Details for: GOLGA3

Gene ID: 2802

Symbol: GOLGA3

Ensembl ID: ENSG00000090615

Description: golgin A3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.71
    Marker Score: 1141
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.61
    Marker Score: 98930
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.59
    Marker Score: 14965
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.57
    Marker Score: 57990
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.57
    Marker Score: 433
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.52
    Marker Score: 15676
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.5
    Marker Score: 12921.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.5
    Marker Score: 14205
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.48
    Marker Score: 442
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.45
    Marker Score: 55036
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.43
    Marker Score: 3257
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.43
    Marker Score: 5923
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.42
    Marker Score: 2186
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.41
    Marker Score: 5454
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.39
    Marker Score: 10684.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.39
    Marker Score: 27617
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.39
    Marker Score: 364
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.34
    Marker Score: 20075.5
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.25
    Marker Score: 618
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.25
    Marker Score: 1841
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.16
    Marker Score: 1222.5
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.14
    Marker Score: 779
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.13
    Marker Score: 4596
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.09
    Marker Score: 508
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.08
    Marker Score: 1239
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.07
    Marker Score: 22940
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.05
    Marker Score: 1162.5
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.05
    Marker Score: 438
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.03
    Marker Score: 297.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.03
    Marker Score: 3536
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.01
    Marker Score: 34514
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.01
    Marker Score: 6441
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1
    Marker Score: 1925
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1
    Marker Score: 348
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71663
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47887
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.98
    Marker Score: 4835.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30386
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.96
    Marker Score: 958.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2392
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.93
    Marker Score: 1967
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.92
    Marker Score: 885
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.91
    Marker Score: 1208
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.9
    Marker Score: 2045
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9
    Marker Score: 10149.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5140
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2692
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.87
    Marker Score: 13586
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.85
    Marker Score: 1070.5
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.85
    Marker Score: 487
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.85
    Marker Score: 274
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.84
    Marker Score: 770
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.83
    Marker Score: 1077
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.83
    Marker Score: 2594
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.82
    Marker Score: 304
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.82
    Marker Score: 849
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.82
    Marker Score: 396.5
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.81
    Marker Score: 200.5
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.81
    Marker Score: 232
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.8
    Marker Score: 324
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.8
    Marker Score: 468
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.8
    Marker Score: 1624
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.8
    Marker Score: 541
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.79
    Marker Score: 542
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 605
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.79
    Marker Score: 216
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.79
    Marker Score: 5136
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.79
    Marker Score: 12642
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.78
    Marker Score: 1118
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.77
    Marker Score: 321
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.77
    Marker Score: 195
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.77
    Marker Score: 190
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.77
    Marker Score: 825
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 303
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.76
    Marker Score: 451
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.75
    Marker Score: 1651.5
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.75
    Marker Score: 1209
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.75
    Marker Score: 802.5
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.75
    Marker Score: 522
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.74
    Marker Score: 708
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.74
    Marker Score: 1143
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.74
    Marker Score: 257
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.74
    Marker Score: 465
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.74
    Marker Score: 614
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.73
    Marker Score: 815
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.73
    Marker Score: 165
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.73
    Marker Score: 174
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.73
    Marker Score: 191
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.72
    Marker Score: 726
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.72
    Marker Score: 872
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 372
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.72
    Marker Score: 156
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.71
    Marker Score: 7235
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.71
    Marker Score: 287
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.7
    Marker Score: 466

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Other Information

**Key characteristics:** * The golgin A3 gene is located on chromosome 15q26.1. * It is a large gene encoding a protein of approximately 1,100 amino acids. * It is a member of the golgin subfamily A of cell adhesion molecules. * It is expressed in a wide range of cell types, including epithelial cells, neuronal cells, and immune cells. **Pathways and functions:** * Golgin A3 is involved in several cellular processes, including cell adhesion, cell migration, and signaling. * It is a key component of the adherens junction, a specialized adhesion junction between epithelial cells. * It is also involved in the regulation of neurotransmitter release and cellular migration. * Mutations in the GOLGA3 gene have been linked to several human diseases, including autism, schizophrenia, and cancer. **Clinical significance:** * Targeting the golgin A3 gene has been explored as a therapeutic strategy for human diseases such as autism and schizophrenia. * Inhibitors of golgin A3 have been shown to be effective in reducing neuronal activity and improving behavioral symptoms in animal models of neurodevelopmental disorders. * However, clinical trials of golgin A3 inhibitors in humans have been unsuccessful so far. **Additional notes:** * Golgin A3 is a highly conserved protein, with similar genes found in other vertebrates. * It is a promising target for therapeutic intervention in neurodevelopmental disorders characterized by abnormal neuronal function. * Further research is needed to develop effective and safe golgin A3 inhibitors for clinical use.

Genular Protein ID: 2769760113

Symbol: GOGA3_HUMAN

Name: Golgin subfamily A member 3

UniProtKB Accession Codes:

Q08378 A5PKX6 O43241 Q6P9C7 Q86XW3 Q8TDA9 Q8WZA3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9295333

Title: Molecular characterization of GCP170, a 170-kDa protein associated with the cytoplasmic face of the Golgi membrane.

PubMed ID: 9295333

DOI: 10.1074/jbc.272.38.23851

PubMed ID: 10791974

Title: Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis.

PubMed ID: 10791974

DOI: 10.1083/jcb.149.3.603

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8315394

Title: Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex.

PubMed ID: 8315394

DOI: 10.1084/jem.178.1.49

PubMed ID: 12130652

Title: The NH2-terminal domain of Golgin-160 contains both Golgi and nuclear targeting information.

PubMed ID: 12130652

DOI: 10.1074/jbc.m206280200

PubMed ID: 14522980

Title: Identification and characterization of GCP16, a novel acylated Golgi protein that interacts with GCP170.

PubMed ID: 14522980

DOI: 10.1074/jbc.m310014200

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15951434

Title: Isoform-specific interaction of golgin-160 with the Golgi-associated protein PIST.

PubMed ID: 15951434

DOI: 10.1074/jbc.m504937200

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1498
  • Mass: 167355
  • Checksum: 4B95CDCFD3D64667
  • Sequence:
    • MDGASAEQDG LQEDRSHSGP SSLPEAPLKP PGPLVPPDQQ DKVQCAEVNR ASTEGESPDG 
PGQGGLCQNG PTPPFPDPPS SLDPTTSPVG PDASPGVAGF HDNLRKSQGT SAEGSVRKEA 
LQSLRLSLPM QETQLCSTDS PLPLEKEEQV RLQARKWLEE QLKQYRVKRQ QERSSQPATK 
TRLFSTLDPE LMLNPENLPR ASTLAMTKEY SFLRTSVPRG PKVGSLGLPA HPREKKTSKS 
SKIRSLADYR TEDSNAGNSG GNVPAPDSTK GSLKQNRSSA ASVVSEISLS PDTDDRLENT 
SLAGDSVSEV DGNDSDSSSY SSASTRGTYG ILSKTVGTQD TPYMVNGQEI PADTLGQFPS 
IKDVLQAAAA EHQDQGQEVN GEVRSRRDSI CSSVSLESSA AETQEEMLQV LKEKMRLEGQ 
LEALSLEASQ ALKEKAELQA QLAALSTKLQ AQVECSHSSQ QRQDSLSSEV DTLKQSCWDL 
ERAMTDLQNM LEAKNASLAS SNNDLQVAEE QYQRLMAKVE DMQRSMLSKD NTVHDLRQQM 
TALQSQLQQV QLERTTLTSK LKASQAEISS LQSVRQWYQQ QLALAQEARV RLQGEMAHIQ 
VGQMTQAGLL EHLKLENVSL SQQLTETQHR SMKEKGRIAA QLQGIEADML DQEAAFMQIQ 
EAKTMVEEDL QRRLEEFEGE RERLQRMADS AASLEQQLEQ VKLTLLQRDQ QLEALQQEHL 
DLMKQLTLTQ EALQSREQSL DALQTHYDEL QARLGELQGE AASREDTICL LQNEKIILEA 
ALQAAKSGKE ELDRGARRLE EGTEETSETL EKLREELAIK SGQVEHLQQE TAALKKQMQK 
IKEQFLQQKV MVEAYRRDAT SKDQLISELK ATRKRLDSEL KELRQELMQV HGEKRTAEAE 
LSRLHREVAQ VRQHMADLEG HLQSAQKERD EMETHLQSLQ FDKEQMVAVT EANEALKKQI 
EELQQEARKA ITEQKQKMRR LGSDLTSAQK EMKTKHKAYE NAVGILSRRL QEALAAKEAA 
DAELGQLRAQ GGSSDSSLAL HERIQALEAE LQAVSHSKTL LEKELQEVIA LTSQELEESR 
EKVLELEDEL QESRGFRKKI KRLEESNKKL ALELEHEKGK LTGLGQSNAA LREHNSILET 
ALAKREADLV QLNLQVQAVL QRKEEEDRQM KHLVQALQAS LEKEKEKVNS LKEQVAAAKV 
EAGHNRRHFK AASLELSEVK KELQAKEHLV QKLQAEADDL QIREGKHSQE IAQFQAELAE 
ARAQLQLLQK QLDEQLSKQP VGNQEMENLK WEVDQKEREI QSLKQQLDLT EQQGRKELEG 
LQQLLQNVKS ELEMAQEDLS MTQKDKFMLQ AKVSELKNNM KTLLQQNQQL KLDLRRGAAK 
TRKEPKGEAS SSNPATPIKI PDCPVPASLL EELLRPPPAV SKEPLKNLNS CLQQLKQEMD 
SLQRQMEEHA LTVHESLSSW TPLEPATASP VPPGGHAGPR GDPQRHSQSR ASKEGPGE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.