Details for: IFNGR1

Gene ID: 3459

Symbol: IFNGR1

Ensembl ID: ENSG00000027697

Description: interferon gamma receptor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.47
    Marker Score: 11363
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.08
    Marker Score: 5908
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.97
    Marker Score: 1478
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.79
    Marker Score: 2401
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.54
    Marker Score: 86325
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.47
    Marker Score: 1007
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.46
    Marker Score: 12077
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.38
    Marker Score: 2380
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.37
    Marker Score: 2706
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.35
    Marker Score: 4281
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.15
    Marker Score: 55155
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.11
    Marker Score: 2461
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.1
    Marker Score: 5121.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.08
    Marker Score: 4048
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.04
    Marker Score: 739
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.04
    Marker Score: 4921
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.01
    Marker Score: 3676
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.98
    Marker Score: 2911
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.97
    Marker Score: 109967
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.94
    Marker Score: 2501
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.88
    Marker Score: 1125
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.86
    Marker Score: 4824
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.86
    Marker Score: 1958
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.85
    Marker Score: 3028
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.85
    Marker Score: 656
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.85
    Marker Score: 6561
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.82
    Marker Score: 4534
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.82
    Marker Score: 2645
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.79
    Marker Score: 6622
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.7
    Marker Score: 7325
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.67
    Marker Score: 1495
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.66
    Marker Score: 514
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.65
    Marker Score: 1932
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.6
    Marker Score: 1061
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.59
    Marker Score: 1093
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.59
    Marker Score: 877
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.59
    Marker Score: 1252
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.59
    Marker Score: 906
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.56
    Marker Score: 759
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.56
    Marker Score: 18170
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.55
    Marker Score: 2626
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.52
    Marker Score: 925
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.5
    Marker Score: 2992
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.5
    Marker Score: 2610
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.49
    Marker Score: 1025
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.49
    Marker Score: 367
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.48
    Marker Score: 4161
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.47
    Marker Score: 1304
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.46
    Marker Score: 1760
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.45
    Marker Score: 2575
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.45
    Marker Score: 6035.5
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.44
    Marker Score: 8725
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.41
    Marker Score: 5444
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.4
    Marker Score: 781
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.39
    Marker Score: 1919
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.39
    Marker Score: 1674
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.39
    Marker Score: 10327
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.38
    Marker Score: 5433
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.37
    Marker Score: 3599
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.37
    Marker Score: 22025
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.37
    Marker Score: 568
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 1.37
    Marker Score: 898
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.37
    Marker Score: 838
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.36
    Marker Score: 3956
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.34
    Marker Score: 1483
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.34
    Marker Score: 320
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.33
    Marker Score: 1205
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.33
    Marker Score: 306
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.33
    Marker Score: 538
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.32
    Marker Score: 1333
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.32
    Marker Score: 336
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.32
    Marker Score: 1464
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.31
    Marker Score: 314
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.3
    Marker Score: 455
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.3
    Marker Score: 277
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.3
    Marker Score: 439.5
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.29
    Marker Score: 1310
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.28
    Marker Score: 807.5
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.28
    Marker Score: 297
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.28
    Marker Score: 580
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.28
    Marker Score: 3053
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.27
    Marker Score: 1371
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.27
    Marker Score: 739
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.26
    Marker Score: 289
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.25
    Marker Score: 949
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.25
    Marker Score: 362
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.25
    Marker Score: 3932
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.23
    Marker Score: 1342
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.23
    Marker Score: 1094
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.22
    Marker Score: 27312
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 1.22
    Marker Score: 512
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.22
    Marker Score: 629
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.22
    Marker Score: 12057
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.21
    Marker Score: 301
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.21
    Marker Score: 320
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.2
    Marker Score: 490
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.2
    Marker Score: 301
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 1.2
    Marker Score: 467
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.19
    Marker Score: 1551
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.19
    Marker Score: 694

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Other Information

**Key characteristics:** - The protein is a type II transmembrane receptor that belongs to the immunoglobulin superfamily. - It is expressed in high levels in immune cells, particularly macrophages and dendritic cells. - It is a key regulator of innate immune responses and inflammation. **Pathways and functions:** - IFNGR1 is a key component of the cytokine-mediated signaling pathway, which is activated by various cytokines. - It is involved in the regulation of inflammation, cell activation, and differentiation. - It plays a role in the immune response to viral infections and bacterial pathogens. - It is involved in the regulation of immune responses to allergens and parasites. - It is also involved in the regulation of tissue repair and regeneration. **Clinical significance:** - Mutations in the IFNGR1 gene have been linked to several human diseases, including systemic sclerosis, lupus, and rheumatoid arthritis. - Inhibition of IFNGR1 signaling has been shown to have anti-inflammatory effects in animal models of disease. - Therefore, IFNGR1 is a potential therapeutic target for inflammatory diseases. **Additional notes:** - The gene is located on chromosome 15q21.1. - It is a highly conserved protein with homologs in other species. - It is a promising target for the development of new therapies for inflammatory diseases.

Genular Protein ID: 3807549703

Symbol: INGR1_HUMAN

Name: CDw119

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2971451

Title: Molecular cloning and expression of the human interferon-gamma receptor.

PubMed ID: 2971451

DOI: 10.1016/0092-8674(88)90050-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8443182

Title: Alignment of disulfide bonds of the extracellular domain of the interferon gamma receptor and investigation of their role in biological activity.

PubMed ID: 8443182

DOI: 10.1021/bi00060a038

PubMed ID: 8156998

Title: Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).

PubMed ID: 8156998

DOI: 10.1002/j.1460-2075.1994.tb06422.x

PubMed ID: 7615558

Title: The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors.

PubMed ID: 7615558

DOI: 10.1074/jbc.270.29.17528

PubMed ID: 7673114

Title: Interaction between the components of the interferon gamma receptor complex.

PubMed ID: 7673114

DOI: 10.1074/jbc.270.36.20915

PubMed ID: 10079289

Title: Association of the interferon-gamma receptor variant (Val14Met) with systemic lupus erythematosus.

PubMed ID: 10079289

DOI: 10.1007/s002510050492

PubMed ID: 10192386

Title: A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection.

PubMed ID: 10192386

DOI: 10.1038/7701

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28883123

Title: Post-translational modification of the interferon-gamma receptor alters its stability and signaling.

PubMed ID: 28883123

DOI: 10.1042/bcj20170548

PubMed ID: 29343571

Title: Casein Kinase 1alpha Mediates the Degradation of Receptors for Type I and Type II Interferons Caused by Hemagglutinin of Influenza A Virus.

PubMed ID: 29343571

DOI: 10.1128/jvi.00006-18

PubMed ID: 7617032

Title: Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor.

PubMed ID: 7617032

DOI: 10.1038/376230a0

PubMed ID: 9367779

Title: Neutralizing epitopes on the extracellular interferon gamma receptor (IFNgammaR) alpha-chain characterized by homolog scanning mutagenesis and X-ray crystal structure of the A6 fab-IFNgammaR1-108 complex.

PubMed ID: 9367779

DOI: 10.1006/jmbi.1997.1336

PubMed ID: 10986460

Title: Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex.

PubMed ID: 10986460

DOI: 10.1016/s0969-2126(00)00184-2

PubMed ID: 9389728

Title: Partial interferon-gamma receptor 1 deficiency in a child with tuberculoid bacillus Calmette-Guerin infection and a sibling with clinical tuberculosis.

PubMed ID: 9389728

DOI: 10.1172/jci119810

PubMed ID: 28744922

Title: IFN-gammaR1 defects: Mutation update and description of the IFNGR1 variation database.

PubMed ID: 28744922

DOI: 10.1002/humu.23302

PubMed ID: 10811850

Title: In a novel form of IFN-gamma receptor 1 deficiency, cell surface receptors fail to bind IFN-gamma.

PubMed ID: 10811850

DOI: 10.1172/jci9166

PubMed ID: 11139207

Title: A point mutation in a domain of gamma interferon receptor 1 provokes severe immunodeficiency.

PubMed ID: 11139207

DOI: 10.1128/cdli.8.1.133-137.2001

PubMed ID: 11240951

Title: Association of IFN-gamma and IFN regulatory factor 1 polymorphisms with childhood atopic asthma.

PubMed ID: 11240951

DOI: 10.1067/mai.2001.113051

PubMed ID: 11335768

Title: Recurrent Mycobacterium avium osteomyelitis associated with a novel dominant interferon gamma receptor mutation.

PubMed ID: 11335768

DOI: 10.1542/peds.107.4.e47

PubMed ID: 12516030

Title: Genomewide linkage analysis identifies polymorphism in the human interferon-gamma receptor affecting Helicobacter pylori infection.

PubMed ID: 12516030

DOI: 10.1086/367714

PubMed ID: 12851715

Title: A novel single-nucleotide substitution, Leu 467 Pro, in the interferon-gamma receptor 1 gene associated with allergic diseases.

PubMed ID: 12851715

PubMed ID: 15589309

Title: Clinical features of dominant and recessive interferon gamma receptor 1 deficiencies.

PubMed ID: 15589309

DOI: 10.1016/s0140-6736(04)17552-1

PubMed ID: 16715106

Title: Successful hematopoietic stem cell transplantation in a child with active disseminated Mycobacterium fortuitum infection and interferon-gamma receptor 1 deficiency.

PubMed ID: 16715106

DOI: 10.1038/sj.bmt.1705399

PubMed ID: 16195661

Title: Disseminated Mycobacterium avium infection in a 20-year-old female with partial recessive IFNgammaR1 deficiency.

PubMed ID: 16195661

DOI: 10.1159/000088682

PubMed ID: 17514500

Title: Two patients with complete defects in interferon gamma receptor-dependent signaling.

PubMed ID: 17514500

DOI: 10.1007/s10875-007-9097-8

PubMed ID: 20186794

Title: Paternal uniparental isodisomy of chromosome 6 causing a complex syndrome including complete IFN-gamma receptor 1 deficiency.

PubMed ID: 20186794

DOI: 10.1002/ajmg.a.33291

PubMed ID: 20015550

Title: Functional analysis of naturally occurring amino acid substitutions in human IFN-gammaR1.

PubMed ID: 20015550

DOI: 10.1016/j.molimm.2009.11.016

PubMed ID: 22708048

Title: Mendelian susceptibility to mycobacterial disease in egyptian children.

PubMed ID: 22708048

DOI: 10.4084/mjhid.2012.033

PubMed ID: 25592983

Title: Hemophagocytic lymphohistiocytosis in 2 patients with underlying IFN-gamma receptor deficiency.

PubMed ID: 25592983

DOI: 10.1016/j.jaci.2014.11.030

PubMed ID: 26343451

Title: Targeted deep sequencing identifies rare loss-of-function variants in IFNGR1 for risk of atopic dermatitis complicated by eczema herpeticum.

PubMed ID: 26343451

DOI: 10.1016/j.jaci.2015.06.047

PubMed ID: 27868075

Title: Novel mutation of interferon-gamma receptor 1 gene presenting as early life mycobacterial bronchial disease.

PubMed ID: 27868075

DOI: 10.1177/2324709616675463

Sequence Information:

  • Length: 489
  • Mass: 54405
  • Checksum: DCF9E574D8F47400
  • Sequence:
  • MALLFLLPLV MQGVSRAEMG TADLGPSSVP TPTNVTIESY NMNPIVYWEY QIMPQVPVFT 
    VEVKNYGVKN SEWIDACINI SHHYCNISDH VGDPSNSLWV RVKARVGQKE SAYAKSEEFA 
    VCRDGKIGPP KLDIRKEEKQ IMIDIFHPSV FVNGDEQEVD YDPETTCYIR VYNVYVRMNG 
    SEIQYKILTQ KEDDCDEIQC QLAIPVSSLN SQYCVSAEGV LHVWGVTTEK SKEVCITIFN 
    SSIKGSLWIP VVAALLLFLV LSLVFICFYI KKINPLKEKS IILPKSLISV VRSATLETKP 
    ESKYVSLITS YQPFSLEKEV VCEEPLSPAT VPGMHTEDNP GKVEHTEELS SITEVVTTEE 
    NIPDVVPGSH LTPIERESSS PLSSNQSEPG SIALNSYHSR NCSESDHSRN GFDTDSSCLE 
    SHSSLSDSEF PPNNKGEIKT EGQELITVIK APTSFGYDKP HVLVDLLVDD SGKESLIGYR 
    PTEDSKEFS

Genular Protein ID: 1719020073

Symbol: A0A2R8Y4U4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 479
  • Mass: 53643
  • Checksum: 4F50EE17490467CA
  • Sequence:
  • MLLKSPENSL LQFQFKYGVP TPTNVTIESY NMNPIVYWEY QIMPQVPVFT VEVKNYGVKN 
    SEWIDACINI SHHYCNISDH VGDPSNSLWV RVKARVGQKE SAYAKSEEFA VCRDGKIGPP 
    KLDIRKEEKQ IMIDIFHPSV FVNGDEQEVD YDPETTCYIR VYNVYVRMNG SEIQYKILTQ 
    KEDDCDEIQC QLAIPVSSLN SQYCVSAEGV LHVWGVTTEK SKEVCITIFN SSIKGSLWIP 
    VVAALLLFLV LSLVFICFYI KKINPLKEKS IILPKSLISV VRSATLETKP ESKYVSLITS 
    YQPFSLEKEV VCEEPLSPAT VPGMHTEDNP GKVEHTEELS SITEVVTTEE NIPDVVPGSH 
    LTPIERESSS PLSSNQSEPG SIALNSYHSR NCSESDHSRN GFDTDSSCLE SHSSLSDSEF 
    PPNNKGEIKT EGQELITVIK APTSFGYDKP HVLVDLLVDD SGKESLIGYR PTEDSKEFS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.