IGKV1D 33 | ENSG00000239975 | NCBI 28896

Details for: IGKV1D 33

Gene ID: 28896

Symbol: IGKV1D 33

Ensembl ID: ENSG00000239975

Description: immunoglobulin kappa variable 1D-33

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
Blood microparticle
(GO:0072562)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0608
Cell Significance Index: 0.9400
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1056
Cell Significance Index: -10.7900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1806
Cell Significance Index: -30.8300
Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.2541
Cell Significance Index: -3.5100
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.2689
Cell Significance Index: -3.0100
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.3316
Cell Significance Index: -4.7600
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.3736
Cell Significance Index: -9.0500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3750
Cell Significance Index: -10.0300
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.4349
Cell Significance Index: -11.0800
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.4480
Cell Significance Index: -8.7600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.5394
Cell Significance Index: -25.1500
Cell Name: stromal cell (CL0000499)
Fold Change: -0.6146
Cell Significance Index: -6.2800
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.6184
Cell Significance Index: -10.5700
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.6613
Cell Significance Index: -10.7100
Cell Name: glial cell (CL0000125)
Fold Change: -0.6928
Cell Significance Index: -7.5900
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.7053
Cell Significance Index: -10.2400
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.7559
Cell Significance Index: -6.2400
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.7578
Cell Significance Index: -8.0500
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.7584
Cell Significance Index: -8.0000
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.7941
Cell Significance Index: -10.8900
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.7995
Cell Significance Index: -9.8900
Cell Name: platelet (CL0000233)
Fold Change: -0.8126
Cell Significance Index: -8.3600
Cell Name: goblet cell (CL0000160)
Fold Change: -0.8325
Cell Significance Index: -7.5300
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.8449
Cell Significance Index: -8.1100
Cell Name: mesothelial cell (CL0000077)
Fold Change: -0.8564
Cell Significance Index: -10.4100
Cell Name: monocyte (CL0000576)
Fold Change: -0.8786
Cell Significance Index: -10.1100
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: -0.9117
Cell Significance Index: -9.1000
Cell Name: neutrophil (CL0000775)
Fold Change: -0.9266
Cell Significance Index: -11.5800
Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: -0.9497
Cell Significance Index: -10.4300
Cell Name: blood cell (CL0000081)
Fold Change: -0.9515
Cell Significance Index: -8.1100
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: -0.9748
Cell Significance Index: -10.4200
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: -0.9756
Cell Significance Index: -7.9000
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: -0.9784
Cell Significance Index: -9.0400
Cell Name: fibroblast (CL0000057)
Fold Change: -0.9853
Cell Significance Index: -9.2500
Cell Name: club cell (CL0000158)
Fold Change: -0.9950
Cell Significance Index: -10.8400
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.9961
Cell Significance Index: -8.8900
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: -1.0034
Cell Significance Index: -10.1100
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: -1.0075
Cell Significance Index: -10.7000
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -1.0165
Cell Significance Index: -13.3400
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: -1.0187
Cell Significance Index: -8.9100
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: -1.0461
Cell Significance Index: -10.8400
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: -1.0477
Cell Significance Index: -10.0700
Cell Name: lung ciliated cell (CL1000271)
Fold Change: -1.0620
Cell Significance Index: -10.3900
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -1.0664
Cell Significance Index: -8.5700
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -1.0667
Cell Significance Index: -11.8100
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -1.0830
Cell Significance Index: -12.8000
Cell Name: dendritic cell, human (CL0001056)
Fold Change: -1.0962
Cell Significance Index: -10.1100
Cell Name: intermediate monocyte (CL0002393)
Fold Change: -1.1168
Cell Significance Index: -10.4100
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: -1.1171
Cell Significance Index: -9.9800
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: -1.1222
Cell Significance Index: -10.3800
Cell Name: muscle cell (CL0000187)
Fold Change: -1.1352
Cell Significance Index: -10.8600
Cell Name: pericyte (CL0000669)
Fold Change: -1.1467
Cell Significance Index: -13.7500
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: -1.1481
Cell Significance Index: -11.7100
Cell Name: intestine goblet cell (CL0019031)
Fold Change: -1.1584
Cell Significance Index: -9.9800
Cell Name: mature NK T cell (CL0000814)
Fold Change: -1.1589
Cell Significance Index: -13.0600
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: -1.1736
Cell Significance Index: -9.1300
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: -1.1820
Cell Significance Index: -9.2700
Cell Name: IgM plasma cell (CL0000986)
Fold Change: -1.1845
Cell Significance Index: -9.1000
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: -1.2002
Cell Significance Index: -10.6900
Cell Name: B-2 B cell (CL0000822)
Fold Change: -1.2118
Cell Significance Index: -10.7400
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -1.2184
Cell Significance Index: -14.3400
Cell Name: promonocyte (CL0000559)
Fold Change: -1.2190
Cell Significance Index: -13.0200
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -1.2259
Cell Significance Index: -11.2100
Cell Name: leukocyte (CL0000738)
Fold Change: -1.2300
Cell Significance Index: -20.8900
Cell Name: germinal center B cell (CL0000844)
Fold Change: -1.2326
Cell Significance Index: -8.7100
Cell Name: precursor B cell (CL0000817)
Fold Change: -1.2365
Cell Significance Index: -16.0000
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: -1.2597
Cell Significance Index: -10.8700
Cell Name: plasmablast (CL0000980)
Fold Change: -1.2736
Cell Significance Index: -11.8200
Cell Name: T cell (CL0000084)
Fold Change: -1.3018
Cell Significance Index: -15.3700
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: -1.3406
Cell Significance Index: -13.1000
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -1.3650
Cell Significance Index: -9.0900
Cell Name: immature B cell (CL0000816)
Fold Change: -1.3823
Cell Significance Index: -13.0800
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -1.4121
Cell Significance Index: -16.2500
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: -1.4253
Cell Significance Index: -10.0300
Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
Fold Change: -1.4345
Cell Significance Index: -15.5100
Cell Name: regulatory T cell (CL0000815)
Fold Change: -1.4354
Cell Significance Index: -16.6500
Cell Name: naive T cell (CL0000898)
Fold Change: -1.4575
Cell Significance Index: -13.2400
Cell Name: B-1 B cell (CL0000819)
Fold Change: -1.4664
Cell Significance Index: -12.7800
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: -1.4777
Cell Significance Index: -11.8100
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -1.4781
Cell Significance Index: -19.3300
Cell Name: naive B cell (CL0000788)
Fold Change: -1.4845
Cell Significance Index: -15.6300
Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: -1.4882
Cell Significance Index: -23.9300
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -1.5091
Cell Significance Index: -22.0000
Cell Name: classical monocyte (CL0000860)
Fold Change: -1.5112
Cell Significance Index: -14.0700
Cell Name: natural killer cell (CL0000623)
Fold Change: -1.5137
Cell Significance Index: -16.7700
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -1.5216
Cell Significance Index: -23.1100
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: -1.5452
Cell Significance Index: -13.0400
Cell Name: myofibroblast cell (CL0000186)
Fold Change: -1.5503
Cell Significance Index: -16.2500
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -1.5656
Cell Significance Index: -18.5000
Cell Name: memory B cell (CL0000787)
Fold Change: -1.5763
Cell Significance Index: -16.7700
Cell Name: helper T cell (CL0000912)
Fold Change: -1.5778
Cell Significance Index: -22.4200
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: -1.5857
Cell Significance Index: -10.1100
Cell Name: fibroblast of lung (CL0002553)
Fold Change: -1.5934
Cell Significance Index: -18.9400
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: -1.6089
Cell Significance Index: -22.1000
Cell Name: melanocyte of skin (CL1000458)
Fold Change: -1.6181
Cell Significance Index: -22.6800
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: -1.6275
Cell Significance Index: -15.4300
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: -1.6334
Cell Significance Index: -15.2800
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: -1.6393
Cell Significance Index: -16.1700
Cell Name: macrophage (CL0000235)
Fold Change: -1.6451
Cell Significance Index: -16.8000
Cell Name: mast cell (CL0000097)
Fold Change: -1.6596
Cell Significance Index: -21.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** IGKV1D 33 is a member of the immunoglobulin kappa family, which is essential for the development and function of B cells, a type of white blood cell responsible for producing antibodies. The IGKV1D 33 gene is specifically expressed in various cell types, including dendritic cells, T cells, granulocyte-monocyte progenitor cells, and leukocytes. This widespread expression highlights the gene's importance in the immune system's ability to respond to pathogens and other foreign substances. **Pathways and Functions:** IGKV1D 33 is involved in several key immune pathways, including: 1. **Adaptive Immune Response:** IGKV1D 33 is essential for the regulation of B cell receptor signaling, which triggers the activation of B cells and the production of antibodies. 2. **Anti-inflammatory Response:** The gene is also involved in the anti-inflammatory response, favoring Leishmania parasite infection, by regulating the expression of anti-inflammatory cytokines. 3. **Antigen Binding:** IGKV1D 33 plays a crucial role in antigen binding, allowing B cells to recognize and respond to pathogens. 4. **Complement Cascade:** The gene is involved in the classical antibody-mediated complement activation pathway, which helps to eliminate pathogens from the body. **Clinical Significance:** The dysregulation of IGKV1D 33 has been implicated in various diseases, including: 1. **Leishmania Infection:** IGKV1D 33 is essential for the regulation of Leishmania parasite growth and survival, highlighting its importance in the development of effective treatments for this disease. 2. **Autoimmune Diseases:** The gene's role in regulating B cell receptor signaling and antibody production makes it a potential target for the treatment of autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Viral Infections:** IGKV1D 33's involvement in the complement cascade and antigen binding pathways makes it a potential target for the treatment of viral infections, such as HIV and influenza. In conclusion, IGKV1D 33 is a critical gene that plays a pivotal role in the regulation of immune responses, particularly in the context of Leishmania parasite infection. Further research on this gene is essential to understand its mechanisms of action and to develop effective treatments for diseases associated with its dysregulation. **Recommendations:** 1. Further studies are necessary to elucidate the mechanisms of IGKV1D 33 in the regulation of immune responses and Leishmania parasite infection. 2. The development of therapeutic strategies targeting IGKV1D 33 may provide effective treatments for autoimmune diseases and viral infections. 3. The expression of IGKV1D 33 in various cell types highlights its importance in the immune system, and further research is necessary to understand its role in different disease contexts. By exploring the intricate mechanisms of IGKV1D 33, we can gain a deeper understanding of the immune system's complex interactions and develop innovative therapies to combat diseases associated with its dysregulation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.