Details for: MAGEB3

Gene ID: 4114

Symbol: MAGEB3

Ensembl ID: ENSG00000198798

Description: MAGE family member B3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.9254
    Cell Significance Index: 9.5800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4014
    Cell Significance Index: 5.8500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.3158
    Cell Significance Index: 4.4300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.2576
    Cell Significance Index: 1.9500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.2051
    Cell Significance Index: 2.6000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.1942
    Cell Significance Index: 2.1600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.1774
    Cell Significance Index: 1.3700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.1716
    Cell Significance Index: 2.1600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.1247
    Cell Significance Index: 1.4500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0873
    Cell Significance Index: 1.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0859
    Cell Significance Index: 1.8800
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.0826
    Cell Significance Index: 1.1600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0734
    Cell Significance Index: 0.8200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0495
    Cell Significance Index: 0.4900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0425
    Cell Significance Index: 0.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0358
    Cell Significance Index: 0.9600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0321
    Cell Significance Index: 0.3900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.0307
    Cell Significance Index: 0.3300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0307
    Cell Significance Index: 0.4500
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.0184
    Cell Significance Index: 0.1800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.0167
    Cell Significance Index: 0.1700
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.0121
    Cell Significance Index: 0.1200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0085
    Cell Significance Index: 0.0800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0075
    Cell Significance Index: 0.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0030
    Cell Significance Index: 0.3400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0016
    Cell Significance Index: 0.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0006
    Cell Significance Index: 0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0000
    Cell Significance Index: 0.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: -0.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0003
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0004
    Cell Significance Index: -0.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0005
    Cell Significance Index: -0.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0006
    Cell Significance Index: -0.1300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0006
    Cell Significance Index: -0.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0007
    Cell Significance Index: -0.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0008
    Cell Significance Index: -0.1500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0022
    Cell Significance Index: -0.0300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0024
    Cell Significance Index: -0.3500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0038
    Cell Significance Index: -0.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0040
    Cell Significance Index: -0.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0041
    Cell Significance Index: -0.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0041
    Cell Significance Index: -0.2300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0043
    Cell Significance Index: -0.1100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0043
    Cell Significance Index: -0.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0045
    Cell Significance Index: -0.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0045
    Cell Significance Index: -0.2000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0053
    Cell Significance Index: -0.0900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0060
    Cell Significance Index: -0.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0060
    Cell Significance Index: -0.1500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0063
    Cell Significance Index: -0.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0063
    Cell Significance Index: -0.1800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0068
    Cell Significance Index: -0.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0068
    Cell Significance Index: -0.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0070
    Cell Significance Index: -0.2300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0073
    Cell Significance Index: -0.1300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0073
    Cell Significance Index: -0.0900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0076
    Cell Significance Index: -0.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0082
    Cell Significance Index: -0.2600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0082
    Cell Significance Index: -0.2000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0084
    Cell Significance Index: -0.1200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0088
    Cell Significance Index: -0.1100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0090
    Cell Significance Index: -0.1100
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0095
    Cell Significance Index: -0.1300
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0096
    Cell Significance Index: -0.0600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0099
    Cell Significance Index: -0.1600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0100
    Cell Significance Index: -0.1300
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0100
    Cell Significance Index: -0.0900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0101
    Cell Significance Index: -0.1200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0105
    Cell Significance Index: -0.2200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0105
    Cell Significance Index: -0.1400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0107
    Cell Significance Index: -0.2100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0108
    Cell Significance Index: -0.1600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0109
    Cell Significance Index: -0.3100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0110
    Cell Significance Index: -0.1200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0113
    Cell Significance Index: -0.2500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0113
    Cell Significance Index: -0.2400
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0114
    Cell Significance Index: -0.1300
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0118
    Cell Significance Index: -0.1400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0119
    Cell Significance Index: -0.1500
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0119
    Cell Significance Index: -0.1300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0119
    Cell Significance Index: -0.2000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0119
    Cell Significance Index: -0.1400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0124
    Cell Significance Index: -0.2000
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0125
    Cell Significance Index: -0.1900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0126
    Cell Significance Index: -0.1700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0127
    Cell Significance Index: -0.2600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0132
    Cell Significance Index: -0.3900
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0133
    Cell Significance Index: -0.1500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0133
    Cell Significance Index: -0.1700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0135
    Cell Significance Index: -0.1800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0137
    Cell Significance Index: -0.2700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0139
    Cell Significance Index: -0.1800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0140
    Cell Significance Index: -0.2100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0143
    Cell Significance Index: -0.1700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0144
    Cell Significance Index: -0.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** MAGEB3 is highly expressed in progenitor cells, blood vessel endothelial cells, T cells, conventional dendritic cells, plasma cells, monocytes, granulocyte-monocyte progenitor cells, B cells, goblet cells, and early T lineage precursors. 2. **Protein Structure:** The MAGEB3 protein belongs to the MAGE family, which consists of proteins with a characteristic β-helix structure. 3. **Function:** MAGEB3 is involved in the regulation of transcription by RNA polymerase II, and it interacts with various proteins, including transcription factors and chromatin remodeling complexes. **Pathways and Functions:** 1. **Negative Regulation of Transcription by RNA Polymerase II:** MAGEB3 acts as a repressor of gene expression by binding to the RNA polymerase II complex and inhibiting its activity. 2. **Protein Binding:** MAGEB3 interacts with various proteins, including transcription factors, such as p53 and p73, and chromatin remodeling complexes, such as the SWI/SNF complex. 3. **Cellular Processes:** MAGEB3 is involved in the regulation of cellular processes, including cell cycle progression, apoptosis, and immune responses. **Clinical Significance:** 1. **Cancer Association:** MAGEB3 has been identified as a tumor antigen in melanoma, highlighting its potential as a therapeutic target for cancer immunotherapy. 2. **Immunotherapy:** MAGEB3-based vaccines and therapies have shown promise in clinical trials, demonstrating its potential as a cancer vaccine. 3. **Autoimmune Diseases:** MAGEB3 has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where it may play a role in the regulation of immune responses. 4. **Immunomodulation:** MAGEB3 may have immunomodulatory effects, influencing the function of immune cells, such as T cells and dendritic cells. In conclusion, the MAGEB3 gene is a complex molecule with multiple functions in immune regulation and cellular processes. Its significance in cancer and autoimmune diseases highlights the need for further research into its therapeutic potential. As our understanding of MAGEB3 expands, it may lead to the development of innovative cancer therapies and treatments for autoimmune diseases.

Genular Protein ID: 2042951850

Symbol: MAGB3_HUMAN

Name: Melanoma-associated antigen B3

UniProtKB Accession Codes:

O15480 A0AVE4 B3KQ52 O75861

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 EMBL 7 Ensembl 2 GO 2 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 3 SMART 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9441743

Title: Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins.

PubMed ID: 9441743

DOI: 10.1006/geno.1997.5052

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 346
  • Mass: 39211
  • Checksum: 053407C60CBEFFE5
  • Sequence:
    • MPRGQKSTLH AREKRQQTRG QTQDHQGAQI TATNKKKVSF SSPLILGATI QKKSAGRSRS 
ALKKPQRALS TTTSVDVSYK KSYKGANSKI EKKQSFSQGL SSTVQSRTDP LIMKTNMLVQ 
FLMEMYKMKK PIMKADMLKI VQKSHKNCFP EILKKASFNM EVVFGVDLKK VDSTKDSYVL 
VSKMDLPNNG TVTRGRGFPK TGLLLNLLGV IFMKGNCATE EKIWEFLNKM RIYDGKKHFI 
FGEPRKLITQ DLVKLKYLEY RQVPNSNPAR YEFLWGPRAH AETSKMKVLE FWAKVNKTVP 
SAFQFWYEEA LRDEEERVQA AAMLNDGSSA MGRKCSKAKA SSSSHA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.