Details for: PLA2G2E

Gene ID: 30814

Symbol: PLA2G2E

Ensembl ID: ENSG00000188784

Description: phospholipase A2 group IIE

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.2043
    Cell Significance Index: 56.1600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.8187
    Cell Significance Index: 13.2600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.8020
    Cell Significance Index: 13.7100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.2758
    Cell Significance Index: 2.9300
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.2394
    Cell Significance Index: 3.1500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.1360
    Cell Significance Index: 1.9100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1209
    Cell Significance Index: 1.7300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0315
    Cell Significance Index: 0.4100
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.0255
    Cell Significance Index: 0.1900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0133
    Cell Significance Index: 0.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0108
    Cell Significance Index: 2.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.0093
    Cell Significance Index: 0.0900
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.0092
    Cell Significance Index: 0.0800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.0085
    Cell Significance Index: 0.0600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.0077
    Cell Significance Index: 0.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0026
    Cell Significance Index: 0.0700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0006
    Cell Significance Index: -0.2900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0017
    Cell Significance Index: -0.0300
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0021
    Cell Significance Index: -0.0200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0028
    Cell Significance Index: -0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0035
    Cell Significance Index: -0.7000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0041
    Cell Significance Index: -0.0400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0049
    Cell Significance Index: -0.1700
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0055
    Cell Significance Index: -0.0600
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.0055
    Cell Significance Index: -0.0300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0062
    Cell Significance Index: -0.0600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0065
    Cell Significance Index: -0.0800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0070
    Cell Significance Index: -0.0900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0076
    Cell Significance Index: -0.0800
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0082
    Cell Significance Index: -0.0800
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.0095
    Cell Significance Index: -0.0500
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0097
    Cell Significance Index: -0.1000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0097
    Cell Significance Index: -0.1200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0099
    Cell Significance Index: -0.1000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0105
    Cell Significance Index: -1.8900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0105
    Cell Significance Index: -0.2100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0106
    Cell Significance Index: -0.1100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0107
    Cell Significance Index: -0.1400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0115
    Cell Significance Index: -0.0800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0123
    Cell Significance Index: -0.1400
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0125
    Cell Significance Index: -0.0900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0127
    Cell Significance Index: -0.3100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0134
    Cell Significance Index: -0.2600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0138
    Cell Significance Index: -0.1700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0139
    Cell Significance Index: -0.1300
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0144
    Cell Significance Index: -0.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0153
    Cell Significance Index: -1.8800
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0167
    Cell Significance Index: -0.1900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0181
    Cell Significance Index: -0.3900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0183
    Cell Significance Index: -0.2400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0187
    Cell Significance Index: -0.2200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0200
    Cell Significance Index: -0.2700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0206
    Cell Significance Index: -0.2400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0225
    Cell Significance Index: -0.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0232
    Cell Significance Index: -0.6200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0232
    Cell Significance Index: -0.3300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0235
    Cell Significance Index: -0.2500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0277
    Cell Significance Index: -0.3100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0292
    Cell Significance Index: -0.3500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0305
    Cell Significance Index: -0.3100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0306
    Cell Significance Index: -0.2700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0314
    Cell Significance Index: -0.6200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0326
    Cell Significance Index: -0.3900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0372
    Cell Significance Index: -0.7500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0379
    Cell Significance Index: -0.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0388
    Cell Significance Index: -1.0400
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0391
    Cell Significance Index: -0.3300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0391
    Cell Significance Index: -0.3000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0394
    Cell Significance Index: -0.3700
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.0418
    Cell Significance Index: -0.3900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0421
    Cell Significance Index: -0.4300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0428
    Cell Significance Index: -0.4900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0441
    Cell Significance Index: -0.4800
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0463
    Cell Significance Index: -0.2900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0521
    Cell Significance Index: -0.6400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0522
    Cell Significance Index: -0.5600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0527
    Cell Significance Index: -0.5000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0531
    Cell Significance Index: -0.6300
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0560
    Cell Significance Index: -0.3000
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0580
    Cell Significance Index: -0.3600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0590
    Cell Significance Index: -0.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0638
    Cell Significance Index: -2.0900
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0656
    Cell Significance Index: -0.6000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0721
    Cell Significance Index: -1.5300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0735
    Cell Significance Index: -1.6100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0748
    Cell Significance Index: -0.6100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0752
    Cell Significance Index: -0.7000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0838
    Cell Significance Index: -2.0900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0993
    Cell Significance Index: -0.6000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0998
    Cell Significance Index: -0.6200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1001
    Cell Significance Index: -2.0900
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.1073
    Cell Significance Index: -0.7800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1091
    Cell Significance Index: -0.7100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1423
    Cell Significance Index: -1.9200
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.1581
    Cell Significance Index: -1.8000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1656
    Cell Significance Index: -2.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PLA2G2E is a member of the phospholipase A2 family, which consists of six subgroups (I to VI). Group IIE is characterized by its ability to hydrolyze phospholipids, releasing arachidonic acid and other bioactive lipids, which are involved in inflammation, immune responses, and cell signaling. The enzyme is secreted and plays a role in extracellular processes, including inflammation, lipid metabolism, and cell-cell interactions. **Pathways and Functions:** PLA2G2E is involved in various biological pathways, including: 1. **Acyl chain remodeling of phospholipids**: PLA2G2E hydrolyzes phospholipids, releasing arachidonic acid and other bioactive lipids, which are involved in inflammation, immune responses, and cell signaling. 2. **Inflammatory response**: PLA2G2E is involved in the production of pro-inflammatory mediators, such as leukotrienes and prostaglandins, which play a crucial role in inflammation and immune responses. 3. **Lipid catabolic process**: PLA2G2E is involved in the degradation of phospholipids, releasing fatty acids and other lipids, which are involved in energy metabolism and lipid homeostasis. 4. **Negative regulation of T cell proliferation**: PLA2G2E has been shown to inhibit T cell proliferation, suggesting a role in immune regulation and tolerance. **Clinical Significance:** PLA2G2E has been implicated in various diseases, including: 1. **Atherosclerosis**: Elevated levels of PLA2G2E have been associated with atherosclerosis, a condition characterized by the buildup of fatty deposits in the arteries. 2. **Inflammatory bowel disease**: PLA2G2E expression is increased in inflammatory bowel disease, suggesting a role in the pathogenesis of this condition. 3. **Cancer**: PLA2G2E has been implicated in the progression of various cancers, including colorectal cancer, suggesting a role in tumor growth and metastasis. 4. **Neurodegenerative diseases**: PLA2G2E has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, suggesting a role in disease pathogenesis. In conclusion, PLA2G2E is a gene that encodes a crucial enzyme involved in various biological processes, including inflammation, lipid metabolism, and cell signaling. Its expression is widespread, and it has been implicated in various diseases, including atherosclerosis, inflammatory bowel disease, cancer, and neurodegenerative diseases. Further research is needed to fully understand the biological significance of PLA2G2E and its role in human disease.

Genular Protein ID: 1732807426

Symbol: PA2GE_HUMAN

Name: Group IIE secretory phospholipase A2

UniProtKB Accession Codes:

Q9NZK7 Q5VXJ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 64 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 15 EC 1 EMBL 2 Ensembl 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 Rhea 21 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10681567

Title: Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s.

PubMed ID: 10681567

DOI: 10.1074/jbc.275.8.5785

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 11922621

Title: Arachidonate release and eicosanoid generation by group IIE phospholipase A(2).

PubMed ID: 11922621

DOI: 10.1006/bbrc.2002.6716

PubMed ID: 28883454

Title: Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A2 group IIE.

PubMed ID: 28883454

DOI: 10.1038/s41598-017-11219-8

Sequence Information:

  • Length: 142
  • Mass: 15989
  • Checksum: 3C360EA710E141FB
  • Sequence:
    • MKSPHVLVFL CLLVALVTGN LVQFGVMIEK MTGKSALQYN DYGCYCGIGG SHWPVDQTDW 
CCHAHDCCYG RLEKLGCEPK LEKYLFSVSE RGIFCAGRTT CQRLTCECDK RAALCFRRNL 
GTYNRKYAHY PNKLCTGPTP PC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.