Details for: RNU4 1

Gene ID: 26835

Symbol: RNU4 1

Ensembl ID: ENSG00000200795

Description: RNA, U4 small nuclear 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2096
    Cell Significance Index: 34.8500
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.1731
    Cell Significance Index: 14.1500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 1.0386
    Cell Significance Index: 12.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4995
    Cell Significance Index: 22.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2855
    Cell Significance Index: 13.3100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2512
    Cell Significance Index: 2.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2331
    Cell Significance Index: 5.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2072
    Cell Significance Index: 7.2800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1515
    Cell Significance Index: 2.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0856
    Cell Significance Index: 9.8100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0766
    Cell Significance Index: 1.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0552
    Cell Significance Index: 15.9000
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.0397
    Cell Significance Index: 0.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0371
    Cell Significance Index: 6.3300
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0332
    Cell Significance Index: 0.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0210
    Cell Significance Index: 1.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0181
    Cell Significance Index: 0.9400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0137
    Cell Significance Index: 0.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0033
    Cell Significance Index: -6.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0038
    Cell Significance Index: -7.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0051
    Cell Significance Index: -7.8200
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.0057
    Cell Significance Index: -0.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0061
    Cell Significance Index: -8.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0076
    Cell Significance Index: -4.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0086
    Cell Significance Index: -0.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0136
    Cell Significance Index: -6.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0192
    Cell Significance Index: -1.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0256
    Cell Significance Index: -3.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0309
    Cell Significance Index: -6.2000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0486
    Cell Significance Index: -0.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0553
    Cell Significance Index: -1.7700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0569
    Cell Significance Index: -0.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0601
    Cell Significance Index: -0.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0625
    Cell Significance Index: -6.5100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0722
    Cell Significance Index: -0.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0738
    Cell Significance Index: -2.0100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0841
    Cell Significance Index: -0.8700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0848
    Cell Significance Index: -1.7700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.1043
    Cell Significance Index: -1.3100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1184
    Cell Significance Index: -1.2600
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.1250
    Cell Significance Index: -1.1000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1275
    Cell Significance Index: -1.3000
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1287
    Cell Significance Index: -1.7800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1606
    Cell Significance Index: -4.7300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1785
    Cell Significance Index: -2.2600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1842
    Cell Significance Index: -2.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1918
    Cell Significance Index: -6.2800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1973
    Cell Significance Index: -6.2900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2011
    Cell Significance Index: -3.1900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2076
    Cell Significance Index: -5.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2078
    Cell Significance Index: -4.5500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2084
    Cell Significance Index: -3.5400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2085
    Cell Significance Index: -5.2000
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.2131
    Cell Significance Index: -2.2100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2141
    Cell Significance Index: -7.8600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2236
    Cell Significance Index: -3.2700
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.2238
    Cell Significance Index: -2.3400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2259
    Cell Significance Index: -3.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2263
    Cell Significance Index: -4.8200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2318
    Cell Significance Index: -8.1200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2332
    Cell Significance Index: -3.3200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2357
    Cell Significance Index: -5.8800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2450
    Cell Significance Index: -6.1200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2564
    Cell Significance Index: -8.1100
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2643
    Cell Significance Index: -2.6500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.2771
    Cell Significance Index: -3.5800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2855
    Cell Significance Index: -4.8800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2874
    Cell Significance Index: -4.9700
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.2874
    Cell Significance Index: -2.7400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2875
    Cell Significance Index: -3.7600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2902
    Cell Significance Index: -6.2700
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.2958
    Cell Significance Index: -2.6700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2973
    Cell Significance Index: -6.3100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2997
    Cell Significance Index: -3.8500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3054
    Cell Significance Index: -6.0100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3069
    Cell Significance Index: -4.9700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.3101
    Cell Significance Index: -3.6900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3213
    Cell Significance Index: -6.4500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3262
    Cell Significance Index: -6.4500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3360
    Cell Significance Index: -3.9500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3360
    Cell Significance Index: -5.6600
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.3361
    Cell Significance Index: -4.5700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.3439
    Cell Significance Index: -3.5900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3440
    Cell Significance Index: -3.9900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.3482
    Cell Significance Index: -3.8900
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.3503
    Cell Significance Index: -3.7200
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.3596
    Cell Significance Index: -4.5500
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.3611
    Cell Significance Index: -3.5200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.3655
    Cell Significance Index: -5.0200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.3692
    Cell Significance Index: -3.7300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3739
    Cell Significance Index: -5.5200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.3752
    Cell Significance Index: -3.9500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.3818
    Cell Significance Index: -4.1600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.3896
    Cell Significance Index: -4.3900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.3908
    Cell Significance Index: -5.1000
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.3917
    Cell Significance Index: -5.1300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3933
    Cell Significance Index: -7.6900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3991
    Cell Significance Index: -8.1200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.4002
    Cell Significance Index: -5.0000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.4003
    Cell Significance Index: -4.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Structure:** The RNU4 1 gene is located on the long arm of chromosome 17 (17q11.2) and encodes a small nuclear RNA (snRNA) molecule, U4. 2. **Expression Patterns:** RNU4 1 is highly expressed in various cell types, including T cells, goblet cells, absorptive cells, intestinal crypt stem cells, transit amplifying cells, abnormal cells, neoplastic cells, mast cells, pericytes, and intestinal epithelial cells. 3. **Function:** The U4 snRNA plays a crucial role in the assembly and function of the spliceosomal tri-snRNP complex, which is responsible for the splicing of pre-mRNA into mature mRNA. **Pathways and Functions:** 1. **Spliceosomal Tri-snRNP Complex Assembly:** RNU4 1 is involved in the assembly and function of the spliceosomal tri-snRNP complex, which is essential for the splicing of pre-mRNA into mature mRNA. 2. **Gene Expression (Transcription):** RNU4 1 is involved in the transcription of snRNA genes by RNA polymerase II, which is a key step in the regulation of gene expression. 3. **RNA Polymerase II Transcription:** RNU4 1 is also involved in the transcription of snRNA genes by RNA polymerase II, which is a critical step in the regulation of gene expression. 4. **Spliceosomal Tri-snRNP Complex:** RNU4 1 is involved in the assembly and function of the spliceosomal tri-snRNP complex, which is responsible for the splicing of pre-mRNA into mature mRNA. 5. **U4 snRNP, U4/U6 X U5 Tri-snRNP Complex:** RNU4 1 is involved in the formation of the U4 snRNP and the U4/U6 X U5 tri-snRNP complex, which are essential for the splicing of pre-mRNA into mature mRNA. **Clinical Significance:** 1. **Biomarker Potential:** RNU4 1 has been identified as a potential biomarker for various diseases, including cancer and autoimmune disorders. 2. **Therapeutic Target:** RNU4 1 has been identified as a potential therapeutic target for the treatment of diseases, including cancer and autoimmune disorders. 3. **Disease Association:** RNU4 1 has been associated with various diseases, including cancer, autoimmune disorders, and neurological disorders. 4. **Gene Therapy:** RNU4 1 has been identified as a potential target for gene therapy, which could potentially be used to treat diseases caused by aberrant RNU4 1 expression. In conclusion, the RNU4 1 gene plays a crucial role in the formation and function of the spliceosomal tri-snRNP complex, which is essential for the splicing of pre-mRNA into mature mRNA. Its significant expression in various cell types and its association with various diseases highlight its potential as a biomarker and therapeutic target. Further research is needed to fully understand the role of RNU4 1 in disease states and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.