Details for: PRKCA

Gene ID: 5578

Symbol: PRKCA

Ensembl ID: ENSG00000154229

Description: protein kinase C alpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 5.59
    Marker Score: 3680
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 5.55
    Marker Score: 29097
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 5.44
    Marker Score: 96583
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 5.44
    Marker Score: 6776
  • Cell Name: granule cell (CL0000120)
    Fold Change: 4.75
    Marker Score: 35829
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 4.65
    Marker Score: 10691
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 4.29
    Marker Score: 23069
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 4.24
    Marker Score: 3659
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 3.75
    Marker Score: 2891
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.57
    Marker Score: 6877
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 3.49
    Marker Score: 1825
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.25
    Marker Score: 69436
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 3.23
    Marker Score: 1704
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 3.1
    Marker Score: 1723
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.89
    Marker Score: 1046
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.83
    Marker Score: 21658
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.81
    Marker Score: 41946
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.8
    Marker Score: 3223
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.8
    Marker Score: 1390
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.74
    Marker Score: 6570
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.63
    Marker Score: 8614
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.58
    Marker Score: 4332
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.51
    Marker Score: 1405
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.45
    Marker Score: 2121
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.45
    Marker Score: 92864
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.44
    Marker Score: 702
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.41
    Marker Score: 88949
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.35
    Marker Score: 6713
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.33
    Marker Score: 9006
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.27
    Marker Score: 2806
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.27
    Marker Score: 2427
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.18
    Marker Score: 2082
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.1
    Marker Score: 1037
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.07
    Marker Score: 7362
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.06
    Marker Score: 747
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.02
    Marker Score: 68261
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2
    Marker Score: 519
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.98
    Marker Score: 39345
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.95
    Marker Score: 20137
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.95
    Marker Score: 18299
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.9
    Marker Score: 7877
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.86
    Marker Score: 1111
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.82
    Marker Score: 15630
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.77
    Marker Score: 1027
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.73
    Marker Score: 441
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.72
    Marker Score: 3783
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.71
    Marker Score: 995
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.65
    Marker Score: 4143
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.6
    Marker Score: 3775
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.58
    Marker Score: 499
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.57
    Marker Score: 1905
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.57
    Marker Score: 6408
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.57
    Marker Score: 1389
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.55
    Marker Score: 24920
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.54
    Marker Score: 483
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.54
    Marker Score: 2379
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.54
    Marker Score: 580
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.53
    Marker Score: 765
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.53
    Marker Score: 14530
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.51
    Marker Score: 1706
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.49
    Marker Score: 9597
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.46
    Marker Score: 790
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 166913
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.45
    Marker Score: 1235
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.4
    Marker Score: 1884
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.39
    Marker Score: 6409
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.38
    Marker Score: 1490
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.38
    Marker Score: 7398
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.37
    Marker Score: 84549
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.37
    Marker Score: 950
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.36
    Marker Score: 509
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.34
    Marker Score: 1903
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.34
    Marker Score: 494
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.33
    Marker Score: 1958
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.33
    Marker Score: 5732
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.31
    Marker Score: 1451
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.31
    Marker Score: 264
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.3
    Marker Score: 782
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.28
    Marker Score: 2611
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.27
    Marker Score: 19871
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.23
    Marker Score: 2239
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.22
    Marker Score: 1145
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.22
    Marker Score: 3077
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.22
    Marker Score: 1467
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.21
    Marker Score: 676
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.18
    Marker Score: 482
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.15
    Marker Score: 25624
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.14
    Marker Score: 1259
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.1
    Marker Score: 1550
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.09
    Marker Score: 420
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.06
    Marker Score: 1098
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.04
    Marker Score: 11767
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.04
    Marker Score: 6270
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.03
    Marker Score: 1087.5
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.02
    Marker Score: 598
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.02
    Marker Score: 353
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.01
    Marker Score: 1125
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71695
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47921
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30394

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Other Information

**Key Characteristics** PKCα is a member of the protein kinase C family, which consists of at least 12 different isoforms, each with distinct subcellular localization and tissue distribution. PKCα is characterized by its ability to be activated by DAG and calcium ions, and it exhibits a high degree of specificity in its substrate recognition. The protein has a unique conformational change upon activation, which allows it to bind to phospholipids and interact with its downstream targets. PKCα is also known for its ability to form heterodimers with other PKC isoforms, which can modulate its activity and substrate specificity. The protein has a high degree of phosphorylation sites, which can be targeted by various kinases, including PKCα itself. This self-phosphorylation mechanism allows PKCα to regulate its own activity and adapt to changing cellular conditions. **Pathways and Functions** PKCα is involved in a wide range of cellular processes, including: 1. **Signal Transduction**: PKCα plays a key role in transmitting signals from the cell surface to the nucleus, where it regulates gene expression and cell growth. 2. **Cell Growth and Differentiation**: PKCα is involved in the regulation of cell proliferation, differentiation, and survival, particularly in the context of cancer. 3. **Metabolism**: PKCα regulates various metabolic pathways, including glycolysis, lipolysis, and gluconeogenesis. 4. **Neurotransmission**: PKCα is involved in the regulation of synaptic plasticity and neurotransmitter release. 5. **Inflammation**: PKCα plays a role in the regulation of inflammatory responses, including the activation of immune cells and the production of pro-inflammatory cytokines. **Clinical Significance** Dysregulation of PKCα has been implicated in various diseases, including: 1. **Cancer**: PKCα overexpression has been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative Diseases**: PKCα has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular Disease**: PKCα has been linked to the development of cardiovascular disease, including hypertension and atherosclerosis. 4. **Inflammatory Disorders**: PKCα has been implicated in the regulation of inflammatory responses, including rheumatoid arthritis and inflammatory bowel disease. In summary, PKCα is a crucial regulator of various cellular processes, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which PKCα regulates cellular processes and to identify potential therapeutic targets for the treatment of these diseases.

Genular Protein ID: 1365639841

Symbol: KPCA_HUMAN

Name: Protein kinase C alpha type

UniProtKB Accession Codes:

P17252 B5BU22 Q15137 Q32M72 Q96RE4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CORUM 1 CPTAC 3 CTD 1 ChEBI 28 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 14 DrugCentral 1 EC 2 EMBL 14 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 50 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 4 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 7 PROSITE-ProRule 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 20 RefSeq 1 Rhea 6 SABIO-RK 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 5 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2336401

Title: Sequence of human protein kinase C alpha.

PubMed ID: 2336401

DOI: 10.1093/nar/18.8.2183

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1714454

Title: Phorbol diester-induced alterations in the expression of protein kinase C isozymes and their mRNAs. Analysis in wild-type and phorbol diester-resistant HL-60 cell clones.

PubMed ID: 1714454

DOI: 10.1016/s0021-9258(18)98596-0

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 9738012

Title: A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis.

PubMed ID: 9738012

DOI: 10.1074/jbc.273.39.25436

PubMed ID: 9830023

Title: Protein kinase C-alpha modulates lipopolysaccharide-induced functions in a murine macrophage cell line.

PubMed ID: 9830023

DOI: 10.1074/jbc.273.49.32787

PubMed ID: 9873035

Title: Interleukin-1-induced nuclear factor-kappaB-IkappaBalpha autoregulatory feedback loop in hepatocytes. A role for protein kinase calpha in post-transcriptional regulation of ikappabalpha resynthesis.

PubMed ID: 9873035

DOI: 10.1074/jbc.274.2.939

PubMed ID: 9927633

Title: Induction of p53-dependent, insulin-like growth factor-binding protein-3-mediated apoptosis in glioblastoma multiforme cells by a protein kinase Calpha antisense oligonucleotide.

PubMed ID: 9927633

DOI: 10.1124/mol.55.2.396

PubMed ID: 10848585

Title: Involvement of p21(Waf1/Cip1) in protein kinase C alpha-induced cell cycle progression.

PubMed ID: 10848585

DOI: 10.1128/mcb.20.13.4580-4590.2000

PubMed ID: 11909826

Title: Inhibition of protein kinase Calpha prevents endothelial cell migration and vascular tube formation in vitro and myocardial neovascularization in vivo.

PubMed ID: 11909826

DOI: 10.1161/01.res.0000012503.30315.e8

PubMed ID: 12893243

Title: Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C.

PubMed ID: 12893243

DOI: 10.1016/s0006-291x(03)01187-2

PubMed ID: 12724315

Title: Direct demonstration of involvement of protein kinase Calpha in the Ca2+-induced platelet aggregation.

PubMed ID: 12724315

DOI: 10.1074/jbc.m212407200

PubMed ID: 12832403

Title: Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin T.

PubMed ID: 12832403

DOI: 10.1074/jbc.m306325200

PubMed ID: 15526160

Title: Signal transduction via the stem cell factor receptor/c-Kit.

PubMed ID: 15526160

DOI: 10.1007/s00018-004-4189-6

PubMed ID: 15016832

Title: Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells.

PubMed ID: 15016832

DOI: 10.1074/jbc.m313975200

PubMed ID: 15247289

Title: The PDZ domain of PICK1 differentially accepts protein kinase C-alpha and GluR2 as interacting ligands.

PubMed ID: 15247289

DOI: 10.1074/jbc.m404499200

PubMed ID: 15504744

Title: Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motility.

PubMed ID: 15504744

DOI: 10.1074/jbc.m411045200

PubMed ID: 16129412

Title: Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor.

PubMed ID: 16129412

DOI: 10.1016/j.bbrc.2005.08.055

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17893151

Title: Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase.

PubMed ID: 17893151

DOI: 10.1074/jbc.m703320200

PubMed ID: 18056764

Title: Protein kinase C alpha promotes angiogenic activity of human endothelial cells via induction of vascular endothelial growth factor.

PubMed ID: 18056764

DOI: 10.1093/cvr/cvm085

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19176525

Title: Phosphorylation of activation transcription factor-2 at serine 121 by protein kinase c controls c-Jun-mediated activation of transcription.

PubMed ID: 19176525

DOI: 10.1074/jbc.m808719200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21576361

Title: Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1.

PubMed ID: 21576361

DOI: 10.1128/mcb.05589-11

PubMed ID: 12417014

Title: Protein kinase C alpha (PKC alpha): regulation and biological function.

PubMed ID: 12417014

DOI: 10.1093/oxfordjournals.jbchem.a003272

PubMed ID: 19969380

Title: Protein kinase Calpha: disease regulator and therapeutic target.

PubMed ID: 19969380

DOI: 10.1016/j.tips.2009.10.006

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23990668

Title: Unraveling the role of KIAA1199, a novel endoplasmic reticulum protein, in cancer cell migration.

PubMed ID: 23990668

DOI: 10.1093/jnci/djt224

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25313067

Title: Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation.

PubMed ID: 25313067

DOI: 10.1073/pnas.1418342111

PubMed ID: 27925688

Title: Rare deleterious PARD3 variants in the aPKC-binding region are implicated in the pathogenesis of human cranial neural tube defects via disrupting apical tight junction formation.

PubMed ID: 27925688

DOI: 10.1002/humu.23153

PubMed ID: 28028151

Title: LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.

PubMed ID: 28028151

DOI: 10.1084/jem.20160068

PubMed ID: 19827831

Title: Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.

PubMed ID: 19827831

DOI: 10.1021/jm901108b

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 672
  • Mass: 76750
  • Checksum: 9EB157789A062349
  • Sequence:
    • MADVFPGNDS TASQDVANRF ARKGALRQKN VHEVKDHKFI ARFFKQPTFC SHCTDFIWGF 
GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPDTDDPRS KHKFKIHTYG SPTFCDHCGS 
LLYGLIHQGM KCDTCDMNVH KQCVINVPSL CGMDHTEKRG RIYLKAEVAD EKLHVTVRDA 
KNLIPMDPNG LSDPYVKLKL IPDPKNESKQ KTKTIRSTLN PQWNESFTFK LKPSDKDRRL 
SVEIWDWDRT TRNDFMGSLS FGVSELMKMP ASGWYKLLNQ EEGEYYNVPI PEGDEEGNME 
LRQKFEKAKL GPAGNKVISP SEDRKQPSNN LDRVKLTDFN FLMVLGKGSF GKVMLADRKG 
TEELYAIKIL KKDVVIQDDD VECTMVEKRV LALLDKPPFL TQLHSCFQTV DRLYFVMEYV 
NGGDLMYHIQ QVGKFKEPQA VFYAAEISIG LFFLHKRGII YRDLKLDNVM LDSEGHIKIA 
DFGMCKEHMM DGVTTRTFCG TPDYIAPEII AYQPYGKSVD WWAYGVLLYE MLAGQPPFDG 
EDEDELFQSI MEHNVSYPKS LSKEAVSVCK GLMTKHPAKR LGCGPEGERD VREHAFFRRI 
DWEKLENREI QPPFKPKVCG KGAENFDKFF TRGQPVLTPP DQLVIANIDQ SDFEGFSYVN 
PQFVHPILQS AV

Genular Protein ID: 1513953695

Symbol: Q7Z727_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z727

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 6 KEGG 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 5 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 380
  • Mass: 43185
  • Checksum: BDFBD8C8EC489604
  • Sequence:
    • ASQRLRLPLP LRAAPARLSP APAAPPRRDL GHRPAPRARG RPEPAPLPRR PRPPGPPRPQ 
LPGGGKRWLG GTMADVFPGN DSTASQDVAN RFARKGALRQ KNVHEVKDHK FIARFFKQPT 
FCSHCTDFIW GFGKQGFQCQ VCCFVVHKRC HEFVTFSCPG ADKGPDTDDP RSKHKFKIHT 
YGSPTFCDHC GSLLYGLIHQ GMKCDTCDMN VHKQCVINVP SLCGMDHTEK RGRIYLKAEV 
ADEKLHVTVR DAKNLIPMDP NGLSDPYVKL KLIPDPKNES KQKTKTIRST LNPQWNESFT 
FKLKPSDKDR RLSVEIWDWD RTTRNDFMGS LSFGVSELMK MPASGWYKLL NQEEGEYYNV 
PIPEGDEEGN MELRQKFEWR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.