Details for: PRKCA
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 63.07rCSI 86.3%PRS 60.07
-
CSI 59.35rCSI 73.83%PRS 46.73
-
CSI 52.35rCSI 62.53%PRS 48.52
-
CSI 51.86rCSI 93.2%PRS 60.53
-
CSI 48.98rCSI 78.77%PRS 50.68
-
CSI 45.84rCSI 76.94%PRS 48.7
-
CSI 44.69rCSI 78.92%PRS 47.76
-
CSI 41.91rCSI 76.16%PRS 58.92
-
CSI 37.81rCSI 80.56%PRS 40.36
-
CSI 37.8rCSI 83.18%PRS 50.97
-
CSI 36.89rCSI 60.41%PRS 56.48
-
CSI 36.66rCSI 82.19%PRS 49.32
-
CSI 34.29rCSI 30.44%PRS 65.12
-
CSI 30.14rCSI 73.62%PRS 60.4
-
CSI 27.42rCSI 21.96%PRS 85.87
-
CSI 27.26rCSI 35.01%PRS 59.28
-
CSI 26.53rCSI 18.63%PRS 84.82
-
CSI 26.12rCSI 56.66%PRS 55.19
-
CSI 25.41rCSI 51.57%PRS 45.9
-
CSI 24.81rCSI 46.47%PRS 55.36
-
CSI 24.72rCSI 34.24%PRS 67.23
-
CSI 23.96rCSI 61.58%PRS 65.89
-
CSI 22.86rCSI 55.56%PRS 47.05
-
CSI 22.54rCSI 29.06%PRS 50
-
CSI 22.45rCSI 71.85%PRS 64.72
-
CSI 22.12rCSI 15.38%PRS 78.89
-
CSI 21.98rCSI 68.71%PRS 50.39
-
CSI 21.73rCSI 59.89%PRS 62.55
-
CSI 18.89rCSI 49.07%PRS 70.38
-
CSI 18.65rCSI 21.54%PRS 60.17
-
CSI 18.6rCSI 27.64%PRS 68.36
-
CSI 17.86rCSI 22.92%PRS 64.13
-
CSI 17.84rCSI 27.24%PRS 68.2
-
CSI 16.9rCSI 21.02%PRS 69.05
-
CSI 16.78rCSI 42.55%PRS 56.89
-
CSI 16.64rCSI 44.31%PRS 56.42
-
CSI 16.5rCSI 12.71%PRS 68.76
-
CSI 16.1rCSI 14.16%PRS 55.31
-
CSI 16.01rCSI 42.78%PRS 58.25
-
CSI 15.73rCSI 33.28%PRS 83.33
-
CSI 15.35rCSI 26.91%PRS 59.85
-
CSI 15.35rCSI 55.24%PRS 46.89
-
CSI 14.88rCSI 38.78%PRS 67.44
-
CSI 14.66rCSI 19.97%PRS 58.88
-
CSI 14.46rCSI 33.07%PRS 67.8
-
CSI 14.03rCSI 35.64%PRS 61.23
-
CSI 13.94rCSI 52.69%PRS 49.23
-
CSI 13.66rCSI 33.81%PRS 66.12
-
CSI 13.35rCSI 44.24%PRS 71.64
-
CSI 13.32rCSI 21.25%PRS 59.58
-
CSI 13.14rCSI 45%PRS 55.58
-
CSI 13.09rCSI 53.35%PRS 60.83
-
CSI 13.09rCSI 40.93%PRS 52.89
-
CSI 12.51rCSI 14.66%PRS 82.98
-
CSI 12.38rCSI 65.05%PRS 71.9
-
CSI 12.35rCSI 28.2%PRS 59.06
-
CSI 12.22rCSI 17.44%PRS 69.31
-
CSI 12.06rCSI 26.56%PRS 71.49
-
CSI 12.05rCSI 20.84%PRS 57.77
-
CSI 12.03rCSI 9.04%PRS 73.25
-
CSI 11.93rCSI 9.43%PRS 54.47
-
CSI 11.67rCSI 20.57%PRS 63.89
-
CSI 11.37rCSI 10.49%PRS 69.21
-
CSI 11.36rCSI 16.31%PRS 56.93
-
CSI 11.33rCSI 26.16%PRS 55.7
-
CSI 11.3rCSI 16.38%PRS 82.64
-
CSI 10.31rCSI 12.45%PRS 76.34
-
CSI 10.29rCSI 54.71%PRS 58.24
-
CSI 10.1rCSI 10.08%PRS 60.85
-
CSI 10.05rCSI 29.12%PRS 56.8
-
CSI 9.92rCSI 17.76%PRS 66.89
-
CSI 9.86rCSI 14.5%PRS 60.48
-
CSI 9.75rCSI 21.36%PRS 74.54
-
CSI 9.75rCSI 36.79%PRS 52.32
-
CSI 9.3rCSI 30.58%PRS 54.03
-
CSI 9.23rCSI 8.73%PRS 66.44
-
CSI 8.97rCSI 36.57%PRS 78.82
-
CSI 8.72rCSI 51.35%PRS 49.83
-
CSI 8.72rCSI 25.72%PRS 69.88
-
CSI 8.61rCSI 24.48%PRS 65.08
-
CSI 8.52rCSI 20.31%PRS 67.8
-
CSI 8.52rCSI 34.29%PRS 70.92
-
CSI 8.5rCSI 42.79%PRS 66.75
-
CSI 8.35rCSI 6.49%PRS 84.22
-
CSI 8.28rCSI 35.2%PRS 60.16
-
CSI 8.26rCSI 16.36%PRS 81.37
-
CSI 8.24rCSI 30.86%PRS 59.33
-
CSI 7.64rCSI 7.35%PRS 67.14
-
CSI 7.51rCSI 11.34%PRS 72.31
-
CSI 7.46rCSI 19.69%PRS 76.01
-
CSI 7.32rCSI 15.05%PRS 56.76
-
CSI 7.31rCSI 5.41%PRS 60.18
-
CSI 7.25rCSI 15.04%PRS 64.46
-
CSI 6.93rCSI 19.42%PRS 77.41
-
CSI 6.82rCSI 10.84%PRS 60.09
-
CSI 6.81rCSI 22.83%PRS 52.07
-
CSI 6.8rCSI 49.98%PRS 53.97
-
CSI 6.79rCSI 13.63%PRS 56.54
-
CSI 6.61rCSI 6.15%PRS 68.1
-
CSI 6.61rCSI 9.75%PRS 81.62
-
CSI 0.2rCSI 3.6%PRS 81.5%
-
CSI 0.3rCSI 2.9%PRS 80.1%
-
CSI 0.3rCSI 3.9%PRS 89.0%
-
CSI 0.4rCSI 1.8%PRS 84.3%
-
CSI 0.5rCSI 7.7%PRS 58.3%
-
CSI 0.6rCSI 3.2%PRS 75.7%
-
CSI 0.7rCSI 1.3%PRS 70.5%
-
CSI 0.7rCSI 3.1%PRS 80.2%
-
CSI 0.8rCSI 5.7%PRS 81.5%
-
CSI 0.8rCSI 5.1%PRS 67.9%
-
CSI 0.8rCSI 2.3%PRS 78.6%
-
CSI 1.0rCSI 1.3%PRS 73.7%
-
CSI 1.1rCSI 2.4%PRS 65.7%
-
CSI 1.2rCSI 3.2%PRS 91.4%
-
CSI 1.2rCSI 2.9%PRS 75.3%
-
CSI 1.3rCSI 4.6%PRS 85.8%
-
CSI 1.4rCSI 3.8%PRS 73.9%
-
CSI 1.4rCSI 34.7%PRS 48.5%
-
CSI 1.5rCSI 11.3%PRS 63.4%
-
CSI 1.5rCSI 9.8%PRS 64.0%
-
CSI 1.6rCSI 3.8%PRS 77.0%
-
CSI 1.6rCSI 2.1%PRS 71.9%
-
CSI 1.8rCSI 3.9%PRS 53.2%
-
CSI 1.8rCSI 11.4%PRS 76.4%
-
CSI 1.8rCSI 2.6%PRS 70.8%
-
CSI 1.9rCSI 2.3%PRS 65.6%
-
CSI 2.1rCSI 12.8%PRS 59.1%
-
CSI 2.1rCSI 1.2%PRS 84.4%
-
CSI 2.1rCSI 5.4%PRS 69.5%
-
CSI 2.1rCSI 22.0%PRS 65.1%
-
CSI 2.1rCSI 3.0%PRS 70.1%
-
CSI 2.1rCSI 6.1%PRS 86.4%
-
CSI 2.1rCSI 11.9%PRS 75.1%
-
CSI 2.3rCSI 10.0%PRS 57.0%
-
CSI 2.3rCSI 2.6%PRS 58.1%
-
CSI 2.4rCSI 2.2%PRS 76.5%
-
CSI 2.4rCSI 5.7%PRS 54.3%
-
CSI 2.4rCSI 14.9%PRS 49.6%
-
CSI 2.4rCSI 2.8%PRS 69.4%
-
CSI 2.5rCSI 7.0%PRS 63.8%
-
CSI 2.6rCSI 6.2%PRS 75.8%
-
CSI 2.6rCSI 12.2%PRS 61.6%
-
CSI 2.6rCSI 63.1%PRS 47.8%
-
CSI 2.8rCSI 69.5%PRS 63.0%
-
CSI 2.8rCSI 2.8%PRS 70.1%
-
CSI 2.8rCSI 6.5%PRS 63.1%
-
CSI 3.0rCSI 13.1%PRS 67.5%
-
CSI 3.1rCSI 9.9%PRS 65.1%
-
CSI 3.2rCSI 6.6%PRS 67.6%
-
CSI 3.2rCSI 7.1%PRS 78.8%
-
CSI 3.2rCSI 26.2%PRS 60.9%
-
CSI 3.3rCSI 10.8%PRS 66.8%
-
CSI 3.3rCSI 3.0%PRS 81.5%
-
CSI 3.4rCSI 29.0%PRS 63.7%
-
CSI 3.5rCSI 10.2%PRS 66.2%
-
CSI 3.5rCSI 21.4%PRS 79.4%
-
CSI 3.5rCSI 5.5%PRS 69.9%
-
CSI 3.7rCSI 8.9%PRS 75.1%
-
CSI 3.8rCSI 11.6%PRS 74.7%
-
CSI 3.8rCSI 6.1%PRS 71.7%
-
CSI 3.8rCSI 3.1%PRS 67.8%
-
CSI 3.9rCSI 3.7%PRS 58.7%
-
CSI 3.9rCSI 18.6%PRS 65.5%
-
CSI 4.1rCSI 3.4%PRS 67.1%
-
CSI 4.1rCSI 7.3%PRS 75.2%
-
CSI 4.2rCSI 3.3%PRS 70.4%
-
CSI 4.3rCSI 8.1%PRS 77.6%
-
CSI 4.3rCSI 10.9%PRS 74.8%
-
CSI 4.4rCSI 6.2%PRS 63.7%
-
CSI 4.4rCSI 17.2%PRS 70.4%
-
CSI 4.4rCSI 25.0%PRS 52.6%
-
CSI 4.5rCSI 51.5%PRS 57.9%
-
CSI 4.5rCSI 4.7%PRS 73.2%
-
CSI 4.6rCSI 19.0%PRS 66.9%
-
CSI 4.6rCSI 12.0%PRS 64.0%
-
CSI 4.7rCSI 11.4%PRS 74.1%
-
CSI 5.0rCSI 7.7%PRS 74.1%
-
CSI 5.0rCSI 51.7%PRS 61.4%
-
CSI 5.0rCSI 11.8%PRS 70.6%
-
CSI 5.1rCSI 4.1%PRS 77.9%
-
CSI 5.1rCSI 8.4%PRS 72.8%
-
CSI 5.1rCSI 23.0%PRS 51.3%
-
CSI 5.2rCSI 11.3%PRS 81.3%
-
CSI 5.3rCSI 6.6%PRS 78.1%
-
CSI 5.4rCSI 21.0%PRS 44.5%
-
CSI 5.5rCSI 14.3%PRS 62.3%
-
CSI 5.6rCSI 26.7%PRS 67.4%
-
CSI 5.6rCSI 21.3%PRS 57.9%
-
CSI 5.6rCSI 4.9%PRS 72.8%
-
CSI 5.6rCSI 26.3%PRS 82.3%
-
CSI 5.7rCSI 8.6%PRS 76.5%
-
CSI 5.8rCSI 8.9%PRS 71.7%
-
CSI 5.9rCSI 6.4%PRS 71.1%
-
CSI 5.9rCSI 17.6%PRS 77.2%
-
CSI 6.1rCSI 52.4%PRS 54.6%
-
CSI 6.2rCSI 43.9%PRS 67.1%
-
CSI 6.2rCSI 4.9%PRS 87.4%
-
CSI 6.4rCSI 4.6%PRS 81.3%
-
CSI 6.4rCSI 25.9%PRS 66.6%
-
CSI 6.5rCSI 8.7%PRS 67.3%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1365639841
Symbol: KPCA_HUMAN
Name: Protein kinase C alpha type
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2336401
PubMed ID: 19054851
Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.
PubMed ID: 19054851
DOI: 10.1038/nmeth.1273
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1714454
Title: Phorbol diester-induced alterations in the expression of protein kinase C isozymes and their mRNAs. Analysis in wild-type and phorbol diester-resistant HL-60 cell clones.
PubMed ID: 1714454
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 9738012
Title: A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis.
PubMed ID: 9738012
PubMed ID: 9830023
Title: Protein kinase C-alpha modulates lipopolysaccharide-induced functions in a murine macrophage cell line.
PubMed ID: 9830023
PubMed ID: 9873035
Title: Interleukin-1-induced nuclear factor-kappaB-IkappaBalpha autoregulatory feedback loop in hepatocytes. A role for protein kinase calpha in post-transcriptional regulation of ikappabalpha resynthesis.
PubMed ID: 9873035
PubMed ID: 9927633
Title: Induction of p53-dependent, insulin-like growth factor-binding protein-3-mediated apoptosis in glioblastoma multiforme cells by a protein kinase Calpha antisense oligonucleotide.
PubMed ID: 9927633
DOI: 10.1124/mol.55.2.396
PubMed ID: 10848585
Title: Involvement of p21(Waf1/Cip1) in protein kinase C alpha-induced cell cycle progression.
PubMed ID: 10848585
PubMed ID: 11909826
Title: Inhibition of protein kinase Calpha prevents endothelial cell migration and vascular tube formation in vitro and myocardial neovascularization in vivo.
PubMed ID: 11909826
PubMed ID: 12893243
Title: Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C.
PubMed ID: 12893243
PubMed ID: 12724315
Title: Direct demonstration of involvement of protein kinase Calpha in the Ca2+-induced platelet aggregation.
PubMed ID: 12724315
PubMed ID: 12832403
Title: Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin T.
PubMed ID: 12832403
PubMed ID: 15526160
Title: Signal transduction via the stem cell factor receptor/c-Kit.
PubMed ID: 15526160
PubMed ID: 15016832
Title: Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells.
PubMed ID: 15016832
PubMed ID: 15247289
Title: The PDZ domain of PICK1 differentially accepts protein kinase C-alpha and GluR2 as interacting ligands.
PubMed ID: 15247289
PubMed ID: 15504744
Title: Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motility.
PubMed ID: 15504744
PubMed ID: 16129412
Title: Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor.
PubMed ID: 16129412
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 17893151
Title: Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase.
PubMed ID: 17893151
PubMed ID: 18056764
Title: Protein kinase C alpha promotes angiogenic activity of human endothelial cells via induction of vascular endothelial growth factor.
PubMed ID: 18056764
DOI: 10.1093/cvr/cvm085
PubMed ID: 18088087
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19176525
Title: Phosphorylation of activation transcription factor-2 at serine 121 by protein kinase c controls c-Jun-mediated activation of transcription.
PubMed ID: 19176525
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21576361
Title: Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1.
PubMed ID: 21576361
DOI: 10.1128/mcb.05589-11
PubMed ID: 12417014
Title: Protein kinase C alpha (PKC alpha): regulation and biological function.
PubMed ID: 12417014
PubMed ID: 19969380
Title: Protein kinase Calpha: disease regulator and therapeutic target.
PubMed ID: 19969380
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23990668
Title: Unraveling the role of KIAA1199, a novel endoplasmic reticulum protein, in cancer cell migration.
PubMed ID: 23990668
DOI: 10.1093/jnci/djt224
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25313067
Title: Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation.
PubMed ID: 25313067
PubMed ID: 27925688
Title: Rare deleterious PARD3 variants in the aPKC-binding region are implicated in the pathogenesis of human cranial neural tube defects via disrupting apical tight junction formation.
PubMed ID: 27925688
DOI: 10.1002/humu.23153
PubMed ID: 28028151
Title: LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.
PubMed ID: 28028151
DOI: 10.1084/jem.20160068
PubMed ID: 36040231
Title: PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain.
PubMed ID: 36040231
DOI: 10.1042/bcj20220308
PubMed ID: 19827831
Title: Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.
PubMed ID: 19827831
DOI: 10.1021/jm901108b
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 672
- Mass: 76750
- Checksum: 9EB157789A062349
- Sequence:
MADVFPGNDS TASQDVANRF ARKGALRQKN VHEVKDHKFI ARFFKQPTFC SHCTDFIWGF GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPDTDDPRS KHKFKIHTYG SPTFCDHCGS LLYGLIHQGM KCDTCDMNVH KQCVINVPSL CGMDHTEKRG RIYLKAEVAD EKLHVTVRDA KNLIPMDPNG LSDPYVKLKL IPDPKNESKQ KTKTIRSTLN PQWNESFTFK LKPSDKDRRL SVEIWDWDRT TRNDFMGSLS FGVSELMKMP ASGWYKLLNQ EEGEYYNVPI PEGDEEGNME LRQKFEKAKL GPAGNKVISP SEDRKQPSNN LDRVKLTDFN FLMVLGKGSF GKVMLADRKG TEELYAIKIL KKDVVIQDDD VECTMVEKRV LALLDKPPFL TQLHSCFQTV DRLYFVMEYV NGGDLMYHIQ QVGKFKEPQA VFYAAEISIG LFFLHKRGII YRDLKLDNVM LDSEGHIKIA DFGMCKEHMM DGVTTRTFCG TPDYIAPEII AYQPYGKSVD WWAYGVLLYE MLAGQPPFDG EDEDELFQSI MEHNVSYPKS LSKEAVSVCK GLMTKHPAKR LGCGPEGERD VREHAFFRRI DWEKLENREI QPPFKPKVCG KGAENFDKFF TRGQPVLTPP DQLVIANIDQ SDFEGFSYVN PQFVHPILQS AV
Genular Protein ID: 1513953695
Symbol: Q7Z727_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 380
- Mass: 43185
- Checksum: BDFBD8C8EC489604
- Sequence:
ASQRLRLPLP LRAAPARLSP APAAPPRRDL GHRPAPRARG RPEPAPLPRR PRPPGPPRPQ LPGGGKRWLG GTMADVFPGN DSTASQDVAN RFARKGALRQ KNVHEVKDHK FIARFFKQPT FCSHCTDFIW GFGKQGFQCQ VCCFVVHKRC HEFVTFSCPG ADKGPDTDDP RSKHKFKIHT YGSPTFCDHC GSLLYGLIHQ GMKCDTCDMN VHKQCVINVP SLCGMDHTEK RGRIYLKAEV ADEKLHVTVR DAKNLIPMDP NGLSDPYVKL KLIPDPKNES KQKTKTIRST LNPQWNESFT FKLKPSDKDR RLSVEIWDWD RTTRNDFMGS LSFGVSELMK MPASGWYKLL NQEEGEYYNV PIPEGDEEGN MELRQKFEWR