Details for: GPR52

Gene ID: 9293

Symbol: GPR52

Ensembl ID: ENSG00000203737

Description: G protein-coupled receptor 52

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.33
    Marker Score: 2,344
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1,180
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.62
    Marker Score: 10,755
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.39
    Marker Score: 879
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.28
    Marker Score: 864
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,583
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,660
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.19
    Marker Score: 493
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.11
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,736
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 515
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,843
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,068
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 468
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,404
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.95
    Marker Score: 379
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,340
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 331
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.88
    Marker Score: 465
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.85
    Marker Score: 13,350
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 630
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 740
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.79
    Marker Score: 3,296
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1,237
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 468
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.73
    Marker Score: 1,385
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.53
    Marker Score: 1,087
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.42
    Marker Score: 253
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.36
    Marker Score: 238
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.33
    Marker Score: 189
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3
    Marker Score: 1,815
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.22
    Marker Score: 211
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.2
    Marker Score: 97
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.19
    Marker Score: 60
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.16
    Marker Score: 376
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.15
    Marker Score: 66
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.15
    Marker Score: 91
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.13
    Marker Score: 78
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.11
    Marker Score: 131
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.09
    Marker Score: 194
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.09
    Marker Score: 747
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.07
    Marker Score: 129
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.07
    Marker Score: 39
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.07
    Marker Score: 103
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.06
    Marker Score: 61
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.06
    Marker Score: 44
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.05
    Marker Score: 3,135
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.05
    Marker Score: 53
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.05
    Marker Score: 1,776
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.05
    Marker Score: 175
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.04
    Marker Score: 323
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.04
    Marker Score: 1,546
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.04
    Marker Score: 39
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.04
    Marker Score: 37
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.04
    Marker Score: 32
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.04
    Marker Score: 35
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.03
    Marker Score: 46
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.03
    Marker Score: 320
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.03
    Marker Score: 293
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.03
    Marker Score: 267
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.03
    Marker Score: 421
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.03
    Marker Score: 114
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.02
    Marker Score: 36
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.02
    Marker Score: 29
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.02
    Marker Score: 38
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.02
    Marker Score: 7

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **G Protein-Coupled Receptor (GPCR) Structure**: GPR52 belongs to the GPCR family, which is characterized by a seven-transmembrane domain structure. This structure allows for the receptor to interact with various ligands, including light, and initiate downstream signaling cascades. 2. **Light-Responsive Function**: GPR52 has been shown to be responsive to light, particularly in the context of phototransduction. This response is mediated through the activation of G-proteins, which in turn modulate downstream signaling pathways. 3. **Tissue-Specific Expression**: GPR52 is expressed in multiple cell types, including blood vessel endothelial cells, colon goblet cells, and granulocyte monocyte progenitor cells. This tissue-specific expression suggests a role in regulating immune responses and modulating cellular behavior. 4. **Association with Neoplastic Cells**: GPR52 has been found to be overexpressed in neoplastic cells, suggesting its potential as a biomarker for cancer diagnosis and treatment. **Pathways and Functions:** 1. **Phototransduction Pathway**: GPR52 plays a crucial role in the phototransduction pathway, which is responsible for converting light into electrical signals in the retina. Activation of GPR52 by light triggers the activation of G-proteins, which modulate downstream signaling pathways. 2. **G Protein-Coupled Receptor Signaling Pathway**: GPR52 is involved in the G protein-coupled receptor signaling pathway, which is a key player in regulating various cellular processes, including immune responses, cell proliferation, and differentiation. 3. **Xenobiotic Response Pathway**: GPR52 has been shown to be involved in the xenobiotic response pathway, which is responsible for regulating the body's response to toxic substances. Activation of GPR52 by xenobiotics triggers the activation of G-proteins, which modulate downstream signaling pathways. 4. **Immune Response Regulation**: GPR52 has been found to be expressed in immune cells, including granulocyte monocyte progenitor cells, suggesting its potential role in regulating immune responses. **Clinical Significance:** 1. **Cancer Diagnosis and Treatment**: GPR52 has been found to be overexpressed in neoplastic cells, suggesting its potential as a biomarker for cancer diagnosis and treatment. 2. **Immunological Disorders**: GPR52's involvement in regulating immune responses and modulating cellular behavior suggests its potential role in the development of immunological disorders, such as autoimmune diseases and immunodeficiency disorders. 3. **Photoreceptor Diseases**: GPR52's role in phototransduction suggests its potential involvement in photoreceptor diseases, such as retinitis pigmentosa and macular degeneration. 4. **Xenobiotic-Induced Toxicity**: GPR52's involvement in the xenobiotic response pathway suggests its potential role in regulating the body's response to toxic substances, which could have implications for the development of therapeutic strategies for xenobiotic-induced toxicity. In conclusion, GPR52 is a novel gene that has been found to be involved in various cellular processes, including phototransduction, immune response regulation, and xenobiotic response. Its clinical significance is multifaceted, with potential applications in cancer diagnosis and treatment, immunological disorder diagnosis and treatment, photoreceptor disease diagnosis and treatment, and xenobiotic-induced toxicity diagnosis and treatment. Further research is needed to fully elucidate the role of GPR52 in these processes and to explore its therapeutic potential.

Genular Protein ID: 2521839393

Symbol: GPR52_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y2T5 O75654 Q4VBL6 Q6ISM0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 2 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 5 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9931487

Title: Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain.

PubMed ID: 9931487

DOI: 10.1016/s0169-328x(98)00277-0

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24587241

Title: Anatomical transcriptome of G protein-coupled receptors leads to the identification of a novel therapeutic candidate GPR52 for psychiatric disorders.

PubMed ID: 24587241

DOI: 10.1371/journal.pone.0090134

PubMed ID: 25738228

Title: A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity.

PubMed ID: 25738228

DOI: 10.7554/elife.05449

Sequence Information:

  • Length: 361
  • Mass: 41354
  • Checksum: 4888D58CEBB2D725
  • Sequence:
    • MNESRWTEWR ILNMSSGIVN VSERHSCPLG FGHYSVVDVC IFETVVIVLL TFLIIAGNLT 
VIFVFHCAPL LHHYTTSYFI QTMAYADLFV GVSCLVPTLS LLHYSTGVHE SLTCQVFGYI 
ISVLKSVSMA CLACISVDRY LAITKPLSYN QLVTPCRLRI CIILIWIYSC LIFLPSFFGW 
GKPGYHGDIF EWCATSWLTS AYFTGFIVCL LYAPAAFVVC FTYFHIFKIC RQHTKEINDR 
RARFPSHEVD SSRETGHSPD RRYAMVLFRI TSVFYMLWLP YIIYFLLESS RVLDNPTLSF 
LTTWLAISNS FCNCVIYSLS NSVFRLGLRR LSETMCTSCM CVKDQEAQEP KPRKRANSCS 
I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.