Gene PWAR5 - ENSG00000279192 | NCBI Gene ID: 8123

Details for: PWAR5

Gene ID: 8123

Symbol: PWAR5

Ensembl ID: ENSG00000279192

Description: Prader Willi/Angelman region RNA 5

Associated with

Nucleolus
(GO:0005730)
Rna processing
(GO:0006396)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: T cell (CL0000084)
Fold Change: 2.49
Marker Score: 4299
Cell Name: plasma cell (CL0000786)
Fold Change: 1.91
Marker Score: 2138
Cell Name: B cell (CL0000236)
Fold Change: 1.25
Marker Score: 1189
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7684
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30390
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2410
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5326
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2734
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5277
Cell Name: mast cell (CL0000097)
Fold Change: 0.84
Marker Score: 488
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.82
Marker Score: 1337
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 703
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.73
Marker Score: 1173
Cell Name: fibroblast (CL0000057)
Fold Change: 0.7
Marker Score: 674
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.63
Marker Score: 504
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.59
Marker Score: 733
Cell Name: lung neuroendocrine cell (CL1000223)
Fold Change: 0.5
Marker Score: 141
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.49
Marker Score: 140
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 0.47
Marker Score: 134
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.47
Marker Score: 119
Cell Name: bronchial smooth muscle cell (CL0002598)
Fold Change: 0.47
Marker Score: 132
Cell Name: type D enteroendocrine cell (CL0000502)
Fold Change: 0.45
Marker Score: 138
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.42
Marker Score: 123
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.4
Marker Score: 359
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.37
Marker Score: 136
Cell Name: melanocyte (CL0000148)
Fold Change: 0.35
Marker Score: 141
Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: 0.34
Marker Score: 141
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.33
Marker Score: 147.5
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.33
Marker Score: 137
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.33
Marker Score: 137
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 0.29
Marker Score: 155
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.29
Marker Score: 133
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.27
Marker Score: 130
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.27
Marker Score: 74
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.25
Marker Score: 119
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.25
Marker Score: 78
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 0.25
Marker Score: 154
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 0.24
Marker Score: 133
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.24
Marker Score: 3711
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.23
Marker Score: 94
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.21
Marker Score: 140
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 0.21
Marker Score: 109
Cell Name: acinar cell (CL0000622)
Fold Change: 0.19
Marker Score: 135
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.19
Marker Score: 140
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.18
Marker Score: 111
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.18
Marker Score: 101
Cell Name: leukocyte (CL0000738)
Fold Change: 0.17
Marker Score: 99.5
Cell Name: pericyte (CL0000669)
Fold Change: 0.17
Marker Score: 101
Cell Name: macrophage (CL0000235)
Fold Change: 0.17
Marker Score: 191
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.16
Marker Score: 437
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 0.16
Marker Score: 126
Cell Name: astrocyte (CL0000127)
Fold Change: 0.16
Marker Score: 137
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.16
Marker Score: 141
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.14
Marker Score: 99
Cell Name: malignant cell (CL0001064)
Fold Change: 0.13
Marker Score: 1808
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.13
Marker Score: 125
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.13
Marker Score: 130
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.12
Marker Score: 131
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.12
Marker Score: 227
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.12
Marker Score: 301
Cell Name: stromal cell (CL0000499)
Fold Change: 0.12
Marker Score: 139
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 0.12
Marker Score: 139
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.11
Marker Score: 110
Cell Name: club cell (CL0000158)
Fold Change: 0.11
Marker Score: 126
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.11
Marker Score: 149
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 0.11
Marker Score: 103
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.11
Marker Score: 134
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.11
Marker Score: 113
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.11
Marker Score: 101
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.1
Marker Score: 113
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.1
Marker Score: 106
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.1
Marker Score: 126
Cell Name: monocyte (CL0000576)
Fold Change: 0.1
Marker Score: 129
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.1
Marker Score: 127
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.1
Marker Score: 140
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.1
Marker Score: 137
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.09
Marker Score: 113
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.09
Marker Score: 137
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.09
Marker Score: 140
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.08
Marker Score: 167
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.08
Marker Score: 115
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.08
Marker Score: 139
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0.08
Marker Score: 136
Cell Name: neuron (CL0000540)
Fold Change: 0.07
Marker Score: 300
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.07
Marker Score: 121.5
Cell Name: microglial cell (CL0000129)
Fold Change: 0.07
Marker Score: 122
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.06
Marker Score: 508
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.05
Marker Score: 119
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.05
Marker Score: 306
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.05
Marker Score: 79.5
Cell Name: Unknown (CL0000003)
Fold Change: 0.05
Marker Score: 152
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.04
Marker Score: 106
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.04
Marker Score: 149
Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.04
Marker Score: 118
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.04
Marker Score: 115
Cell Name: amacrine cell (CL0000561)
Fold Change: 0.04
Marker Score: 114
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.03
Marker Score: 97
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.03
Marker Score: 96
Cell Name: enterocyte (CL0000584)
Fold Change: 0.03
Marker Score: 139
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.02
Marker Score: 231

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Other Information

Description

**Key Characteristics:** The PWAR5 gene is a non-coding RNA, specifically a long non-coding RNA (lncRNA), which plays a crucial role in regulating gene expression at the post-transcriptional level. Its expression is widespread, with notable presence in various immune cells, including T cells, plasma cells, B cells, and mast cells. Additionally, PWAR5 has been detected in goblet cells, absorptive cells, intestinal crypt stem cells of the colon, transit amplifying cells, and even in abnormal and neoplastic cells. This suggests that PWAR5 may have a broad impact on cellular homeostasis and disease progression. **Pathways and Functions:** PWAR5 has been associated with the nucleolus, a key organelle involved in ribosome biogenesis and RNA processing. The gene's involvement in RNA processing pathways is thought to be mediated through its interaction with other regulatory elements, such as microRNAs and chromatin-modifying enzymes. The precise mechanisms by which PWAR5 regulates gene expression are not yet fully understood, but its presence in various cellular compartments suggests that it may influence multiple aspects of cellular behavior, including proliferation, differentiation, and survival. **Clinical Significance:** The clinical significance of PWAR5 is an area of active research, with potential implications for the diagnosis and treatment of various diseases. Given its widespread expression in immune cells, PWAR5 may serve as a biomarker for immune-related disorders, such as autoimmune diseases or cancer. Furthermore, its involvement in RNA processing pathways suggests that dysregulation of PWAR5 may contribute to the development of various diseases, including those characterized by aberrant gene expression, such as cancer. In addition, the presence of PWAR5 in neoplastic cells highlights its potential role in tumorigenesis. Further investigation into the mechanisms by which PWAR5 regulates gene expression in cancer cells may lead to the identification of novel therapeutic targets. Moreover, the gene's presence in intestinal stem cells and goblet cells suggests that PWAR5 may play a role in maintaining intestinal homeostasis, which could have implications for the treatment of gastrointestinal disorders. In conclusion, the PWAR5 gene is a complex and multifaceted molecule that plays a crucial role in regulating RNA processing and has far-reaching implications for our understanding of immune regulation and disease. Further research is necessary to fully elucidate the mechanisms by which PWAR5 functions and to explore its potential as a biomarker or therapeutic target for various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.