Details for: UBE2H

Gene ID: 7328

Symbol: UBE2H

Ensembl ID: ENSG00000186591

Description: ubiquitin conjugating enzyme E2 H

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.48
    Marker Score: 61829
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 3.47
    Marker Score: 2994
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 3.4
    Marker Score: 2791
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.31
    Marker Score: 73969
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.98
    Marker Score: 3139
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.97
    Marker Score: 2632
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.97
    Marker Score: 7431
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.97
    Marker Score: 3990
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.86
    Marker Score: 2207
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.72
    Marker Score: 1586
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.72
    Marker Score: 3294
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.71
    Marker Score: 11328
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.57
    Marker Score: 752
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.57
    Marker Score: 741
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.52
    Marker Score: 1715
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.47
    Marker Score: 5426.5
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.45
    Marker Score: 1360
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.41
    Marker Score: 51409
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.41
    Marker Score: 760
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.39
    Marker Score: 2705
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.34
    Marker Score: 1626
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.32
    Marker Score: 2351
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.32
    Marker Score: 1220
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.29
    Marker Score: 45638
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.23
    Marker Score: 75886
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.23
    Marker Score: 84506
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.22
    Marker Score: 17028
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.22
    Marker Score: 9192
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.19
    Marker Score: 2418
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.19
    Marker Score: 3877
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.18
    Marker Score: 32652
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.18
    Marker Score: 80543
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.18
    Marker Score: 1534.5
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.17
    Marker Score: 1266
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.15
    Marker Score: 9958
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.15
    Marker Score: 2470
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.14
    Marker Score: 1251
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.13
    Marker Score: 1677
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 2.13
    Marker Score: 2567
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.13
    Marker Score: 4091
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.12
    Marker Score: 73458
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.11
    Marker Score: 5149
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.09
    Marker Score: 2254
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.08
    Marker Score: 1243
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.07
    Marker Score: 3014
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.07
    Marker Score: 1975
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.06
    Marker Score: 17898
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.05
    Marker Score: 6712
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.03
    Marker Score: 2171
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.02
    Marker Score: 960
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2
    Marker Score: 1118
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2
    Marker Score: 8331.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.98
    Marker Score: 5305
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.97
    Marker Score: 2906
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.94
    Marker Score: 6666
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.93
    Marker Score: 31027
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.93
    Marker Score: 7841
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.92
    Marker Score: 7428
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.91
    Marker Score: 1258
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.91
    Marker Score: 117257
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.91
    Marker Score: 17920
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.89
    Marker Score: 3169
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.87
    Marker Score: 9186.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.86
    Marker Score: 2405
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.85
    Marker Score: 4419
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.84
    Marker Score: 668
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.82
    Marker Score: 578
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.82
    Marker Score: 18811
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.81
    Marker Score: 1918
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.8
    Marker Score: 2546
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.78
    Marker Score: 5078
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.77
    Marker Score: 16823
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.76
    Marker Score: 953.5
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.75
    Marker Score: 680
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.75
    Marker Score: 733
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.75
    Marker Score: 6215.5
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.74
    Marker Score: 2168
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.74
    Marker Score: 899
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.71
    Marker Score: 3905
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.69
    Marker Score: 8879
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.68
    Marker Score: 14433
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.68
    Marker Score: 6603
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.67
    Marker Score: 3178
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.67
    Marker Score: 5927
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.66
    Marker Score: 820
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.65
    Marker Score: 624
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.64
    Marker Score: 4133
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.63
    Marker Score: 1415
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.63
    Marker Score: 2294
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.63
    Marker Score: 515
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.59
    Marker Score: 405
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.57
    Marker Score: 8429
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.54
    Marker Score: 5706
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.54
    Marker Score: 51983
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.53
    Marker Score: 1163.5
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.53
    Marker Score: 1301
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.52
    Marker Score: 1777
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.52
    Marker Score: 307
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.52
    Marker Score: 350
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.52
    Marker Score: 2347

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics:** UBE2H is a member of the ubiquitin-conjugating enzyme family, which is crucial for the ubiquitination process. This process involves the transfer of ubiquitin protein from one molecule to another, leading to protein degradation, modification, or regulation. UBE2H specifically recognizes and conjugates ubiquitin to lysine residues on target proteins, facilitating their degradation by the proteasome. This enzyme is highly expressed in various cell types, including cortical cells of the adrenal gland, taste receptor cells, and cardiac myocytes. **Pathways and Functions:** UBE2H is integral to several key pathways, including: 1. **Adaptive Immune System:** UBE2H plays a crucial role in antigen processing and presentation, where it helps to regulate the ubiquitination and degradation of proteins involved in immune responses. 2. **Antigen Processing:** UBE2H is involved in the ubiquitination and proteasome degradation of antigens, facilitating their presentation to T-cells by MHC class I molecules. 3. **Protein Modification:** UBE2H is a key enzyme in the synthesis of active ubiquitin, which is essential for protein modification and regulation. 4. **Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process:** UBE2H participates in the degradation of proteins by the proteasome, which is a vital process for maintaining protein homeostasis. **Clinical Significance:** UBE2H's role in the adaptive immune system and cellular regulation makes it an important gene for several diseases and conditions. Dysregulation of UBE2H has been implicated in: 1. **Autoimmune Diseases:** UBE2H's involvement in antigen processing and presentation makes it a potential target for autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** Alterations in UBE2H expression and function have been linked to various types of cancer, including breast cancer and colorectal cancer. 3. **Neurodegenerative Diseases:** UBE2H's role in protein modification and regulation makes it a potential target for neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, UBE2H is a crucial gene that plays a significant role in the adaptive immune system and various cellular processes. Its dysregulation has been implicated in several diseases and conditions, highlighting the importance of further research into this gene's functions and clinical significance.

Genular Protein ID: 3504733878

Symbol: UBE2H_HUMAN

Name: Ubiquitin-conjugating enzyme E2 H

UniProtKB Accession Codes:

P62256 A4D1L6 C9JY93 P37286 Q7Z6F4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 10 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8132613

Title: A human ubiquitin-conjugating enzyme homologous to yeast UBC8.

PubMed ID: 8132613

DOI: 10.1016/s0021-9258(17)37039-4

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17588522

Title: E3-independent monoubiquitination of ubiquitin-binding proteins.

PubMed ID: 17588522

DOI: 10.1016/j.molcel.2007.05.014

PubMed ID: 20061386

Title: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

PubMed ID: 20061386

DOI: 10.1074/jbc.m109.089003

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 29911972

Title: The multi-subunit GID/CTLH E3 ligase promotes proliferation and targets the transcription factor Hbp1 for degradation.

PubMed ID: 29911972

DOI: 10.7554/elife.35528

PubMed ID: 22496338

Title: A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.

PubMed ID: 22496338

DOI: 10.1074/mcp.o111.013706

Sequence Information:

  • Length: 183
  • Mass: 20655
  • Checksum: 3DD5D365945F708C
  • Sequence:
    • MSSPSPGKRR MDTDVVKLIE SKHEVTILGG LNEFVVKFYG PQGTPYEGGV WKVRVDLPDK 
YPFKSPSIGF MNKIFHPNID EASGTVCLDV INQTWTALYD LTNIFESFLP QLLAYPNPID 
PLNGDAAAMY LHRPEEYKQK IKEYIQKYAT EEALKEQEEG TGDSSSESSM SDFSEDEAQD 
MEL

Genular Protein ID: 3540953849

Symbol: A0A3B3IU20_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A3B3IU20

Database IDs:

ARBA 7 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 EPD 1 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

Sequence Information:

  • Length: 113
  • Mass: 12859
  • Checksum: BF298CFBCE558909
  • Sequence:
    • MNKIFHPNID EASGTVCLDV INQTWTALYD LTNIFESFLP QLLAYPNPID PLNGDAAAMY 
LHRPEEYKQK IKEYIQKYAT EEALKEQEEG TGDSSSESSM SDFSEDEAQD MEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.