Details for: KCNA6

Gene ID: 3742

Symbol: KCNA6

Ensembl ID: ENSG00000151079

Description: potassium voltage-gated channel subfamily A member 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.02
    Marker Score: 8403.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.18
    Marker Score: 2231
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.05
    Marker Score: 16392
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.79
    Marker Score: 1607
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.77
    Marker Score: 463
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.77
    Marker Score: 3132.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.57
    Marker Score: 3414
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.47
    Marker Score: 223
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.35
    Marker Score: 1615
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.35
    Marker Score: 202
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.34
    Marker Score: 119
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.33
    Marker Score: 131.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.29
    Marker Score: 128
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.25
    Marker Score: 217
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.16
    Marker Score: 5396
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.13
    Marker Score: 83.5
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.13
    Marker Score: 59
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.13
    Marker Score: 672
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1
    Marker Score: 116
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.1
    Marker Score: 320
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.09
    Marker Score: 104
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.09
    Marker Score: 354
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.09
    Marker Score: 941
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.09
    Marker Score: 59
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.09
    Marker Score: 905
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.09
    Marker Score: 659
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.09
    Marker Score: 198.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.08
    Marker Score: 89.5
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.08
    Marker Score: 32
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.08
    Marker Score: 99
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.08
    Marker Score: 183
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.07
    Marker Score: 34
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.07
    Marker Score: 38.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.06
    Marker Score: 80
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.06
    Marker Score: 326
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.06
    Marker Score: 127
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.06
    Marker Score: 91.5
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.05
    Marker Score: 15.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.05
    Marker Score: 67
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.05
    Marker Score: 77
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.04
    Marker Score: 80
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.04
    Marker Score: 135
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.04
    Marker Score: 52
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.04
    Marker Score: 38
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.03
    Marker Score: 32
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.03
    Marker Score: 40
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 70.5
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.02
    Marker Score: 50
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.02
    Marker Score: 15.5
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.02
    Marker Score: 32
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.02
    Marker Score: 38
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.01
    Marker Score: 12

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Other Information

**Key characteristics**: * KCNA6 is a transmembrane protein that is expressed in a variety of cell types, including neurons, cardiac endothelial cells, cardiac myoblasts, and interneurons. * It is a member of the potassium voltage-gated channel subfamily A, which is characterized by its selectivity for potassium ions and its ability to form a homomeric channel complex. * KCNA6 is a highly hydrophobic protein that is thought to interact with other proteins to form the voltage-gated potassium channel complex. * It is a key regulator of neuronal excitability, and its expression is often altered in conditions such as epilepsy and depression. **Pathways and functions**: * KCNA6 is a key component of the voltage-gated potassium channel complex, which is responsible for maintaining the resting membrane potential of neurons. * The complex is composed of four transmembrane subunits that are arranged in a tetrameric structure. * Each subunit of the complex has a pore that allows potassium ions to flow down their concentration gradient. * The complex is gated by a variety of factors, including changes in the membrane potential and the activity of other ions. * When the membrane potential becomes negative, the complex opens, allowing potassium ions to flow into the cell. * This helps to depolarize the cell and restore the resting membrane potential. **Clinical significance**: * Mutations in KCNA6 have been linked to a variety of neurological disorders, including epilepsy, depression, and heart disease. * The expression of KCNA6 is often altered in these disorders, suggesting that it may play a role in the disease process. * Targeting KCNA6 with drugs is a promising strategy for treating these disorders.

Genular Protein ID: 3399057737

Symbol: KCNA6_HUMAN

Name: Potassium voltage-gated channel subfamily A member 6

UniProtKB Accession Codes:

P17658

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 2 Ensembl 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 6 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2347305

Title: Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family.

PubMed ID: 2347305

DOI: 10.1002/j.1460-2075.1990.tb08299.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14575698

Title: Human Kv1.6 current displays a C-type-like inactivation when re-expressed in cos-7 cells.

PubMed ID: 14575698

DOI: 10.1016/j.bbrc.2003.09.167

PubMed ID: 36318112

Title: De novo KCNA6 variants with attenuated KV 1.6 channel deactivation in patients with epilepsy.

PubMed ID: 36318112

DOI: 10.1111/epi.17455

Sequence Information:

  • Length: 529
  • Mass: 58729
  • Checksum: CFF0710A1F9CD69F
  • Sequence:
    • MRSEKSLTLA APGEVRGPEG EQQDAGDFPE AGGGGGCCSS ERLVINISGL RFETQLRTLS 
LFPDTLLGDP GRRVRFFDPL RNEYFFDRNR PSFDAILYYY QSGGRLRRPV NVPLDIFLEE 
IRFYQLGDEA LAAFREDEGC LPEGGEDEKP LPSQPFQRQV WLLFEYPESS GPARGIAIVS 
VLVILISIVI FCLETLPQFR VDGRGGNNGG VSRVSPVSRG SQEEEEDEDD SYTFHHGITP 
GEMGTGGSSS LSTLGGSFFT DPFFLVETLC IVWFTFELLV RFSACPSKPA FFRNIMNIID 
LVAIFPYFIT LGTELVQQQE QQPASGGGGQ NGQQAMSLAI LRVIRLVRVF RIFKLSRHSK 
GLQILGKTLQ ASMRELGLLI FFLFIGVILF SSAVYFAEAD DDDSLFPSIP DAFWWAVVTM 
TTVGYGDMYP MTVGGKIVGS LCAIAGVLTI ALPVPVIVSN FNYFYHRETE QEEQGQYTHV 
TCGQPAPDLR ATDNGLGKPD FPEANRERRP SYLPTPHRAY AEKRMLTEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.