Details for: FDPSP3

Gene ID: 2227

Symbol: FDPSP3

Ensembl ID: ENSG00000258872

Description: farnesyl diphosphate synthase pseudogene 3

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 0.6504
    Cell Significance Index: 5.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2146
    Cell Significance Index: 5.8400
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.1285
    Cell Significance Index: 1.5500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.1130
    Cell Significance Index: 1.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0100
    Cell Significance Index: -0.5200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0186
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0202
    Cell Significance Index: -3.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0360
    Cell Significance Index: -1.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0364
    Cell Significance Index: -4.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0686
    Cell Significance Index: -3.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0809
    Cell Significance Index: -2.3300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0865
    Cell Significance Index: -2.1600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0942
    Cell Significance Index: -0.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1289
    Cell Significance Index: -4.5300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1962
    Cell Significance Index: -4.0700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2008
    Cell Significance Index: -2.0500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2051
    Cell Significance Index: -3.4500
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.2147
    Cell Significance Index: -2.6000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2183
    Cell Significance Index: -6.4300
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.2258
    Cell Significance Index: -2.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2392
    Cell Significance Index: -6.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2411
    Cell Significance Index: -3.2900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2425
    Cell Significance Index: -2.8500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2445
    Cell Significance Index: -3.3900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2502
    Cell Significance Index: -3.4700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2538
    Cell Significance Index: -4.3100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2638
    Cell Significance Index: -4.5100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2662
    Cell Significance Index: -2.7200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2698
    Cell Significance Index: -3.2100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2725
    Cell Significance Index: -3.3500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2886
    Cell Significance Index: -6.3200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2921
    Cell Significance Index: -2.7200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2955
    Cell Significance Index: -2.4900
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.2960
    Cell Significance Index: -3.1200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3040
    Cell Significance Index: -5.2400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.3089
    Cell Significance Index: -2.9000
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.3132
    Cell Significance Index: -4.3300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3243
    Cell Significance Index: -4.8600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3250
    Cell Significance Index: -3.7400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.3267
    Cell Significance Index: -3.3100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.3294
    Cell Significance Index: -3.6800
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.3393
    Cell Significance Index: -3.5000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3410
    Cell Significance Index: -4.2600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.3453
    Cell Significance Index: -4.1400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.3465
    Cell Significance Index: -3.3300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.3488
    Cell Significance Index: -4.7900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.3530
    Cell Significance Index: -2.1900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.3568
    Cell Significance Index: -4.3400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3647
    Cell Significance Index: -4.8000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3657
    Cell Significance Index: -4.8600
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.3659
    Cell Significance Index: -3.5000
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.3732
    Cell Significance Index: -4.0400
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.3757
    Cell Significance Index: -3.9000
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.3814
    Cell Significance Index: -4.6400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3830
    Cell Significance Index: -4.0400
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.3864
    Cell Significance Index: -4.3900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.3919
    Cell Significance Index: -3.9500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.3931
    Cell Significance Index: -5.0500
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.3985
    Cell Significance Index: -4.6300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.4065
    Cell Significance Index: -4.7200
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.4089
    Cell Significance Index: -4.3400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.4234
    Cell Significance Index: -5.3500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.4324
    Cell Significance Index: -5.1100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.4350
    Cell Significance Index: -4.7100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.4384
    Cell Significance Index: -4.9400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.4390
    Cell Significance Index: -4.6700
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.4394
    Cell Significance Index: -4.6100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.4435
    Cell Significance Index: -4.6300
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.4549
    Cell Significance Index: -4.9300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.4564
    Cell Significance Index: -4.5800
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.4576
    Cell Significance Index: -5.0100
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.4621
    Cell Significance Index: -5.0100
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.4625
    Cell Significance Index: -5.1000
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.4686
    Cell Significance Index: -4.3700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.4697
    Cell Significance Index: -5.2000
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.4819
    Cell Significance Index: -5.2500
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.4859
    Cell Significance Index: -5.1700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.4860
    Cell Significance Index: -4.9100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.4958
    Cell Significance Index: -5.2200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.5072
    Cell Significance Index: -6.4000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.5141
    Cell Significance Index: -6.0700
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.5350
    Cell Significance Index: -6.7000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.5355
    Cell Significance Index: -5.2200
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.5360
    Cell Significance Index: -4.3400
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.5379
    Cell Significance Index: -6.7500
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.5403
    Cell Significance Index: -6.7500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.5463
    Cell Significance Index: -6.3500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.5536
    Cell Significance Index: -6.7100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.5580
    Cell Significance Index: -5.2200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5587
    Cell Significance Index: -6.6600
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.5609
    Cell Significance Index: -3.8900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.5653
    Cell Significance Index: -6.4700
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.5666
    Cell Significance Index: -6.5600
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.5718
    Cell Significance Index: -6.4600
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.5737
    Cell Significance Index: -6.1700
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.5785
    Cell Significance Index: -6.5700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.5838
    Cell Significance Index: -5.5400
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: -0.5978
    Cell Significance Index: -4.8400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.6026
    Cell Significance Index: -5.2000
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.6058
    Cell Significance Index: -5.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FDPSP3 is a pseudogene, which implies that it does not encode a functional protein. However, its expression in numerous cell types suggests that it may play a regulatory or scaffolding role, potentially influencing cellular behavior and interactions. Notably, FDPSP3 is significantly expressed in cells of the immune system, including neutrophils, B cells, granulocytes, and NK T cells, which are key players in the innate and adaptive immune responses. **Pathways and Functions:** While FDPSP3 lacks a functional coding sequence, its expression in immune cells and other cell types may be linked to various signaling pathways and cellular processes. Some potential pathways and functions of FDPSP3 include: 1. **Regulation of cell signaling:** FDPSP3 may serve as a scaffolding protein, facilitating the assembly and regulation of signaling complexes that control cellular responses to stimuli. 2. **Modulation of gene expression:** As a pseudogene, FDPSP3 may influence gene expression by regulating the activity of nearby genes or by interacting with transcriptional regulators. 3. **Cellular differentiation and proliferation:** FDPSP3 may play a role in regulating cellular differentiation and proliferation, particularly in the context of immune cell development and tissue homeostasis. 4. **Autophagy and stress response:** FDPSP3 may be involved in regulating autophagy and stress response pathways, which are critical for maintaining cellular homeostasis and responding to environmental challenges. **Clinical Significance:** The expression of FDPSP3 in various cell types and tissues raises several questions about its potential clinical significance. Some potential implications of FDPSP3 include: 1. **Immunological disorders:** Abnormal expression or function of FDPSP3 may contribute to immunological disorders, such as autoimmune diseases or cancer. 2. **Cancer biology:** FDPSP3 may play a role in regulating cellular processes that contribute to cancer development and progression. 3. **Neurological disorders:** The expression of FDPSP3 in retinal pigment epithelial cells and other neural cells may be relevant to the pathogenesis of neurological disorders, such as age-related macular degeneration or Alzheimer's disease. 4. **Stem cell biology:** FDPSP3 may influence the regulation of stem cell self-renewal, differentiation, and maintenance, with implications for tissue repair and regeneration. In conclusion, the FDPSP3 gene represents a fascinating example of a pseudogene with widespread expression in immune cells and tissue-specific contexts. Further research is needed to elucidate the functional significance of FDPSP3 and its role in regulating cellular processes, with potential implications for our understanding of immunological disorders, cancer biology, and other diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.