Details for: PDX1

Gene ID: 3651

Symbol: PDX1

Ensembl ID: ENSG00000139515

Description: pancreatic and duodenal homeobox 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 5.2809
    Cell Significance Index: 169.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.0838
    Cell Significance Index: 66.8100
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 2.9487
    Cell Significance Index: 22.3600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.5378
    Cell Significance Index: 31.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4539
    Cell Significance Index: 41.8900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9383
    Cell Significance Index: 56.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7461
    Cell Significance Index: 15.8900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5587
    Cell Significance Index: 60.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5105
    Cell Significance Index: 83.0300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4966
    Cell Significance Index: 49.1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4277
    Cell Significance Index: 386.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3097
    Cell Significance Index: 21.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1664
    Cell Significance Index: 31.6600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1290
    Cell Significance Index: 1.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0573
    Cell Significance Index: 9.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0322
    Cell Significance Index: 1.1300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0304
    Cell Significance Index: 3.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0016
    Cell Significance Index: 0.3500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0003
    Cell Significance Index: 0.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0005
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0016
    Cell Significance Index: -1.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0053
    Cell Significance Index: -0.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0088
    Cell Significance Index: -0.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0088
    Cell Significance Index: -0.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0251
    Cell Significance Index: -2.9300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0502
    Cell Significance Index: -0.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0511
    Cell Significance Index: -10.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0544
    Cell Significance Index: -10.9100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1015
    Cell Significance Index: -1.5300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1232
    Cell Significance Index: -2.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1459
    Cell Significance Index: -9.4100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2460
    Cell Significance Index: -6.1500
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: -0.2507
    Cell Significance Index: -2.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2753
    Cell Significance Index: -7.3500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2779
    Cell Significance Index: -4.7500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3345
    Cell Significance Index: -4.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3560
    Cell Significance Index: -9.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3670
    Cell Significance Index: -9.6500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3952
    Cell Significance Index: -7.8800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.3959
    Cell Significance Index: -5.7700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3964
    Cell Significance Index: -10.1000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.4228
    Cell Significance Index: -5.3100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.4248
    Cell Significance Index: -6.8800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4344
    Cell Significance Index: -7.2700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.4471
    Cell Significance Index: -2.9200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4504
    Cell Significance Index: -10.9100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4517
    Cell Significance Index: -9.8900
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.4691
    Cell Significance Index: -5.6700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.4853
    Cell Significance Index: -7.3700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.5158
    Cell Significance Index: -5.5300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.5166
    Cell Significance Index: -10.1000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.5180
    Cell Significance Index: -7.3600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.5258
    Cell Significance Index: -7.3700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.5443
    Cell Significance Index: -7.3400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.5536
    Cell Significance Index: -7.3800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.5819
    Cell Significance Index: -6.6600
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.5820
    Cell Significance Index: -7.3300
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.5827
    Cell Significance Index: -7.3800
  • Cell Name: duodenum glandular cell (CL1001589)
    Fold Change: -0.6045
    Cell Significance Index: -4.3300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.6226
    Cell Significance Index: -7.3200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.6345
    Cell Significance Index: -8.3500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.6348
    Cell Significance Index: -8.3300
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.6364
    Cell Significance Index: -6.4700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.6509
    Cell Significance Index: -6.9200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.6576
    Cell Significance Index: -11.0600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.6631
    Cell Significance Index: -8.5800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6654
    Cell Significance Index: -9.9700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6756
    Cell Significance Index: -11.3800
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.6784
    Cell Significance Index: -7.3700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.6812
    Cell Significance Index: -8.8900
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.6835
    Cell Significance Index: -7.3800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.6907
    Cell Significance Index: -9.5800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.6916
    Cell Significance Index: -9.1900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.7058
    Cell Significance Index: -9.9000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.7203
    Cell Significance Index: -9.4200
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.7210
    Cell Significance Index: -6.6800
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.7402
    Cell Significance Index: -7.3300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.7461
    Cell Significance Index: -9.4400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.7501
    Cell Significance Index: -10.8900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.7544
    Cell Significance Index: -9.5600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.7557
    Cell Significance Index: -9.6900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.7569
    Cell Significance Index: -10.3800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.7607
    Cell Significance Index: -9.9300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.7701
    Cell Significance Index: -9.1000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.7735
    Cell Significance Index: -8.9000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.7737
    Cell Significance Index: -9.3400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.7814
    Cell Significance Index: -7.3100
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.7823
    Cell Significance Index: -7.2600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.7857
    Cell Significance Index: -10.7900
  • Cell Name: brush cell (CL0002204)
    Fold Change: -0.7941
    Cell Significance Index: -7.2800
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.7944
    Cell Significance Index: -7.2700
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.7957
    Cell Significance Index: -9.6800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.7988
    Cell Significance Index: -10.0800
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.8088
    Cell Significance Index: -8.5500
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.8098
    Cell Significance Index: -7.3800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.8123
    Cell Significance Index: -8.8500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.8155
    Cell Significance Index: -9.4600
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.8160
    Cell Significance Index: -8.9900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.8172
    Cell Significance Index: -5.0700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.8183
    Cell Significance Index: -9.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcriptional regulation**: PDX1 acts as a transcription factor, binding to specific DNA sequences to regulate the expression of target genes involved in pancreatic development, function, and maintenance. 2. **Pancreatic specificity**: PDX1 is highly expressed in pancreatic beta cells, acinar cells, and endocrine cells, but its expression is limited to these tissues. 3. **Cellular differentiation**: PDX1 promotes the differentiation of pancreatic precursor cells into beta cells, acinar cells, and endocrine cells. 4. **Insulin secretion**: PDX1 regulates the expression of genes involved in insulin secretion, including insulin and glucagon genes. 5. **Cell proliferation**: PDX1 inhibits the proliferation of pancreatic cells, preventing excessive cell growth and maintaining tissue homeostasis. **Pathways and Functions** 1. **Insulin secretion pathway**: PDX1 regulates the expression of genes involved in insulin secretion, including insulin and glucagon genes. 2. **Cell proliferation pathway**: PDX1 inhibits the proliferation of pancreatic cells, preventing excessive cell growth and maintaining tissue homeostasis. 3. **Differentiation pathway**: PDX1 promotes the differentiation of pancreatic precursor cells into beta cells, acinar cells, and endocrine cells. 4. **Apoptosis pathway**: PDX1 regulates the expression of genes involved in apoptosis, preventing excessive cell death and maintaining tissue homeostasis. 5. **Stem cell differentiation pathway**: PDX1 regulates the expression of genes involved in stem cell differentiation, promoting the development of pancreatic precursor cells into functional cells. **Clinical Significance** 1. **Diabetes**: Dysregulation of PDX1 has been implicated in the development of diabetes, particularly type 2 diabetes, where PDX1 expression is reduced or altered. 2. **Pancreatitis**: PDX1 dysregulation has been linked to pancreatitis, a condition characterized by inflammation of the pancreas, which can lead to tissue damage and dysfunction. 3. **Cancer**: PDX1 has been identified as a tumor suppressor gene in pancreatic cancer, where its expression is often reduced or altered. 4. **Regenerative medicine**: PDX1 has been identified as a potential therapeutic target for regenerative medicine approaches aimed at repairing or replacing damaged pancreatic tissues. In conclusion, PDX1 is a crucial transcription factor that regulates key cellular processes in pancreatic and duodenal tissues. Its dysregulation has been implicated in various pancreatic disorders, including diabetes, pancreatitis, and cancer. Further research is needed to fully understand the mechanisms by which PDX1 regulates pancreatic development, function, and maintenance, and to explore its potential as a therapeutic target for regenerative medicine approaches.

Genular Protein ID: 3624856797

Symbol: PDX1_HUMAN

Name: Pancreas/duodenum homeobox protein 1

UniProtKB Accession Codes:

P52945 O60594 Q5VYW2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 10 Ensembl 1 GO 47 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7590740

Title: Localization of human homeodomain transcription factor insulin promoter factor 1 (IPF1) to chromosome band 13q12.1.

PubMed ID: 7590740

DOI: 10.1006/geno.1995.1120

PubMed ID: 8635654

Title: Isolation, characterization, and chromosomal mapping of the human insulin promoter factor 1 (IPF-1) gene.

PubMed ID: 8635654

DOI: 10.2337/diab.45.6.789

PubMed ID: 9252422

Title: The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells.

PubMed ID: 9252422

DOI: 10.1074/jbc.272.33.20936

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 8988180

Title: Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence.

PubMed ID: 8988180

DOI: 10.1038/ng0197-106

PubMed ID: 9326926

Title: Early-onset type-II diabetes mellitus (MODY4) linked to IPF1.

PubMed ID: 9326926

DOI: 10.1038/ng1097-138

PubMed ID: 16141209

Title: Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription.

PubMed ID: 16141209

DOI: 10.1074/jbc.m505741200

PubMed ID: 20637728

Title: Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization.

PubMed ID: 20637728

DOI: 10.1016/j.bbrc.2010.07.035

PubMed ID: 10545530

Title: Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes.

PubMed ID: 10545530

DOI: 10.1172/jci7449

PubMed ID: 10545531

Title: Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus.

PubMed ID: 10545531

DOI: 10.1172/jci7469

Sequence Information:

  • Length: 283
  • Mass: 30771
  • Checksum: 5D48EC8D3289F72B
  • Sequence:
    • MNGEEQYYAA TQLYKDPCAF QRGPAPEFSA SPPACLYMGR QPPPPPPHPF PGALGALEQG 
SPPDISPYEV PPLADDPAVA HLHHHLPAQL ALPHPPAGPF PEGAEPGVLE EPNRVQLPFP 
WMKSTKAHAW KGQWAGGAYA AEPEENKRTR TAYTRAQLLE LEKEFLFNKY ISRPRRVELA 
VMLNLTERHI KIWFQNRRMK WKKEEDKKRG GGTAVGGGGV AEPEQDCAVT SGEELLALPP 
PPPPGGAVPP AAPVAAREGR LPPGLSASPQ PSSVAPRRPQ EPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.