Details for: TAF15

Gene ID: 8148

Symbol: TAF15

Ensembl ID: ENSG00000270647

Description: TATA-box binding protein associated factor 15

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 5.63
    Marker Score: 74927
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 4.47
    Marker Score: 12630
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 4.23
    Marker Score: 8756
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 4.01
    Marker Score: 1945
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.21
    Marker Score: 6184
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 3.13
    Marker Score: 1897
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.87
    Marker Score: 3251
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.59
    Marker Score: 2794
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.58
    Marker Score: 2735
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.49
    Marker Score: 6275
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.44
    Marker Score: 5363
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.35
    Marker Score: 3891
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.3
    Marker Score: 49180
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.25
    Marker Score: 9435
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.25
    Marker Score: 1586
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.23
    Marker Score: 1981
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 2.23
    Marker Score: 902
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.2
    Marker Score: 1149
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.18
    Marker Score: 82710
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.17
    Marker Score: 48525
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.17
    Marker Score: 634
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.17
    Marker Score: 7711
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.17
    Marker Score: 1262
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.16
    Marker Score: 2694
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.15
    Marker Score: 42730
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.13
    Marker Score: 676
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.13
    Marker Score: 31847
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.13
    Marker Score: 1478
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.09
    Marker Score: 2531
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.07
    Marker Score: 15885
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.07
    Marker Score: 2289
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.06
    Marker Score: 1837
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.06
    Marker Score: 75864
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.05
    Marker Score: 2754
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.05
    Marker Score: 1144
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.03
    Marker Score: 9385
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.02
    Marker Score: 2858.5
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.01
    Marker Score: 8341
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.01
    Marker Score: 1345.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.99
    Marker Score: 7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.97
    Marker Score: 1155
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.97
    Marker Score: 1177
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.96
    Marker Score: 822
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.95
    Marker Score: 18337
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.94
    Marker Score: 1278
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.93
    Marker Score: 22414
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9
    Marker Score: 117090
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.89
    Marker Score: 2723
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.89
    Marker Score: 2180
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.89
    Marker Score: 692
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.89
    Marker Score: 711
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.87
    Marker Score: 1228
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.86
    Marker Score: 474
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.84
    Marker Score: 637
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.81
    Marker Score: 571.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.8
    Marker Score: 17062
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.78
    Marker Score: 644.5
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.77
    Marker Score: 960
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.75
    Marker Score: 15011
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.75
    Marker Score: 503
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.74
    Marker Score: 3117
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.72
    Marker Score: 634
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.71
    Marker Score: 1801
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.7
    Marker Score: 2796
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.7
    Marker Score: 2910
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.69
    Marker Score: 4596
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.67
    Marker Score: 830
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.66
    Marker Score: 1783
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.66
    Marker Score: 3249
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.66
    Marker Score: 4916
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.65
    Marker Score: 7095
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.65
    Marker Score: 1196
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 1.65
    Marker Score: 486
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.64
    Marker Score: 613.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.63
    Marker Score: 2047
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.63
    Marker Score: 1728
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.62
    Marker Score: 906
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.62
    Marker Score: 4547
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.6
    Marker Score: 6654
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.6
    Marker Score: 1544
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.59
    Marker Score: 1517
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.58
    Marker Score: 888
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.58
    Marker Score: 538
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.58
    Marker Score: 1238
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.57
    Marker Score: 453
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.57
    Marker Score: 1073
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.57
    Marker Score: 2312
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.57
    Marker Score: 1043
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.57
    Marker Score: 1142
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.55
    Marker Score: 424
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.55
    Marker Score: 4896.5
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.54
    Marker Score: 4404
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.54
    Marker Score: 812
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.53
    Marker Score: 659
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.52
    Marker Score: 4150
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.52
    Marker Score: 2151
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.52
    Marker Score: 1591
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.52
    Marker Score: 80321
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.5
    Marker Score: 359
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.5
    Marker Score: 2308

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Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** TAF15 is a transcriptional regulator that interacts with TBP to facilitate the recruitment of RNA polymerase II to the promoter region of target genes. 2. **HIV Infection:** TAF15 has been shown to be specifically involved in the regulation of HIV transcription, suggesting its potential as a therapeutic target for HIV infection. 3. **Cell Type-Specific Expression:** TAF15 is highly expressed in various cell types, including cardiac muscle cells, tracheal goblet cells, and kidney epithelial cells, indicating its widespread role in maintaining cellular homeostasis. 4. **Metal Ion Binding:** TAF15 has been shown to bind to metal ions, which may play a role in its transcriptional regulatory function. **Pathways and Functions:** 1. **Generic Transcription Pathway:** TAF15 is involved in the generic transcription pathway, which is essential for the regulation of gene expression in eukaryotic cells. 2. **HIV Transcription Initiation:** TAF15 plays a crucial role in the regulation of HIV transcription, particularly in the context of HIV infection. 3. **Transcriptional Regulation by TP53:** TAF15 has been shown to interact with TP53, a tumor suppressor protein, to regulate its activity and promote transcriptional regulation. 4. **RNA Polymerase II Transcription:** TAF15 interacts with RNA polymerase II to facilitate the initiation of transcription, and its dysregulation may lead to impaired transcriptional regulation. **Clinical Significance:** 1. **HIV Infection:** TAF15 may serve as a potential therapeutic target for HIV infection, particularly in the context of HIV transcriptional regulation. 2. **Cancer:** TAF15 has been shown to interact with TP53, which is a tumor suppressor protein, and its dysregulation may contribute to cancer development. 3. **Cardiovascular Disease:** TAF15 is highly expressed in cardiac muscle cells, and its dysregulation may contribute to cardiovascular disease. 4. **Respiratory Disease:** TAF15 is highly expressed in tracheal goblet cells, and its dysregulation may contribute to respiratory disease. In conclusion, TAF15 is a crucial regulator of transcription and a key player in HIV infection. Its dysregulation may contribute to various diseases, including HIV infection, cancer, cardiovascular disease, and respiratory disease. Further research is needed to fully understand the role of TAF15 in these diseases and to explore its potential as a therapeutic target.

Genular Protein ID: 1718774152

Symbol: RBP56_HUMAN

Name: TATA-binding protein-associated factor 2N

UniProtKB Accession Codes:

Q92804 B2R837 Q86X94 Q92751

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 11 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 9 RefSeq 2 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8954779

Title: Cloning and mapping of a human RBP56 gene encoding a putative RNA binding protein similar to FUS/TLS and EWS proteins.

PubMed ID: 8954779

DOI: 10.1006/geno.1996.0591

PubMed ID: 8890175

Title: hTAF(II)68, a novel RNA/ssDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II.

PubMed ID: 8890175

DOI: 10.1002/j.1460-2075.1996.tb00882.x

PubMed ID: 9795213

Title: Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes.

PubMed ID: 9795213

DOI: 10.1016/s0378-1119(98)00463-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9660765

Title: The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription.

PubMed ID: 9660765

DOI: 10.1074/jbc.273.29.18086

PubMed ID: 10602519

Title: Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11).

PubMed ID: 10602519

DOI: 10.1038/sj.onc.1203155

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19124016

Title: PRMT1 mediated methylation of TAF15 is required for its positive gene regulatory function.

PubMed ID: 19124016

DOI: 10.1016/j.yexcr.2008.12.008

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24055347

Title: Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses.

PubMed ID: 24055347

DOI: 10.1016/j.molcel.2013.08.026

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 592
  • Mass: 61830
  • Checksum: 73D37C171E1E2BCA
  • Sequence:
    • MSDSGSYGQS GGEQQSYSTY GNPGSQGYGQ ASQSYSGYGQ TTDSSYGQNY SGYSSYGQSQ 
SGYSQSYGGY ENQKQSSYSQ QPYNNQGQQQ NMESSGSQGG RAPSYDQPDY GQQDSYDQQS 
GYDQHQGSYD EQSNYDQQHD SYSQNQQSYH SQRENYSHHT QDDRRDVSRY GEDNRGYGGS 
QGGGRGRGGY DKDGRGPMTG SSGGDRGGFK NFGGHRDYGP RTDADSESDN SDNNTIFVQG 
LGEGVSTDQV GEFFKQIGII KTNKKTGKPM INLYTDKDTG KPKGEATVSF DDPPSAKAAI 
DWFDGKEFHG NIIKVSFATR RPEFMRGGGS GGGRRGRGGY RGRGGFQGRG GDPKSGDWVC 
PNPSCGNMNF ARRNSCNQCN EPRPEDSRPS GGDFRGRGYG GERGYRGRGG RGGDRGGYGG 
DRSGGGYGGD RSSGGGYSGD RSGGGYGGDR SGGGYGGDRG GGYGGDRGGG YGGDRGGGYG 
GDRGGYGGDR GGGYGGDRGG YGGDRGGYGG DRGGYGGDRG GYGGDRSRGG YGGDRGGGSG 
YGGDRSGGYG GDRSGGGYGG DRGGGYGGDR GGYGGKMGGR NDYRNDQRNR PY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.