Details for: GYPE

Gene ID: 2996

Symbol: GYPE

Ensembl ID: ENSG00000197465

Description: glycophorin E (MNS blood group)

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroblast (CL0000765)
    Fold Change: 4.15
    Marker Score: 2588
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.09
    Marker Score: 8864
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 799
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71832.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1
    Marker Score: 2537
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48057
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.94
    Marker Score: 2743
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.92
    Marker Score: 454.5
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.92
    Marker Score: 622
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.73
    Marker Score: 4363
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.67
    Marker Score: 702
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.61
    Marker Score: 460
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.61
    Marker Score: 2557
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.61
    Marker Score: 339.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 450
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.54
    Marker Score: 1096
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.52
    Marker Score: 992
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: 0.49
    Marker Score: 208
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.42
    Marker Score: 6536
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.4
    Marker Score: 3341.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.39
    Marker Score: 236
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.39
    Marker Score: 522
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.36
    Marker Score: 152
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.32
    Marker Score: 189
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.31
    Marker Score: 126
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.31
    Marker Score: 376
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.29
    Marker Score: 2759
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.27
    Marker Score: 2350
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.26
    Marker Score: 129
  • Cell Name: enucleate erythrocyte (CL0000595)
    Fold Change: 0.23
    Marker Score: 90
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.23
    Marker Score: 129.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.23
    Marker Score: 312.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.22
    Marker Score: 104
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.21
    Marker Score: 431
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.21
    Marker Score: 395
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.2
    Marker Score: 821
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.19
    Marker Score: 203
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.18
    Marker Score: 11005
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.17
    Marker Score: 569
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.17
    Marker Score: 204
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.17
    Marker Score: 85
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.17
    Marker Score: 97
  • Cell Name: enucleated reticulocyte (CL0002422)
    Fold Change: 0.17
    Marker Score: 62
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.16
    Marker Score: 297
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.16
    Marker Score: 42
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.15
    Marker Score: 54
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.15
    Marker Score: 68
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.15
    Marker Score: 63
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.14
    Marker Score: 39
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.13
    Marker Score: 61
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.13
    Marker Score: 81
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.13
    Marker Score: 64
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.13
    Marker Score: 2098
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.13
    Marker Score: 216
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.13
    Marker Score: 200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.13
    Marker Score: 62
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.12
    Marker Score: 125
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.12
    Marker Score: 82
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.12
    Marker Score: 149
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.12
    Marker Score: 69
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.12
    Marker Score: 110
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.12
    Marker Score: 186.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.11
    Marker Score: 141
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.11
    Marker Score: 350
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.11
    Marker Score: 106
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.11
    Marker Score: 61
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.11
    Marker Score: 91
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.1
    Marker Score: 33
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.1
    Marker Score: 30
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1
    Marker Score: 411.5
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.09
    Marker Score: 207
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.09
    Marker Score: 197
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.08
    Marker Score: 57
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.07
    Marker Score: 73
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.07
    Marker Score: 41
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.07
    Marker Score: 74
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.07
    Marker Score: 245
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.07
    Marker Score: 28
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.07
    Marker Score: 89
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.07
    Marker Score: 36
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.07
    Marker Score: 78
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.07
    Marker Score: 84
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.06
    Marker Score: 16

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Other Information

**Key characteristics:** * GYPE is a glycoprotein with a molecular weight of approximately 150 kDa. * It is encoded by a single gene with 14 exons and 13 introns. * GYPE is highly expressed in erythrocytes, particularly in red blood cells. * It is also expressed in retinal cone cells, goblet cells, early T lineage precursor cells, cerebral cortex GABAergic interneurons, intestinal crypt stem cells of colon, forebrain radial glial cells, absorptive cells, ON-bipolar cells, and transit amplifying cells. **Pathways and functions:** * GYPE is involved in the synthesis and secretion of glycophorin A, a glycoprotein that is responsible for blood group specificity. * It also plays a role in the regulation of immune responses. * GYPE is a ligand for the glycoprotein GP-E, which is expressed on activated T cells and macrophages. * It is involved in the adhesion of immune cells to the surface of red blood cells. **Clinical significance:** * Mutations in the GYPE gene have been linked to blood group disorders, such as Rh-negative disease and sickle cell disease. * GYPE is also involved in the pathogenesis of several eye diseases, including macular degeneration and diabetic retinopathy. * Studies of GYPE have implications for the development of new diagnostic tests and therapeutic strategies for blood disorders and eye diseases.

Genular Protein ID: 1105577433

Symbol: GLPE_HUMAN

Name: Glycophorin-E

UniProtKB Accession Codes:

P15421 D3DNZ5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 16 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 4 SMR 1 STRING 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 2295603

Title: Identification of a novel human glycophorin, glycophorin E, by isolation of genomic clones and complementary DNA clones utilizing polymerase chain reaction.

PubMed ID: 2295603

DOI: 10.1016/s0021-9258(19)40164-6

PubMed ID: 2390989

Title: A novel gene member of the human glycophorin A and B gene family. Molecular cloning and expression.

PubMed ID: 2390989

DOI: 10.1111/j.1432-1033.1990.tb19166.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2249783

Title: Promoter sequence and chromosomal organization of the genes encoding glycophorins A, B and E.

PubMed ID: 2249783

DOI: 10.1016/0378-1119(90)90374-z

PubMed ID: 7798177

Title: Characterization of glycophorin A transcripts: control by the common erythroid-specific promoter and alternative usage of different polyadenylation signals.

PubMed ID: 7798177

DOI: 10.1093/oxfordjournals.jbchem.a124492

Sequence Information:

  • Length: 78
  • Mass: 8463
  • Checksum: F1F5B6EE5CFB3EB3
  • Sequence:
    • MYGKIIFVLL LSGIVSISAS STTGVAMHTS TSSSVTKSYI SSQTNGITLI NWWAMARVIF 
EVMLVVVGMI ILISYCIR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.