IFNGR1 | ENSG00000027697 | NCBI 3459

Details for: IFNGR1

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Ifng signaling activates mapks
(R-HSA-9732724)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interferon gamma signaling
(R-HSA-877300)
Interferon signaling
(R-HSA-913531)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of ifng signaling
(R-HSA-877312)
Sars-cov infections
(R-HSA-9679506)
Viral infection pathways
(R-HSA-9824446)
Astrocyte activation
(GO:0048143)
Cellular response to virus
(GO:0098586)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine binding
(GO:0019955)
Cytokine receptor activity
(GO:0004896)
Membrane
(GO:0016020)
Microglial cell activation
(GO:0001774)
Negative regulation of amyloid-beta clearance
(GO:1900222)
Plasma membrane
(GO:0005886)
Positive regulation of amyloid-beta formation
(GO:1902004)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Protein binding
(GO:0005515)
Response to virus
(GO:0009615)
Signal transduction
(GO:0007165)
Type iii interferon-mediated signaling pathway
(GO:0038196)
Type ii interferon-mediated signaling pathway
(GO:0060333)
Type ii interferon receptor activity
(GO:0004906)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

pulmonary artery endothelial cell CL1001568

CSI 39.9

rCSI 54.29%

PRS 56.13
myeloid leukocyte CL0000766

CSI 30.1

rCSI 27.77%

PRS 44.24
Hofbauer cell CL3000001

CSI 29.89

rCSI 56.43%

PRS 53.35
CD1c-positive myeloid dendritic cell CL0002399

CSI 24.41

rCSI 29.49%

PRS 50.83
Langerhans cell CL0000453

CSI 21.01

rCSI 32.09%

PRS 60.57
myeloid dendritic cell CL0000782

CSI 17.19

rCSI 24.91%

PRS 59.36
central nervous system macrophage CL0000878

CSI 16.97

rCSI 56.24%

PRS 45.26
capillary endothelial cell CL0002144

CSI 15.82

rCSI 29.01%

PRS 66.67
elicited macrophage CL0000861

CSI 14.81

rCSI 13.6%

PRS 50.48
CD14-low, CD16-positive monocyte CL0002396

CSI 14

rCSI 10.79%

PRS 42
transit amplifying cell CL0009010

CSI 13.48

rCSI 20.62%

PRS 59.54
conventional dendritic cell CL0000990

CSI 13.2

rCSI 11.02%

PRS 64.4
colon macrophage CL0009038

CSI 12.97

rCSI 59.91%

PRS 65.71
macrophage CL0000235

CSI 11.68

rCSI 21.25%

PRS 72.18
ciliated cell CL0000064

CSI 10.75

rCSI 17.41%

PRS 41.94
syncytiotrophoblast cell CL0000525

CSI 10.24

rCSI 29.49%

PRS 61.07
immature B cell CL0000816

CSI 10.22

rCSI 7.59%

PRS 56.29
enteroendocrine cell CL0000164

CSI 10

rCSI 13.66%

PRS 45.8
intermediate monocyte CL0002393

CSI 9.72

rCSI 14.67%

PRS 45.16
activated CD8-positive, alpha-beta T cell CL0000906

CSI 9.32

rCSI 9.16%

PRS 70.62
group 3 innate lymphoid cell CL0001071

CSI 9.29

rCSI 6.98%

PRS 46.55
vascular leptomeningeal cell CL4023051

CSI 8.99

rCSI 15.77%

PRS 35.99
endothelial cell of artery CL1000413

CSI 8.85

rCSI 12.96%

PRS 75.13
cardiac muscle cell CL0000746

CSI 8.78

rCSI 12.59%

PRS 35.11
CD14-positive, CD16-positive monocyte CL0002397

CSI 8.3

rCSI 10.88%

PRS 56.26
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 7.81

rCSI 20.18%

PRS 39.62
natural T-regulatory cell CL0000903

CSI 7.71

rCSI 14.6%

PRS 77.17
intestine goblet cell CL0019031

CSI 7.67

rCSI 6.81%

PRS 42.41
mesenchymal cell CL0008019

CSI 7.47

rCSI 18.97%

PRS 39.57
dendritic cell CL0000451

CSI 7.4

rCSI 9.12%

PRS 67.49
hepatic stellate cell CL0000632

CSI 6.86

rCSI 25.72%

PRS 36.76
granulocyte CL0000094

CSI 6.82

rCSI 10.42%

PRS 52.17
endothelial cell of placenta CL0009092

CSI 6.78

rCSI 33.41%

PRS 54.91
pulmonary capillary endothelial cell CL4028001

CSI 6.74

rCSI 12.86%

PRS 60.03
Mueller cell CL0000636

CSI 6.37

rCSI 14.54%

PRS 37.15
inflammatory macrophage CL0000863

CSI 6.33

rCSI 10.82%

PRS 69.21
memory T cell CL0000813

CSI 5.7

rCSI 10.98%

PRS 73.23
alternatively activated macrophage CL0000890

CSI 5.54

rCSI 6.97%

PRS 56.63
retinal rod cell CL0000604

CSI 5.53

rCSI 9.76%

PRS 41.81
enteric smooth muscle cell CL0002504

CSI 5.28

rCSI 7.54%

PRS 45.92
glioblast CL0000030

CSI 5.26

rCSI 8.38%

PRS 37.44
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 5.26

rCSI 30.95%

PRS 29.82
CD4-positive, alpha-beta memory T cell CL0000897

CSI 5.25

rCSI 3.77%

PRS 55.96
kidney interstitial alternatively activated macrophage CL1000695

CSI 5.19

rCSI 13.53%

PRS 42.43
cerebral cortex endothelial cell CL1001602

CSI 5.02

rCSI 8.68%

PRS 34.5
fallopian tube secretory epithelial cell CL4030006

CSI 4.63

rCSI 4.46%

PRS 43.82
colon epithelial cell CL0011108

CSI 4.62

rCSI 4.84%

PRS 40.69
mature T cell CL0002419

CSI 4.61

rCSI 3.58%

PRS 59.94
astrocyte of the cerebral cortex CL0002605

CSI 4.49

rCSI 10.06%

PRS 29.09
fibroblast of cardiac tissue CL0002548

CSI 4.48

rCSI 21.47%

PRS 41.8
megakaryocyte CL0000556

CSI 4.4

rCSI 19.08%

PRS 59.12
lung ciliated cell CL1000271

CSI 4.27

rCSI 4.94%

PRS 33.87
hepatocyte CL0000182

CSI 4.25

rCSI 7.6%

PRS 41.68
plasmacytoid dendritic cell, human CL0001058

CSI 4.24

rCSI 2.96%

PRS 45.01
adipocyte CL0000136

CSI 4.2

rCSI 5.4%

PRS 39.15
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 4.15

rCSI 2.8%

PRS 53.3
alveolar adventitial fibroblast CL4028006

CSI 4.14

rCSI 6.55%

PRS 44.23
respiratory suprabasal cell CL4033048

CSI 4.11

rCSI 5.27%

PRS 47.99
parietal epithelial cell CL1000452

CSI 4.07

rCSI 10.88%

PRS 36.62
lung pericyte CL0009089

CSI 4.03

rCSI 10.64%

PRS 50.65
monocyte CL0000576

CSI 3.99

rCSI 7.22%

PRS 65.62
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 3.94

rCSI 2.62%

PRS 69.11
extravillous trophoblast CL0008036

CSI 3.84

rCSI 4.75%

PRS 39.32
fibroblast of lung CL0002553

CSI 3.84

rCSI 3.57%

PRS 43.19
neuroblast (sensu Vertebrata) CL0000031

CSI 3.8

rCSI 4.88%

PRS 41.39
plasmablast CL0000980

CSI 3.74

rCSI 2.94%

PRS 49.62
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 3.74

rCSI 22.62%

PRS 68.02
melanocyte CL0000148

CSI 3.63

rCSI 2.69%

PRS 37.26
microglial cell CL0000129

CSI 3.59

rCSI 14.45%

PRS 54.34
lung microvascular endothelial cell CL2000016

CSI 3.54

rCSI 68.38%

PRS 68.53
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 3.53

rCSI 4.28%

PRS 39.34
myofibroblast cell CL0000186

CSI 3.48

rCSI 4.82%

PRS 48.34
kidney connecting tubule epithelial cell CL1000768

CSI 3.41

rCSI 8.65%

PRS 34.33
mucosal invariant T cell CL0000940

CSI 3.39

rCSI 2.74%

PRS 54.39
paneth cell of epithelium of small intestine CL1000343

CSI 3.35

rCSI 9.4%

PRS 57.72
regular ventricular cardiac myocyte CL0002131

CSI 3.35

rCSI 20.93%

PRS 36.16
respiratory hillock cell CL4030023

CSI 3.3

rCSI 5.88%

PRS 58.87
alveolar macrophage CL0000583

CSI 3.28

rCSI 5.4%

PRS 48.73
nasal mucosa goblet cell CL0002480

CSI 3.24

rCSI 3.76%

PRS 54.13
placental villous trophoblast CL2000060

CSI 3.21

rCSI 4.95%

PRS 41.26
retinal bipolar neuron CL0000748

CSI 3.14

rCSI 5.88%

PRS 33.63
non-classical monocyte CL0000875

CSI 3.12

rCSI 5%

PRS 71.93
CD4-positive, alpha-beta thymocyte CL0000810

CSI 3.1

rCSI 2.48%

PRS 64.62
secretory cell CL0000151

CSI 3.08

rCSI 3.21%

PRS 43.95
blood vessel endothelial cell CL0000071

CSI 3.05

rCSI 6.33%

PRS 41.29
adventitial cell CL0002503

CSI 3.02

rCSI 7.21%

PRS 53.94
alpha-beta T cell CL0000789

CSI 3.01

rCSI 3.52%

PRS 58.72
ependymal cell CL0000065

CSI 2.99

rCSI 6.07%

PRS 26.66
periportal region hepatocyte CL0019026

CSI 2.95

rCSI 11.47%

PRS 52.12
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 2.93

rCSI 2.2%

PRS 75.65
ionocyte CL0005006

CSI 2.9

rCSI 3.11%

PRS 41.26
epithelial cell of lower respiratory tract CL0002632

CSI 2.85

rCSI 2.21%

PRS 43.67
Kupffer cell CL0000091

CSI 2.85

rCSI 6.51%

PRS 42.7
cardiac endothelial cell CL0010008

CSI 2.84

rCSI 11.45%

PRS 41.91
platelet CL0000233

CSI 2.81

rCSI 11.65%

PRS 52.93
alveolar type 1 fibroblast cell CL4028004

CSI 2.8

rCSI 3.07%

PRS 47.06
pulmonary alveolar type 2 cell CL0002063

CSI 2.8

rCSI 4.34%

PRS 53.28
unswitched memory B cell CL0000970

CSI 2.77

rCSI 2.33%

PRS 60.48
T-helper 1 cell CL0000545

CSI 2.68

rCSI 4.85%

PRS 70.05
radial glial cell CL0000681

CSI 2.66

rCSI 3.7%

PRS 42.77

acinar cell of salivary gland CL0002623

CSI 0.1

rCSI 2.4%

PRS 66.1%
odontoblast CL0000060

CSI 0.1

rCSI 3.2%

PRS 77.7%
prostate gland microvascular endothelial cell CL2000059

CSI 0.2

rCSI 5.2%

PRS 70.0%
respiratory goblet cell CL0002370

CSI 0.3

rCSI 2.8%

PRS 64.0%
mesenchymal lymphangioblast CL0005021

CSI 0.3

rCSI 7.3%

PRS 77.7%
erythroid progenitor cell CL0000038

CSI 0.3

rCSI 1.6%

PRS 54.0%
helper T cell CL0000912

CSI 0.4

rCSI 0.5%

PRS 52.2%
basal cell of epithelium of trachea CL1000348

CSI 0.4

rCSI 2.6%

PRS 67.5%
L6b glutamatergic cortical neuron CL4023038

CSI 0.4

rCSI 1.2%

PRS 29.6%
metallothionein-positive alveolar macrophage CL4033042

CSI 0.4

rCSI 4.4%

PRS 74.4%
intestinal crypt stem cell of small intestine CL0009017

CSI 0.5

rCSI 1.2%

PRS 52.1%
mesenchymal stem cell CL0000134

CSI 0.5

rCSI 5.1%

PRS 59.7%
tissue-resident macrophage CL0000864

CSI 0.5

rCSI 2.2%

PRS 62.1%
pancreatic stellate cell CL0002410

CSI 0.5

rCSI 2.8%

PRS 54.2%
enterocyte of epithelium of large intestine CL0002071

CSI 0.5

rCSI 2.7%

PRS 58.1%
retinal cone cell CL0000573

CSI 0.5

rCSI 0.9%

PRS 34.5%
microcirculation associated smooth muscle cell CL0008035

CSI 0.6

rCSI 1.7%

PRS 45.8%
luminal epithelial cell of mammary gland CL0002326

CSI 0.6

rCSI 1.0%

PRS 59.6%
type EC enteroendocrine cell CL0000577

CSI 0.6

rCSI 2.0%

PRS 56.2%
endothelial cell of uterus CL0009095

CSI 0.6

rCSI 4.3%

PRS 69.3%
regular atrial cardiac myocyte CL0002129

CSI 0.6

rCSI 2.0%

PRS 42.7%
basophil CL0000767

CSI 0.7

rCSI 1.5%

PRS 64.6%
vasa recta ascending limb cell CL1001131

CSI 0.7

rCSI 3.1%

PRS 71.1%
luminal cell of prostate epithelium CL0002340

CSI 0.7

rCSI 3.7%

PRS 58.6%
tracheal goblet cell CL1000329

CSI 0.7

rCSI 1.6%

PRS 63.0%
podocyte CL0000653

CSI 0.7

rCSI 3.3%

PRS 42.0%
follicular B cell CL0000843

CSI 0.8

rCSI 2.7%

PRS 76.9%
bronchial goblet cell CL1000312

CSI 0.8

rCSI 3.1%

PRS 64.9%
keratocyte CL0002363

CSI 0.8

rCSI 1.9%

PRS 53.4%
basal cell of epidermis CL0002187

CSI 0.8

rCSI 1.4%

PRS 26.9%
vasa recta descending limb cell CL1001285

CSI 0.8

rCSI 6.6%

PRS 74.4%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 0.9

rCSI 4.3%

PRS 54.1%
tracheobronchial smooth muscle cell CL0019019

CSI 0.9

rCSI 1.5%

PRS 51.8%
lamp5 GABAergic cortical interneuron CL4023011

CSI 0.9

rCSI 1.5%

PRS 28.5%
corneal epithelial cell CL0000575

CSI 0.9

rCSI 2.6%

PRS 60.4%
fibroblast of breast CL4006000

CSI 0.9

rCSI 3.8%

PRS 65.4%
transitional stage B cell CL0000818

CSI 0.9

rCSI 3.0%

PRS 75.5%
mucus secreting cell CL0000319

CSI 0.9

rCSI 1.5%

PRS 53.6%
pancreatic ductal cell CL0002079

CSI 1.0

rCSI 1.9%

PRS 45.2%
intrahepatic cholangiocyte CL0002538

CSI 1.0

rCSI 2.3%

PRS 59.0%
neutrophil CL0000775

CSI 1.0

rCSI 5.6%

PRS 56.4%
intraepithelial lymphocyte CL0002496

CSI 1.0

rCSI 2.7%

PRS 81.1%
type B pancreatic cell CL0000169

CSI 1.0

rCSI 2.2%

PRS 40.7%
common myeloid progenitor CL0000049

CSI 1.0

rCSI 0.8%

PRS 43.9%
professional antigen presenting cell CL0000145

CSI 1.0

rCSI 3.5%

PRS 75.0%
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI 1.0

rCSI 2.7%

PRS 74.5%
hair follicular keratinocyte CL2000092

CSI 1.0

rCSI 18.1%

PRS 77.4%
lung macrophage CL1001603

CSI 1.1

rCSI 2.4%

PRS 49.7%
paneth cell CL0000510

CSI 1.1

rCSI 1.6%

PRS 60.6%
chondrocyte CL0000138

CSI 1.1

rCSI 1.8%

PRS 36.8%
club cell CL0000158

CSI 1.2

rCSI 1.7%

PRS 43.0%
conjunctival epithelial cell CL1000432

CSI 1.2

rCSI 1.8%

PRS 43.9%
mammary gland epithelial cell CL0002327

CSI 1.2

rCSI 4.1%

PRS 58.7%
glycinergic amacrine cell CL4030028

CSI 1.2

rCSI 3.2%

PRS 43.3%
glial cell CL0000125

CSI 1.2

rCSI 4.7%

PRS 37.2%
mature B cell CL0000785

CSI 1.2

rCSI 1.1%

PRS 52.3%
transit amplifying cell of colon CL0009011

CSI 1.3

rCSI 1.5%

PRS 47.0%
choroid plexus epithelial cell CL0000706

CSI 1.3

rCSI 2.1%

PRS 34.5%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.3

rCSI 2.3%

PRS 27.5%
lung secretory cell CL1000272

CSI 1.3

rCSI 3.3%

PRS 41.4%
common lymphoid progenitor CL0000051

CSI 1.4

rCSI 1.9%

PRS 65.6%
promyelocyte CL0000836

CSI 1.4

rCSI 2.0%

PRS 53.3%
stromal cell of ovary CL0002132

CSI 1.4

rCSI 3.9%

PRS 58.6%
keratinocyte CL0000312

CSI 1.5

rCSI 1.2%

PRS 48.3%
double-positive, alpha-beta thymocyte CL0000809

CSI 1.5

rCSI 1.5%

PRS 56.3%
enterocyte CL0000584

CSI 1.5

rCSI 2.4%

PRS 52.2%
multi-ciliated epithelial cell CL0005012

CSI 1.5

rCSI 1.5%

PRS 37.8%
rod bipolar cell CL0000751

CSI 1.5

rCSI 2.7%

PRS 37.0%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 1.5

rCSI 3.4%

PRS 42.0%
pulmonary ionocyte CL0017000

CSI 1.5

rCSI 1.9%

PRS 50.8%
epithelial cell of lung CL0000082

CSI 1.5

rCSI 1.3%

PRS 41.8%
class switched memory B cell CL0000972

CSI 1.6

rCSI 1.2%

PRS 61.7%
VIP GABAergic cortical interneuron CL4023016

CSI 1.6

rCSI 1.9%

PRS 28.4%
common dendritic progenitor CL0001029

CSI 1.6

rCSI 2.0%

PRS 52.9%
myoepithelial cell CL0000185

CSI 1.6

rCSI 4.1%

PRS 51.5%
glandular epithelial cell CL0000150

CSI 1.6

rCSI 4.3%

PRS 65.9%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 1.7

rCSI 5.1%

PRS 55.5%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 1.7

rCSI 2.0%

PRS 63.5%
lymphoid lineage restricted progenitor cell CL0000838

CSI 1.7

rCSI 6.5%

PRS 63.5%
epithelial cell CL0000066

CSI 1.7

rCSI 2.6%

PRS 45.6%
activated type II NK T cell CL0000931

CSI 1.7

rCSI 1.9%

PRS 59.5%
duct epithelial cell CL0000068

CSI 1.7

rCSI 2.5%

PRS 46.1%
intestinal epithelial cell CL0002563

CSI 1.7

rCSI 1.8%

PRS 42.9%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 1.7

rCSI 6.1%

PRS 27.4%
granulocyte monocyte progenitor cell CL0000557

CSI 1.7

rCSI 1.5%

PRS 46.9%
BEST4+ enteroycte CL4030026

CSI 1.7

rCSI 2.2%

PRS 46.0%
lung neuroendocrine cell CL1000223

CSI 1.7

rCSI 2.6%

PRS 48.1%
neural crest cell CL0011012

CSI 1.8

rCSI 1.4%

PRS 31.7%
lung interstitial macrophage CL4033043

CSI 1.8

rCSI 4.0%

PRS 63.4%
promonocyte CL0000559

CSI 1.8

rCSI 3.0%

PRS 52.5%
acinar cell CL0000622

CSI 1.8

rCSI 2.6%

PRS 54.3%
centrilobular region hepatocyte CL0019029

CSI 1.8

rCSI 4.6%

PRS 51.6%
mucous neck cell CL0000651

CSI 1.8

rCSI 2.6%

PRS 56.8%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 1.9

rCSI 1.7%

PRS 40.1%
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 1.9

rCSI 2.2%

PRS 37.9%
vascular associated smooth muscle cell CL0000359

CSI 1.9

rCSI 6.1%

PRS 46.2%
CD8-positive, alpha-beta thymocyte CL0000811

CSI 1.9

rCSI 2.9%

PRS 70.4%
T-helper 17 cell CL0000899

CSI 1.9

rCSI 1.5%

PRS 65.2%
retinal blood vessel endothelial cell CL0002585

CSI 1.9

rCSI 3.0%

PRS 47.0%
pvalb GABAergic cortical interneuron CL4023018

CSI 1.9

rCSI 2.4%

PRS 27.0%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary Analyzed for its expression specificity (CSI Z-Score), interferon gamma receptor 1 ([IFNGR1](/details-gene/3459)) is revealed not as a cell-defining marker, but as a broadly expressed and functionally essential receptor. Its consistently low CSI (Z-SCORE) of 0.00 across a wide array of immune and non-immune cells, including myeloid, dendritic, and endothelial lineages, indicates that its presence is a fundamental requirement for cellular responsiveness to interferon-gamma (IFN-γ) rather than a feature that distinguishes one cell type from another. This widespread expression pattern is consistent with its central role in orchestrating systemic immune responses, particularly against viral and intracellular pathogens. ## Cellular Roles and Expression Landscape The expression profile of [IFNGR1](/details-gene/3459) is characterized by its breadth rather than its specificity. The analysis, based on the **CSI (Z-SCORE)**, shows no significant cell-type-specific enrichment. In the **Overall** context, [IFNGR1](/details-gene/3459) is expressed in diverse cell populations, including [myeloid leukocyte](/details-cell/CL0000766), various macrophage subtypes like [Hofbauer cell](/details-cell/CL3000001), [central nervous system macrophage](/details-cell/CL0000878), and [colon macrophage](/details-cell/CL0009038), as well as antigen-presenting cells such as [CD1c-positive myeloid dendritic cell](/details-cell/CL0002399) and [Langerhans cell](/details-cell/CL0000453). Its presence is also noted in structural cells like [pulmonary artery endothelial cell](/details-cell/CL1001568) and [capillary endothelial cell](/details-cell/CL0002144). For all these cell types, the CSI (Z-SCORE) is 0.00 with non-significant p-values, and percentile ranks (PRS) are generally in the mid-range (42-72%). This statistical profile strongly suggests that while [IFNGR1](/details-gene/3459) is functionally active in these cells, its expression level is not a unique or distinguishing characteristic. Instead, this pattern highlights the universal importance of the IFN-γ signaling axis across the immune system and at barrier tissues. The receptor enables a wide variety of cells to sense and respond to IFN-γ, a pleiotropic cytokine critical for host defense. ## Pathways and Molecular Function The functional annotations for [IFNGR1](/details-gene/3459) align perfectly with its broad cellular expression, underscoring its role as the primary sensor for IFN-γ. As a type II interferon receptor, it is a key component of the '[Interferon gamma signaling](/details-pathway/R-HSA-877300)' pathway, which is integral to the broader '[Cytokine signaling in immune system](/details-pathway/R-HSA-1280215)' network. Upon ligand binding, the receptor initiates a signaling cascade, as described in '[Type ii interferon-mediated signaling pathway](/details-pathway/GO:0060333)', that is crucial for mounting immune responses. This function is essential for processes like '[Cellular response to virus](/details-pathway/GO:0098586)' and is implicated in pathways related to '[Infectious disease](/details-pathway/R-HSA-5663205)'. The expression of [IFNGR1](/details-gene/3459) on myeloid cells such as macrophages and dendritic cells is consistent with its role in '[Microglial cell activation](/details-pathway/GO:0001774)' and the regulation of TNF production ([GO:0032760](https://www.ebi.ac.uk/QuickGO/term/GO:0032760)). Its function is so critical that genetic defects are associated with severe immunodeficiencies, particularly increased susceptibility to mycobacterial infections ([209950](https://omim.org/entry/209950)), highlighting its non-redundant role in host defense. Furthermore, variants have been associated with autoimmune conditions like systemic lupus erythematosus ([PubMed: 10079289](https://pubmed.ncbi.nlm.nih.gov/10079289/)), demonstrating the importance of tightly regulated IFN-γ signaling. ## Research Directions The widespread but non-specific expression of [IFNGR1](/details-gene/3459) suggests that its functional outcomes are likely dictated by the cellular context, including post-translational modifications and the availability of downstream signaling partners, rather than by transcript abundance alone. ### Testable Hypotheses 1. **Hypothesis:** Given the uniform expression but diverse functional roles of IFN-γ across different cell types, the signaling output of [IFNGR1](/details-gene/3459) is determined by cell-type-specific composition of its signalosome. For example, signaling in endothelial cells may be biased towards antiviral responses, while in macrophages it may favor pro-inflammatory cytokine production. * **Experimental Approach:** Utilize co-immunoprecipitation followed by mass spectrometry (Co-IP/MS) in primary [pulmonary artery endothelial cells](/details-cell/CL1001568) versus primary human [macrophages](/details-cell/CL0000235) stimulated with IFN-γ. This will identify differential association of [IFNGR1](/details-gene/3459) with adaptor proteins, kinases (e.g., JAK1/2), and phosphatases, providing a mechanistic basis for cell-specific signaling outcomes. 2. **Hypothesis:** Within a seemingly homogenous population like [myeloid leukocytes](/details-cell/CL0000766), the functional responsiveness to IFN-γ is heterogeneous and correlates with the surface protein density of IFNGR1 (CDw119) rather than its mRNA transcript level. * **Experimental Approach:** Employ CITE-seq (Cellular Indexing of Transcriptomes and Epitopes by Sequencing) on human PBMCs. This will allow for the simultaneous quantification of [IFNGR1](/details-gene/3459) mRNA and surface protein on a single-cell basis. Following IFN-γ stimulation, the expression of downstream target genes (e.g., *IRF1*, *CXCL10*) can be correlated with pre-stimulation protein levels to determine if surface receptor density is the primary determinant of signaling capacity. 3. **Hypothesis:** Pathogens have evolved cell-type-specific mechanisms to antagonize [IFNGR1](/details-gene/3459) signaling as an immune evasion strategy. A virus infecting epithelial or endothelial cells might target the receptor for degradation, a mechanism that may be different or less effective in professional antigen-presenting cells like [Langerhans cells](/details-cell/CL0000453). * **Experimental Approach:** Infect primary human [capillary endothelial cells](/details-cell/CL0002144) and [Langerhans cells](/details-cell/CL0000453) with a virus known to modulate interferon signaling, such as influenza A virus, which has been shown to mediate receptor degradation ([PubMed: 29343571](https://pubmed.ncbi.nlm.nih.gov/29343571/)). Quantify IFNGR1 surface levels via flow cytometry and total protein levels via western blot over a time course of infection to identify cell-specific differences in receptor stability and function. ### Therapeutic Potential The ubiquitous expression of [IFNGR1](/details-gene/3459) makes it a challenging therapeutic target for cell-specific interventions, as systemic modulation would likely cause widespread effects. However, its central role in immunity presents significant opportunities. In oncology, augmenting IFN-γ signaling via targeted agonists or by inhibiting negative regulators could enhance anti-tumor immunity. Conversely, in autoimmune diseases driven by IFN-γ, such as systemic lupus erythematosus, targeted antagonism of the receptor or its downstream pathways could be beneficial. Finally, for patients with Mendelian susceptibility to mycobacterial disease due to mutations in [IFNGR1](/details-gene/3459) ([PubMed: 10192386](https://pubmed.ncbi.nlm.nih.gov/10192386/)), gene therapy or strategies to restore receptor function represent a direct therapeutic path.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

CDw119
A0A2R8Y4U4_HUMAN

Genular Protein ID: 3807549703

Symbol: INGR1_HUMAN

Name: CDw119

UniProtKB Accession Codes:

P15260 B4DFT7 E1P587 Q53Y96

Database IDs:

Citations:

PubMed ID: 2971451

Title: Molecular cloning and expression of the human interferon-gamma receptor.

PubMed ID: 2971451

DOI: 10.1016/0092-8674(88)90050-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8443182

Title: Alignment of disulfide bonds of the extracellular domain of the interferon gamma receptor and investigation of their role in biological activity.

PubMed ID: 8443182

DOI: 10.1021/bi00060a038

PubMed ID: 8156998

Title: Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).

PubMed ID: 8156998

DOI: 10.1002/j.1460-2075.1994.tb06422.x

PubMed ID: 7615558

Title: The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors.

PubMed ID: 7615558

DOI: 10.1074/jbc.270.29.17528

PubMed ID: 7673114

Title: Interaction between the components of the interferon gamma receptor complex.

PubMed ID: 7673114

DOI: 10.1074/jbc.270.36.20915

PubMed ID: 10079289

Title: Association of the interferon-gamma receptor variant (Val14Met) with systemic lupus erythematosus.

PubMed ID: 10079289

DOI: 10.1007/s002510050492

PubMed ID: 10192386

Title: A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection.

PubMed ID: 10192386

DOI: 10.1038/7701

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28883123

Title: Post-translational modification of the interferon-gamma receptor alters its stability and signaling.

PubMed ID: 28883123

DOI: 10.1042/bcj20170548

PubMed ID: 29343571

Title: Casein Kinase 1alpha Mediates the Degradation of Receptors for Type I and Type II Interferons Caused by Hemagglutinin of Influenza A Virus.

PubMed ID: 29343571

DOI: 10.1128/jvi.00006-18

PubMed ID: 7617032

Title: Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor.

PubMed ID: 7617032

DOI: 10.1038/376230a0

PubMed ID: 9367779

Title: Neutralizing epitopes on the extracellular interferon gamma receptor (IFNgammaR) alpha-chain characterized by homolog scanning mutagenesis and X-ray crystal structure of the A6 fab-IFNgammaR1-108 complex.

PubMed ID: 9367779

DOI: 10.1006/jmbi.1997.1336

PubMed ID: 10986460

Title: Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex.

PubMed ID: 10986460

DOI: 10.1016/s0969-2126(00)00184-2

PubMed ID: 9389728

Title: Partial interferon-gamma receptor 1 deficiency in a child with tuberculoid bacillus Calmette-Guerin infection and a sibling with clinical tuberculosis.

PubMed ID: 9389728

DOI: 10.1172/jci119810

PubMed ID: 28744922

Title: IFN-gammaR1 defects: Mutation update and description of the IFNGR1 variation database.

PubMed ID: 28744922

DOI: 10.1002/humu.23302

PubMed ID: 10811850

Title: In a novel form of IFN-gamma receptor 1 deficiency, cell surface receptors fail to bind IFN-gamma.

PubMed ID: 10811850

DOI: 10.1172/jci9166

PubMed ID: 11139207

Title: A point mutation in a domain of gamma interferon receptor 1 provokes severe immunodeficiency.

PubMed ID: 11139207

DOI: 10.1128/cdli.8.1.133-137.2001

PubMed ID: 11240951

Title: Association of IFN-gamma and IFN regulatory factor 1 polymorphisms with childhood atopic asthma.

PubMed ID: 11240951

DOI: 10.1067/mai.2001.113051

PubMed ID: 11335768

Title: Recurrent Mycobacterium avium osteomyelitis associated with a novel dominant interferon gamma receptor mutation.

PubMed ID: 11335768

DOI: 10.1542/peds.107.4.e47

PubMed ID: 12516030

Title: Genomewide linkage analysis identifies polymorphism in the human interferon-gamma receptor affecting Helicobacter pylori infection.

PubMed ID: 12516030

DOI: 10.1086/367714

PubMed ID: 12851715

Title: A novel single-nucleotide substitution, Leu 467 Pro, in the interferon-gamma receptor 1 gene associated with allergic diseases.

PubMed ID: 12851715

PubMed ID: 15589309

Title: Clinical features of dominant and recessive interferon gamma receptor 1 deficiencies.

PubMed ID: 15589309

DOI: 10.1016/s0140-6736(04)17552-1

PubMed ID: 16715106

Title: Successful hematopoietic stem cell transplantation in a child with active disseminated Mycobacterium fortuitum infection and interferon-gamma receptor 1 deficiency.

PubMed ID: 16715106

DOI: 10.1038/sj.bmt.1705399

PubMed ID: 16195661

Title: Disseminated Mycobacterium avium infection in a 20-year-old female with partial recessive IFNgammaR1 deficiency.

PubMed ID: 16195661

DOI: 10.1159/000088682

PubMed ID: 17514500

Title: Two patients with complete defects in interferon gamma receptor-dependent signaling.

PubMed ID: 17514500

DOI: 10.1007/s10875-007-9097-8

PubMed ID: 20186794

Title: Paternal uniparental isodisomy of chromosome 6 causing a complex syndrome including complete IFN-gamma receptor 1 deficiency.

PubMed ID: 20186794

DOI: 10.1002/ajmg.a.33291

PubMed ID: 20015550

Title: Functional analysis of naturally occurring amino acid substitutions in human IFN-gammaR1.

PubMed ID: 20015550

DOI: 10.1016/j.molimm.2009.11.016

PubMed ID: 22708048

Title: Mendelian susceptibility to mycobacterial disease in egyptian children.

PubMed ID: 22708048

DOI: 10.4084/mjhid.2012.033

PubMed ID: 25592983

Title: Hemophagocytic lymphohistiocytosis in 2 patients with underlying IFN-gamma receptor deficiency.

PubMed ID: 25592983

DOI: 10.1016/j.jaci.2014.11.030

PubMed ID: 26343451

Title: Targeted deep sequencing identifies rare loss-of-function variants in IFNGR1 for risk of atopic dermatitis complicated by eczema herpeticum.

PubMed ID: 26343451

DOI: 10.1016/j.jaci.2015.06.047

PubMed ID: 27868075

Title: Novel mutation of interferon-gamma receptor 1 gene presenting as early life mycobacterial bronchial disease.

PubMed ID: 27868075

DOI: 10.1177/2324709616675463

Sequence Information:

Length: 489
Mass: 54405
Checksum: DCF9E574D8F47400
Sequence:

MALLFLLPLV MQGVSRAEMG TADLGPSSVP TPTNVTIESY NMNPIVYWEY QIMPQVPVFT 
VEVKNYGVKN SEWIDACINI SHHYCNISDH VGDPSNSLWV RVKARVGQKE SAYAKSEEFA 
VCRDGKIGPP KLDIRKEEKQ IMIDIFHPSV FVNGDEQEVD YDPETTCYIR VYNVYVRMNG 
SEIQYKILTQ KEDDCDEIQC QLAIPVSSLN SQYCVSAEGV LHVWGVTTEK SKEVCITIFN 
SSIKGSLWIP VVAALLLFLV LSLVFICFYI KKINPLKEKS IILPKSLISV VRSATLETKP 
ESKYVSLITS YQPFSLEKEV VCEEPLSPAT VPGMHTEDNP GKVEHTEELS SITEVVTTEE 
NIPDVVPGSH LTPIERESSS PLSSNQSEPG SIALNSYHSR NCSESDHSRN GFDTDSSCLE 
SHSSLSDSEF PPNNKGEIKT EGQELITVIK APTSFGYDKP HVLVDLLVDD SGKESLIGYR 
PTEDSKEFS

Genular Protein ID: 1719020073

Symbol: A0A2R8Y4U4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A2R8Y4U4 Q5TFD1

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

Length: 479
Mass: 53643
Checksum: 4F50EE17490467CA
Sequence:

MLLKSPENSL LQFQFKYGVP TPTNVTIESY NMNPIVYWEY QIMPQVPVFT VEVKNYGVKN 
SEWIDACINI SHHYCNISDH VGDPSNSLWV RVKARVGQKE SAYAKSEEFA VCRDGKIGPP 
KLDIRKEEKQ IMIDIFHPSV FVNGDEQEVD YDPETTCYIR VYNVYVRMNG SEIQYKILTQ 
KEDDCDEIQC QLAIPVSSLN SQYCVSAEGV LHVWGVTTEK SKEVCITIFN SSIKGSLWIP 
VVAALLLFLV LSLVFICFYI KKINPLKEKS IILPKSLISV VRSATLETKP ESKYVSLITS 
YQPFSLEKEV VCEEPLSPAT VPGMHTEDNP GKVEHTEELS SITEVVTTEE NIPDVVPGSH 
LTPIERESSS PLSSNQSEPG SIALNSYHSR NCSESDHSRN GFDTDSSCLE SHSSLSDSEF 
PPNNKGEIKT EGQELITVIK APTSFGYDKP HVLVDLLVDD SGKESLIGYR PTEDSKEFS

	Overall overall
	Acute kidney failure MONDO0002492
	Adrenal gland UBERON0002369
	Alzheimer disease MONDO0004975
	Amyotrophic lateral sclerosis MONDO0004976
	Ascending colon UBERON0001156
	\|— Ascending colon Healthy UBERON0001156_PATO0000461
	Atherosclerosis MONDO0005311
	Basal cell carcinoma MONDO0020804
	Bipolar disorder MONDO0004985
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caecum UBERON0001153
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Chronic kidney disease MONDO0005300
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	Colorectal cancer MONDO0005575
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar disorder UBERON0009834_MONDO0004985
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Fallopian tube UBERON0003889
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung adenocarcinoma MONDO0005061
	\|— Lung parenchyma UBERON0008946
	Lymph node UBERON0000029
	\|— Lymph node Metastatic melanoma UBERON0000029_MONDO0005191
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Metastatic melanoma MONDO0005191
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neuroblastoma MONDO0005072
	Nonpapillary renal cell carcinoma MONDO0007763
	Occipital cortex UBERON0016540
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Parkinson disease MONDO0005180
	Placenta UBERON0001987
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	\|— Sigmoid colon Healthy UBERON0001159_PATO0000461
	Skin of body UBERON0002097
	\|— Skin of body Healthy UBERON0002097_PATO0000461
	Small cell lung carcinoma MONDO0008433
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Stomach UBERON0000945
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	Trachea UBERON0003126
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952
	Vascular dementia MONDO0004648

Details for: IFNGR1

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Molecular cloning and expression of the human interferon-gamma receptor. PubMed ID: 2971451

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Alignment of disulfide bonds of the extracellular domain of the interferon gamma receptor and investigation of their role in biological activity. PubMed ID: 8443182

Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91). PubMed ID: 8156998

The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors. PubMed ID: 7615558

Interaction between the components of the interferon gamma receptor complex. PubMed ID: 7673114

Association of the interferon-gamma receptor variant (Val14Met) with systemic lupus erythematosus. PubMed ID: 10079289

A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection. PubMed ID: 10192386

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Post-translational modification of the interferon-gamma receptor alters its stability and signaling. PubMed ID: 28883123

Casein Kinase 1alpha Mediates the Degradation of Receptors for Type I and Type II Interferons Caused by Hemagglutinin of Influenza A Virus. PubMed ID: 29343571

Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor. PubMed ID: 7617032

Neutralizing epitopes on the extracellular interferon gamma receptor (IFNgammaR) alpha-chain characterized by homolog scanning mutagenesis and X-ray crystal structure of the A6 fab-IFNgammaR1-108 complex. PubMed ID: 9367779

Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex. PubMed ID: 10986460

Partial interferon-gamma receptor 1 deficiency in a child with tuberculoid bacillus Calmette-Guerin infection and a sibling with clinical tuberculosis. PubMed ID: 9389728

IFN-gammaR1 defects: Mutation update and description of the IFNGR1 variation database. PubMed ID: 28744922

In a novel form of IFN-gamma receptor 1 deficiency, cell surface receptors fail to bind IFN-gamma. PubMed ID: 10811850

A point mutation in a domain of gamma interferon receptor 1 provokes severe immunodeficiency. PubMed ID: 11139207

Association of IFN-gamma and IFN regulatory factor 1 polymorphisms with childhood atopic asthma. PubMed ID: 11240951

Recurrent Mycobacterium avium osteomyelitis associated with a novel dominant interferon gamma receptor mutation. PubMed ID: 11335768

Genomewide linkage analysis identifies polymorphism in the human interferon-gamma receptor affecting Helicobacter pylori infection. PubMed ID: 12516030

A novel single-nucleotide substitution, Leu 467 Pro, in the interferon-gamma receptor 1 gene associated with allergic diseases. PubMed ID: 12851715

Clinical features of dominant and recessive interferon gamma receptor 1 deficiencies. PubMed ID: 15589309

Successful hematopoietic stem cell transplantation in a child with active disseminated Mycobacterium fortuitum infection and interferon-gamma receptor 1 deficiency. PubMed ID: 16715106

Disseminated Mycobacterium avium infection in a 20-year-old female with partial recessive IFNgammaR1 deficiency. PubMed ID: 16195661

Two patients with complete defects in interferon gamma receptor-dependent signaling. PubMed ID: 17514500

Paternal uniparental isodisomy of chromosome 6 causing a complex syndrome including complete IFN-gamma receptor 1 deficiency. PubMed ID: 20186794

Functional analysis of naturally occurring amino acid substitutions in human IFN-gammaR1. PubMed ID: 20015550

Mendelian susceptibility to mycobacterial disease in egyptian children. PubMed ID: 22708048

Hemophagocytic lymphohistiocytosis in 2 patients with underlying IFN-gamma receptor deficiency. PubMed ID: 25592983

Targeted deep sequencing identifies rare loss-of-function variants in IFNGR1 for risk of atopic dermatitis complicated by eczema herpeticum. PubMed ID: 26343451

Novel mutation of interferon-gamma receptor 1 gene presenting as early life mycobacterial bronchial disease. PubMed ID: 27868075

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

PubMed ID: 2971451

PubMed ID: 14702039

PubMed ID: 14574404

PubMed ID: 15489334

PubMed ID: 8443182

PubMed ID: 8156998

PubMed ID: 7615558

PubMed ID: 7673114

PubMed ID: 10079289

PubMed ID: 10192386

PubMed ID: 23186163

PubMed ID: 28883123

PubMed ID: 29343571

PubMed ID: 7617032

PubMed ID: 9367779

PubMed ID: 10986460

PubMed ID: 9389728

PubMed ID: 28744922

PubMed ID: 10811850

PubMed ID: 11139207

PubMed ID: 11240951

PubMed ID: 11335768

PubMed ID: 12516030

PubMed ID: 12851715

PubMed ID: 15589309

PubMed ID: 16715106

PubMed ID: 16195661

PubMed ID: 17514500

PubMed ID: 20186794

PubMed ID: 20015550

PubMed ID: 22708048

PubMed ID: 25592983

PubMed ID: 26343451

PubMed ID: 27868075

PubMed ID: 11237011

PubMed ID: 14574404

PubMed ID: 15496913

PubMed ID: 23186163