Details for: TRNL2

Gene ID: 4568

Symbol: TRNL2

Ensembl ID: ENSG00000210191

Description: tRNA-Leu

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 16.8986
    Cell Significance Index: 130.0100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 3.6266
    Cell Significance Index: 37.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.9390
    Cell Significance Index: 87.8900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.6556
    Cell Significance Index: 41.3500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.5427
    Cell Significance Index: 21.9600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6627
    Cell Significance Index: 9.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5001
    Cell Significance Index: 14.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3738
    Cell Significance Index: 17.4300
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.2353
    Cell Significance Index: 2.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2181
    Cell Significance Index: 11.3300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.2012
    Cell Significance Index: 2.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1964
    Cell Significance Index: 12.3800
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.1151
    Cell Significance Index: 1.3700
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.1061
    Cell Significance Index: 1.2800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0807
    Cell Significance Index: 1.2800
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.0154
    Cell Significance Index: 0.1700
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0039
    Cell Significance Index: -0.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0078
    Cell Significance Index: -2.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0087
    Cell Significance Index: -1.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0166
    Cell Significance Index: -3.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0185
    Cell Significance Index: -8.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0211
    Cell Significance Index: -0.6900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0217
    Cell Significance Index: -0.6900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0226
    Cell Significance Index: -0.2900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0325
    Cell Significance Index: -0.6900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0344
    Cell Significance Index: -0.6900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0349
    Cell Significance Index: -0.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0362
    Cell Significance Index: -5.2600
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.0509
    Cell Significance Index: -0.5500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0517
    Cell Significance Index: -0.6000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0593
    Cell Significance Index: -0.6300
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0665
    Cell Significance Index: -0.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0709
    Cell Significance Index: -2.2700
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0729
    Cell Significance Index: -0.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0794
    Cell Significance Index: -2.3400
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.0816
    Cell Significance Index: -0.7600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0925
    Cell Significance Index: -0.9000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0975
    Cell Significance Index: -1.3300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0977
    Cell Significance Index: -0.9800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1006
    Cell Significance Index: -0.8500
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1022
    Cell Significance Index: -1.0600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1071
    Cell Significance Index: -1.4000
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: -0.1077
    Cell Significance Index: -0.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1160
    Cell Significance Index: -7.1100
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1376
    Cell Significance Index: -1.5100
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.1430
    Cell Significance Index: -1.2500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1479
    Cell Significance Index: -1.7400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1800
    Cell Significance Index: -2.4000
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1953
    Cell Significance Index: -2.7000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2127
    Cell Significance Index: -3.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2527
    Cell Significance Index: -8.8800
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.2544
    Cell Significance Index: -2.6600
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.2624
    Cell Significance Index: -2.5100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2704
    Cell Significance Index: -6.8900
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.3193
    Cell Significance Index: -3.7100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3337
    Cell Significance Index: -3.5200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3548
    Cell Significance Index: -7.3600
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.3710
    Cell Significance Index: -3.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3762
    Cell Significance Index: -8.1500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.3935
    Cell Significance Index: -4.2600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.4104
    Cell Significance Index: -4.1900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4148
    Cell Significance Index: -11.2900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4172
    Cell Significance Index: -4.8000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.4180
    Cell Significance Index: -5.7400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.4211
    Cell Significance Index: -4.4800
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.4456
    Cell Significance Index: -4.0300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.4465
    Cell Significance Index: -5.2500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.4480
    Cell Significance Index: -8.7600
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.4582
    Cell Significance Index: -6.2300
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.4623
    Cell Significance Index: -5.6900
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.4804
    Cell Significance Index: -5.7600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.4873
    Cell Significance Index: -5.9900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.5026
    Cell Significance Index: -6.5600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.5139
    Cell Significance Index: -6.4200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.5144
    Cell Significance Index: -5.3700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.5166
    Cell Significance Index: -4.8500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.5271
    Cell Significance Index: -7.3100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.5489
    Cell Significance Index: -5.9800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.5540
    Cell Significance Index: -9.4700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.5653
    Cell Significance Index: -6.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5794
    Cell Significance Index: -12.3400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.5806
    Cell Significance Index: -5.6600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.5827
    Cell Significance Index: -6.5100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.5937
    Cell Significance Index: -7.0100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.6049
    Cell Significance Index: -7.9600
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -0.6290
    Cell Significance Index: -4.3200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.6406
    Cell Significance Index: -6.5000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.6457
    Cell Significance Index: -7.6300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.6543
    Cell Significance Index: -7.9600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.6579
    Cell Significance Index: -7.5300
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.6622
    Cell Significance Index: -7.8800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.6624
    Cell Significance Index: -7.8100
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.6853
    Cell Significance Index: -7.0500
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.6860
    Cell Significance Index: -7.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6886
    Cell Significance Index: -24.1200
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.6888
    Cell Significance Index: -7.2200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.6959
    Cell Significance Index: -7.0300
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.7019
    Cell Significance Index: -7.3800
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.7161
    Cell Significance Index: -6.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Tissue distribution:** TRNL2 is expressed in a wide range of cell types, including immune cells (T cells, plasma cells, B cells), epithelial cells (goblet cells, absorptive cells, intestinal crypt stem cells), and stem cells (transit amplifying cells). 2. **Cellular localization:** TRNL2 is predominantly found in the cytoplasm of cells, where it plays a crucial role in protein synthesis. 3. **Gene expression:** TRNL2 is transcribed and translated into a mature tRNA molecule that carries the amino acid leucine to the ribosome for protein synthesis. 4. **Regulatory mechanisms:** TRNL2 expression is tightly regulated by various cellular mechanisms, including transcriptional control, post-transcriptional modification, and epigenetic modifications. **Pathways and Functions:** 1. **Immune cell regulation:** TRNL2 plays a critical role in regulating immune cell function, including T cell activation, proliferation, and differentiation. Dysregulation of TRNL2 expression has been implicated in autoimmune and inflammatory disorders. 2. **Intestinal homeostasis:** TRNL2 is essential for maintaining intestinal homeostasis, including the regulation of epithelial cell proliferation, differentiation, and survival. Abnormal TRNL2 expression has been linked to intestinal disorders, such as inflammatory bowel disease (IBD). 3. **Protein synthesis:** TRNL2 is involved in the translation of mRNAs into proteins, which is essential for various cellular processes, including cell growth, differentiation, and apoptosis. 4. **Cell signaling:** TRNL2 can interact with other cellular components, including ribosomes, translation factors, and signaling proteins, to regulate cellular responses to environmental stimuli. **Clinical Significance:** 1. **Autoimmune disorders:** Dysregulation of TRNL2 expression has been implicated in autoimmune disorders, such as rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Inflammatory bowel disease (IBD):** Abnormal TRNL2 expression has been linked to IBD, including Crohn's disease and ulcerative colitis. 3. **Cancer:** TRNL2 expression has been altered in various types of cancer, including leukemia, lymphoma, and colorectal cancer. 4. **Therapeutic targets:** TRNL2 has emerged as a potential therapeutic target for the treatment of autoimmune and inflammatory disorders, as well as cancer. In conclusion, TRNL2 is a critical gene that plays a pivotal role in regulating immune cell function and intestinal homeostasis. Further research is needed to elucidate the mechanisms underlying TRNL2 expression and its role in various diseases, with a view to developing novel therapeutic strategies for the treatment of autoimmune and inflammatory disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.