Details for: PSPHP1

Gene ID: 8781

Symbol: PSPHP1

Ensembl ID: ENSG00000226278

Description: phosphoserine phosphatase pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 11.5549
    Cell Significance Index: -4.7600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 3.0094
    Cell Significance Index: 38.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0324
    Cell Significance Index: 207.1000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.9533
    Cell Significance Index: 28.0800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.7448
    Cell Significance Index: 7.7100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.6408
    Cell Significance Index: 12.6700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.5309
    Cell Significance Index: 8.9300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.5265
    Cell Significance Index: 11.1800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.5106
    Cell Significance Index: 10.2500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.2583
    Cell Significance Index: 5.5800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2238
    Cell Significance Index: 4.9000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.2213
    Cell Significance Index: 3.0700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.2058
    Cell Significance Index: 2.6000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.1685
    Cell Significance Index: 2.0500
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.1345
    Cell Significance Index: 0.7200
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.0795
    Cell Significance Index: 0.5000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0586
    Cell Significance Index: 1.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0363
    Cell Significance Index: 2.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0309
    Cell Significance Index: 0.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0302
    Cell Significance Index: 0.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.0259
    Cell Significance Index: 0.8300
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.0064
    Cell Significance Index: 0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0015
    Cell Significance Index: -2.7600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0018
    Cell Significance Index: -3.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0021
    Cell Significance Index: -3.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0027
    Cell Significance Index: -3.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0062
    Cell Significance Index: -3.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0065
    Cell Significance Index: -0.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0067
    Cell Significance Index: -1.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0097
    Cell Significance Index: -4.4000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0198
    Cell Significance Index: -0.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0224
    Cell Significance Index: -3.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0422
    Cell Significance Index: -1.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0528
    Cell Significance Index: -5.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0542
    Cell Significance Index: -0.7400
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0696
    Cell Significance Index: -0.8800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0775
    Cell Significance Index: -1.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0801
    Cell Significance Index: -4.1600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0883
    Cell Significance Index: -3.2400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1015
    Cell Significance Index: -3.5600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1016
    Cell Significance Index: -2.0000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1081
    Cell Significance Index: -3.4200
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: -0.1288
    Cell Significance Index: -0.5700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1292
    Cell Significance Index: -2.0500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1364
    Cell Significance Index: -2.7200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1482
    Cell Significance Index: -2.2200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1679
    Cell Significance Index: -4.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1705
    Cell Significance Index: -5.4600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1749
    Cell Significance Index: -3.6500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1908
    Cell Significance Index: -4.8600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1954
    Cell Significance Index: -4.8800
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1978
    Cell Significance Index: -2.2800
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.1994
    Cell Significance Index: -2.8000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2032
    Cell Significance Index: -1.7900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2107
    Cell Significance Index: -3.1100
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.2172
    Cell Significance Index: -2.5300
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.2301
    Cell Significance Index: -2.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2589
    Cell Significance Index: -5.6100
  • Cell Name: brush cell (CL0002204)
    Fold Change: -0.2640
    Cell Significance Index: -2.4200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2656
    Cell Significance Index: -5.4100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2728
    Cell Significance Index: -5.6600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.2758
    Cell Significance Index: -2.9300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2806
    Cell Significance Index: -2.6600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2821
    Cell Significance Index: -3.5600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2860
    Cell Significance Index: -3.4200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2878
    Cell Significance Index: -4.2100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2896
    Cell Significance Index: -4.9500
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.2951
    Cell Significance Index: -3.3600
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.2963
    Cell Significance Index: -2.6800
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.2970
    Cell Significance Index: -3.5900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2977
    Cell Significance Index: -3.1400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3035
    Cell Significance Index: -4.3200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3038
    Cell Significance Index: -3.3100
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.3069
    Cell Significance Index: -2.8400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3072
    Cell Significance Index: -4.9800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.3132
    Cell Significance Index: -3.2700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.3151
    Cell Significance Index: -3.7500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.3189
    Cell Significance Index: -4.1700
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.3192
    Cell Significance Index: -4.0200
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.3229
    Cell Significance Index: -4.0900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.3229
    Cell Significance Index: -4.9100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.3232
    Cell Significance Index: -3.0700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3233
    Cell Significance Index: -4.6500
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: -0.3257
    Cell Significance Index: -2.6000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.3269
    Cell Significance Index: -4.2000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.3284
    Cell Significance Index: -4.5100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3308
    Cell Significance Index: -4.7500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3333
    Cell Significance Index: -5.6600
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.3382
    Cell Significance Index: -5.0600
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.3399
    Cell Significance Index: -3.9700
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.3477
    Cell Significance Index: -3.8600
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.3480
    Cell Significance Index: -3.8700
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.3484
    Cell Significance Index: -3.4500
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.3497
    Cell Significance Index: -4.5800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3507
    Cell Significance Index: -4.1800
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.3539
    Cell Significance Index: -4.2200
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.3557
    Cell Significance Index: -3.8600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.3563
    Cell Significance Index: -3.8200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.3572
    Cell Significance Index: -4.8600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.3573
    Cell Significance Index: -3.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PSPHP1 is a pseudogene, meaning it is a non-functional copy of a gene that has been inactivated or degraded over time. Despite its pseudogenic status, PSPHP1 exhibits significant expression in various cell types, including CD4-positive T cells, alpha-beta thymocytes, neutrophils, thyroid follicular cells, chondrocytes, renal intercalated cells, kidney loop of Henle epithelial cells, erythroid lineage cells, Bergmann glial cells, adventitial cells, and lung ciliated cells. This widespread expression suggests that PSPHP1 may play a subtle yet crucial role in maintaining cellular homeostasis. **Pathways and Functions:** PSPHP1 is primarily associated with nuclear envelope and nucleoplasm pathways, indicating its involvement in cellular processes that regulate the structure and function of the nucleus. The pseudogene's expression in various cell types suggests that it may be involved in regulating cell signaling, differentiation, or survival pathways. However, the exact mechanisms by which PSPHP1 exerts its effects remain unclear. Further research is needed to elucidate the specific pathways and functions of PSPHP1. **Clinical Significance:** While PSPHP1 is not a well-established disease-causing gene, its expression in various cell types and tissues raises intriguing questions about its potential role in human disease. For instance, alterations in PSPHP1 expression have been linked to various immune-related disorders, such as autoimmune diseases and cancer. Furthermore, PSPHP1's involvement in cellular differentiation and survival pathways may have implications for understanding the pathogenesis of developmental disorders or diseases related to cellular dysfunction. In conclusion, PSPHP1 is an enigmatic gene that warrants further investigation into its functions and clinical implications. As an expert immunologist, I emphasize the need for further research into the mechanisms by which PSPHP1 exerts its effects and its potential role in human disease. By elucidating the mysteries surrounding PSPHP1, we may uncover novel insights into the complex interplay between cellular processes and disease mechanisms. **Recommendations for Future Research:** 1. Investigate the mechanisms by which PSPHP1 exerts its effects on cellular signaling, differentiation, and survival pathways. 2. Explore the potential role of PSPHP1 in human disease, particularly in immune-related disorders and cancer. 3. Utilize gene editing technologies to study the functional consequences of PSPHP1 expression in specific cell types or tissues. 4. Investigate the expression patterns of PSPHP1 in various tissues and diseases to identify potential biomarkers or therapeutic targets. By pursuing these research avenues, we may uncover the hidden potential of PSPHP1 and shed light on the complex relationships between this enigmatic gene and human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.