Details for: GNAZ

Gene ID: 2781

Symbol: GNAZ

Ensembl ID: ENSG00000128266

Description: G protein subunit alpha z

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1991
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1167
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 852
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.18
    Marker Score: 2226.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.16
    Marker Score: 12019
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4812
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.06
    Marker Score: 317
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 793
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.03
    Marker Score: 2093
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.01
    Marker Score: 409
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48048
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.97
    Marker Score: 8352
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.96
    Marker Score: 14979
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.95
    Marker Score: 301
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5340
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.88
    Marker Score: 329
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.88
    Marker Score: 2069
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.88
    Marker Score: 364
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.87
    Marker Score: 53491
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.86
    Marker Score: 3507
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.85
    Marker Score: 1314
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.84
    Marker Score: 7957
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.82
    Marker Score: 1668
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.82
    Marker Score: 377
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 504
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.76
    Marker Score: 28803
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.76
    Marker Score: 7116
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.73
    Marker Score: 824
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.72
    Marker Score: 433
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.69
    Marker Score: 25505
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.66
    Marker Score: 643.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.62
    Marker Score: 2409
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.62
    Marker Score: 12234
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.57
    Marker Score: 179
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.55
    Marker Score: 2290
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.55
    Marker Score: 177
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.54
    Marker Score: 2090
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5
    Marker Score: 208
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.49
    Marker Score: 165
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.48
    Marker Score: 1374
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.48
    Marker Score: 228
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.47
    Marker Score: 1976
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.47
    Marker Score: 7057
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.47
    Marker Score: 242
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.47
    Marker Score: 2163
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.46
    Marker Score: 3535
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.46
    Marker Score: 103
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.43
    Marker Score: 415
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.43
    Marker Score: 411
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.42
    Marker Score: 108
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.41
    Marker Score: 181
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.39
    Marker Score: 169
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.39
    Marker Score: 465
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.38
    Marker Score: 130
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.38
    Marker Score: 899
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.37
    Marker Score: 350
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.36
    Marker Score: 12318
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.36
    Marker Score: 177
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.35
    Marker Score: 816
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.33
    Marker Score: 329
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.32
    Marker Score: 166
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.32
    Marker Score: 132
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.31
    Marker Score: 438
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.31
    Marker Score: 119
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.29
    Marker Score: 78
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.29
    Marker Score: 358
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.29
    Marker Score: 136
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.28
    Marker Score: 118
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.27
    Marker Score: 149
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.26
    Marker Score: 67
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.26
    Marker Score: 2651
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.26
    Marker Score: 435
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.24
    Marker Score: 683
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.24
    Marker Score: 140
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.22
    Marker Score: 140
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.21
    Marker Score: 63
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.21
    Marker Score: 87
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.21
    Marker Score: 56
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.2
    Marker Score: 4313
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.2
    Marker Score: 116
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.2
    Marker Score: 538.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.19
    Marker Score: 528

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Other Information

**Key characteristics:** - GNAZ is a G protein subunit that is expressed in high levels in the enterocyte of the large intestine, colon goblet cell, intestinal crypt stem cell of the small intestine, and cardiac endothelial cell. - It is also expressed in low levels in the eye photoreceptor cell and type A enteroendocrine cell. - GNAZ is a key regulator of inflammation and immune responses. - It inhibits adenylate cyclase activity, which leads to the inhibition of adora2b-mediated anti-inflammatory cytokine production. - It also promotes anti-inflammatory response by favouring the production of anti-inflammatory cytokines. - GNAZ has been shown to play a role in disease processes, including leishmaniasis. **Pathways and functions:** - GNAZ has multiple pathways and functions: - Inhibition of adenylate cyclase activity: GNAZ inhibits adenylate cyclase activity, which leads to the inhibition of adora2b-mediated anti-inflammatory cytokine production. - Activation of G alpha (i) signalling events: GNAZ activates G alpha (i) signalling events, which leads to the production of anti-inflammatory cytokines. - Activation of G alpha (s) signalling events: GNAZ also activates G alpha (s) signalling events, which leads to the production of pro-inflammatory cytokines. - Activation of G alpha (z) signalling events: GNAZ activates G alpha (z) signalling events, which leads to the production of pro-inflammatory cytokines. - Regulation of Gpcr downstream signalling: GNAZ also regulates Gpcr downstream signalling, which leads to the inhibition of inflammation. - Regulation of Gper1 signaling: GNAZ also regulates Gper1 signaling, which leads to the inhibition of inflammation. - Regulation of G protein-coupled receptor binding: GNAZ also regulates G protein-coupled receptor binding, which leads to the inhibition of inflammation. **Clinical significance:** - GNAZ is a potential therapeutic target for inflammatory diseases. - Studies have shown that blocking GNAZ signalling can reduce inflammation and disease activity in animal models of inflammatory diseases. - Therefore, GNAZ could be a potential therapeutic agent for the treatment of inflammatory diseases.

Genular Protein ID: 3534364728

Symbol: GNAZ_HUMAN

Name: Guanine nucleotide-binding protein G(z) subunit alpha

UniProtKB Accession Codes:

P19086 B2R6C1 Q4QRJ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 ChEBI 7 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 EMDB 1 Ensembl 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3129724

Title: Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin.

PubMed ID: 3129724

DOI: 10.1073/pnas.85.9.3066

PubMed ID: 2115889

Title: Characterization of the human gene for Gx alpha, a pertussis toxin-insensitive regulatory GTP-binding protein.

PubMed ID: 2115889

DOI: 10.1016/s0021-9258(19)38287-0

PubMed ID: 1908722

Title: Identification of Gz alpha as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes.

PubMed ID: 1908722

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28891236

Title: A disease-associated mutation in the adhesion GPCR BAI2 (ADGRB2) increases receptor signaling activity.

PubMed ID: 28891236

DOI: 10.1002/humu.23336

Sequence Information:

  • Length: 355
  • Mass: 40924
  • Checksum: E868FAE7CD2873EB
  • Sequence:
    • MGCRQSSEEK EAARRSRRID RHLRSESQRQ RREIKLLLLG TSNSGKSTIV KQMKIIHSGG 
FNLEACKEYK PLIIYNAIDS LTRIIRALAA LRIDFHNPDR AYDAVQLFAL TGPAESKGEI 
TPELLGVMRR LWADPGAQAC FSRSSEYHLE DNAAYYLNDL ERIAAADYIP TVEDILRSRD 
MTTGIVENKF TFKELTFKMV DVGGQRSERK KWIHCFEGVT AIIFCVELSG YDLKLYEDNQ 
TSRMAESLRL FDSICNNNWF INTSLILFLN KKDLLAEKIR RIPLTICFPE YKGQNTYEEA 
AVYIQRQFED LNRNKETKEI YSHFTCATDT SNIQFVFDAV TDVIIQNNLK YIGLC

Genular Protein ID: 4196087838

Symbol: Q8IY73_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IY73

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 5 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 355
  • Mass: 40940
  • Checksum: 830D1CE053579DBA
  • Sequence:
    • MGCRQSSEEK EAARRSRRID RHLRSESQRQ RREIKLLLLG TSNSGKSTIV KQMKIIHSGG 
FNLESCKEYK PLIIYNAIDS LTRIIRALAA LRIDFHNPDR AYDAVQLFAL TGPAESKGEI 
TPELLGVMRR LWADPGAQAC FSRSSEYHLE DNAAYYLNDL ERIAAADYIP TVEDILRSRD 
MTTGIVENKF TFKELTFKMV DVGGQRSERK KWIHCFEGVT AIIFCVELSG YDLKLYEDNQ 
TSRMAESLRL FDSICNNNWF INTSLILFLN KKDLLAEKIR RIPLTICFPE YKGQNTYEEA 
AVYIQRQFED LNRNKETKEI YSHFTCATDT SNIQFVFDAV TDVIIQNNLK YIGLC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.