Details for: PDX1

Gene ID: 3651

Symbol: PDX1

Ensembl ID: ENSG00000139515

Description: pancreatic and duodenal homeobox 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.46
    Marker Score: 3787
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.35
    Marker Score: 4054
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.72
    Marker Score: 1213
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.54
    Marker Score: 1720
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3
    Marker Score: 1298
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.15
    Marker Score: 833
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.1
    Marker Score: 1049
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.07
    Marker Score: 556
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.02
    Marker Score: 1060
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5279
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.88
    Marker Score: 351
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.85
    Marker Score: 5674
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.82
    Marker Score: 478
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.8
    Marker Score: 369
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.78
    Marker Score: 341
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.76
    Marker Score: 296
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 681
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1164
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.69
    Marker Score: 168
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2816
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.66
    Marker Score: 446
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.64
    Marker Score: 412
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.57
    Marker Score: 297
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.56
    Marker Score: 138
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.53
    Marker Score: 218
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.5
    Marker Score: 126
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.48
    Marker Score: 463
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.48
    Marker Score: 278
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.46
    Marker Score: 111
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.46
    Marker Score: 114
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.45
    Marker Score: 451
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.45
    Marker Score: 482
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.44
    Marker Score: 114
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.43
    Marker Score: 135
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.42
    Marker Score: 112
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.42
    Marker Score: 120
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.41
    Marker Score: 858
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.41
    Marker Score: 152
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.4
    Marker Score: 632
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.37
    Marker Score: 95
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.37
    Marker Score: 334
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.37
    Marker Score: 106
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: 0.36
    Marker Score: 116
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.36
    Marker Score: 190
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.35
    Marker Score: 79
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.35
    Marker Score: 339
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.34
    Marker Score: 106
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.33
    Marker Score: 89
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.32
    Marker Score: 120.5
  • Cell Name: duodenum glandular cell (CL1001589)
    Fold Change: 0.32
    Marker Score: 120
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.32
    Marker Score: 121
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.31
    Marker Score: 174
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.3
    Marker Score: 123
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.3
    Marker Score: 97
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.3
    Marker Score: 78
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.3
    Marker Score: 65
  • Cell Name: GIP cell (CL0002278)
    Fold Change: 0.3
    Marker Score: 97
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.3
    Marker Score: 119.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.29
    Marker Score: 105
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.28
    Marker Score: 536
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.28
    Marker Score: 587
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.28
    Marker Score: 116
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.27
    Marker Score: 68
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.27
    Marker Score: 1311
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.27
    Marker Score: 94
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.27
    Marker Score: 100.5
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.27
    Marker Score: 124
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.26
    Marker Score: 121
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.26
    Marker Score: 110
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.26
    Marker Score: 125
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.25
    Marker Score: 127
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.24
    Marker Score: 140.5
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.24
    Marker Score: 92
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.24
    Marker Score: 84
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.24
    Marker Score: 68
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.24
    Marker Score: 73
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.24
    Marker Score: 125
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.23
    Marker Score: 78
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.23
    Marker Score: 467
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.22
    Marker Score: 1424
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.22
    Marker Score: 3487
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 119
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.21
    Marker Score: 95
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.21
    Marker Score: 64
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.21
    Marker Score: 125
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.21
    Marker Score: 124
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.21
    Marker Score: 378.5
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.21
    Marker Score: 126
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.2
    Marker Score: 113
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.2
    Marker Score: 528.5

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Other Information

## Summary PDX1 is a transcription factor that plays a crucial role in the development and maintenance of the pancreas and duodenum. It is highly expressed in the developing gut and persists in the adult pancreas, where it plays a role in cell survival, differentiation, and regulation of pancreatic epithelial cells. ## Key characteristics * PDX1 is a transcription factor belonging to the PDX family of homeobox genes. * It is expressed in a variety of cell types in the gut, including enterocytes, T cells, acinar cells, plasma cells, enterocytes of the large intestine, colon goblet cells, B cells, endocrine cells, and pancreatic ductal cells. * PDX1 is a key regulator of beta-cell development and survival in the pancreas. * It is also involved in the regulation of gene expression in early pancreatic precursor cells and the regulation of transcription by rna polymerase ii. ## Pathways and functions * PDX1 is a key regulator of pancreatic epithelial cell survival and differentiation. * It is required for the maintenance of the differentiated state of pancreatic cells and for their proper differentiation into secretory and absorptive lineages. * PDX1 also plays a role in the regulation of beta-cell development and survival. * It is involved in the regulation of gene expression in early pancreatic precursor cells and the regulation of transcription by rna polymerase ii. * PDX1 is also involved in the response to xenobiotic stimuli, where it promotes the expression of genes involved in the repair of DNA damage. ## Clinical significance * Mutations in the PDX1 gene have been linked to the development of several human diseases, including pancreatitis, duodenal atresia, and cancer. * PDX1 is a promising target for the treatment of these diseases, as it can be used to inhibit the growth and proliferation of cancer cells. * Several drugs that target PDX1 are currently in clinical trials for the treatment of cancer and other diseases.

Genular Protein ID: 3624856797

Symbol: PDX1_HUMAN

Name: Pancreas/duodenum homeobox protein 1

UniProtKB Accession Codes:

P52945 O60594 Q5VYW2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 10 Ensembl 1 GO 48 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7590740

Title: Localization of human homeodomain transcription factor insulin promoter factor 1 (IPF1) to chromosome band 13q12.1.

PubMed ID: 7590740

DOI: 10.1006/geno.1995.1120

PubMed ID: 8635654

Title: Isolation, characterization, and chromosomal mapping of the human insulin promoter factor 1 (IPF-1) gene.

PubMed ID: 8635654

DOI: 10.2337/diab.45.6.789

PubMed ID: 9252422

Title: The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells.

PubMed ID: 9252422

DOI: 10.1074/jbc.272.33.20936

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 8988180

Title: Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence.

PubMed ID: 8988180

DOI: 10.1038/ng0197-106

PubMed ID: 9326926

Title: Early-onset type-II diabetes mellitus (MODY4) linked to IPF1.

PubMed ID: 9326926

DOI: 10.1038/ng1097-138

PubMed ID: 16141209

Title: Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription.

PubMed ID: 16141209

DOI: 10.1074/jbc.m505741200

PubMed ID: 20637728

Title: Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization.

PubMed ID: 20637728

DOI: 10.1016/j.bbrc.2010.07.035

PubMed ID: 10545530

Title: Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes.

PubMed ID: 10545530

DOI: 10.1172/jci7449

PubMed ID: 10545531

Title: Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus.

PubMed ID: 10545531

DOI: 10.1172/jci7469

Sequence Information:

  • Length: 283
  • Mass: 30771
  • Checksum: 5D48EC8D3289F72B
  • Sequence:
    • MNGEEQYYAA TQLYKDPCAF QRGPAPEFSA SPPACLYMGR QPPPPPPHPF PGALGALEQG 
SPPDISPYEV PPLADDPAVA HLHHHLPAQL ALPHPPAGPF PEGAEPGVLE EPNRVQLPFP 
WMKSTKAHAW KGQWAGGAYA AEPEENKRTR TAYTRAQLLE LEKEFLFNKY ISRPRRVELA 
VMLNLTERHI KIWFQNRRMK WKKEEDKKRG GGTAVGGGGV AEPEQDCAVT SGEELLALPP 
PPPPGGAVPP AAPVAAREGR LPPGLSASPQ PSSVAPRRPQ EPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.