Details for: SIGLEC5

Gene ID: 8778

Symbol: SIGLEC5

Ensembl ID: ENSG00000268500

Description: sialic acid binding Ig like lectin 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 4.0615
    Cell Significance Index: -1.6500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.8814
    Cell Significance Index: 12.8900
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.6276
    Cell Significance Index: 7.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.5377
    Cell Significance Index: 7.7000
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.2429
    Cell Significance Index: 2.1400
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.1012
    Cell Significance Index: 0.8200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0772
    Cell Significance Index: 0.9200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0718
    Cell Significance Index: 0.8700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0035
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0059
    Cell Significance Index: -1.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0087
    Cell Significance Index: -1.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0116
    Cell Significance Index: -2.3300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0144
    Cell Significance Index: -0.1800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0190
    Cell Significance Index: -0.9900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0238
    Cell Significance Index: -0.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0239
    Cell Significance Index: -1.4700
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0327
    Cell Significance Index: -0.4100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0400
    Cell Significance Index: -0.9700
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0464
    Cell Significance Index: -0.5600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0489
    Cell Significance Index: -0.6500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0496
    Cell Significance Index: -0.9700
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0539
    Cell Significance Index: -0.6200
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0550
    Cell Significance Index: -0.5700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0585
    Cell Significance Index: -1.0000
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0593
    Cell Significance Index: -0.7400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0600
    Cell Significance Index: -1.4400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0632
    Cell Significance Index: -0.7900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0637
    Cell Significance Index: -0.9400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0645
    Cell Significance Index: -0.8700
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0677
    Cell Significance Index: -0.8500
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0728
    Cell Significance Index: -0.9700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0729
    Cell Significance Index: -1.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0736
    Cell Significance Index: -2.4100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0759
    Cell Significance Index: -1.6100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0780
    Cell Significance Index: -1.0000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0796
    Cell Significance Index: -0.9400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0800
    Cell Significance Index: -0.9200
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0804
    Cell Significance Index: -0.8700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0808
    Cell Significance Index: -0.8800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0813
    Cell Significance Index: -0.8300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0814
    Cell Significance Index: -0.9900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0816
    Cell Significance Index: -2.6000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0838
    Cell Significance Index: -1.8100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0843
    Cell Significance Index: -1.1000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0848
    Cell Significance Index: -0.7900
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0854
    Cell Significance Index: -1.0200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0883
    Cell Significance Index: -1.7600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0885
    Cell Significance Index: -0.9800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0897
    Cell Significance Index: -1.8000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0898
    Cell Significance Index: -1.0200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0914
    Cell Significance Index: -1.0800
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0920
    Cell Significance Index: -1.0100
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0920
    Cell Significance Index: -0.9900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0933
    Cell Significance Index: -0.7700
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0939
    Cell Significance Index: -0.9900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0953
    Cell Significance Index: -3.3400
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0955
    Cell Significance Index: -1.0200
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0964
    Cell Significance Index: -1.0300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0990
    Cell Significance Index: -1.0000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0993
    Cell Significance Index: -1.1000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0993
    Cell Significance Index: -1.0000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1002
    Cell Significance Index: -2.5000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1023
    Cell Significance Index: -0.9600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1024
    Cell Significance Index: -1.2100
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1024
    Cell Significance Index: -1.1100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1042
    Cell Significance Index: -2.0500
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1045
    Cell Significance Index: -1.1000
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.1047
    Cell Significance Index: -0.9200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1052
    Cell Significance Index: -1.3800
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1090
    Cell Significance Index: -1.1600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1092
    Cell Significance Index: -2.1600
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1093
    Cell Significance Index: -1.0000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1096
    Cell Significance Index: -1.2300
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1100
    Cell Significance Index: -0.9800
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1118
    Cell Significance Index: -0.8600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1119
    Cell Significance Index: -1.3600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1132
    Cell Significance Index: -0.9900
  • Cell Name: CD14-positive, CD16-low monocyte (CL0001055)
    Fold Change: -0.1154
    Cell Significance Index: -1.1100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1159
    Cell Significance Index: -1.0000
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.1159
    Cell Significance Index: -1.0100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1178
    Cell Significance Index: -1.5500
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: -0.1239
    Cell Significance Index: -1.1100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1241
    Cell Significance Index: -1.4400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1246
    Cell Significance Index: -2.6000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1285
    Cell Significance Index: -1.0000
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: -0.1295
    Cell Significance Index: -1.0000
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1330
    Cell Significance Index: -1.1000
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.1330
    Cell Significance Index: -1.4200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1334
    Cell Significance Index: -1.5500
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.1409
    Cell Significance Index: -1.6100
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.1424
    Cell Significance Index: -1.5700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1443
    Cell Significance Index: -1.7000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1473
    Cell Significance Index: -1.8100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1487
    Cell Significance Index: -1.4100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1505
    Cell Significance Index: -1.6400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1509
    Cell Significance Index: -1.8100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1510
    Cell Significance Index: -2.6100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1561
    Cell Significance Index: -1.4600
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.1635
    Cell Significance Index: -1.6000
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.1653
    Cell Significance Index: -1.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Sialic acid binding:** SIGLEC5 recognizes and binds to sialic acid-containing molecules, such as sialyl Lewis X and sialyloligosaccharides, which are present on the surface of various cells, including immune cells and tumor cells. 2. **Cell surface localization:** SIGLEC5 is primarily expressed on the surface of myeloid cells, which are key players in the innate immune response. It is also found on some lymphoid cells, suggesting a role in regulating interactions between immune cells and non-immune cells. 3. **Lectin-like structure:** SIGLEC5 belongs to the Ig-like lectin family, which shares structural similarities with immunoglobulins. This suggests that SIGLEC5 may have evolved from a common ancestor with immunoglobulins and has retained some of its functional properties. 4. **Regulation of immune responses:** SIGLEC5 has been implicated in regulating immune responses, including the activation of neutrophils, the regulation of cell adhesion, and the modulation of immune cell interactions. **Pathways and Functions:** 1. **Innate immune response:** SIGLEC5 is involved in the recognition and binding to sialic acid-containing molecules on the surface of pathogen-associated molecular patterns (PAMPs), which triggers the activation of innate immune cells, such as neutrophils and macrophages. 2. **Cell adhesion:** SIGLEC5 interacts with sialic acid-containing molecules on the surface of other cells, regulating cell adhesion and migration, which is essential for immune cell trafficking and tissue homing. 3. **Neutrophil degranulation:** SIGLEC5 has been shown to regulate the degranulation of neutrophils, which is a key mechanism of immune defense against pathogens. 4. **Immunoregulatory interactions:** SIGLEC5 interacts with other immune cells, such as dendritic cells and T cells, regulating the activation and function of these cells, which is essential for maintaining immune homeostasis. **Clinical Significance:** 1. **Cancer:** SIGLEC5 has been implicated in the progression of various cancers, including leukemia, lymphoma, and solid tumors. Its expression on tumor cells and immune cells suggests a potential role in cancer immunotherapy. 2. **Autoimmune diseases:** SIGLEC5 may play a role in the regulation of immune responses in autoimmune diseases, such as rheumatoid arthritis and lupus. Its dysregulation may contribute to disease pathogenesis. 3. **Immunodeficiency disorders:** SIGLEC5 may be involved in the regulation of immune responses in immunodeficiency disorders, such as chronic inflammatory diseases and cancer. 4. **Vaccine development:** SIGLEC5's role in regulating immune responses makes it an attractive target for vaccine development, particularly for cancer and infectious disease vaccines. In conclusion, SIGLEC5 is a multifunctional protein that plays a crucial role in regulating immune responses, including the recognition of pathogens, cell adhesion, and immunoregulatory interactions. Its dysregulation may contribute to various diseases, making it an attractive target for therapeutic applications and vaccine development.

Genular Protein ID: 1654305820

Symbol: SIGL5_HUMAN

Name: Sialic acid-binding Ig-like lectin 5

UniProtKB Accession Codes:

O15389

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 3 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9731071

Title: Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33.

PubMed ID: 9731071

PubMed ID: 10428856

Title: OB-BP1/Siglec-6. A leptin- and sialic acid-binding protein of the immunoglobulin superfamily.

PubMed ID: 10428856

DOI: 10.1074/jbc.274.32.22729

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18022638

Title: Structural implications of Siglec-5-mediated sialoglycan recognition.

PubMed ID: 18022638

DOI: 10.1016/j.jmb.2007.10.009

Sequence Information:

  • Length: 551
  • Mass: 60715
  • Checksum: 2FEA2B6B341EFEAF
  • Sequence:
    • MLPLLLLPLL WGGSLQEKPV YELQVQKSVT VQEGLCVLVP CSFSYPWRSW YSSPPLYVYW 
FRDGEIPYYA EVVATNNPDR RVKPETQGRF RLLGDVQKKN CSLSIGDARM EDTGSYFFRV 
ERGRDVKYSY QQNKLNLEVT ALIEKPDIHF LEPLESGRPT RLSCSLPGSC EAGPPLTFSW 
TGNALSPLDP ETTRSSELTL TPRPEDHGTN LTCQMKRQGA QVTTERTVQL NVSYAPQTIT 
IFRNGIALEI LQNTSYLPVL EGQALRLLCD APSNPPAHLS WFQGSPALNA TPISNTGILE 
LRRVRSAEEG GFTCRAQHPL GFLQIFLNLS VYSLPQLLGP SCSWEAEGLH CRCSFRARPA 
PSLCWRLEEK PLEGNSSQGS FKVNSSSAGP WANSSLILHG GLSSDLKVSC KAWNIYGSQS 
GSVLLLQGRS NLGTGVVPAA LGGAGVMALL CICLCLIFFL IVKARRKQAA GRPEKMDDED 
PIMGTITSGS RKKPWPDSPG DQASPPGDAP PLEEQKELHY ASLSFSEMKS REPKDQEAPS 
TTEYSEIKTS K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.