Details for: RPL23AP3

Gene ID: 8489

Symbol: RPL23AP3

Ensembl ID: ENSG00000214914

Description: ribosomal protein L23a pseudogene 3

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.5888
    Cell Significance Index: 4.5300
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.2164
    Cell Significance Index: 2.6100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.1357
    Cell Significance Index: 2.3400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1141
    Cell Significance Index: 1.8100
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.1107
    Cell Significance Index: 1.3900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0669
    Cell Significance Index: 1.6700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0447
    Cell Significance Index: 0.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0146
    Cell Significance Index: 2.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0056
    Cell Significance Index: 0.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0015
    Cell Significance Index: -2.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0020
    Cell Significance Index: -3.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0022
    Cell Significance Index: -3.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0038
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0065
    Cell Significance Index: -0.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0065
    Cell Significance Index: -2.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0092
    Cell Significance Index: -0.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0116
    Cell Significance Index: -1.6900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0356
    Cell Significance Index: -0.7800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0447
    Cell Significance Index: -0.6600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0450
    Cell Significance Index: -1.5800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0465
    Cell Significance Index: -1.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0472
    Cell Significance Index: -1.5500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0599
    Cell Significance Index: -1.5000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0622
    Cell Significance Index: -1.3200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0659
    Cell Significance Index: -1.9400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0660
    Cell Significance Index: -1.4300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0682
    Cell Significance Index: -1.3700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0703
    Cell Significance Index: -1.3900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0712
    Cell Significance Index: -0.9200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0717
    Cell Significance Index: -1.0200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0734
    Cell Significance Index: -0.7600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0734
    Cell Significance Index: -0.9500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0761
    Cell Significance Index: -1.3000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0769
    Cell Significance Index: -1.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0777
    Cell Significance Index: -1.0600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0793
    Cell Significance Index: -1.5600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0797
    Cell Significance Index: -1.5900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0888
    Cell Significance Index: -1.5400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0914
    Cell Significance Index: -2.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0929
    Cell Significance Index: -2.5300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0951
    Cell Significance Index: -1.0100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0957
    Cell Significance Index: -1.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0963
    Cell Significance Index: -1.6500
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1067
    Cell Significance Index: -1.2400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1090
    Cell Significance Index: -1.1500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1116
    Cell Significance Index: -1.1400
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.1123
    Cell Significance Index: -1.0100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1147
    Cell Significance Index: -1.1100
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.1187
    Cell Significance Index: -1.5200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1203
    Cell Significance Index: -1.4000
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1244
    Cell Significance Index: -1.7200
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1275
    Cell Significance Index: -1.1800
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1283
    Cell Significance Index: -1.6800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1287
    Cell Significance Index: -1.4500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1311
    Cell Significance Index: -1.3300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1318
    Cell Significance Index: -1.8100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1368
    Cell Significance Index: -1.4900
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.1374
    Cell Significance Index: -1.4400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1384
    Cell Significance Index: -1.4500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1385
    Cell Significance Index: -1.7300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1460
    Cell Significance Index: -1.6800
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1473
    Cell Significance Index: -1.4200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1477
    Cell Significance Index: -1.4400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1513
    Cell Significance Index: -1.8000
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.1524
    Cell Significance Index: -2.1400
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.1532
    Cell Significance Index: -1.7400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1535
    Cell Significance Index: -2.0400
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.1540
    Cell Significance Index: -1.7100
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.1547
    Cell Significance Index: -1.8700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.1547
    Cell Significance Index: -1.8500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1578
    Cell Significance Index: -1.9400
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.1607
    Cell Significance Index: -1.8300
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1624
    Cell Significance Index: -1.9300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.1626
    Cell Significance Index: -1.8900
  • Cell Name: serous cell of epithelium of trachea (CL1000330)
    Fold Change: -0.1636
    Cell Significance Index: -1.2600
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.1640
    Cell Significance Index: -1.9700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1644
    Cell Significance Index: -2.0800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1649
    Cell Significance Index: -2.1700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1674
    Cell Significance Index: -1.8700
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.1686
    Cell Significance Index: -1.8300
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1690
    Cell Significance Index: -1.9200
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.1693
    Cell Significance Index: -1.9600
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1695
    Cell Significance Index: -1.5300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1711
    Cell Significance Index: -2.0400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1718
    Cell Significance Index: -1.4500
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.1726
    Cell Significance Index: -1.9200
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.1732
    Cell Significance Index: -1.2900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1749
    Cell Significance Index: -1.8100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1751
    Cell Significance Index: -2.1300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1760
    Cell Significance Index: -2.1100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1763
    Cell Significance Index: -1.8000
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1769
    Cell Significance Index: -2.1500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1777
    Cell Significance Index: -2.1000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1779
    Cell Significance Index: -1.6700
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.1779
    Cell Significance Index: -1.7400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1783
    Cell Significance Index: -1.9800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1805
    Cell Significance Index: -1.5900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1837
    Cell Significance Index: -2.1700
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.1840
    Cell Significance Index: -2.1900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1846
    Cell Significance Index: -2.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RPL23AP3 is a pseudogene, meaning it is a non-functional copy of a gene that has evolved to be non-coding and non-expressing. Despite this, it exhibits significant expression in a wide range of cell types, including plasma cells, CD4+ and CD8+ T cells, alpha-beta thymocytes, choroid plexus epithelial cells, hematopoietic stem cells, malignant cells, mesenchymal stem cells, adventitial cells, epithelial cells, and skeletal muscle satellite stem cells. This ubiquitous expression suggests that RPL23AP3 may play a role in regulating cellular processes, although its exact function remains unclear. **Pathways and Functions:** The functional significance of RPL23AP3 is multifaceted, and its role in various cellular pathways is an area of active research. Some potential pathways and functions of RPL23AP3 include: 1. **Ribosome biogenesis and translation regulation**: As a pseudogene, RPL23AP3 may influence ribosome biogenesis and translation regulation, potentially affecting protein synthesis and cellular growth. 2. **Immune cell development and function**: RPL23AP3 expression in immune cells, such as CD4+ and CD8+ T cells, suggests a role in immune cell development and function, possibly influencing T cell differentiation, proliferation, and cytokine production. 3. **Stem cell maintenance and proliferation**: RPL23AP3 expression in hematopoietic stem cells and mesenchymal stem cells implies a potential role in maintaining stem cell pluripotency, self-renewal, and differentiation. 4. **Cellular stress response and apoptosis**: The presence of RPL23AP3 in malignant cells and cells undergoing apoptosis suggests that it may be involved in regulating cellular stress responses and programmed cell death. **Clinical Significance:** The clinical significance of RPL23AP3 is an area of ongoing research, and its implications for human disease are still being explored. Some potential clinical applications and implications of RPL23AP3 include: 1. **Cancer research**: RPL23AP3 expression in malignant cells suggests that it may be a useful biomarker for cancer diagnosis or a target for cancer therapy. 2. **Immunotherapy**: RPL23AP3's role in immune cell development and function implies that it may be a useful target for immunotherapeutic interventions, such as T cell activation or modulation. 3. **Stem cell transplantation**: RPL23AP3 expression in hematopoietic stem cells and mesenchymal stem cells suggests that it may be involved in stem cell maintenance and proliferation, potentially influencing the success of stem cell transplantation therapies. In conclusion, RPL23AP3 is a complex pseudogene with widespread expression in various cell types, suggesting a multifaceted role in cellular processes. Further research is needed to elucidate the functional significance of RPL23AP3 and its clinical implications, but its potential applications in cancer research, immunotherapy, and stem cell transplantation therapies hold promise for advancing our understanding of human disease and developing novel therapeutic strategies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.