Gene FGF4 - ENSG00000075388 | NCBI Gene ID: 2249

Details for: FGF4

Gene ID: 2249

Symbol: FGF4

Ensembl ID: ENSG00000075388

Description: fibroblast growth factor 4

Associated with

Activated point mutants of fgfr2
(R-HSA-2033519)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling of activated fgfr1
(R-HSA-5654687)
Downstream signaling of activated fgfr2
(R-HSA-5654696)
Downstream signaling of activated fgfr3
(R-HSA-5654708)
Downstream signaling of activated fgfr4
(R-HSA-5654716)
Fgfr1 ligand binding and activation
(R-HSA-190242)
Fgfr1 mutant receptor activation
(R-HSA-1839124)
Fgfr1c ligand binding and activation
(R-HSA-190373)
Fgfr2 ligand binding and activation
(R-HSA-190241)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Fgfr2c ligand binding and activation
(R-HSA-190375)
Fgfr3 ligand binding and activation
(R-HSA-190239)
Fgfr3 mutant receptor activation
(R-HSA-2033514)
Fgfr3c ligand binding and activation
(R-HSA-190372)
Fgfr4 ligand binding and activation
(R-HSA-190322)
Fgfrl1 modulation of fgfr1 signaling
(R-HSA-5658623)
Frs-mediated fgfr1 signaling
(R-HSA-5654693)
Frs-mediated fgfr2 signaling
(R-HSA-5654700)
Frs-mediated fgfr3 signaling
(R-HSA-5654706)
Frs-mediated fgfr4 signaling
(R-HSA-5654712)
Gastrulation
(R-HSA-9758941)
Igf1r signaling cascade
(R-HSA-2428924)
Insulin receptor signalling cascade
(R-HSA-74751)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of fgfr1 signaling
(R-HSA-5654726)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of fgfr3 signaling
(R-HSA-5654732)
Negative regulation of fgfr4 signaling
(R-HSA-5654733)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Phospholipase c-mediated cascade: fgfr1
(R-HSA-5654219)
Phospholipase c-mediated cascade; fgfr2
(R-HSA-5654221)
Phospholipase c-mediated cascade; fgfr3
(R-HSA-5654227)
Phospholipase c-mediated cascade; fgfr4
(R-HSA-5654228)
Pi-3k cascade:fgfr1
(R-HSA-5654689)
Pi-3k cascade:fgfr2
(R-HSA-5654695)
Pi-3k cascade:fgfr3
(R-HSA-5654710)
Pi-3k cascade:fgfr4
(R-HSA-5654720)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Raf/map kinase cascade
(R-HSA-5673001)
Shc-mediated cascade:fgfr1
(R-HSA-5654688)
Shc-mediated cascade:fgfr2
(R-HSA-5654699)
Shc-mediated cascade:fgfr3
(R-HSA-5654704)
Shc-mediated cascade:fgfr4
(R-HSA-5654719)
Signaling by activated point mutants of fgfr1
(R-HSA-1839122)
Signaling by activated point mutants of fgfr3
(R-HSA-1839130)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr3 in disease
(R-HSA-5655332)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Specification of the neural plate border
(R-HSA-9834899)
Animal organ morphogenesis
(GO:0009887)
Apoptotic process involved in morphogenesis
(GO:0060561)
Cartilage condensation
(GO:0001502)
Cell-cell signaling
(GO:0007267)
Cell differentiation
(GO:0030154)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Chondroblast differentiation
(GO:0060591)
Cranial suture morphogenesis
(GO:0060363)
Embryonic hindlimb morphogenesis
(GO:0035116)
Epithelial cell apoptotic process
(GO:1904019)
Fibroblast growth factor receptor binding
(GO:0005104)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Growth factor activity
(GO:0008083)
Heparin binding
(GO:0008201)
Mesenchymal cell proliferation
(GO:0010463)
Negative regulation of apoptotic process
(GO:0043066)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Regulation of cell migration
(GO:0030334)
Regulation of endothelial cell chemotaxis to fibroblast growth factor
(GO:2000544)
Signal transduction
(GO:0007165)
Somatic stem cell population maintenance
(GO:0035019)
Stem cell proliferation
(GO:0072089)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: T cell (CL0000084)
Fold Change: 2.47
Marker Score: 4252.5
Cell Name: plasma cell (CL0000786)
Fold Change: 1.98
Marker Score: 2215.5
Cell Name: connective tissue cell (CL0002320)
Fold Change: 1.94
Marker Score: 502
Cell Name: late promyelocyte (CL0002151)
Fold Change: 1.76
Marker Score: 442
Cell Name: male germ cell (CL0000015)
Fold Change: 1.52
Marker Score: 439
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.41
Marker Score: 442
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 1.37
Marker Score: 435
Cell Name: B cell (CL0000236)
Fold Change: 1.28
Marker Score: 1218
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.21
Marker Score: 440
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.21
Marker Score: 389
Cell Name: podocyte (CL0000653)
Fold Change: 1.2
Marker Score: 443
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7690.5
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 1.09
Marker Score: 498
Cell Name: pericyte (CL0000669)
Fold Change: 1.02
Marker Score: 594
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30401
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.97
Marker Score: 443
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5288
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2740
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5280
Cell Name: mast cell (CL0000097)
Fold Change: 0.87
Marker Score: 502
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.81
Marker Score: 1537.5
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.8
Marker Score: 424
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.8
Marker Score: 356
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 714
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1269
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.76
Marker Score: 443
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.75
Marker Score: 1201
Cell Name: fibroblast (CL0000057)
Fold Change: 0.73
Marker Score: 704
Cell Name: neutrophil (CL0000775)
Fold Change: 0.73
Marker Score: 444
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.71
Marker Score: 440
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.69
Marker Score: 550
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.67
Marker Score: 709
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.66
Marker Score: 444
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.64
Marker Score: 439
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.63
Marker Score: 414
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.59
Marker Score: 9227
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 0.58
Marker Score: 444
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.58
Marker Score: 278
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.56
Marker Score: 432
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.55
Marker Score: 1126
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.43
Marker Score: 389
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.43
Marker Score: 439
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.42
Marker Score: 442
Cell Name: macrophage (CL0000235)
Fold Change: 0.39
Marker Score: 429
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.37
Marker Score: 224
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.35
Marker Score: 2081.5
Cell Name: basal cell (CL0000646)
Fold Change: 0.34
Marker Score: 444
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.34
Marker Score: 364
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.34
Marker Score: 440
Cell Name: stromal cell (CL0000499)
Fold Change: 0.33
Marker Score: 388
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.32
Marker Score: 444
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.31
Marker Score: 440
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.3
Marker Score: 470
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.26
Marker Score: 433
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.26
Marker Score: 443
Cell Name: supporting cell (CL0000630)
Fold Change: 0.26
Marker Score: 484
Cell Name: germ cell (CL0000586)
Fold Change: 0.25
Marker Score: 437
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.24
Marker Score: 497
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.22
Marker Score: 435
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.18
Marker Score: 439
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.16
Marker Score: 337
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.14
Marker Score: 493
Cell Name: secretory cell (CL0000151)
Fold Change: 0.14
Marker Score: 250
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.13
Marker Score: 351
Cell Name: Unknown (CL0000003)
Fold Change: 0.13
Marker Score: 390
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.13
Marker Score: 444
Cell Name: neuron (CL0000540)
Fold Change: 0.12
Marker Score: 503
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.12
Marker Score: 280
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.12
Marker Score: 431
Cell Name: progenitor cell (CL0011026)
Fold Change: 0.07
Marker Score: 442
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.04
Marker Score: 444
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.04
Marker Score: 413
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.03
Marker Score: 441
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.01
Marker Score: 442
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.01
Marker Score: 444
Cell Name: mural cell (CL0008034)
Fold Change: 0
Marker Score: 493
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0
Marker Score: 428

Hover over a box to see details here...

**Key characteristics:** * FGF4 is a secreted protein that is produced by a variety of cell types. * It is a member of the fibroblast growth factor family of proteins. * FGF4 is a key regulator of cell proliferation and migration. * It is also involved in the regulation of cell survival, proliferation, and apoptosis. * FGF4 is a key regulator of epithelial-mesenchymal transition (EMT). **Pathways and functions:** * FGF4 is involved in the regulation of cell proliferation and migration. It does this by binding to receptors on the surface of epithelial cells and promoting their migration. * It is also involved in the regulation of cell survival. It does this by binding to the PI3K/AKT pathway, which is a major regulator of cell survival. * FGF4 is also involved in the regulation of cell differentiation. It does this by binding to receptors on the surface of epithelial cells and promoting their differentiation into mesenchymal cells. **Clinical significance:** FGF4 is a promising target for cancer therapy. It is expressed in high levels in many types of cancer cells, and its overexpression is associated with cancer progression and metastasis. Inhibition of FGF4 has been shown to be effective in inhibiting cancer growth and metastasis. **Additional information:** * The gene encoding FGF4 is located on chromosome 17q25. * It is a highly conserved protein, with a similar sequence in mammals and humans. * FGF4 is a well-characterized protein that has been extensively studied in both basic and clinical research.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Heparin-binding growth factor 4

Genular Protein ID: 775705899

Symbol: FGF4_HUMAN

Name: Heparin-binding growth factor 4

UniProtKB Accession Codes:

P08620 B7U994

Database IDs:

Citations:

PubMed ID: 18192227

Title: Fibroblast growth factor 4 and its novel splice isoform have opposing effects on the maintenance of human embryonic stem cell self-renewal.

PubMed ID: 18192227

DOI: 10.1634/stemcells.2007-1037

PubMed ID: 2959959

Title: Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein.

PubMed ID: 2959959

DOI: 10.1073/pnas.84.20.7305

PubMed ID: 2953031

Title: cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity.

PubMed ID: 2953031

DOI: 10.1073/pnas.84.9.2980

PubMed ID: 2957062

Title: An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family.

PubMed ID: 2957062

DOI: 10.1016/0092-8674(87)90331-x

PubMed ID: 8663044

Title: Receptor specificity of the fibroblast growth factor family.

PubMed ID: 8663044

DOI: 10.1074/jbc.271.25.15292

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 11486033

Title: Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis.

PubMed ID: 11486033

DOI: 10.1128/mcb.21.17.5946-5957.2001

Sequence Information:

Length: 206
Mass: 22048
Checksum: C7FD54A0272A1569
Sequence:

MSGPGTAAVA LLPAVLLALL APWAGRGGAA APTAPNGTLE AELERRWESL VALSLARLPV 
AAQPKEAAVQ SGAGDYLLGI KRLRRLYCNV GIGFHLQALP DGRIGGAHAD TRDSLLELSP 
VERGVVSIFG VASRFFVAMS SKGKLYGSPF FTDECTFKEI LLPNNYNAYE SYKYPGMFIA 
LSKNGKTKKG NRVSPTMKVT HFLPRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: FGF4

Associated with

Cells (max top 100)

Other Information

Fibroblast growth factor 4 and its novel splice isoform have opposing effects on the maintenance of human embryonic stem cell self-renewal. PubMed ID: 18192227

Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein. PubMed ID: 2959959

cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity. PubMed ID: 2953031

An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family. PubMed ID: 2957062

Receptor specificity of the fibroblast growth factor family. PubMed ID: 8663044

Fibroblast growth factor signalling: from development to cancer. PubMed ID: 20094046

Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis. PubMed ID: 11486033