Details for: IKBKB

Gene ID: 3551

Symbol: IKBKB

Ensembl ID: ENSG00000104365

Description: inhibitor of nuclear factor kappa B kinase subunit beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.88
    Marker Score: 2078
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.76
    Marker Score: 1052
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.75
    Marker Score: 1988
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.56
    Marker Score: 1380
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.55
    Marker Score: 1076
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.41
    Marker Score: 406
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.38
    Marker Score: 685
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.36
    Marker Score: 427
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.35
    Marker Score: 784
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.21
    Marker Score: 509
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.21
    Marker Score: 46082
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.15
    Marker Score: 2033
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.14
    Marker Score: 24338
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.14
    Marker Score: 2319
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.12
    Marker Score: 2459
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.11
    Marker Score: 1719
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1
    Marker Score: 67657
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.09
    Marker Score: 4448
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.06
    Marker Score: 1538
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.06
    Marker Score: 1423
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.06
    Marker Score: 9062
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.05
    Marker Score: 1101
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.03
    Marker Score: 10652
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.03
    Marker Score: 9782
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.03
    Marker Score: 207
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.02
    Marker Score: 3958
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.01
    Marker Score: 677
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1
    Marker Score: 317.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71659
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47884
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30386
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.98
    Marker Score: 14625
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.97
    Marker Score: 7430
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.96
    Marker Score: 1109
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.96
    Marker Score: 1038
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.96
    Marker Score: 1414
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.96
    Marker Score: 1843.5
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.94
    Marker Score: 258
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2390
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.93
    Marker Score: 3193
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.92
    Marker Score: 628
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.92
    Marker Score: 33935
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.92
    Marker Score: 221
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.92
    Marker Score: 1184
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.91
    Marker Score: 3818
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.91
    Marker Score: 1104
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.91
    Marker Score: 14536
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2692
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.89
    Marker Score: 8397
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.88
    Marker Score: 681
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.88
    Marker Score: 2206
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.88
    Marker Score: 6519
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.88
    Marker Score: 282
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.87
    Marker Score: 8814
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.85
    Marker Score: 1545
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.84
    Marker Score: 340
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.83
    Marker Score: 1353
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.83
    Marker Score: 4744
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.83
    Marker Score: 306
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.83
    Marker Score: 261
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.83
    Marker Score: 1169
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.83
    Marker Score: 401
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.83
    Marker Score: 377
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.82
    Marker Score: 752
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.82
    Marker Score: 283
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.81
    Marker Score: 867
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.81
    Marker Score: 206
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.8
    Marker Score: 720
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 319
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.79
    Marker Score: 297
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.79
    Marker Score: 985
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 599
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.78
    Marker Score: 281
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.76
    Marker Score: 446
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.76
    Marker Score: 401
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.76
    Marker Score: 15038
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.76
    Marker Score: 682
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.75
    Marker Score: 1318.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.75
    Marker Score: 1719
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.75
    Marker Score: 798
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.75
    Marker Score: 3155
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.75
    Marker Score: 168
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.75
    Marker Score: 3106
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.75
    Marker Score: 174
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.75
    Marker Score: 647
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.74
    Marker Score: 176
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.74
    Marker Score: 183
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.73
    Marker Score: 316
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.73
    Marker Score: 341
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.73
    Marker Score: 425
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.73
    Marker Score: 11412
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.72
    Marker Score: 405
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.72
    Marker Score: 295
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.72
    Marker Score: 157
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.72
    Marker Score: 356
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics**: * IKBKB is a protein of the immunoglobulin superfamily. * It is expressed in a variety of cell types, including epithelial cells, macrophages, and dendritic cells. * IKBKB is a key regulator of the innate immune response, and its inhibition can lead to the activation of the adaptive immune response. * IKBKB is also involved in the regulation of inflammation and cell death. **Pathways and functions**: * IKBKB inhibits the activity of the IKK-B kinase, a key enzyme in the innate immune response. * When IKK-B is inhibited, the IKK-B kinase is unable to activate the transcription factors that are targeted by IKK-B. * This leads to the inhibition of the activation of downstream target genes, which can lead to the inhibition of inflammation and cell death. * IKBKB also plays a role in the regulation of cell growth and differentiation. **Clinical significance**: * Mutations in the IKBKB gene have been linked to a number of human diseases, including cancer and autoimmune disorders. * IKBKB inhibitors are being developed as potential treatments for these diseases. * By inhibiting IKK-B, these inhibitors could be used to activate the immune system and treat cancer and autoimmune disorders. **Additional information**: * IKBKB is a promising target for cancer immunotherapy. * Inhibitors of IKK-B have been shown to be effective in preclinical models of cancer. * IKBKB is a complex protein that is involved in a variety of cellular processes. * Further research is needed to understand how IKBKB works and to develop more effective inhibitors.

Genular Protein ID: 2753458638

Symbol: IKKB_HUMAN

Name: Inhibitor of nuclear factor kappa-B kinase subunit beta

UniProtKB Accession Codes:

O14920 B4DZ30 B4E0U4 O75327

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CPTAC 2 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EC 3 ELM 1 EMBL 9 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 47 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 26 RefSeq 3 Rhea 9 SABIO-RK 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9346484

Title: IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.

PubMed ID: 9346484

DOI: 10.1126/science.278.5339.860

PubMed ID: 9346485

Title: IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.

PubMed ID: 9346485

DOI: 10.1126/science.278.5339.866

PubMed ID: 9813230

Title: IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes.

PubMed ID: 9813230

DOI: 10.1016/s0378-1119(98)00462-4

PubMed ID: 9763654

Title: Assignment of IkappaB kinase beta (IKBKB) to human chromosome band 8p12-->p11 by in situ hybridization.

PubMed ID: 9763654

DOI: 10.1159/000015058

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17116858

Title: Acetylation of MEK2 and I kappa B kinase (IKK) activation loop residues by YopJ inhibits signaling.

PubMed ID: 17116858

DOI: 10.1073/pnas.0608995103

PubMed ID: 9819420

Title: Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.

PubMed ID: 9819420

DOI: 10.1128/mcb.18.12.7336

PubMed ID: 9751059

Title: IKAP is a scaffold protein of the IkappaB kinase complex.

PubMed ID: 9751059

DOI: 10.1038/26254

PubMed ID: 10356400

Title: The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.

PubMed ID: 10356400

DOI: 10.1093/emboj/18.11.3044

PubMed ID: 10022904

Title: Activation of IkappaB kinase beta by protein kinase C isoforms.

PubMed ID: 10022904

DOI: 10.1128/mcb.19.3.2180

PubMed ID: 10195894

Title: Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.

PubMed ID: 10195894

DOI: 10.1126/science.284.5412.309

PubMed ID: 10848580

Title: PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.

PubMed ID: 10848580

DOI: 10.1128/mcb.20.13.4532-4542.2000

PubMed ID: 10783893

Title: NAK is an IkappaB kinase-activating kinase.

PubMed ID: 10783893

DOI: 10.1038/35008109

PubMed ID: 11297557

Title: Direct phosphorylation of NF-kappa B1 p105 by the Ikappa B kinase complex on serine 927 is essential for signal-induced p105 proteolysis.

PubMed ID: 11297557

DOI: 10.1074/jbc.m101754200

PubMed ID: 11460167

Title: TAK1 is a ubiquitin-dependent kinase of MKK and IKK.

PubMed ID: 11460167

DOI: 10.1038/35085597

PubMed ID: 12133833

Title: Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases.

PubMed ID: 12133833

DOI: 10.1074/jbc.m205069200

PubMed ID: 11971985

Title: Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) coactivator activity by I kappa B kinase.

PubMed ID: 11971985

DOI: 10.1128/mcb.22.10.3549-3561.2002

PubMed ID: 12612076

Title: Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation.

PubMed ID: 12612076

DOI: 10.1128/mcb.23.6.2029-2041.2003

PubMed ID: 15084260

Title: IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.

PubMed ID: 15084260

DOI: 10.1016/s0092-8674(04)00302-2

PubMed ID: 14739303

Title: Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways.

PubMed ID: 14739303

DOI: 10.1074/jbc.m311629200

PubMed ID: 15456791

Title: PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages.

PubMed ID: 15456791

DOI: 10.1074/jbc.m406741200

PubMed ID: 14673179

Title: Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing.

PubMed ID: 14673179

DOI: 10.1128/mcb.24.1.475-486.2004

PubMed ID: 15173580

Title: beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha.

PubMed ID: 15173580

DOI: 10.1073/pnas.0402851101

PubMed ID: 15184672

Title: Nitric oxide represses inhibitory kappaB kinase through S-nitrosylation.

PubMed ID: 15184672

DOI: 10.1073/pnas.0400588101

PubMed ID: 15951441

Title: NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation.

PubMed ID: 15951441

DOI: 10.1074/jbc.m501670200

PubMed ID: 16207722

Title: 3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling.

PubMed ID: 16207722

DOI: 10.1074/jbc.m506235200

PubMed ID: 16267042

Title: Site-specific monoubiquitination of IkappaB kinase IKKbeta regulates its phosphorylation and persistent activation.

PubMed ID: 16267042

DOI: 10.1074/jbc.m508656200

PubMed ID: 16177806

Title: Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.

PubMed ID: 16177806

DOI: 10.1038/nature04193

PubMed ID: 17114296

Title: Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity.

PubMed ID: 17114296

DOI: 10.1073/pnas.0602235103

PubMed ID: 16728640

Title: Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation.

PubMed ID: 16728640

DOI: 10.1126/science.1126867

PubMed ID: 16497931

Title: Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli.

PubMed ID: 16497931

DOI: 10.1126/science.1121513

PubMed ID: 17287217

Title: Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1.

PubMed ID: 17287217

DOI: 10.1074/jbc.m609157200

PubMed ID: 17684021

Title: FAF1 suppresses IkappaB kinase (IKK) activation by disrupting the IKK complex assembly.

PubMed ID: 17684021

DOI: 10.1074/jbc.c700106200

PubMed ID: 17213322

Title: Negative feedback loop in T cell activation through IkappaB kinase-induced phosphorylation and degradation of Bcl10.

PubMed ID: 17213322

DOI: 10.1073/pnas.0606982104

PubMed ID: 10712233

Title: The I kappa B/NF-kappa B system: a key determinant of mucosal inflammation and protection.

PubMed ID: 10712233

DOI: 10.1152/ajpcell.2000.278.3.c451

PubMed ID: 18626576

Title: The IkappaB kinase complex: master regulator of NF-kappaB signaling.

PubMed ID: 18626576

DOI: 10.1007/s12026-008-8025-1

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19716809

Title: Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation.

PubMed ID: 19716809

DOI: 10.1016/j.bbrc.2009.08.127

PubMed ID: 18930133

Title: PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation.

PubMed ID: 18930133

DOI: 10.1016/j.cellsig.2008.09.012

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20434986

Title: NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways.

PubMed ID: 20434986

DOI: 10.1016/j.cell.2010.03.040

PubMed ID: 19675099

Title: Ro52-mediated monoubiquitination of IKK{beta} down-regulates NF-{kappa}B signalling.

PubMed ID: 19675099

DOI: 10.1093/jb/mvp127

PubMed ID: 20410276

Title: Respiratory syncytial virus-mediated NF-kappa B p65 phosphorylation at serine 536 is dependent on RIG-I, TRAF6, and IKK beta.

PubMed ID: 20410276

DOI: 10.1128/jvi.00142-10

PubMed ID: 20797629

Title: Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation.

PubMed ID: 20797629

DOI: 10.1016/j.molcel.2010.07.030

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21138416

Title: Novel cross-talk within the IKK family controls innate immunity.

PubMed ID: 21138416

DOI: 10.1042/bj20101701

PubMed ID: 23091055

Title: The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-kappaB signaling.

PubMed ID: 23091055

DOI: 10.1074/jbc.m112.399923

PubMed ID: 23453969

Title: IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.

PubMed ID: 23453969

DOI: 10.1016/j.celrep.2013.01.031

PubMed ID: 23776175

Title: SASH1 is a scaffold molecule in endothelial TLR4 signaling.

PubMed ID: 23776175

DOI: 10.4049/jimmunol.1200583

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23090968

Title: A-kinase-anchoring protein-Lbc anchors IkappaB kinase beta to support interleukin-6-mediated cardiomyocyte hypertrophy.

PubMed ID: 23090968

DOI: 10.1128/mcb.00887-12

PubMed ID: 24369075

Title: Deficiency of innate and acquired immunity caused by an IKBKB mutation.

PubMed ID: 24369075

DOI: 10.1056/nejmoa1309199

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25326418

Title: Protein kinase IKKbeta-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells.

PubMed ID: 25326418

DOI: 10.1073/pnas.1418399111

PubMed ID: 26334375

Title: IFIT5 positively regulates NF-kappaB signaling through synergizing the recruitment of IkappaB kinase (IKK) to TGF-beta-activated kinase 1 (TAK1).

PubMed ID: 26334375

DOI: 10.1016/j.cellsig.2015.08.018

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26296658

Title: Dimer of arfaptin 2 regulates NF-kappaB signaling by interacting with IKKbeta/NEMO and inhibiting IKKbeta kinase activity.

PubMed ID: 26296658

DOI: 10.1016/j.cellsig.2015.08.012

PubMed ID: 26101251

Title: FKBP51 employs both scaffold and isomerase functions to promote NF-kappaB activation in melanoma.

PubMed ID: 26101251

DOI: 10.1093/nar/gkv615

PubMed ID: 27426725

Title: LRRC14 attenuates Toll-like receptor-mediated NF-kappa-B signaling through disruption of IKK complex.

PubMed ID: 27426725

DOI: 10.1016/j.yexcr.2016.07.011

PubMed ID: 29748387

Title: Mechanism of vaccinia viral protein B14 mediated inhibition of IkappaB kinase beta activation.

PubMed ID: 29748387

DOI: 10.1074/jbc.ra118.002817

PubMed ID: 30337470

Title: Gain-of-function IKBKB mutation causes human combined immune deficiency.

PubMed ID: 30337470

DOI: 10.1084/jem.20180639

PubMed ID: 31434731

Title: Novel Functions of IFI44L as a Feedback Regulator of Host Antiviral Responses.

PubMed ID: 31434731

DOI: 10.1128/jvi.01159-19

PubMed ID: 32935379

Title: Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2.

PubMed ID: 32935379

DOI: 10.15252/embj.2020105139

PubMed ID: 18462684

Title: Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site.

PubMed ID: 18462684

DOI: 10.1016/j.str.2008.02.012

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 756
  • Mass: 86564
  • Checksum: F9CADF671AE9E14E
  • Sequence:
    • MSWSPSLTTQ TCGAWEMKER LGTGGFGNVI RWHNQETGEQ IAIKQCRQEL SPRNRERWCL 
EIQIMRRLTH PNVVAARDVP EGMQNLAPND LPLLAMEYCQ GGDLRKYLNQ FENCCGLREG 
AILTLLSDIA SALRYLHENR IIHRDLKPEN IVLQQGEQRL IHKIIDLGYA KELDQGSLCT 
SFVGTLQYLA PELLEQQKYT VTVDYWSFGT LAFECITGFR PFLPNWQPVQ WHSKVRQKSE 
VDIVVSEDLN GTVKFSSSLP YPNNLNSVLA ERLEKWLQLM LMWHPRQRGT DPTYGPNGCF 
KALDDILNLK LVHILNMVTG TIHTYPVTED ESLQSLKARI QQDTGIPEED QELLQEAGLA 
LIPDKPATQC ISDGKLNEGH TLDMDLVFLF DNSKITYETQ ISPRPQPESV SCILQEPKRN 
LAFFQLRKVW GQVWHSIQTL KEDCNRLQQG QRAAMMNLLR NNSCLSKMKN SMASMSQQLK 
AKLDFFKTSI QIDLEKYSEQ TEFGITSDKL LLAWREMEQA VELCGRENEV KLLVERMMAL 
QTDIVDLQRS PMGRKQGGTL DDLEEQAREL YRRLREKPRD QRTEGDSQEM VRLLLQAIQS 
FEKKVRVIYT QLSKTVVCKQ KALELLPKVE EVVSLMNEDE KTVVRLQEKR QKELWNLLKI 
ACSKVRGPVS GSPDSMNASR LSQPGQLMSQ PSTASNSLPE PAKKSEELVA EAHNLCTLLE 
NAIQDTVREQ DQSFTALDWS WLQTEEEEHS CLEQAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.