Details for: MTMR2
Gene ID: 8898
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: MTMR2
Ensembl ID: ENSG00000087053
Description: myotubularin related protein 2
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 14.84rCSI 24.22%PRS 37.12
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CSI 11.83rCSI 33.27%PRS 65.51
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CSI 11.56rCSI 14.01%PRS 53.22
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CSI 9.06rCSI 12.35%PRS 37.96
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CSI 6.94rCSI 22.34%PRS 66.81
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CSI 6.88rCSI 10.87%PRS 71.58
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CSI 6.86rCSI 17.41%PRS 58.87
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CSI 6.65rCSI 15.17%PRS 60.79
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CSI 6.04rCSI 13.77%PRS 64.65
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CSI 5.22rCSI 4.72%PRS 66.61
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CSI 5.11rCSI 12.42%PRS 48.92
-
CSI 5.06rCSI 8.05%PRS 61.96
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CSI 4.69rCSI 7.88%PRS 50.51
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CSI 4.55rCSI 8.06%PRS 40.99
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CSI 4.49rCSI 11.86%PRS 77.8
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CSI 4.34rCSI 7.51%PRS 59.72
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CSI 4.14rCSI 4.21%PRS 80.74
-
CSI 4.12rCSI 6.57%PRS 61.16
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CSI 3.87rCSI 6.82%PRS 65.64
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CSI 3.82rCSI 8.56%PRS 51.2
-
CSI 3.77rCSI 7.66%PRS 47.58
-
CSI 3.57rCSI 6.69%PRS 57.14
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CSI 3.55rCSI 5.28%PRS 70.27
-
CSI 3.25rCSI 4.51%PRS 67.93
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CSI 3.2rCSI 6.43%PRS 58.57
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CSI 3.13rCSI 7.16%PRS 69.88
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CSI 3.09rCSI 3.83%PRS 66.23
-
CSI 3.08rCSI 4.42%PRS 58.77
-
CSI 3.03rCSI 4.46%PRS 62.47
-
CSI 3.02rCSI 2.24%PRS 62.16
-
CSI 2.86rCSI 2.81%PRS 72
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CSI 2.78rCSI 2.68%PRS 61.02
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CSI 2.77rCSI 3.77%PRS 60.79
-
CSI 2.75rCSI 10.75%PRS 46.41
-
CSI 2.7rCSI 2.13%PRS 56.56
-
CSI 2.56rCSI 3.63%PRS 65.45
-
CSI 2.53rCSI 2.77%PRS 72.68
-
CSI 2.49rCSI 2.98%PRS 67.68
-
CSI 2.45rCSI 2.57%PRS 72.92
-
CSI 2.42rCSI 3.31%PRS 75.09
-
CSI 2.4rCSI 4.99%PRS 66.36
-
CSI 2.33rCSI 8.75%PRS 61.31
-
CSI 2.3rCSI 7.2%PRS 54.72
-
CSI 2.25rCSI 10.77%PRS 69.25
-
CSI 2.21rCSI 2.21%PRS 62.82
-
CSI 2.18rCSI 3.83%PRS 61.73
-
CSI 2.18rCSI 3.57%PRS 58.36
-
CSI 2.16rCSI 10.36%PRS 67.07
-
CSI 2.15rCSI 3.87%PRS 62.44
-
CSI 2.15rCSI 2.76%PRS 60.78
-
CSI 2.11rCSI 2.63%PRS 48.56
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CSI 1.98rCSI 2.29%PRS 61.97
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CSI 1.96rCSI 5.57%PRS 66.6
-
CSI 1.94rCSI 2.5%PRS 66
-
CSI 1.93rCSI 2.64%PRS 61.69
-
CSI 1.92rCSI 4.85%PRS 76.36
-
CSI 1.9rCSI 3.93%PRS 68.99
-
CSI 1.9rCSI 1.67%PRS 57.32
-
CSI 1.89rCSI 4.92%PRS 69.6
-
CSI 1.86rCSI 2.86%PRS 78.58
-
CSI 1.84rCSI 2.94%PRS 73.51
-
CSI 1.83rCSI 1.92%PRS 66.23
-
CSI 1.82rCSI 2.78%PRS 69.97
-
CSI 1.81rCSI 2.31%PRS 75.4
-
CSI 1.76rCSI 10.36%PRS 51.63
-
CSI 1.73rCSI 4.29%PRS 68.04
-
CSI 1.72rCSI 4.11%PRS 69.67
-
CSI 1.69rCSI 6.08%PRS 48.7
-
CSI 1.69rCSI 4.12%PRS 62.33
-
CSI 1.59rCSI 4.1%PRS 64.18
-
CSI 1.58rCSI 1.88%PRS 50.28
-
CSI 1.48rCSI 1.91%PRS 51.83
-
CSI 1.46rCSI 5.87%PRS 68.52
-
CSI 1.41rCSI 4.52%PRS 66.52
-
CSI 1.41rCSI 2.8%PRS 65.95
-
CSI 1.3rCSI 2.1%PRS 52.44
-
CSI 1.26rCSI 3.92%PRS 52.3
-
CSI 1.23rCSI 2.73%PRS 67.88
-
CSI 1.21rCSI 1.4%PRS 60.22
-
CSI 1.18rCSI 3.96%PRS 53.83
-
CSI 1.1rCSI 3.03%PRS 64.27
-
CSI 1.08rCSI 1.91%PRS 76.7
-
CSI 1.07rCSI 4.06%PRS 59.77
-
CSI 1.05rCSI 4.3%PRS 80.54
-
CSI 1.05rCSI 2.8%PRS 60.25
-
CSI 1rCSI 2.21%PRS 55.2
-
CSI 0.98rCSI 4.29%PRS 58.73
-
CSI 0.97rCSI 1.38%PRS 72.03
-
CSI 0.97rCSI 2.79%PRS 70.01
-
CSI 0.96rCSI 2.78%PRS 58.55
-
CSI 0.95rCSI 1.67%PRS 49.62
-
CSI 0.93rCSI 1.5%PRS 58.74
-
CSI 0.9rCSI 21.66%PRS 49.64
-
CSI 0.85rCSI 20.61%PRS 50.26
-
CSI 0.85rCSI 3.2%PRS 51.1
-
CSI 0.82rCSI 4.04%PRS 79.65
-
CSI 0.74rCSI 2.43%PRS 55.87
-
CSI 0.73rCSI 5.37%PRS 55.87
-
CSI 0.72rCSI 4.52%PRS 60.74
-
CSI 0.68rCSI 3.03%PRS 69.5
-
CSI 0.2rCSI 1.6%PRS 56.4%
-
CSI 0.3rCSI 5.5%PRS 59.6%
-
CSI 0.4rCSI 3.3%PRS 62.8%
-
CSI 0.4rCSI 5.8%PRS 60.2%
-
CSI 0.6rCSI 1.5%PRS 63.1%
-
CSI 0.6rCSI 1.5%PRS 56.1%
-
CSI 0.7rCSI 3.0%PRS 69.5%
-
CSI 0.7rCSI 4.5%PRS 60.7%
-
CSI 0.7rCSI 5.4%PRS 55.9%
-
CSI 0.7rCSI 2.4%PRS 55.9%
-
CSI 0.8rCSI 4.0%PRS 79.7%
-
CSI 0.9rCSI 3.2%PRS 51.1%
-
CSI 0.9rCSI 20.6%PRS 50.3%
-
CSI 0.9rCSI 21.7%PRS 49.6%
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CSI 0.9rCSI 1.5%PRS 58.7%
-
CSI 1.0rCSI 1.7%PRS 49.6%
-
CSI 1.0rCSI 2.8%PRS 58.6%
-
CSI 1.0rCSI 2.8%PRS 70.0%
-
CSI 1.0rCSI 1.4%PRS 72.0%
-
CSI 1.0rCSI 4.3%PRS 58.7%
-
CSI 1.0rCSI 2.2%PRS 55.2%
-
CSI 1.1rCSI 2.8%PRS 60.3%
-
CSI 1.1rCSI 4.3%PRS 80.5%
-
CSI 1.1rCSI 4.1%PRS 59.8%
-
CSI 1.1rCSI 1.9%PRS 76.7%
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CSI 1.1rCSI 3.0%PRS 64.3%
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CSI 1.2rCSI 4.0%PRS 53.8%
-
CSI 1.2rCSI 1.4%PRS 60.2%
-
CSI 1.2rCSI 2.7%PRS 67.9%
-
CSI 1.3rCSI 3.9%PRS 52.3%
-
CSI 1.3rCSI 2.1%PRS 52.4%
-
CSI 1.4rCSI 2.8%PRS 66.0%
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CSI 1.4rCSI 4.5%PRS 66.5%
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CSI 1.5rCSI 5.9%PRS 68.5%
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CSI 1.5rCSI 1.9%PRS 51.8%
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CSI 1.6rCSI 1.9%PRS 50.3%
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CSI 1.6rCSI 4.1%PRS 64.2%
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CSI 1.7rCSI 4.1%PRS 62.3%
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CSI 1.7rCSI 6.1%PRS 48.7%
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CSI 1.7rCSI 4.1%PRS 69.7%
-
CSI 1.7rCSI 4.3%PRS 68.0%
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CSI 1.8rCSI 10.4%PRS 51.6%
-
CSI 1.8rCSI 2.3%PRS 75.4%
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CSI 1.8rCSI 2.8%PRS 70.0%
-
CSI 1.8rCSI 1.9%PRS 66.2%
-
CSI 1.8rCSI 2.9%PRS 73.5%
-
CSI 1.9rCSI 2.9%PRS 78.6%
-
CSI 1.9rCSI 4.9%PRS 69.6%
-
CSI 1.9rCSI 1.7%PRS 57.3%
-
CSI 1.9rCSI 3.9%PRS 69.0%
-
CSI 1.9rCSI 4.9%PRS 76.4%
-
CSI 1.9rCSI 2.6%PRS 61.7%
-
CSI 1.9rCSI 2.5%PRS 66.0%
-
CSI 2.0rCSI 5.6%PRS 66.6%
-
CSI 2.0rCSI 2.3%PRS 62.0%
-
CSI 2.1rCSI 2.6%PRS 48.6%
-
CSI 2.2rCSI 2.8%PRS 60.8%
-
CSI 2.2rCSI 3.9%PRS 62.4%
-
CSI 2.2rCSI 10.4%PRS 67.1%
-
CSI 2.2rCSI 3.6%PRS 58.4%
-
CSI 2.2rCSI 3.8%PRS 61.7%
-
CSI 2.2rCSI 2.2%PRS 62.8%
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CSI 2.3rCSI 10.8%PRS 69.3%
-
CSI 2.3rCSI 7.2%PRS 54.7%
-
CSI 2.3rCSI 8.8%PRS 61.3%
-
CSI 2.4rCSI 5.0%PRS 66.4%
-
CSI 2.4rCSI 3.3%PRS 75.1%
-
CSI 2.5rCSI 2.6%PRS 72.9%
-
CSI 2.5rCSI 3.0%PRS 67.7%
-
CSI 2.5rCSI 2.8%PRS 72.7%
-
CSI 2.6rCSI 3.6%PRS 65.5%
-
CSI 2.7rCSI 2.1%PRS 56.6%
-
CSI 2.8rCSI 10.8%PRS 46.4%
-
CSI 2.8rCSI 3.8%PRS 60.8%
-
CSI 2.8rCSI 2.7%PRS 61.0%
-
CSI 2.9rCSI 2.8%PRS 72.0%
-
CSI 3.0rCSI 2.2%PRS 62.2%
-
CSI 3.0rCSI 4.5%PRS 62.5%
-
CSI 3.1rCSI 4.4%PRS 58.8%
-
CSI 3.1rCSI 3.8%PRS 66.2%
-
CSI 3.1rCSI 7.2%PRS 69.9%
-
CSI 3.2rCSI 6.4%PRS 58.6%
-
CSI 3.3rCSI 4.5%PRS 67.9%
-
CSI 3.6rCSI 5.3%PRS 70.3%
-
CSI 3.6rCSI 6.7%PRS 57.1%
-
CSI 3.8rCSI 7.7%PRS 47.6%
-
CSI 3.8rCSI 8.6%PRS 51.2%
-
CSI 3.9rCSI 6.8%PRS 65.6%
-
CSI 4.1rCSI 6.6%PRS 61.2%
-
CSI 4.1rCSI 4.2%PRS 80.7%
-
CSI 4.3rCSI 7.5%PRS 59.7%
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CSI 4.5rCSI 11.9%PRS 77.8%
-
CSI 4.6rCSI 8.1%PRS 41.0%
-
CSI 4.7rCSI 7.9%PRS 50.5%
-
CSI 5.1rCSI 8.1%PRS 62.0%
-
CSI 5.1rCSI 12.4%PRS 48.9%
-
CSI 5.2rCSI 4.7%PRS 66.6%
-
CSI 6.0rCSI 13.8%PRS 64.7%
-
CSI 6.7rCSI 15.2%PRS 60.8%
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CSI 6.9rCSI 17.4%PRS 58.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 4025488370
Symbol: MTMR2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10470851
Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10470851
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9736772
Title: Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human.
PubMed ID: 9736772
PubMed ID: 8640223
Title: A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast.
PubMed ID: 8640223
DOI: 10.1038/ng0696-175
PubMed ID: 10802647
Title: Charcot-Marie-Tooth type 4B is caused by mutations in the gene encoding myotubularin-related protein-2.
PubMed ID: 10802647
DOI: 10.1038/75542
PubMed ID: 11733541
Title: Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease.
PubMed ID: 11733541
PubMed ID: 12668758
Title: Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase.
PubMed ID: 12668758
PubMed ID: 12847286
Title: Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP.
PubMed ID: 12847286
PubMed ID: 15998640
Title: The phosphoinositide-3-phosphatase MTMR2 associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-Tooth disease.
PubMed ID: 15998640
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21372139
Title: Endosomal targeting of the phosphoinositide 3-phosphatase MTMR2 is regulated by an N-terminal phosphorylation site.
PubMed ID: 21372139
PubMed ID: 14690594
Title: Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome.
PubMed ID: 14690594
PubMed ID: 16410353
Title: Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase.
PubMed ID: 16410353
PubMed ID: 12398840
Title: A novel homozygous missense mutation in the myotubularin-related protein 2 gene associated with recessive Charcot-Marie-Tooth disease with irregularly folded myelin sheaths.
PubMed ID: 12398840
PubMed ID: 35580604
Title: Myotubularin-related phosphatase 5 is a critical determinant of autophagy in neurons.
PubMed ID: 35580604
PubMed ID: 34718573
Title: Distinct roles for the Charcot-Marie-Tooth disease-causing endosomal regulators Mtmr5 and Mtmr13 in axon radial sorting and Schwann cell myelination.
PubMed ID: 34718573
DOI: 10.1093/hmg/ddab311
Sequence Information:
- Length: 643
- Mass: 73381
- Checksum: 10FD6508D0CDA719
- Sequence:
MEKSSSCESL GSQPAAARPP SVDSLSSAST SHSENSVHTK SASVVSSDSI STSADNFSPD LRVLRESNKL AEMEEPPLLP GENIKDMAKD VTYICPFTGA VRGTLTVTNY RLYFKSMERD PPFVLDASLG VINRVEKIGG ASSRGENSYG LETVCKDIRN LRFAHKPEGR TRRSIFENLM KYAFPVSNNL PLFAFEYKEV FPENGWKLYD PLLEYRRQGI PNESWRITKI NERYELCDTY PALLVVPANI PDEELKRVAS FRSRGRIPVL SWIHPESQAT ITRCSQPMVG VSGKRSKEDE KYLQAIMDSN AQSHKIFIFD ARPSVNAVAN KAKGGGYESE DAYQNAELVF LDIHNIHVMR ESLRKLKEIV YPNIEETHWL SNLESTHWLE HIKLILAGAL RIADKVESGK TSVVVHCSDG WDRTAQLTSL AMLMLDGYYR TIRGFEVLVE KEWLSFGHRF QLRVGHGDKN HADADRSPVF LQFIDCVWQM TRQFPTAFEF NEYFLITILD HLYSCLFGTF LCNSEQQRGK ENLPKRTVSL WSYINSQLED FTNPLYGSYS NHVLYPVASM RHLELWVGYY IRWNPRMKPQ EPIHNRYKEL LAKRAELQKK VEELQREISN RSTSSSERAS SPAQCVTPVQ TVV