Details for: SOX5

Gene ID: 6660

Symbol: SOX5

Ensembl ID: ENSG00000134532

Description: SRY-box transcription factor 5

Associated with

  • Asymmetric neuroblast division
    (GO:0055059)
  • Cartilage condensation
    (GO:0001502)
  • Cartilage development
    (GO:0051216)
  • Cell fate commitment
    (GO:0045165)
  • Cellular response to transforming growth factor beta stimulus
    (GO:0071560)
  • Chondrocyte differentiation
    (GO:0002062)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Nucleus
    (GO:0005634)
  • Positive regulation of cartilage development
    (GO:0061036)
  • Positive regulation of chondrocyte differentiation
    (GO:0032332)
  • Positive regulation of mesenchymal stem cell differentiation
    (GO:2000741)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 6.13
    Marker Score: 25556
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 4.94
    Marker Score: 25941
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 4.33
    Marker Score: 2409
  • Cell Name: fat cell (CL0000136)
    Fold Change: 3.97
    Marker Score: 2219
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.97
    Marker Score: 7631.5
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.82
    Marker Score: 12528.5
  • Cell Name: granule cell (CL0000120)
    Fold Change: 3.59
    Marker Score: 27053
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.49
    Marker Score: 7668
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 3.44
    Marker Score: 2266
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.26
    Marker Score: 69588
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 3.22
    Marker Score: 2483
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.15
    Marker Score: 3006
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 3.14
    Marker Score: 3618
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 3.13
    Marker Score: 1696
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.81
    Marker Score: 13006
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.79
    Marker Score: 1622
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.77
    Marker Score: 41416
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.73
    Marker Score: 2365
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.7
    Marker Score: 9613
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.67
    Marker Score: 1593
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.53
    Marker Score: 10501
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.53
    Marker Score: 1061
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.44
    Marker Score: 2959
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.43
    Marker Score: 766
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.42
    Marker Score: 89273
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.41
    Marker Score: 2984
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.38
    Marker Score: 4002.5
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.24
    Marker Score: 5152
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 2.24
    Marker Score: 2787.5
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 2.21
    Marker Score: 833
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.21
    Marker Score: 1452
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.19
    Marker Score: 20642
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.19
    Marker Score: 1132
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.12
    Marker Score: 1191
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.11
    Marker Score: 771
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.05
    Marker Score: 590
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.99
    Marker Score: 2804
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.91
    Marker Score: 18141
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.84
    Marker Score: 501.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.82
    Marker Score: 36137.5
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.78
    Marker Score: 9570
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.76
    Marker Score: 3575
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.73
    Marker Score: 14859
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.7
    Marker Score: 27247
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.68
    Marker Score: 10781
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.65
    Marker Score: 6730
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.65
    Marker Score: 2541
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.64
    Marker Score: 432
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1161
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.59
    Marker Score: 97623
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.57
    Marker Score: 946
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.57
    Marker Score: 687
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.57
    Marker Score: 59549
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.52
    Marker Score: 6569.5
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.5
    Marker Score: 1870
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.48
    Marker Score: 1986
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.45
    Marker Score: 1094
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.4
    Marker Score: 10754
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.39
    Marker Score: 360
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 862
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.33
    Marker Score: 7160
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.32
    Marker Score: 770
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.27
    Marker Score: 1798
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.23
    Marker Score: 591
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.21
    Marker Score: 5068
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.21
    Marker Score: 18909
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.2
    Marker Score: 819
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.19
    Marker Score: 303
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.18
    Marker Score: 135590
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.18
    Marker Score: 408
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.16
    Marker Score: 1977
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.16
    Marker Score: 472
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4790
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.13
    Marker Score: 1187
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.12
    Marker Score: 616
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.1
    Marker Score: 531
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.08
    Marker Score: 6464
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.07
    Marker Score: 23990
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.05
    Marker Score: 714
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.04
    Marker Score: 1115.5
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.04
    Marker Score: 210
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.04
    Marker Score: 431
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251764
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.04
    Marker Score: 4005
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 1.04
    Marker Score: 494
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.02
    Marker Score: 1098
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 1.01
    Marker Score: 361
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.01
    Marker Score: 1067
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1
    Marker Score: 1212
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71782
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48008
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.97
    Marker Score: 1774
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.97
    Marker Score: 1037
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.97
    Marker Score: 444
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.93
    Marker Score: 930
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5297

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Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** SOX5 acts as a transcriptional regulator by binding to specific DNA sequences and activating or repressing the expression of target genes. 2. **Cell Fate Commitment:** SOX5 is involved in the commitment of mesenchymal stem cells to a chondrocytic lineage, a critical step in cartilage development. 3. **Chondrocyte Differentiation:** SOX5 is essential for the differentiation of chondrocytes, the cells responsible for cartilage formation and maintenance. 4. **Cartilage Development:** SOX5 is involved in the regulation of cartilage development, including the condensation of cartilage precursors and the formation of cartilage tissue. **Pathways and Functions:** 1. **Asymmetric Neuroblast Division:** SOX5 is involved in the asymmetric division of neuroblasts, a process critical for the development of the nervous system. 2. **Cartilage Condensation:** SOX5 regulates the condensation of cartilage precursors, a key step in cartilage formation. 3. **Cellular Response to TGF-β:** SOX5 is part of the TGF-β signaling pathway, which regulates cell growth, differentiation, and apoptosis. 4. **Chromatin Remodeling:** SOX5 interacts with chromatin remodeling complexes to regulate gene expression and maintain chromatin structure. **Clinical Significance:** 1. **Osteoarthritis:** SOX5 has been implicated in the pathogenesis of osteoarthritis, a degenerative joint disease characterized by cartilage degradation and bone-on-bone contact. 2. **Chondrodysplasias:** Mutations in the SOX5 gene have been associated with chondrodysplasias, a group of genetic disorders characterized by abnormal cartilage development. 3. **Cancer:** SOX5 has been identified as an oncogene in certain types of cancer, including chondrosarcoma and osteosarcoma. 4. **Regenerative Medicine:** SOX5 has potential applications in regenerative medicine, including the development of cartilage tissue engineering and bone grafting therapies. In conclusion, SOX5 is a critical regulator of cartilage development and chondrocyte differentiation, and its dysregulation has been implicated in various diseases, including osteoarthritis and chondrodysplasias. Further research is needed to fully elucidate the role of SOX5 in human health and disease.

Genular Protein ID: 2529468305

Symbol: SOX5_HUMAN

Name: N/A

UniProtKB Accession Codes:

P35711 B7Z8V0 F5H5B0 Q86UK8 Q8J017 Q8J018 Q8J019 Q8J020 Q8N1D9 Q8N7E0 Q8TEA4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 17 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 RefSeq 7 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12406576

Title: Identification and characterization of the human long form of Sox5 (L-SOX5) gene.

PubMed ID: 12406576

DOI: 10.1016/s0378-1119(02)00927-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8812465

Title: Cloning and characterization of SOX5, a new member of the human SOX gene family.

PubMed ID: 8812465

DOI: 10.1006/geno.1996.0474

PubMed ID: 1614875

Title: A conserved family of genes related to the testis determining gene, SRY.

PubMed ID: 1614875

DOI: 10.1093/nar/20.11.2887

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 22290657

Title: Haploinsufficiency of SOX5 at 12p12.1 is associated with developmental delays with prominent language delay, behavior problems, and mild dysmorphic features.

PubMed ID: 22290657

DOI: 10.1002/humu.22037

PubMed ID: 23220431

Title: Haploinsufficiency of SOX5, a member of the SOX (SRY-related HMG-box) family of transcription factors is a cause of intellectual disability.

PubMed ID: 23220431

DOI: 10.1016/j.ejmg.2012.11.001

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23498568

Title: Deletion 12p12 involving SOX5 in two children with developmental delay and dysmorphic features.

PubMed ID: 23498568

DOI: 10.1016/j.pediatrneurol.2012.12.013

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26111154

Title: Exome sequencing expands the mechanism of SOX5-associated intellectual disability: A case presentation with review of sox-related disorders.

PubMed ID: 26111154

DOI: 10.1002/ajmg.a.37221

PubMed ID: 21220648

Title: Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis.

PubMed ID: 21220648

DOI: 10.1001/archneurol.2010.351

Sequence Information:

  • Length: 763
  • Mass: 84026
  • Checksum: 02B5B13429A59CAA
  • Sequence:
    • MLTDPDLPQE FERMSSKRPA SPYGEADGEV AMVTSRQKVE EEESDGLPAF HLPLHVSFPN 
KPHSEEFQPV SLLTQETCGH RTPTSQHNTM EVDGNKVMSS FAPHNSSTSP QKAEEGGRQS 
GESLSSTALG TPERRKGSLA DVVDTLKQRK MEELIKNEPE ETPSIEKLLS KDWKDKLLAM 
GSGNFGEIKG TPESLAEKER QLMGMINQLT SLREQLLAAH DEQKKLAASQ IEKQRQQMEL 
AKQQQEQIAR QQQQLLQQQH KINLLQQQIQ VQGQLPPLMI PVFPPDQRTL AAAAQQGFLL 
PPGFSYKAGC SDPYPVQLIP TTMAAAAAAT PGLGPLQLQQ LYAAQLAAMQ VSPGGKLPGI 
PQGNLGAAVS PTSIHTDKST NSPPPKSKDE VAQPLNLSAK PKTSDGKSPT SPTSPHMPAL 
RINSGAGPLK ASVPAALASP SARVSTIGYL NDHDAVTKAI QEARQMKEQL RREQQVLDGK 
VAVVNSLGLN NCRTEKEKTT LESLTQQLAV KQNEEGKFSH AMMDFNLSGD SDGSAGVSES 
RIYRESRGRG SNEPHIKRPM NAFMVWAKDE RRKILQAFPD MHNSNISKIL GSRWKAMTNL 
EKQPYYEEQA RLSKQHLEKY PDYKYKPRPK RTCLVDGKKL RIGEYKAIMR NRRQEMRQYF 
NVGQQAQIPI ATAGVVYPGA IAMAGMPSPH LPSEHSSVSS SPEPGMPVIQ STYGVKGEEP 
HIKEEIQAED INGEIYDEYD EEEDDPDVDY GSDSENHIAG QAN

Genular Protein ID: 3947771197

Symbol: F5H0I3_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H0I3

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 10 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 728
  • Mass: 80077
  • Checksum: C465EFBA8009AC73
  • Sequence:
    • MLTDPDLPQE FERMSSKRPA SPYGEADGEV AMVTSRQKVE EEESDGLPAF HLPLHEVDGN 
KVMSSFAPHN SSTSPQKAEE GGRQSGESLS STALGTPERR KGSLADVVDT LKQRKMEELI 
KNEPEETPSI EKLLSKDWKD KLLAMGSGNF GEIKGTPESL AEKERQLMGM INQLTSLREQ 
LLAAHDEQKK LAASQIEKQR QQMELAKQQQ EQIARQQQQL LQQQHKINLL QQQIQVQGQL 
PPLMIPVFPP DQRTLAAAAQ QGFLLPPGFS YKAGCSDPYP VQLIPTTMAA AAAATPGLGP 
LQLQQLYAAQ LAAMQVSPGG KLPGIPQGNL GAAVSPTSIH TDKSTNSPPP KSKDEVAQPL 
NLSAKPKTSD GKSPTSPTSP HMPALRINSG AGPLKASVPA ALASPSARVS TIGYLNDHDA 
VTKAIQEARQ MKEQLRREQQ VLDGKVAVVN SLGLNNCRTE KEKTTLESLT QQLAVKQNEE 
GKFSHAMMDF NLSGDSDGSA GVSESRIYRE SRGRGSNEPH IKRPMNAFMV WAKDERRKIL 
QAFPDMHNSN ISKILGSRWK AMTNLEKQPY YEEQARLSKQ HLEKYPDYKY KPRPKRTCLV 
DGKKLRIGEY KAIMRNRRQE MRQYFNVGQQ AQIPIATAGV VYPGAIAMAG MPSPHLPSEH 
SSVSSSPEPG MPVIQSTYGV KGEEPHIKEE IQAEDINGEI YDEYDEEEDD PDVDYGSDSE 
NHIAGQAN

Genular Protein ID: 1234096668

Symbol: T2CYZ2_HUMAN

Name: N/A

UniProtKB Accession Codes:

T2CYZ2

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 Pfam 1 RefSeq 2 SAM 2 SMART 1 SMR 1 SUPFAM 1 UCSC 1

Citations:

PubMed ID: 24945754

Title: High Levels of SOX5 Decrease Proliferative Capacity of Human B Cells, but Permit Plasmablast Differentiation.

PubMed ID: 24945754

Sequence Information:

  • Length: 750
  • Mass: 82453
  • Checksum: F8152F0BD72E6734
  • Sequence:
    • MSSKRPASPY GEADGEVAMV TSRQKVEEEE SDGLPAFHLP LHVSFPNKPH SEEFQPVSLL 
TQETCGHRTP TSQHNTMEVD GNKVMSSFAP HNSSTSPQKA EEGGRQSGES LSSTALGTPE 
RRKGSLADVV DTLKQRKMEE LIKNEPEETP SIEKLLSKDW KDKLLAMGSG NFGEIKGTPE 
SLAEKERQLM GMINQLTSLR EQLLAAHDEQ KKLAASQIEK QRQQMELAKQ QQEQIARQQQ 
QLLQQQHKIN LLQQQIQVQG QLPPLMIPVF PPDQRTLAAA AQQGFLLPPG FSYKAGCSDP 
YPVQLIPTTM AAAAAATPGL GPLQLQQLYA AQLAAMQVSP GGKLPGIPQG NLGAAVSPTS 
IHTDKSTNSP PPKSKDEVAQ PLNLSAKPKT SDGKSPTSPT SPHMPALRIN SGAGPLKASV 
PAALASPSAR VSTIGYLNDH DAVTKAIQEA RQMKEQLRRE QQVLDGKVAV VNSLGLNNCR 
TEKEKTTLES LTQQLAVKQN EEGKFSHAMM DFNLSGDSDG SAGVSESRIY RESRGRGSNE 
PHIKRPMNAF MVWAKDERRK ILQAFPDMHN SNISKILGSR WKAMTNLEKQ PYYEEQARLS 
KQHLEKYPDY KYKPRPKRTC LVDGKKLRIG EYKAIMRNRR QEMRQYFNVG QQAQIPIATA 
GVVYPGAIAM AGMPSPHLPS EHSSVSSSPE PGMPVIQSTY GVKGEEPHIK EEIQAEDING 
EIYDEYDEEE DDPDVDYGSD SENHIAGQAN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.