FGF4 | ENSG00000075388 | NCBI 2249

Details for: FGF4

Gene ID: 2249

Symbol: FGF4

Ensembl ID: ENSG00000075388

Description: fibroblast growth factor 4

Associated with

Activated point mutants of fgfr2
(R-HSA-2033519)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling of activated fgfr1
(R-HSA-5654687)
Downstream signaling of activated fgfr2
(R-HSA-5654696)
Downstream signaling of activated fgfr3
(R-HSA-5654708)
Downstream signaling of activated fgfr4
(R-HSA-5654716)
Fgfr1 ligand binding and activation
(R-HSA-190242)
Fgfr1 mutant receptor activation
(R-HSA-1839124)
Fgfr1c ligand binding and activation
(R-HSA-190373)
Fgfr2 ligand binding and activation
(R-HSA-190241)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Fgfr2c ligand binding and activation
(R-HSA-190375)
Fgfr3 ligand binding and activation
(R-HSA-190239)
Fgfr3 mutant receptor activation
(R-HSA-2033514)
Fgfr3c ligand binding and activation
(R-HSA-190372)
Fgfr4 ligand binding and activation
(R-HSA-190322)
Fgfrl1 modulation of fgfr1 signaling
(R-HSA-5658623)
Frs-mediated fgfr1 signaling
(R-HSA-5654693)
Frs-mediated fgfr2 signaling
(R-HSA-5654700)
Frs-mediated fgfr3 signaling
(R-HSA-5654706)
Frs-mediated fgfr4 signaling
(R-HSA-5654712)
Gastrulation
(R-HSA-9758941)
Igf1r signaling cascade
(R-HSA-2428924)
Insulin receptor signalling cascade
(R-HSA-74751)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of fgfr1 signaling
(R-HSA-5654726)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of fgfr3 signaling
(R-HSA-5654732)
Negative regulation of fgfr4 signaling
(R-HSA-5654733)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Phospholipase c-mediated cascade: fgfr1
(R-HSA-5654219)
Phospholipase c-mediated cascade; fgfr2
(R-HSA-5654221)
Phospholipase c-mediated cascade; fgfr3
(R-HSA-5654227)
Phospholipase c-mediated cascade; fgfr4
(R-HSA-5654228)
Pi-3k cascade:fgfr1
(R-HSA-5654689)
Pi-3k cascade:fgfr2
(R-HSA-5654695)
Pi-3k cascade:fgfr3
(R-HSA-5654710)
Pi-3k cascade:fgfr4
(R-HSA-5654720)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Raf/map kinase cascade
(R-HSA-5673001)
Shc-mediated cascade:fgfr1
(R-HSA-5654688)
Shc-mediated cascade:fgfr2
(R-HSA-5654699)
Shc-mediated cascade:fgfr3
(R-HSA-5654704)
Shc-mediated cascade:fgfr4
(R-HSA-5654719)
Signaling by activated point mutants of fgfr1
(R-HSA-1839122)
Signaling by activated point mutants of fgfr3
(R-HSA-1839130)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr3 in disease
(R-HSA-5655332)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Specification of the neural plate border
(R-HSA-9834899)
Apoptotic process involved in morphogenesis
(GO:0060561)
Cartilage condensation
(GO:0001502)
Cell-cell signaling
(GO:0007267)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Chondroblast differentiation
(GO:0060591)
Cranial suture morphogenesis
(GO:0060363)
Embryonic hindlimb morphogenesis
(GO:0035116)
Epithelial cell apoptotic process
(GO:1904019)
Extracellular region
(GO:0005576)
Fibroblast growth factor receptor binding
(GO:0005104)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Growth factor activity
(GO:0008083)
Heparin binding
(GO:0008201)
Mesenchymal cell proliferation
(GO:0010463)
Negative regulation of apoptotic process
(GO:0043066)
Neurogenesis
(GO:0022008)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of stem cell proliferation
(GO:2000648)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Regulation of cell migration
(GO:0030334)
Regulation of endothelial cell chemotaxis to fibroblast growth factor
(GO:2000544)
Signal transduction
(GO:0007165)
Somatic stem cell population maintenance
(GO:0035019)
Stem cell proliferation
(GO:0072089)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 0.8168
Cell Significance Index: 10.4600
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.4121
Cell Significance Index: 4.4900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.1664
Cell Significance Index: 2.2700
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.1054
Cell Significance Index: 1.5100
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.0230
Cell Significance Index: 0.2800
Cell Name: thymocyte (CL0000893)
Fold Change: 0.0174
Cell Significance Index: 0.2200
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.0165
Cell Significance Index: 0.1400
Cell Name: erythroblast (CL0000765)
Fold Change: 0.0164
Cell Significance Index: 0.2000
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0113
Cell Significance Index: 2.2400
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.0007
Cell Significance Index: 0.0100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0011
Cell Significance Index: -0.2300
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: -0.0080
Cell Significance Index: -0.0700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0087
Cell Significance Index: -0.4100
Cell Name: astrocyte (CL0000127)
Fold Change: -0.0096
Cell Significance Index: -0.1100
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0107
Cell Significance Index: -0.2900
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.0114
Cell Significance Index: -0.1900
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0129
Cell Significance Index: -0.4100
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0143
Cell Significance Index: -0.1900
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0150
Cell Significance Index: -0.4900
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0160
Cell Significance Index: -0.4000
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: -0.0163
Cell Significance Index: -0.1500
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0165
Cell Significance Index: -0.3300
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: -0.0166
Cell Significance Index: -0.1600
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0169
Cell Significance Index: -0.4100
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0174
Cell Significance Index: -0.5000
Cell Name: microglial cell (CL0000129)
Fold Change: -0.0183
Cell Significance Index: -0.2200
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0184
Cell Significance Index: -0.4600
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0184
Cell Significance Index: -0.4900
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0199
Cell Significance Index: -0.6900
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0199
Cell Significance Index: -0.3900
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.0203
Cell Significance Index: -0.4000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0219
Cell Significance Index: -0.6500
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0231
Cell Significance Index: -0.5000
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.0231
Cell Significance Index: -0.4000
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0232
Cell Significance Index: -0.2400
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0233
Cell Significance Index: -0.4000
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0234
Cell Significance Index: -0.8200
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: -0.0234
Cell Significance Index: -0.2200
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: -0.0238
Cell Significance Index: -0.3100
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0244
Cell Significance Index: -0.4900
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.0249
Cell Significance Index: -0.5200
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.0249
Cell Significance Index: -0.3000
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: -0.0255
Cell Significance Index: -0.2600
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0258
Cell Significance Index: -0.5100
Cell Name: pericyte (CL0000669)
Fold Change: -0.0267
Cell Significance Index: -0.3200
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0273
Cell Significance Index: -0.5800
Cell Name: endothelial cell (CL0000115)
Fold Change: -0.0277
Cell Significance Index: -0.3400
Cell Name: mast cell (CL0000097)
Fold Change: -0.0281
Cell Significance Index: -0.3700
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: -0.0282
Cell Significance Index: -0.2900
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0289
Cell Significance Index: -0.7600
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.0290
Cell Significance Index: -0.3800
Cell Name: malignant cell (CL0001064)
Fold Change: -0.0299
Cell Significance Index: -0.1600
Cell Name: late promyelocyte (CL0002151)
Fold Change: -0.0304
Cell Significance Index: -0.2000
Cell Name: B cell (CL0000236)
Fold Change: -0.0305
Cell Significance Index: -0.3600
Cell Name: T cell (CL0000084)
Fold Change: -0.0313
Cell Significance Index: -0.3700
Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: -0.0314
Cell Significance Index: -0.3500
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0329
Cell Significance Index: -0.4300
Cell Name: stem cell (CL0000034)
Fold Change: -0.0330
Cell Significance Index: -0.2400
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.0331
Cell Significance Index: -0.3600
Cell Name: neural cell (CL0002319)
Fold Change: -0.0334
Cell Significance Index: -0.3900
Cell Name: basal cell (CL0000646)
Fold Change: -0.0336
Cell Significance Index: -0.4000
Cell Name: glial cell (CL0000125)
Fold Change: -0.0338
Cell Significance Index: -0.3700
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.0341
Cell Significance Index: -0.3600
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.0344
Cell Significance Index: -0.4100
Cell Name: secretory cell (CL0000151)
Fold Change: -0.0345
Cell Significance Index: -0.2400
Cell Name: ciliated cell (CL0000064)
Fold Change: -0.0351
Cell Significance Index: -0.3800
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.0354
Cell Significance Index: -0.4500
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.0355
Cell Significance Index: -0.4000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0356
Cell Significance Index: -0.6000
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: -0.0358
Cell Significance Index: -0.3700
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: -0.0367
Cell Significance Index: -0.2800
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.0370
Cell Significance Index: -0.4100
Cell Name: myelocyte (CL0002193)
Fold Change: -0.0370
Cell Significance Index: -0.4000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0370
Cell Significance Index: -0.7700
Cell Name: oligodendrocyte (CL0000128)
Fold Change: -0.0373
Cell Significance Index: -0.4000
Cell Name: fibroblast (CL0000057)
Fold Change: -0.0373
Cell Significance Index: -0.3500
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.0374
Cell Significance Index: -0.3700
Cell Name: neuroplacodal cell (CL0000032)
Fold Change: -0.0382
Cell Significance Index: -0.4700
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.0383
Cell Significance Index: -0.5000
Cell Name: mural cell (CL0008034)
Fold Change: -0.0386
Cell Significance Index: -0.4700
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: -0.0388
Cell Significance Index: -0.4000
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.0388
Cell Significance Index: -0.4300
Cell Name: naive B cell (CL0000788)
Fold Change: -0.0389
Cell Significance Index: -0.4100
Cell Name: muscle cell (CL0000187)
Fold Change: -0.0390
Cell Significance Index: -0.3700
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.0406
Cell Significance Index: -0.3900
Cell Name: Kupffer cell (CL0000091)
Fold Change: -0.0410
Cell Significance Index: -0.3800
Cell Name: macrophage (CL0000235)
Fold Change: -0.0411
Cell Significance Index: -0.4200
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: -0.0414
Cell Significance Index: -0.3500
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.0419
Cell Significance Index: -0.5700
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.0422
Cell Significance Index: -0.5000
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: -0.0434
Cell Significance Index: -0.3800
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.0442
Cell Significance Index: -0.4700
Cell Name: classical monocyte (CL0000860)
Fold Change: -0.0462
Cell Significance Index: -0.4300
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.0477
Cell Significance Index: -0.5700
Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
Fold Change: -0.0486
Cell Significance Index: -0.3600
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: -0.0494
Cell Significance Index: -0.4400
Cell Name: neuron (CL0000540)
Fold Change: -0.0496
Cell Significance Index: -0.4700
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: -0.0499
Cell Significance Index: -0.4700
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: -0.0500
Cell Significance Index: -0.4600
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: -0.0508
Cell Significance Index: -0.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** FGF4 exhibits several key characteristics that are essential for its function: 1. **Heparin-binding**: FGF4 binds to heparin, which is a negatively charged polysaccharide, to activate its receptor and initiate signaling. 2. **Receptor binding**: FGF4 binds to its receptor, FGF4 receptor (FGFR4), which is a tyrosine kinase receptor. 3. **Tyrosine kinase activity**: Upon binding to FGF4, FGFR4 undergoes autophosphorylation, which activates its tyrosine kinase activity. 4. **Signaling pathways**: FGF4 activates several signaling pathways, including the PI3K/AKT, MAPK, and RAF/MAPK cascades, which regulate cell proliferation, differentiation, and survival. **Pathways and Functions** FGF4 plays a crucial role in various biological processes, including: 1. **Cell proliferation**: FGF4 promotes cell proliferation in various cell types, including T cells, plasma cells, and connective tissue cells. 2. **Differentiation**: FGF4 regulates cell differentiation, particularly in the development of the neural plate border and the specification of the neural plate border. 3. **Survival**: FGF4 promotes cell survival by activating anti-apoptotic signaling pathways. 4. **Angiogenesis**: FGF4 is involved in angiogenesis, the process of new blood vessel formation. 5. **Wound healing**: FGF4 plays a role in wound healing by promoting cell proliferation and differentiation. **Clinical Significance** Dysregulation of FGF4 has been implicated in various diseases, including: 1. **Cancer**: FGF4 is overexpressed in several types of cancer, including breast cancer, lung cancer, and colon cancer. 2. **Neurological disorders**: FGF4 is involved in the development of neurological disorders, such as autism spectrum disorder and schizophrenia. 3. **Diabetes**: FGF4 is implicated in the development of diabetes, particularly in the regulation of insulin signaling. 4. **Wound healing disorders**: FGF4 is involved in wound healing disorders, such as delayed wound healing and chronic wounds. In conclusion, FGF4 is a multifunctional growth factor that plays a crucial role in various biological processes, including cell proliferation, differentiation, survival, angiogenesis, and wound healing. Dysregulation of FGF4 has been implicated in various diseases, highlighting the importance of this growth factor in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Heparin-binding growth factor 4

Genular Protein ID: 775705899

Symbol: FGF4_HUMAN

Name: Heparin-binding growth factor 4

UniProtKB Accession Codes:

P08620 B7U994

Database IDs:

Citations:

PubMed ID: 18192227

Title: Fibroblast growth factor 4 and its novel splice isoform have opposing effects on the maintenance of human embryonic stem cell self-renewal.

PubMed ID: 18192227

DOI: 10.1634/stemcells.2007-1037

PubMed ID: 2959959

Title: Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein.

PubMed ID: 2959959

DOI: 10.1073/pnas.84.20.7305

PubMed ID: 2953031

Title: cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity.

PubMed ID: 2953031

DOI: 10.1073/pnas.84.9.2980

PubMed ID: 2957062

Title: An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family.

PubMed ID: 2957062

DOI: 10.1016/0092-8674(87)90331-x

PubMed ID: 8663044

Title: Receptor specificity of the fibroblast growth factor family.

PubMed ID: 8663044

DOI: 10.1074/jbc.271.25.15292

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 11486033

Title: Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis.

PubMed ID: 11486033

DOI: 10.1128/mcb.21.17.5946-5957.2001

Sequence Information:

Length: 206
Mass: 22048
Checksum: C7FD54A0272A1569
Sequence:

MSGPGTAAVA LLPAVLLALL APWAGRGGAA APTAPNGTLE AELERRWESL VALSLARLPV 
AAQPKEAAVQ SGAGDYLLGI KRLRRLYCNV GIGFHLQALP DGRIGGAHAD TRDSLLELSP 
VERGVVSIFG VASRFFVAMS SKGKLYGSPF FTDECTFKEI LLPNNYNAYE SYKYPGMFIA 
LSKNGKTKKG NRVSPTMKVT HFLPRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FGF4

Associated with

Cells (max top 100)

Other Information

Fibroblast growth factor 4 and its novel splice isoform have opposing effects on the maintenance of human embryonic stem cell self-renewal. PubMed ID: 18192227

Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein. PubMed ID: 2959959

cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity. PubMed ID: 2953031

An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family. PubMed ID: 2957062

Receptor specificity of the fibroblast growth factor family. PubMed ID: 8663044

Fibroblast growth factor signalling: from development to cancer. PubMed ID: 20094046

Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis. PubMed ID: 11486033