PCED1B | ENSG00000179715 | NCBI 91523

Details for: PCED1B

Gene ID: 91523

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: PCED1B

Ensembl ID: ENSG00000179715

Description: PC-esterase domain containing 1B

Cell Significance Landscape

Display Count:

Associated with

Protein binding
(GO:0005515)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

central memory CD8-positive, alpha-beta T cell CL0000907

CSI 17.93

rCSI 12.08%

PRS 94.58
CD4-positive, alpha-beta memory T cell CL0000897

CSI 13.22

rCSI 9.49%

PRS 94.4
mucosal invariant T cell CL0000940

CSI 12.15

rCSI 9.82%

PRS 91.09
epithelial cell CL0000066

CSI 11.23

rCSI 17.26%

PRS 72.86
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 10.9

rCSI 19.25%

PRS 66.85
mesothelial cell CL0000077

CSI 10.32

rCSI 40.38%

PRS 63.71
GABAergic amacrine cell CL4030027

CSI 9.77

rCSI 33.46%

PRS 70.15
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 8.96

rCSI 6.29%

PRS 94.08
adipocyte CL0000136

CSI 8.8

rCSI 11.3%

PRS 74.57
neuroendocrine cell CL0000165

CSI 8.66

rCSI 33.49%

PRS 90.26
blood vessel endothelial cell CL0000071

CSI 7.48

rCSI 15.53%

PRS 81.02
podocyte CL0000653

CSI 7.37

rCSI 32.74%

PRS 84.67
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 7.27

rCSI 18.81%

PRS 79.95
early lymphoid progenitor CL0000936

CSI 7.12

rCSI 6.25%

PRS 88.4
alpha-beta T cell CL0000789

CSI 6.92

rCSI 8.11%

PRS 94.61
kidney interstitial alternatively activated macrophage CL1000695

CSI 6.77

rCSI 17.66%

PRS 84.96
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 6.71

rCSI 3.96%

PRS 96.14
innate lymphoid cell CL0001065

CSI 6.66

rCSI 13.74%

PRS 80.11
alveolar macrophage CL0000583

CSI 6.6

rCSI 10.87%

PRS 87.35
stromal cell CL0000499

CSI 6.55

rCSI 18.43%

PRS 79.19
ependymal cell CL0000065

CSI 6.18

rCSI 12.54%

PRS 63.62
fibroblast of lung CL0002553

CSI 6.17

rCSI 5.75%

PRS 84.81
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 5.51

rCSI 5.02%

PRS 93.55
effector CD8-positive, alpha-beta T cell CL0001050

CSI 5.5

rCSI 4.18%

PRS 94.48
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 5.14

rCSI 18.51%

PRS 65.17
kidney collecting duct intercalated cell CL1001432

CSI 5.13

rCSI 36.64%

PRS 81.4
regulatory T cell CL0000815

CSI 4.97

rCSI 5.77%

PRS 82.43
subcutaneous adipocyte CL0002521

CSI 4.96

rCSI 25.42%

PRS 86.48
cardiac blood vessel endothelial cell CL0010006

CSI 4.79

rCSI 33.89%

PRS 76.78
basal cell CL0000646

CSI 4.7

rCSI 6.28%

PRS 81.95
near-projecting glutamatergic cortical neuron CL4023012

CSI 4.63

rCSI 17.5%

PRS 67.72
amacrine cell CL0000561

CSI 4.52

rCSI 13.1%

PRS 73.97
unswitched memory B cell CL0000970

CSI 4.43

rCSI 3.73%

PRS 94.33
endocardial cell CL0002350

CSI 4.4

rCSI 21.06%

PRS 80.06
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 4.32

rCSI 5.43%

PRS 95.16
mononuclear phagocyte CL0000113

CSI 4.3

rCSI 9.47%

PRS 87.23
Kupffer cell CL0000091

CSI 4.22

rCSI 9.64%

PRS 84.84
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 4.12

rCSI 4.92%

PRS 95.67
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 4.09

rCSI 4.02%

PRS 94.6
retinal bipolar neuron CL0000748

CSI 4.08

rCSI 7.64%

PRS 73.21
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 4.05

rCSI 5.74%

PRS 81.14
GABAergic neuron CL0000617

CSI 4.04

rCSI 13.54%

PRS 68.39
parietal epithelial cell CL1000452

CSI 4.02

rCSI 10.75%

PRS 76.63
rod bipolar cell CL0000751

CSI 4

rCSI 7.18%

PRS 77.77
activated type II NK T cell CL0000931

CSI 3.93

rCSI 4.42%

PRS 94.17
naive T cell CL0000898

CSI 3.77

rCSI 2.62%

PRS 94.85
mature alpha-beta T cell CL0000791

CSI 3.63

rCSI 13.16%

PRS 96.14
cardiac neuron CL0010022

CSI 3.55

rCSI 11.35%

PRS 81.82
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 3.54

rCSI 8.61%

PRS 65.14
hepatic stellate cell CL0000632

CSI 3.48

rCSI 13.04%

PRS 77.07
extravillous trophoblast CL0008036

CSI 3.46

rCSI 4.28%

PRS 82.17
contractile cell CL0000183

CSI 3.3

rCSI 9.73%

PRS 83.08
kidney connecting tubule epithelial cell CL1000768

CSI 3.19

rCSI 8.1%

PRS 75.33
endothelial cell of vascular tree CL0002139

CSI 3.11

rCSI 17.01%

PRS 80.14
retinal ganglion cell CL0000740

CSI 3.07

rCSI 6.78%

PRS 70.68
epicardial adipocyte CL1000309

CSI 2.97

rCSI 9.65%

PRS 81.22
renal interstitial pericyte CL1001318

CSI 2.95

rCSI 8.14%

PRS 79.56
mature T cell CL0002419

CSI 2.94

rCSI 2.29%

PRS 94.81
double negative thymocyte CL0002489

CSI 2.89

rCSI 2.01%

PRS 93.7
astrocyte of the cerebral cortex CL0002605

CSI 2.84

rCSI 6.36%

PRS 68.19
fibroblast of cardiac tissue CL0002548

CSI 2.83

rCSI 13.53%

PRS 84.01
mature microglial cell CL0002629

CSI 2.79

rCSI 11.58%

PRS 84.03
cerebral cortex endothelial cell CL1001602

CSI 2.77

rCSI 4.8%

PRS 76.29
Mueller cell CL0000636

CSI 2.69

rCSI 6.15%

PRS 75.98
tracheobronchial smooth muscle cell CL0019019

CSI 2.62

rCSI 4.63%

PRS 88.27
elicited macrophage CL0000861

CSI 2.62

rCSI 2.4%

PRS 90.65
kidney distal convoluted tubule epithelial cell CL1000849

CSI 2.57

rCSI 27.28%

PRS 80.14
plasmablast CL0000980

CSI 2.5

rCSI 1.97%

PRS 88.12
lung ciliated cell CL1000271

CSI 2.31

rCSI 2.67%

PRS 77.04
Schwann cell CL0002573

CSI 2.25

rCSI 6.39%

PRS 79.78
effector CD4-positive, alpha-beta T cell CL0001044

CSI 2.2

rCSI 6.3%

PRS 96.65
T follicular helper cell CL0002038

CSI 2.1

rCSI 1.57%

PRS 94.16
cardiac endothelial cell CL0010008

CSI 2.06

rCSI 8.31%

PRS 84.09
conjunctival epithelial cell CL1000432

CSI 2

rCSI 3.06%

PRS 83.89
myoepithelial cell CL0000185

CSI 1.99

rCSI 5.04%

PRS 87.87
Bergmann glial cell CL0000644

CSI 1.97

rCSI 2.7%

PRS 75.44
epithelial cell of proximal tubule CL0002306

CSI 1.89

rCSI 4.62%

PRS 76.52
L2/3 intratelencephalic projecting glutamatergic neuron CL4030059

CSI 1.83

rCSI 3.98%

PRS 71.74
CD4-positive helper T cell CL0000492

CSI 1.79

rCSI 1.35%

PRS 94.03
lung neuroendocrine cell CL1000223

CSI 1.76

rCSI 2.6%

PRS 86.91
myeloid dendritic cell CL0000782

CSI 1.76

rCSI 2.54%

PRS 94.24
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI 1.67

rCSI 4.32%

PRS 95.88
renal principal cell CL0005009

CSI 1.67

rCSI 4.33%

PRS 83.82
pulmonary alveolar type 1 cell CL0002062

CSI 1.61

rCSI 9.28%

PRS 80.3
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 1.59

rCSI 2.72%

PRS 93.87
renal beta-intercalated cell CL0002201

CSI 1.59

rCSI 3.79%

PRS 83.78
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 1.57

rCSI 3.13%

PRS 93.39
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 1.54

rCSI 3.68%

PRS 71.25
CD1c-positive myeloid dendritic cell CL0002399

CSI 1.51

rCSI 1.82%

PRS 90.59
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 1.37

rCSI 1.87%

PRS 96.46
Hofbauer cell CL3000001

CSI 1.2

rCSI 2.26%

PRS 90.75
starburst amacrine cell CL0004232

CSI 0.97

rCSI 8.17%

PRS 71.62
central nervous system neuron CL2000029

CSI 0.7

rCSI 5.18%

PRS 72.38
direct pathway medium spiny neuron CL4023026

CSI 0.68

rCSI 16.3%

PRS 65.18
endothelial cell of placenta CL0009092

CSI 0.62

rCSI 3.07%

PRS 90.14
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 0.5

rCSI 2.51%

PRS 93.74
blood vessel smooth muscle cell CL0019018

CSI 0.39

rCSI 3.2%

PRS 78.96
cytotoxic T cell CL0000910

CSI 0.2

rCSI 1.17%

PRS 86.05

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

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Node Color (Target Cell CSI, relative to current network):
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- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [PCED1B](/details-gene/91523), also known as PC-esterase domain containing 1B or FAM113B, is a protein-coding gene located on chromosome 12q13.11. While its precise molecular function remains largely uncharacterized, it is annotated as being involved in protein binding. Expression data from the **Overall** context reveals that [PCED1B](/details-gene/91523) has a widespread significance across diverse cell lineages, including the immune system, epithelial tissues, and the nervous system. It shows particularly high significance in adaptive immune cells, most notably in [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907) and [CD4-positive, alpha-beta memory T cell](/details-cell/CL0000897), suggesting a potential role in immunological memory. The gene was identified as part of a large-scale cDNA collection project, but detailed functional studies are lacking [Link](https://doi.org/10.1101/gr.2596504). ## Cellular Roles and Expression Landscape The expression profile of [PCED1B](/details-gene/91523) suggests it is a functionally important gene in a wide array of cell types, rather than a lineage-specific marker. A prominent role for [PCED1B](/details-gene/91523) is suggested within the T lymphocyte compartment. It is a highly significant gene in several T cell subsets, including: * [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907) (CSI: 17.93) * [CD4-positive, alpha-beta memory T cell](/details-cell/CL0000897) (CSI: 13.22) * [mucosal invariant T cell](/details-cell/CL0000940) (CSI: 12.15) * [naive thymus-derived CD8-positive, alpha-beta T cell](/details-cell/CL0000900) (CSI: 8.96) * [alpha-beta T cell](/details-cell/CL0000789) (CSI: 6.92) This strong signature in both naive and memory T cells points towards a potential function in T cell homeostasis, activation, or the maintenance of long-term immunity. Beyond the immune system, [PCED1B](/details-gene/91523) demonstrates high significance in various non-hematopoietic cells. This includes a strong signal in [epithelial cell](/details-cell/CL0000066) (CSI: 11.23), [mesothelial cell](/details-cell/CL0000077) (CSI: 10.32), and specialized cells such as [podocyte](/details-cell/CL0000653)s in the kidney and [adipocyte](/details-cell/CL0000136)s. Furthermore, the gene is also significant in specific neuronal populations, including [caudal ganglionic eminence derived cortical interneuron](/details-cell/CL4023064) (CSI: 10.90) and [GABAergic amacrine cell](/details-cell/CL4030027) (CSI: 9.77). This broad expression pattern across functionally distinct cell types suggests that [PCED1B](/details-gene/91523) may be involved in a fundamental cellular process common to these diverse cells. ## Pathways and Molecular Function The molecular function of [PCED1B](/details-gene/91523) is currently poorly defined. The primary functional annotation available is for [protein binding ([GO:0005515](https://www.ebi.ac.uk/QuickGO/term/GO:0005515))](https://www.ebi.ac.uk/QuickGO/term/GO:0005515). This suggests that the PCED1B protein likely does not function in isolation but acts as part of a larger protein complex, perhaps serving as an adaptor, scaffold, or regulatory subunit. The specific binding partners of PCED1B may differ across cell types, which could explain its high significance in such varied cellular contexts as T cell memory and neuronal function. Elucidating these protein-protein interactions is a critical next step to understanding its biological role. ## Research Directions The broad expression pattern of [PCED1B](/details-gene/91523), combined with its minimal functional annotation, highlights it as a candidate for foundational biological research. Its high significance in memory T cells is particularly intriguing. ### Proposed Hypotheses 1. **Role in Immunological Memory:** Given its high significance in [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907) and [CD4-positive, alpha-beta memory T cell](/details-cell/CL0000897), [PCED1B](/details-gene/91523) may be a key regulator of T cell memory formation or survival. It could act by binding to and stabilizing key transcription factors or signaling molecules that maintain the long-lived memory state. 2. **Function as a Cellular Scaffolding Protein:** The gene's importance across diverse and specialized cell types (neurons, podocytes, T cells) suggests a more fundamental role. [PCED1B](/details-gene/91523) may function as a widely expressed scaffold or adaptor protein, whose cell-specific binding partners dictate its contextual role in cellular architecture, signaling, or metabolism. ### Experimental Approach To test the hypothesis that [PCED1B](/details-gene/91523) is critical for T cell memory (Hypothesis 1), a multi-pronged approach could be employed. A T cell-specific conditional knockout mouse model (e.g., *Pced1b*^fl/fl;CD4-Cre) would be instrumental. These mice could be challenged with a model infection, such as Lymphocytic Choriomeningitis Virus (LCMV), and the development, persistence, and recall capacity of antigen-specific memory T cells could be quantified via flow cytometry and *in vivo* cytotoxicity assays. In parallel, identifying the binding partners of PCED1B in primary human memory T cells using co-immunoprecipitation coupled with mass spectrometry (Co-IP/MS) would provide direct mechanistic insight into the pathways it regulates. ### Therapeutic Potential The therapeutic potential of [PCED1B](/details-gene/91523) is currently undefined. Its broad expression pattern across many healthy tissues suggests that systemic inhibition or activation could lead to substantial off-target toxicities. Therefore, it is unlikely to be a viable target for systemic therapies in its current state of understanding. However, if future research demonstrates that [PCED1B](/details-gene/91523) is selectively overexpressed or becomes a critical dependency in a specific disease, such as a T-cell lymphoma or a particular solid tumor, it could emerge as a candidate for highly targeted therapeutic strategies. Further investigation into its role in pathology is required before its value as a drug target can be properly assessed.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Protein FAM113B

Genular Protein ID: 916508459

Symbol: PED1B_HUMAN

Name: Protein FAM113B

UniProtKB Accession Codes:

Q96HM7 Q96B20

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 432
Mass: 49727
Checksum: F21497B76A791926
Sequence:

MILLRASEVR QLLHNKFVVI LGDSVHRAVY KDLVLLLQKD RLLTPGQLRA RGELNFEQDE 
LVDGGQRGHM HNGLNYREVR EFRSDHHLVR FYFLTRVYSD YLQTILKELQ SGEHAPDLVI 
MNSCLWDISR YGPNSWRSYL ENLENLFQCL GQVLPESCLL VWNTAMPVGE EVTGGFLPPK 
LRRQKATFLK NEVVKANFHS ATEARKHNFD VLDLHFHFRH ARENLHWDGV HWNGRVHRCL 
SQLLLAHVAD AWGVELPHRH PVGEWIKKKK PGPRVEGPPQ ANRNHPALPL SPPLPSPTYR 
PLLGFPPQRL PLLPLLSPQP PPPILHHQGM PRFPQGPPDA CFSSDHTFQS DQFYCHSDVP 
SSAHAGFFVE DNFMVGPQLP MPFFPTPRYQ RPAPVVHRGF GRYRPRGPYT PWGQRPRPSK 
RRAPANPEPR PQ