Details for: IKBKB
Gene ID: 3551
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: IKBKB
Ensembl ID: ENSG00000104365
Description: inhibitor of nuclear factor kappa B kinase subunit beta
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 12.31rCSI 9.95%PRS 24.33
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CSI 10.01rCSI 10.72%PRS 22.18
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CSI 8.49rCSI 13.04%PRS 28.96
-
CSI 7.94rCSI 9.18%PRS 17.82
-
CSI 7.27rCSI 11.12%PRS 27.45
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CSI 6.59rCSI 15.07%PRS 23.53
-
CSI 5.87rCSI 8.63%PRS 22.16
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CSI 5.46rCSI 5.26%PRS 24.91
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CSI 5.39rCSI 8.24%PRS 31.16
-
CSI 4.9rCSI 11.16%PRS 24.64
-
CSI 4.38rCSI 5.45%PRS 33.28
-
CSI 4.26rCSI 6.24%PRS 27.03
-
CSI 4.09rCSI 9.84%PRS 37.81
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CSI 3.93rCSI 10.84%PRS 22.45
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CSI 3.66rCSI 5.85%PRS 26.35
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CSI 3.51rCSI 5.65%PRS 18.43
-
CSI 3.5rCSI 8.41%PRS 34.55
-
CSI 3.1rCSI 2.22%PRS 33.15
-
CSI 3.09rCSI 11.13%PRS 13.61
-
CSI 3.02rCSI 3.12%PRS 28.44
-
CSI 2.96rCSI 11.19%PRS 14.92
-
CSI 2.92rCSI 2.22%PRS 31.97
-
CSI 2.9rCSI 2.58%PRS 24.3
-
CSI 2.88rCSI 2.38%PRS 22.85
-
CSI 2.83rCSI 4.47%PRS 24.15
-
CSI 2.74rCSI 2.41%PRS 27.87
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CSI 2.68rCSI 1.78%PRS 28.72
-
CSI 2.6rCSI 2.28%PRS 31.81
-
CSI 2.57rCSI 12.31%PRS 20.07
-
CSI 2.5rCSI 2.61%PRS 24.64
-
CSI 2.49rCSI 1.73%PRS 33.88
-
CSI 2.43rCSI 1.81%PRS 35.21
-
CSI 2.38rCSI 3.05%PRS 27.78
-
CSI 2.37rCSI 5.41%PRS 20.62
-
CSI 2.32rCSI 6.88%PRS 33.19
-
CSI 2.28rCSI 1.69%PRS 20.68
-
CSI 2.27rCSI 12.2%PRS 40.73
-
CSI 2.27rCSI 5.06%PRS 28.26
-
CSI 2.26rCSI 2.31%PRS 34.26
-
CSI 2.26rCSI 3.31%PRS 25.52
-
CSI 2.24rCSI 2.11%PRS 25.24
-
CSI 2.18rCSI 5.2%PRS 27.05
-
CSI 2.18rCSI 3.56%PRS 18.52
-
CSI 2.17rCSI 3.58%PRS 28.36
-
CSI 2.16rCSI 1.87%PRS 27.13
-
CSI 2.13rCSI 1.66%PRS 35.28
-
CSI 2.13rCSI 4%PRS 17.46
-
CSI 2.1rCSI 1.46%PRS 29.09
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CSI 2.09rCSI 7.83%PRS 20.22
-
CSI 2.08rCSI 1.62%PRS 23.28
-
CSI 2.06rCSI 2.42%PRS 33.7
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CSI 2.05rCSI 1.73%PRS 38.07
-
CSI 2.02rCSI 4.82%PRS 35.33
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CSI 2.02rCSI 1.19%PRS 33.93
-
CSI 2.01rCSI 11.85%PRS 15.13
-
CSI 2rCSI 1.87%PRS 24.09
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CSI 2rCSI 3.98%PRS 25.06
-
CSI 1.99rCSI 4.46%PRS 15.04
-
CSI 1.96rCSI 1.54%PRS 29.25
-
CSI 1.96rCSI 1.37%PRS 25.71
-
CSI 1.91rCSI 2.56%PRS 26.13
-
CSI 1.91rCSI 2.91%PRS 24.23
-
CSI 1.9rCSI 2.49%PRS 34.15
-
CSI 1.9rCSI 3.94%PRS 23.88
-
CSI 1.89rCSI 7.64%PRS 22.27
-
CSI 1.89rCSI 3.43%PRS 36.49
-
CSI 1.89rCSI 4.23%PRS 44.79
-
CSI 1.88rCSI 1.56%PRS 24.57
-
CSI 1.86rCSI 3.18%PRS 47.37
-
CSI 1.84rCSI 1.89%PRS 38.26
-
CSI 1.83rCSI 1.41%PRS 22.54
-
CSI 1.81rCSI 2.12%PRS 27.52
-
CSI 1.8rCSI 1.58%PRS 17.55
-
CSI 1.78rCSI 1.49%PRS 28.51
-
CSI 1.78rCSI 1.34%PRS 25.8
-
CSI 1.78rCSI 2%PRS 37.96
-
CSI 1.77rCSI 4.31%PRS 23.25
-
CSI 1.74rCSI 1.61%PRS 25.16
-
CSI 1.74rCSI 3.01%PRS 18.39
-
CSI 1.74rCSI 1.17%PRS 29.91
-
CSI 1.7rCSI 3.24%PRS 37.48
-
CSI 1.68rCSI 2.09%PRS 25.7
-
CSI 1.68rCSI 3.69%PRS 27.56
-
CSI 1.62rCSI 1.49%PRS 28.54
-
CSI 1.61rCSI 1.28%PRS 42.2
-
CSI 1.51rCSI 6.62%PRS 22.66
-
CSI 1.5rCSI 1.44%PRS 47.01
-
CSI 1.49rCSI 3%PRS 17.81
-
CSI 1.45rCSI 2.22%PRS 22.21
-
CSI 1.45rCSI 2.73%PRS 30.57
-
CSI 1.42rCSI 2.01%PRS 33.41
-
CSI 1.42rCSI 11.57%PRS 23.19
-
CSI 1.39rCSI 5.44%PRS 9.01
-
CSI 1.37rCSI 3.56%PRS 22.55
-
CSI 1.37rCSI 1.63%PRS 41.07
-
CSI 1.36rCSI 2.39%PRS 18.49
-
CSI 1.35rCSI 2.42%PRS 22.35
-
CSI 1.35rCSI 1.17%PRS 30.44
-
CSI 1.34rCSI 2.02%PRS 24.62
-
CSI 1.33rCSI 3.1%PRS 52.03
-
CSI 0.1rCSI 0.4%PRS 44.7%
-
CSI 0.2rCSI 4.5%PRS 14.0%
-
CSI 0.2rCSI 4.1%PRS 21.1%
-
CSI 0.3rCSI 6.1%PRS 13.1%
-
CSI 0.3rCSI 0.8%PRS 16.5%
-
CSI 0.3rCSI 1.8%PRS 35.1%
-
CSI 0.4rCSI 2.5%PRS 56.7%
-
CSI 0.4rCSI 1.3%PRS 15.3%
-
CSI 0.4rCSI 2.4%PRS 61.8%
-
CSI 0.5rCSI 0.8%PRS 14.4%
-
CSI 0.5rCSI 2.8%PRS 50.1%
-
CSI 0.5rCSI 1.3%PRS 35.3%
-
CSI 0.7rCSI 2.8%PRS 22.0%
-
CSI 0.7rCSI 1.5%PRS 17.2%
-
CSI 0.7rCSI 3.6%PRS 31.8%
-
CSI 0.8rCSI 1.9%PRS 18.3%
-
CSI 0.8rCSI 2.1%PRS 31.1%
-
CSI 0.8rCSI 1.9%PRS 14.1%
-
CSI 0.8rCSI 1.3%PRS 15.7%
-
CSI 0.8rCSI 2.1%PRS 28.7%
-
CSI 0.8rCSI 2.0%PRS 22.3%
-
CSI 0.8rCSI 1.5%PRS 14.2%
-
CSI 0.9rCSI 3.3%PRS 22.7%
-
CSI 0.9rCSI 2.5%PRS 36.1%
-
CSI 0.9rCSI 1.8%PRS 39.7%
-
CSI 0.9rCSI 1.3%PRS 22.3%
-
CSI 0.9rCSI 1.4%PRS 36.2%
-
CSI 1.0rCSI 2.9%PRS 34.9%
-
CSI 1.0rCSI 1.2%PRS 31.2%
-
CSI 1.0rCSI 1.0%PRS 17.7%
-
CSI 1.0rCSI 0.9%PRS 21.9%
-
CSI 1.0rCSI 1.4%PRS 35.8%
-
CSI 1.0rCSI 2.8%PRS 19.9%
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CSI 1.1rCSI 4.8%PRS 62.6%
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CSI 1.1rCSI 6.0%PRS 14.3%
-
CSI 1.1rCSI 2.2%PRS 13.0%
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CSI 1.1rCSI 1.7%PRS 35.0%
-
CSI 1.1rCSI 2.9%PRS 57.2%
-
CSI 1.1rCSI 1.1%PRS 20.6%
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CSI 1.2rCSI 3.0%PRS 22.3%
-
CSI 1.2rCSI 1.4%PRS 29.1%
-
CSI 1.2rCSI 1.5%PRS 15.0%
-
CSI 1.2rCSI 1.8%PRS 27.5%
-
CSI 1.2rCSI 2.9%PRS 29.5%
-
CSI 1.2rCSI 1.9%PRS 20.3%
-
CSI 1.2rCSI 2.2%PRS 23.5%
-
CSI 1.3rCSI 1.5%PRS 14.3%
-
CSI 1.3rCSI 1.6%PRS 13.5%
-
CSI 1.3rCSI 2.1%PRS 24.1%
-
CSI 1.3rCSI 2.3%PRS 32.5%
-
CSI 1.3rCSI 3.1%PRS 52.0%
-
CSI 1.3rCSI 2.0%PRS 24.6%
-
CSI 1.4rCSI 1.2%PRS 30.4%
-
CSI 1.4rCSI 2.4%PRS 22.4%
-
CSI 1.4rCSI 2.4%PRS 18.5%
-
CSI 1.4rCSI 1.6%PRS 41.1%
-
CSI 1.4rCSI 3.6%PRS 22.6%
-
CSI 1.4rCSI 5.4%PRS 9.0%
-
CSI 1.4rCSI 11.6%PRS 23.2%
-
CSI 1.4rCSI 2.0%PRS 33.4%
-
CSI 1.5rCSI 2.7%PRS 30.6%
-
CSI 1.5rCSI 2.2%PRS 22.2%
-
CSI 1.5rCSI 3.0%PRS 17.8%
-
CSI 1.5rCSI 1.4%PRS 47.0%
-
CSI 1.5rCSI 6.6%PRS 22.7%
-
CSI 1.6rCSI 1.3%PRS 42.2%
-
CSI 1.6rCSI 1.5%PRS 28.5%
-
CSI 1.7rCSI 3.7%PRS 27.6%
-
CSI 1.7rCSI 2.1%PRS 25.7%
-
CSI 1.7rCSI 3.2%PRS 37.5%
-
CSI 1.7rCSI 1.2%PRS 29.9%
-
CSI 1.7rCSI 3.0%PRS 18.4%
-
CSI 1.7rCSI 1.6%PRS 25.2%
-
CSI 1.8rCSI 4.3%PRS 23.3%
-
CSI 1.8rCSI 2.0%PRS 38.0%
-
CSI 1.8rCSI 1.3%PRS 25.8%
-
CSI 1.8rCSI 1.5%PRS 28.5%
-
CSI 1.8rCSI 1.6%PRS 17.6%
-
CSI 1.8rCSI 2.1%PRS 27.5%
-
CSI 1.8rCSI 1.4%PRS 22.5%
-
CSI 1.8rCSI 1.9%PRS 38.3%
-
CSI 1.9rCSI 3.2%PRS 47.4%
-
CSI 1.9rCSI 1.6%PRS 24.6%
-
CSI 1.9rCSI 4.2%PRS 44.8%
-
CSI 1.9rCSI 3.4%PRS 36.5%
-
CSI 1.9rCSI 7.6%PRS 22.3%
-
CSI 1.9rCSI 3.9%PRS 23.9%
-
CSI 1.9rCSI 2.5%PRS 34.2%
-
CSI 1.9rCSI 2.9%PRS 24.2%
-
CSI 1.9rCSI 2.6%PRS 26.1%
-
CSI 2.0rCSI 1.4%PRS 25.7%
-
CSI 2.0rCSI 1.5%PRS 29.3%
-
CSI 2.0rCSI 4.5%PRS 15.0%
-
CSI 2.0rCSI 4.0%PRS 25.1%
-
CSI 2.0rCSI 1.9%PRS 24.1%
-
CSI 2.0rCSI 11.9%PRS 15.1%
-
CSI 2.0rCSI 1.2%PRS 33.9%
-
CSI 2.0rCSI 4.8%PRS 35.3%
-
CSI 2.1rCSI 1.7%PRS 38.1%
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CSI 2.1rCSI 2.4%PRS 33.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2753458638
Symbol: IKKB_HUMAN
Name: Inhibitor of nuclear factor kappa-B kinase subunit beta
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9346484
Title: IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.
PubMed ID: 9346484
PubMed ID: 9346485
Title: IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.
PubMed ID: 9346485
PubMed ID: 9813230
Title: IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes.
PubMed ID: 9813230
PubMed ID: 9763654
Title: Assignment of IkappaB kinase beta (IKBKB) to human chromosome band 8p12-->p11 by in situ hybridization.
PubMed ID: 9763654
DOI: 10.1159/000015058
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17116858
Title: Acetylation of MEK2 and I kappa B kinase (IKK) activation loop residues by YopJ inhibits signaling.
PubMed ID: 17116858
PubMed ID: 9819420
Title: Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.
PubMed ID: 9819420
PubMed ID: 9751059
Title: IKAP is a scaffold protein of the IkappaB kinase complex.
PubMed ID: 9751059
DOI: 10.1038/26254
PubMed ID: 10356400
Title: The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.
PubMed ID: 10356400
PubMed ID: 10022904
Title: Activation of IkappaB kinase beta by protein kinase C isoforms.
PubMed ID: 10022904
PubMed ID: 10195894
Title: Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.
PubMed ID: 10195894
PubMed ID: 10848580
Title: PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.
PubMed ID: 10848580
PubMed ID: 10783893
PubMed ID: 11297557
Title: Direct phosphorylation of NF-kappa B1 p105 by the Ikappa B kinase complex on serine 927 is essential for signal-induced p105 proteolysis.
PubMed ID: 11297557
PubMed ID: 11460167
Title: TAK1 is a ubiquitin-dependent kinase of MKK and IKK.
PubMed ID: 11460167
DOI: 10.1038/35085597
PubMed ID: 12133833
Title: Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases.
PubMed ID: 12133833
PubMed ID: 11971985
Title: Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) coactivator activity by I kappa B kinase.
PubMed ID: 11971985
PubMed ID: 12612076
Title: Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation.
PubMed ID: 12612076
PubMed ID: 15084260
Title: IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.
PubMed ID: 15084260
PubMed ID: 14739303
Title: Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways.
PubMed ID: 14739303
PubMed ID: 15456791
Title: PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages.
PubMed ID: 15456791
PubMed ID: 14673179
Title: Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing.
PubMed ID: 14673179
PubMed ID: 15173580
Title: beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha.
PubMed ID: 15173580
PubMed ID: 15184672
Title: Nitric oxide represses inhibitory kappaB kinase through S-nitrosylation.
PubMed ID: 15184672
PubMed ID: 15951441
Title: NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation.
PubMed ID: 15951441
PubMed ID: 16207722
Title: 3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling.
PubMed ID: 16207722
PubMed ID: 16267042
Title: Site-specific monoubiquitination of IkappaB kinase IKKbeta regulates its phosphorylation and persistent activation.
PubMed ID: 16267042
PubMed ID: 16177806
Title: Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.
PubMed ID: 16177806
DOI: 10.1038/nature04193
PubMed ID: 17114296
Title: Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity.
PubMed ID: 17114296
PubMed ID: 16728640
Title: Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation.
PubMed ID: 16728640
PubMed ID: 16497931
Title: Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli.
PubMed ID: 16497931
PubMed ID: 17287217
Title: Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1.
PubMed ID: 17287217
PubMed ID: 17684021
Title: FAF1 suppresses IkappaB kinase (IKK) activation by disrupting the IKK complex assembly.
PubMed ID: 17684021
PubMed ID: 17213322
Title: Negative feedback loop in T cell activation through IkappaB kinase-induced phosphorylation and degradation of Bcl10.
PubMed ID: 17213322
PubMed ID: 10712233
Title: The I kappa B/NF-kappa B system: a key determinant of mucosal inflammation and protection.
PubMed ID: 10712233
PubMed ID: 18626576
Title: The IkappaB kinase complex: master regulator of NF-kappaB signaling.
PubMed ID: 18626576
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19716809
Title: Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation.
PubMed ID: 19716809
PubMed ID: 18930133
Title: PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation.
PubMed ID: 18930133
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20434986
Title: NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways.
PubMed ID: 20434986
PubMed ID: 19675099
Title: Ro52-mediated monoubiquitination of IKK{beta} down-regulates NF-{kappa}B signalling.
PubMed ID: 19675099
DOI: 10.1093/jb/mvp127
PubMed ID: 20410276
Title: Respiratory syncytial virus-mediated NF-kappa B p65 phosphorylation at serine 536 is dependent on RIG-I, TRAF6, and IKK beta.
PubMed ID: 20410276
DOI: 10.1128/jvi.00142-10
PubMed ID: 20797629
Title: Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation.
PubMed ID: 20797629
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21138416
Title: Novel cross-talk within the IKK family controls innate immunity.
PubMed ID: 21138416
DOI: 10.1042/bj20101701
PubMed ID: 23091055
Title: The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-kappaB signaling.
PubMed ID: 23091055
PubMed ID: 23453969
Title: IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.
PubMed ID: 23453969
PubMed ID: 23776175
Title: SASH1 is a scaffold molecule in endothelial TLR4 signaling.
PubMed ID: 23776175
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23090968
Title: A-kinase-anchoring protein-Lbc anchors IkappaB kinase beta to support interleukin-6-mediated cardiomyocyte hypertrophy.
PubMed ID: 23090968
DOI: 10.1128/mcb.00887-12
PubMed ID: 24369075
Title: Deficiency of innate and acquired immunity caused by an IKBKB mutation.
PubMed ID: 24369075
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25326418
Title: Protein kinase IKKbeta-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells.
PubMed ID: 25326418
PubMed ID: 26334375
Title: IFIT5 positively regulates NF-kappaB signaling through synergizing the recruitment of IkappaB kinase (IKK) to TGF-beta-activated kinase 1 (TAK1).
PubMed ID: 26334375
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 26296658
Title: Dimer of arfaptin 2 regulates NF-kappaB signaling by interacting with IKKbeta/NEMO and inhibiting IKKbeta kinase activity.
PubMed ID: 26296658
PubMed ID: 26101251
Title: FKBP51 employs both scaffold and isomerase functions to promote NF-kappaB activation in melanoma.
PubMed ID: 26101251
DOI: 10.1093/nar/gkv615
PubMed ID: 27426725
Title: LRRC14 attenuates Toll-like receptor-mediated NF-kappa-B signaling through disruption of IKK complex.
PubMed ID: 27426725
PubMed ID: 29748387
Title: Mechanism of vaccinia viral protein B14 mediated inhibition of IkappaB kinase beta activation.
PubMed ID: 29748387
PubMed ID: 30337470
Title: Gain-of-function IKBKB mutation causes human combined immune deficiency.
PubMed ID: 30337470
DOI: 10.1084/jem.20180639
PubMed ID: 31434731
Title: Novel Functions of IFI44L as a Feedback Regulator of Host Antiviral Responses.
PubMed ID: 31434731
DOI: 10.1128/jvi.01159-19
PubMed ID: 32935379
Title: Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2.
PubMed ID: 32935379
PubMed ID: 32209697
Title: Noncanonical STAT1 phosphorylation expands its transcriptional activity into promoting LPS-induced IL-6 and IL-12p40 production.
PubMed ID: 32209697
PubMed ID: 38621137
Title: Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses.
PubMed ID: 38621137
PubMed ID: 18462684
Title: Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site.
PubMed ID: 18462684
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 756
- Mass: 86564
- Checksum: F9CADF671AE9E14E
- Sequence:
MSWSPSLTTQ TCGAWEMKER LGTGGFGNVI RWHNQETGEQ IAIKQCRQEL SPRNRERWCL EIQIMRRLTH PNVVAARDVP EGMQNLAPND LPLLAMEYCQ GGDLRKYLNQ FENCCGLREG AILTLLSDIA SALRYLHENR IIHRDLKPEN IVLQQGEQRL IHKIIDLGYA KELDQGSLCT SFVGTLQYLA PELLEQQKYT VTVDYWSFGT LAFECITGFR PFLPNWQPVQ WHSKVRQKSE VDIVVSEDLN GTVKFSSSLP YPNNLNSVLA ERLEKWLQLM LMWHPRQRGT DPTYGPNGCF KALDDILNLK LVHILNMVTG TIHTYPVTED ESLQSLKARI QQDTGIPEED QELLQEAGLA LIPDKPATQC ISDGKLNEGH TLDMDLVFLF DNSKITYETQ ISPRPQPESV SCILQEPKRN LAFFQLRKVW GQVWHSIQTL KEDCNRLQQG QRAAMMNLLR NNSCLSKMKN SMASMSQQLK AKLDFFKTSI QIDLEKYSEQ TEFGITSDKL LLAWREMEQA VELCGRENEV KLLVERMMAL QTDIVDLQRS PMGRKQGGTL DDLEEQAREL YRRLREKPRD QRTEGDSQEM VRLLLQAIQS FEKKVRVIYT QLSKTVVCKQ KALELLPKVE EVVSLMNEDE KTVVRLQEKR QKELWNLLKI ACSKVRGPVS GSPDSMNASR LSQPGQLMSQ PSTASNSLPE PAKKSEELVA EAHNLCTLLE NAIQDTVREQ DQSFTALDWS WLQTEEEEHS CLEQAS