Details for: KCNA6

Gene ID: 3742

Symbol: KCNA6

Ensembl ID: ENSG00000151079

Description: potassium voltage-gated channel subfamily A member 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: 11.5698
    Cell Significance Index: 156.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9699
    Cell Significance Index: 194.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3872
    Cell Significance Index: 267.8000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.1522
    Cell Significance Index: 3.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.0144
    Cell Significance Index: 0.4600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0333
    Cell Significance Index: -0.4900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0949
    Cell Significance Index: -0.9000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1022
    Cell Significance Index: -2.1700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1071
    Cell Significance Index: -1.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1747
    Cell Significance Index: -5.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2665
    Cell Significance Index: -76.6900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3117
    Cell Significance Index: -10.9200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6823
    Cell Significance Index: -17.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6854
    Cell Significance Index: -42.1300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6941
    Cell Significance Index: -9.9400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7322
    Cell Significance Index: -14.7000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.7790
    Cell Significance Index: -16.8300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.8796
    Cell Significance Index: -17.5400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.9260
    Cell Significance Index: -11.6900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.9353
    Cell Significance Index: -19.5200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.1500
    Cell Significance Index: -29.3000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.1645
    Cell Significance Index: -22.9200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.3794
    Cell Significance Index: -40.5100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.5538
    Cell Significance Index: -30.3800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.8789
    Cell Significance Index: -20.4700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.9806
    Cell Significance Index: -47.5000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -2.1668
    Cell Significance Index: -44.0900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -2.2001
    Cell Significance Index: -48.1800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -2.3077
    Cell Significance Index: -39.9000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -2.4706
    Cell Significance Index: -29.3300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -2.5446
    Cell Significance Index: -29.2800
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -2.7238
    Cell Significance Index: -40.7500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -2.8584
    Cell Significance Index: -30.4100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -2.8873
    Cell Significance Index: -30.4000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -2.9210
    Cell Significance Index: -33.6200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -2.9383
    Cell Significance Index: -25.7000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -2.9541
    Cell Significance Index: -29.9800
  • Cell Name: platelet (CL0000233)
    Fold Change: -2.9544
    Cell Significance Index: -30.4000
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -3.0438
    Cell Significance Index: -30.3800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -3.1176
    Cell Significance Index: -36.8400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -3.1306
    Cell Significance Index: -30.0900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -3.2629
    Cell Significance Index: -30.3800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -3.2837
    Cell Significance Index: -29.2400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -3.4159
    Cell Significance Index: -40.7200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -3.4925
    Cell Significance Index: -42.3400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -3.5319
    Cell Significance Index: -46.1000
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -3.5611
    Cell Significance Index: -40.6800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -3.6885
    Cell Significance Index: -44.1100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -3.8211
    Cell Significance Index: -40.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -3.9701
    Cell Significance Index: -106.3800
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -4.0148
    Cell Significance Index: -29.8700
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -4.0478
    Cell Significance Index: -36.7700
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -4.1224
    Cell Significance Index: -36.7700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -4.1802
    Cell Significance Index: -41.3600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -4.2132
    Cell Significance Index: -48.2200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -4.3368
    Cell Significance Index: -92.7000
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -4.6152
    Cell Significance Index: -38.2500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -4.6950
    Cell Significance Index: -52.0000
  • Cell Name: glial cell (CL0000125)
    Fold Change: -4.6983
    Cell Significance Index: -51.4800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -4.7239
    Cell Significance Index: -36.7500
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -4.7435
    Cell Significance Index: -41.7900
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -4.8511
    Cell Significance Index: -39.1700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -4.9006
    Cell Significance Index: -57.6200
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -4.9867
    Cell Significance Index: -40.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -4.9965
    Cell Significance Index: -83.6200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -5.1105
    Cell Significance Index: -51.4900
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -5.1355
    Cell Significance Index: -50.8600
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -5.1517
    Cell Significance Index: -39.3100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -5.4118
    Cell Significance Index: -58.0300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -5.4395
    Cell Significance Index: -68.7300
  • Cell Name: sst chodl GABAergic cortical interneuron (CL4023121)
    Fold Change: -5.4451
    Cell Significance Index: -38.1800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -5.4503
    Cell Significance Index: -91.6700
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -5.4771
    Cell Significance Index: -63.4200
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -5.5149
    Cell Significance Index: -38.2500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -5.5240
    Cell Significance Index: -66.2400
  • Cell Name: granule cell (CL0000120)
    Fold Change: -5.5495
    Cell Significance Index: -63.1800
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -5.5611
    Cell Significance Index: -38.2500
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -5.5714
    Cell Significance Index: -63.2700
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -5.5821
    Cell Significance Index: -58.5100
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -5.6519
    Cell Significance Index: -58.4700
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -5.8218
    Cell Significance Index: -64.6300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -5.9552
    Cell Significance Index: -78.1500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -6.0768
    Cell Significance Index: -68.4800
  • Cell Name: B cell (CL0000236)
    Fold Change: -6.2101
    Cell Significance Index: -73.3900
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -6.2217
    Cell Significance Index: -77.9200
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -6.2467
    Cell Significance Index: -67.7900
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -6.3592
    Cell Significance Index: -58.8200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -6.4443
    Cell Significance Index: -95.1400
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -6.4646
    Cell Significance Index: -58.4700
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -6.4991
    Cell Significance Index: -91.2800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -6.5719
    Cell Significance Index: -90.2500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -6.7252
    Cell Significance Index: -78.0100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -6.7518
    Cell Significance Index: -82.1400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -6.8670
    Cell Significance Index: -40.7500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -6.9000
    Cell Significance Index: -91.6900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -6.9545
    Cell Significance Index: -85.4800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -7.1000
    Cell Significance Index: -91.2100
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -7.1175
    Cell Significance Index: -82.0400
  • Cell Name: club cell (CL0000158)
    Fold Change: -7.1709
    Cell Significance Index: -78.1300
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -7.2938
    Cell Significance Index: -93.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KCNA6 is a member of the voltage-gated potassium channel subfamily A, consisting of six transmembrane domains. It is expressed in a wide range of cell types, including neurons, cardiac cells, and immune cells. KCNA6 is known for its unique properties, such as its high affinity for potassium ions and its ability to form homooligomers with other Kv channel subunits. This subunit is also known for its role in modulating the activity of other potassium channels. **Pathways and Functions:** KCNA6 is a critical component of Kv channels, which are essential for maintaining the resting membrane potential and regulating the excitability of neurons. In neurons, KCNA6 helps to balance the excitatory and inhibitory signals, thereby fine-tuning the neuronal activity. In the heart, KCNA6 plays a crucial role in regulating the cardiac action potential, which is essential for maintaining cardiac function. KCNA6 is also involved in the regulation of immune cell development and function. It is expressed in immature innate lymphoid cells and lymphoid lineage-restricted progenitor cells, where it helps to regulate the maturation and function of these cells. **Clinical Significance:** Dysregulation of KCNA6 has been implicated in various diseases, including: 1. **Epilepsy:** KCNA6 mutations have been associated with epilepsy, a neurological disorder characterized by seizures. 2. **Cardiac arrhythmias:** KCNA6 mutations have been linked to cardiac arrhythmias, including long QT syndrome. 3. **Autoimmune disorders:** KCNA6 has been implicated in the pathogenesis of autoimmune disorders, such as lupus and rheumatoid arthritis. 4. **Immune cell dysfunction:** KCNA6 dysregulation has been associated with immune cell dysfunction, leading to impaired immune responses. In addition to its role in disease pathogenesis, KCNA6 has also been explored as a potential therapeutic target. For example, KCNA6 inhibitors have been investigated as a potential treatment for epilepsy and cardiac arrhythmias. **Conclusion:** In conclusion, KCNA6 is a critical component of voltage-gated potassium channels, playing a pivotal role in regulating neuronal function, cardiovascular regulation, and immune cell development. Its dysregulation has been implicated in various diseases, making it a promising target for therapeutic interventions. Further research is needed to fully elucidate the mechanisms of KCNA6 and its role in disease pathogenesis, ultimately leading to the development of effective treatments for these disorders.

Genular Protein ID: 3399057737

Symbol: KCNA6_HUMAN

Name: Potassium voltage-gated channel subfamily A member 6

UniProtKB Accession Codes:

P17658

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 2 Ensembl 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 6 Rhea 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2347305

Title: Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family.

PubMed ID: 2347305

DOI: 10.1002/j.1460-2075.1990.tb08299.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14575698

Title: Human Kv1.6 current displays a C-type-like inactivation when re-expressed in cos-7 cells.

PubMed ID: 14575698

DOI: 10.1016/j.bbrc.2003.09.167

PubMed ID: 36318112

Title: De novo KCNA6 variants with attenuated KV 1.6 channel deactivation in patients with epilepsy.

PubMed ID: 36318112

DOI: 10.1111/epi.17455

Sequence Information:

  • Length: 529
  • Mass: 58729
  • Checksum: CFF0710A1F9CD69F
  • Sequence:
    • MRSEKSLTLA APGEVRGPEG EQQDAGDFPE AGGGGGCCSS ERLVINISGL RFETQLRTLS 
LFPDTLLGDP GRRVRFFDPL RNEYFFDRNR PSFDAILYYY QSGGRLRRPV NVPLDIFLEE 
IRFYQLGDEA LAAFREDEGC LPEGGEDEKP LPSQPFQRQV WLLFEYPESS GPARGIAIVS 
VLVILISIVI FCLETLPQFR VDGRGGNNGG VSRVSPVSRG SQEEEEDEDD SYTFHHGITP 
GEMGTGGSSS LSTLGGSFFT DPFFLVETLC IVWFTFELLV RFSACPSKPA FFRNIMNIID 
LVAIFPYFIT LGTELVQQQE QQPASGGGGQ NGQQAMSLAI LRVIRLVRVF RIFKLSRHSK 
GLQILGKTLQ ASMRELGLLI FFLFIGVILF SSAVYFAEAD DDDSLFPSIP DAFWWAVVTM 
TTVGYGDMYP MTVGGKIVGS LCAIAGVLTI ALPVPVIVSN FNYFYHRETE QEEQGQYTHV 
TCGQPAPDLR ATDNGLGKPD FPEANRERRP SYLPTPHRAY AEKRMLTEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.