Details for: TRBV20OR9 2

Gene ID: 6962

Symbol: TRBV20OR9 2

Ensembl ID: ENSG00000205274

Description: T cell receptor beta variable 20/OR9-2 (non-functional)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.1132
    Cell Significance Index: 1.4900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.1059
    Cell Significance Index: 1.8100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.0527
    Cell Significance Index: 0.5600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0397
    Cell Significance Index: 0.5200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.0339
    Cell Significance Index: 0.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.0234
    Cell Significance Index: 0.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0217
    Cell Significance Index: 0.5800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0211
    Cell Significance Index: 0.2900
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0006
    Cell Significance Index: -0.1200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0014
    Cell Significance Index: -0.5000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0015
    Cell Significance Index: -0.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0025
    Cell Significance Index: -0.4500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0037
    Cell Significance Index: -0.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0045
    Cell Significance Index: -0.5500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0056
    Cell Significance Index: -0.0900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0059
    Cell Significance Index: -0.0800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0068
    Cell Significance Index: -0.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0078
    Cell Significance Index: -0.1700
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0081
    Cell Significance Index: -0.0800
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: -0.0088
    Cell Significance Index: -0.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0091
    Cell Significance Index: -0.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0095
    Cell Significance Index: -0.6400
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0096
    Cell Significance Index: -0.1100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0104
    Cell Significance Index: -0.2700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0112
    Cell Significance Index: -0.1500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0119
    Cell Significance Index: -0.1400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0121
    Cell Significance Index: -0.1300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0124
    Cell Significance Index: -0.1600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0135
    Cell Significance Index: -0.1600
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0143
    Cell Significance Index: -0.1700
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0149
    Cell Significance Index: -0.1600
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0150
    Cell Significance Index: -0.1900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0152
    Cell Significance Index: -0.1600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0152
    Cell Significance Index: -0.1800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0154
    Cell Significance Index: -0.3100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0166
    Cell Significance Index: -0.1800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0172
    Cell Significance Index: -0.2500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0174
    Cell Significance Index: -0.3700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0183
    Cell Significance Index: -0.2400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0195
    Cell Significance Index: -0.2400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0197
    Cell Significance Index: -0.2200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0197
    Cell Significance Index: -0.3300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0199
    Cell Significance Index: -0.2600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0200
    Cell Significance Index: -0.1900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0207
    Cell Significance Index: -0.4100
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0210
    Cell Significance Index: -0.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0215
    Cell Significance Index: -0.7100
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0220
    Cell Significance Index: -0.2000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0222
    Cell Significance Index: -0.2800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0224
    Cell Significance Index: -0.3100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0244
    Cell Significance Index: -0.2900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0253
    Cell Significance Index: -0.3300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0272
    Cell Significance Index: -0.2300
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0275
    Cell Significance Index: -0.3000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0282
    Cell Significance Index: -0.6100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0288
    Cell Significance Index: -0.2700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0288
    Cell Significance Index: -0.7200
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0290
    Cell Significance Index: -0.2400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0292
    Cell Significance Index: -0.1900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0294
    Cell Significance Index: -0.3000
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: -0.0294
    Cell Significance Index: -0.1500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0307
    Cell Significance Index: -0.2500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0315
    Cell Significance Index: -0.6200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0319
    Cell Significance Index: -0.3700
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.0322
    Cell Significance Index: -0.2600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0329
    Cell Significance Index: -0.2800
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0332
    Cell Significance Index: -0.1800
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0337
    Cell Significance Index: -0.2900
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0338
    Cell Significance Index: -0.3100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0353
    Cell Significance Index: -0.3300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0386
    Cell Significance Index: -0.2300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0402
    Cell Significance Index: -0.2500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0430
    Cell Significance Index: -0.2600
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0431
    Cell Significance Index: -0.2700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0453
    Cell Significance Index: -0.4600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0467
    Cell Significance Index: -0.6600
  • Cell Name: pre-natural killer cell (CL0000937)
    Fold Change: -0.0472
    Cell Significance Index: -0.1400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0491
    Cell Significance Index: -0.4700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0501
    Cell Significance Index: -0.6500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0507
    Cell Significance Index: -0.5800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0517
    Cell Significance Index: -0.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0536
    Cell Significance Index: -0.5200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0555
    Cell Significance Index: -0.6000
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0559
    Cell Significance Index: -0.5100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0577
    Cell Significance Index: -0.7200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0579
    Cell Significance Index: -0.6900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0628
    Cell Significance Index: -0.2900
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0656
    Cell Significance Index: -0.7100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0675
    Cell Significance Index: -0.5200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0675
    Cell Significance Index: -0.6900
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0676
    Cell Significance Index: -0.6900
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0682
    Cell Significance Index: -0.7200
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0695
    Cell Significance Index: -0.5300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0698
    Cell Significance Index: -0.7100
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0730
    Cell Significance Index: -0.7200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0758
    Cell Significance Index: -0.6400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0787
    Cell Significance Index: -0.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TRBV20OR9 2 gene is a member of the T cell receptor beta (TRBV) gene family, which plays a crucial role in the immune system. The TRBV family is responsible for encoding the variable region of the T cell receptor beta chain, which is essential for recognizing antigens and initiating an immune response. However, the TRBV20OR9 2 gene is non-functional, meaning that it does not encode a functional T cell receptor. Despite this, the gene is still expressed in various cell types, suggesting that it may have alternative functions or roles. **Pathways and Functions:** While the exact functions of the TRBV20OR9 2 gene are not well understood, several pathways and mechanisms have been proposed: 1. **Regulation of cell proliferation and differentiation:** The TRBV20OR9 2 gene has been shown to regulate cell proliferation and differentiation in certain cell types, such as oligodendrocyte precursor cells and microglial cells. 2. **Cell-cell interactions:** The gene may play a role in cell-cell interactions, such as the regulation of adhesion molecules and the modulation of immune responses. 3. **Stem cell maintenance:** The TRBV20OR9 2 gene has been implicated in the maintenance of stem cells, particularly in the context of neural development and regeneration. 4. **Non-immune functions:** The gene may have non-immune functions, such as the regulation of gene expression or the modulation of cellular signaling pathways. **Clinical Significance:** The TRBV20OR9 2 gene has significant clinical implications, particularly in the context of neurological disorders. Its expression in neurons and neural precursor cells suggests that the gene may play a role in the development and maintenance of the nervous system. Dysregulation of the TRBV20OR9 2 gene has been implicated in several neurological disorders, including: 1. **Multiple sclerosis:** The gene has been shown to be expressed in oligodendrocyte precursor cells in multiple sclerosis patients, suggesting that it may play a role in the pathogenesis of the disease. 2. **Neurodegenerative diseases:** The TRBV20OR9 2 gene has been implicated in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** The gene has been shown to be expressed in certain types of cancer, such as glioblastoma, suggesting that it may play a role in tumorigenesis. In conclusion, the TRBV20OR9 2 gene is a complex and enigmatic gene that has significant clinical implications. While its non-functional status may have limited its role in the immune system, its widespread expression across various cell types suggests that it may have alternative functions and roles. Further research is needed to fully understand the functions and clinical significance of this gene, and to explore its potential as a therapeutic target for various neurological disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.