiation, and survival. **Clinical Significance:** The clinical significance of PWAR5 is an area of active research, with potential implications for the diagnosis and treatment of various diseases. Given its widespread expression in immune cells, PWAR5 may serve as a biomarker for immune-related disorders, such as autoimmune diseases or cancer. Furthermore, its involvement in RNA processing pathways suggests that dysregulation of PWAR5 may contribute to the development of various diseases, including those characterized by aberrant gene expression, such as cancer. In addition, the presence of PWAR5 in neoplastic cells highlights its potential role in tumorigenesis. Further investigation into the mechanisms by which PWAR5 regulates gene expression in cancer cells may lead to the identification of novel therapeutic targets. Moreover, the gene's presence in intestinal stem cells and goblet cells suggests that PWAR5 may play a role in maintaining intestinal homeostasis, which could have implications for the treatment of gastrointestinal disorders. In conclusion, the PWAR5 gene is a complex and multifaceted molecule that plays a crucial role in regulating RNA processing and has far-reaching implications for our understanding of immune regulation and disease. Further research is necessary to fully elucidate the mechanisms by which PWAR5 functions and to explore its potential as a biomarker or therapeutic target for various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.