Details for: SPRR2G

Gene ID: 6706

Symbol: SPRR2G

Ensembl ID: ENSG00000159516

Description: small proline rich protein 2G

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6850
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3182
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.78
    Marker Score: 1581
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.28
    Marker Score: 1771
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7580
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3656
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32731
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71838
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48063
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5347
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.85
    Marker Score: 707
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.83
    Marker Score: 347
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 740
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 403.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.75
    Marker Score: 428
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.74
    Marker Score: 390.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440.5
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.53
    Marker Score: 470
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.53
    Marker Score: 305
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 284
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.38
    Marker Score: 716
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.36
    Marker Score: 202
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.35
    Marker Score: 231
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.27
    Marker Score: 1777
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.24
    Marker Score: 480
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.23
    Marker Score: 137
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.17
    Marker Score: 2631
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.15
    Marker Score: 923
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.13
    Marker Score: 79
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.11
    Marker Score: 51
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1
    Marker Score: 116
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.06
    Marker Score: 45
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.05
    Marker Score: 74
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.04
    Marker Score: 68
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.04
    Marker Score: 232
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.03
    Marker Score: 247
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.02
    Marker Score: 201
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.02
    Marker Score: 47
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.02
    Marker Score: 29
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.02
    Marker Score: 6
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.02
    Marker Score: 64
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.02
    Marker Score: 29
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.01
    Marker Score: 12.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.01
    Marker Score: 26
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.01
    Marker Score: 28
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.01
    Marker Score: 28
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.01
    Marker Score: 23.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.01
    Marker Score: 57
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.01
    Marker Score: 55
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0
    Marker Score: 11
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0
    Marker Score: 12
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0
    Marker Score: 10
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0
    Marker Score: 19
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0
    Marker Score: 12

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Other Information

**Key characteristics:** - The SPRR2G protein is a transmembrane protein with a predicted molecular weight of approximately 300 amino acids. - It is expressed in high levels in the skin, hair, and lungs. - It is also expressed in the developing cerebral cortex. - It is a key regulator of skin development and hair growth. **Pathways and functions:** - SPRR2G is involved in the formation of the cornified envelope, a protective barrier that surrounds the skin and hair. - It is also involved in keratinization, a process that converts the outer layer of skin into a waterproof barrier. - It is also involved in the development of the immune system. - SPRR2G is a key regulator of the differentiation of epithelial cells into keratinocytes, the cells that produce the outer layer of skin and hair. **Clinical significance:** - Mutations in the SPRR2G gene have been linked to a number of skin disorders, including psoriasis, acne, and alopecia. - These mutations can also lead to hair loss and other skin problems. - Therefore, SPRR2G is an important target for the treatment of skin disorders.

Genular Protein ID: 1921112905

Symbol: SPR2G_HUMAN

Name: Small proline-rich protein 2G

UniProtKB Accession Codes:

Q9BYE4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 5 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SAM 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 11279051

Title: Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function.

PubMed ID: 11279051

DOI: 10.1074/jbc.m100336200

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 73
  • Mass: 8158
  • Checksum: E9BEC5CF6A77DE46
  • Sequence:
    • MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPYLPPP CPPEHCPPPP CQDKCPPVQP 
YPPCQQKYPP KSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.