Details for: NOS1AP
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 39.85rCSI 54.53%PRS 88.74
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CSI 32.93rCSI 55.27%PRS 85.65
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CSI 32.76rCSI 42.24%PRS 86.41
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CSI 22.67rCSI 55.11%PRS 83.54
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CSI 18.89rCSI 33.8%PRS 92.89
-
CSI 18.61rCSI 58.17%PRS 86.47
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CSI 18.06rCSI 38.4%PRS 88.85
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CSI 17.43rCSI 54.51%PRS 88
-
CSI 17.36rCSI 20.73%PRS 85.49
-
CSI 16.94rCSI 27.24%PRS 86.39
-
CSI 16.19rCSI 58.27%PRS 83.8
-
CSI 15.39rCSI 17.77%PRS 88.35
-
CSI 15.01rCSI 37.15%PRS 95.64
-
CSI 14.57rCSI 47.9%PRS 85.49
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CSI 12.76rCSI 33.14%PRS 93.93
-
CSI 12.76rCSI 15.87%PRS 83.35
-
CSI 11.3rCSI 44.18%PRS 82.79
-
CSI 10.89rCSI 20.39%PRS 88.46
-
CSI 10.62rCSI 40.12%PRS 85.59
-
CSI 10.57rCSI 25.28%PRS 86.63
-
CSI 10.42rCSI 23.79%PRS 89.75
-
CSI 10.34rCSI 18.26%PRS 84.95
-
CSI 10.26rCSI 16.37%PRS 88.61
-
CSI 9.93rCSI 25.66%PRS 92.81
-
CSI 9.8rCSI 15.77%PRS 88.26
-
CSI 9.74rCSI 15.1%PRS 94.74
-
CSI 9.57rCSI 20.76%PRS 85.4
-
CSI 9.53rCSI 19.33%PRS 80.26
-
CSI 9.45rCSI 55.63%PRS 85.84
-
CSI 9.21rCSI 20.64%PRS 85.67
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CSI 9.15rCSI 13.39%PRS 96.62
-
CSI 8.34rCSI 32.44%PRS 91.2
-
CSI 8rCSI 21.3%PRS 84.46
-
CSI 7.89rCSI 12.92%PRS 89.43
-
CSI 7.76rCSI 17.92%PRS 87.83
-
CSI 7.76rCSI 19.67%PRS 90.69
-
CSI 7.71rCSI 20.12%PRS 90.66
-
CSI 7.12rCSI 7.63%PRS 95.2
-
CSI 6.76rCSI 13.57%PRS 90.32
-
CSI 6.72rCSI 6.48%PRS 91.85
-
CSI 6.71rCSI 25.15%PRS 91.84
-
CSI 6.3rCSI 8.59%PRS 89.61
-
CSI 6.29rCSI 23.74%PRS 83.17
-
CSI 6.22rCSI 8.93%PRS 88.21
-
CSI 5.87rCSI 12.97%PRS 86.82
-
CSI 5.71rCSI 9.87%PRS 91.03
-
CSI 5.48rCSI 22.32%PRS 88.61
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CSI 5.47rCSI 14.24%PRS 89.57
-
CSI 5.45rCSI 17.54%PRS 91.4
-
CSI 5.45rCSI 23.97%PRS 85.54
-
CSI 5.43rCSI 26%PRS 91.95
-
CSI 5.27rCSI 26.2%PRS 90.09
-
CSI 5.21rCSI 38.28%PRS 88.86
-
CSI 4.88rCSI 11.93%PRS 89.57
-
CSI 4.87rCSI 5.08%PRS 93.64
-
CSI 4.8rCSI 24.16%PRS 90.91
-
CSI 4.79rCSI 29.94%PRS 89.6
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CSI 4.68rCSI 10.97%PRS 91.51
-
CSI 4.6rCSI 20.43%PRS 94.35
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CSI 4.38rCSI 6.47%PRS 94.87
-
CSI 4.35rCSI 24.56%PRS 86.39
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CSI 4.2rCSI 6.4%PRS 92
-
CSI 4.14rCSI 12.3%PRS 97.56
-
CSI 3.91rCSI 11.33%PRS 88.16
-
CSI 3.79rCSI 5.38%PRS 93.1
-
CSI 3.78rCSI 9.72%PRS 91.06
-
CSI 3.74rCSI 2.9%PRS 96.07
-
CSI 3.67rCSI 5.6%PRS 93.5
-
CSI 3.54rCSI 5.21%PRS 90.83
-
CSI 3.43rCSI 2.71%PRS 89.73
-
CSI 3.38rCSI 11.57%PRS 84.45
-
CSI 3.35rCSI 4.48%PRS 92.11
-
CSI 3.34rCSI 7.64%PRS 95.32
-
CSI 3.33rCSI 8.9%PRS 90.98
-
CSI 3.33rCSI 7.93%PRS 94.77
-
CSI 3.29rCSI 4.4%PRS 96.18
-
CSI 3.22rCSI 6.63%PRS 85.05
-
CSI 3.17rCSI 5.56%PRS 92.37
-
CSI 3.15rCSI 19.7%PRS 78.25
-
CSI 3.09rCSI 3.84%PRS 93.8
-
CSI 3.05rCSI 21.8%PRS 91.2
-
CSI 3.03rCSI 8.16%PRS 95.43
-
CSI 2.94rCSI 4.49%PRS 95.21
-
CSI 2.93rCSI 16.88%PRS 92.35
-
CSI 2.87rCSI 9.62%PRS 83.93
-
CSI 2.64rCSI 23.25%PRS 84.78
-
CSI 2.51rCSI 21.65%PRS 90.4
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CSI 2.42rCSI 6.13%PRS 95.84
-
CSI 2.35rCSI 4.28%PRS 89.97
-
CSI 2.34rCSI 2.71%PRS 90.3
-
CSI 2.31rCSI 4.59%PRS 91.91
-
CSI 2.29rCSI 4.17%PRS 97.02
-
CSI 2.26rCSI 3.6%PRS 97.07
-
CSI 2.24rCSI 23.75%PRS 91.4
-
CSI 2.17rCSI 5.98%PRS 93.09
-
CSI 2.15rCSI 9.63%PRS 82.64
-
CSI 2.15rCSI 8.51%PRS 89.66
-
CSI 1.7rCSI 10.85%PRS 95.1
-
CSI 1.52rCSI 4.27%PRS 95.82
-
CSI 1.45rCSI 5.53%PRS 89.36
-
CSI 0.9rCSI 6.0%PRS 89.8%
-
CSI 1.0rCSI 6.1%PRS 88.9%
-
CSI 1.5rCSI 5.5%PRS 89.4%
-
CSI 1.5rCSI 4.3%PRS 95.8%
-
CSI 1.7rCSI 10.9%PRS 95.1%
-
CSI 2.2rCSI 8.5%PRS 89.7%
-
CSI 2.2rCSI 9.6%PRS 82.6%
-
CSI 2.2rCSI 6.0%PRS 93.1%
-
CSI 2.2rCSI 23.8%PRS 91.4%
-
CSI 2.3rCSI 3.6%PRS 97.1%
-
CSI 2.3rCSI 4.2%PRS 97.0%
-
CSI 2.3rCSI 4.6%PRS 91.9%
-
CSI 2.3rCSI 2.7%PRS 90.3%
-
CSI 2.4rCSI 4.3%PRS 90.0%
-
CSI 2.4rCSI 6.1%PRS 95.8%
-
CSI 2.5rCSI 21.7%PRS 90.4%
-
CSI 2.6rCSI 23.3%PRS 84.8%
-
CSI 2.9rCSI 9.6%PRS 83.9%
-
CSI 2.9rCSI 16.9%PRS 92.4%
-
CSI 2.9rCSI 4.5%PRS 95.2%
-
CSI 3.0rCSI 8.2%PRS 95.4%
-
CSI 3.1rCSI 21.8%PRS 91.2%
-
CSI 3.1rCSI 3.8%PRS 93.8%
-
CSI 3.2rCSI 19.7%PRS 78.3%
-
CSI 3.2rCSI 5.6%PRS 92.4%
-
CSI 3.2rCSI 6.6%PRS 85.1%
-
CSI 3.3rCSI 4.4%PRS 96.2%
-
CSI 3.3rCSI 7.9%PRS 94.8%
-
CSI 3.3rCSI 8.9%PRS 91.0%
-
CSI 3.3rCSI 7.6%PRS 95.3%
-
CSI 3.4rCSI 4.5%PRS 92.1%
-
CSI 3.4rCSI 11.6%PRS 84.5%
-
CSI 3.4rCSI 2.7%PRS 89.7%
-
CSI 3.5rCSI 5.2%PRS 90.8%
-
CSI 3.7rCSI 5.6%PRS 93.5%
-
CSI 3.7rCSI 2.9%PRS 96.1%
-
CSI 3.8rCSI 9.7%PRS 91.1%
-
CSI 3.8rCSI 5.4%PRS 93.1%
-
CSI 3.9rCSI 11.3%PRS 88.2%
-
CSI 4.1rCSI 12.3%PRS 97.6%
-
CSI 4.2rCSI 6.4%PRS 92.0%
-
CSI 4.4rCSI 24.6%PRS 86.4%
-
CSI 4.4rCSI 6.5%PRS 94.9%
-
CSI 4.6rCSI 20.4%PRS 94.4%
-
CSI 4.7rCSI 11.0%PRS 91.5%
-
CSI 4.8rCSI 29.9%PRS 89.6%
-
CSI 4.8rCSI 24.2%PRS 90.9%
-
CSI 4.9rCSI 5.1%PRS 93.6%
-
CSI 4.9rCSI 11.9%PRS 89.6%
-
CSI 5.2rCSI 38.3%PRS 88.9%
-
CSI 5.3rCSI 26.2%PRS 90.1%
-
CSI 5.4rCSI 26.0%PRS 92.0%
-
CSI 5.5rCSI 24.0%PRS 85.5%
-
CSI 5.5rCSI 17.5%PRS 91.4%
-
CSI 5.5rCSI 14.2%PRS 89.6%
-
CSI 5.5rCSI 22.3%PRS 88.6%
-
CSI 5.7rCSI 9.9%PRS 91.0%
-
CSI 5.9rCSI 13.0%PRS 86.8%
-
CSI 6.2rCSI 8.9%PRS 88.2%
-
CSI 6.3rCSI 23.7%PRS 83.2%
-
CSI 6.3rCSI 8.6%PRS 89.6%
-
CSI 6.7rCSI 25.2%PRS 91.8%
-
CSI 6.7rCSI 6.5%PRS 91.9%
-
CSI 6.8rCSI 13.6%PRS 90.3%
-
CSI 7.1rCSI 7.6%PRS 95.2%
-
CSI 7.7rCSI 20.1%PRS 90.7%
-
CSI 7.8rCSI 19.7%PRS 90.7%
-
CSI 7.8rCSI 17.9%PRS 87.8%
-
CSI 7.9rCSI 12.9%PRS 89.4%
-
CSI 8.0rCSI 21.3%PRS 84.5%
-
CSI 8.3rCSI 32.4%PRS 91.2%
-
CSI 9.2rCSI 13.4%PRS 96.6%
-
CSI 9.2rCSI 20.6%PRS 85.7%
-
CSI 9.5rCSI 55.6%PRS 85.8%
-
CSI 9.5rCSI 19.3%PRS 80.3%
-
CSI 9.6rCSI 20.8%PRS 85.4%
-
CSI 9.7rCSI 15.1%PRS 94.7%
-
CSI 9.8rCSI 15.8%PRS 88.3%
-
CSI 9.9rCSI 25.7%PRS 92.8%
-
CSI 10.3rCSI 16.4%PRS 88.6%
-
CSI 10.3rCSI 18.3%PRS 85.0%
-
CSI 10.4rCSI 23.8%PRS 89.8%
-
CSI 10.6rCSI 25.3%PRS 86.6%
-
CSI 10.6rCSI 40.1%PRS 85.6%
-
CSI 10.9rCSI 20.4%PRS 88.5%
-
CSI 11.3rCSI 44.2%PRS 82.8%
-
CSI 12.8rCSI 15.9%PRS 83.4%
-
CSI 12.8rCSI 33.1%PRS 93.9%
-
CSI 14.6rCSI 47.9%PRS 85.5%
-
CSI 15.0rCSI 37.2%PRS 95.6%
-
CSI 15.4rCSI 17.8%PRS 88.4%
-
CSI 16.2rCSI 58.3%PRS 83.8%
-
CSI 16.9rCSI 27.2%PRS 86.4%
-
CSI 17.4rCSI 20.7%PRS 85.5%
-
CSI 17.4rCSI 54.5%PRS 88.0%
-
CSI 18.1rCSI 38.4%PRS 88.9%
-
CSI 18.6rCSI 58.2%PRS 86.5%
-
CSI 18.9rCSI 33.8%PRS 92.9%
-
CSI 22.7rCSI 55.1%PRS 83.5%
-
CSI 32.8rCSI 42.2%PRS 86.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1230917810
Symbol: CAPON_HUMAN
Name: C-terminal PDZ ligand of neuronal nitric oxide synthase protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9455484
Title: Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.
PubMed ID: 9455484
PubMed ID: 16146415
Title: Increased expression in dorsolateral prefrontal cortex of CAPON in schizophrenia and bipolar disorder.
PubMed ID: 16146415
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9459447
Title: CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95.
PubMed ID: 9459447
PubMed ID: 16648850
Title: A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization.
PubMed ID: 16648850
DOI: 10.1038/ng1790
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 33523862
Title: Recessive NOS1AP variants impair actin remodeling and cause glomerulopathy in humans and mice.
PubMed ID: 33523862
Sequence Information:
- Length: 506
- Mass: 56150
- Checksum: D969C65E87684A7C
- Sequence:
MPSKTKYNLV DDGHDLRIPL HNEDAFQHGI CFEAKYVGSL DVPRPNSRVE IVAAMRRIRY EFKAKNIKKK KVSIMVSVDG VKVILKKKKK LLLLQKKEWT WDESKMLVMQ DPIYRIFYVS HDSQDLKIFS YIARDGASNI FRCNVFKSKK KSQAMRIVRT VGQAFEVCHK LSLQHTQQNA DGQEDGESER NSNSSGDPGR QLTGAERAST ATAEETDIDA VEVPLPGNDV LEFSRGVTDL DAVGKEGGSH TGSKVSHPQE PMLTASPRML LPSSSSKPPG LGTETPLSTH HQMQLLQQLL QQQQQQTQVA VAQVHLLKDQ LAAEAAARLE AQARVHQLLL QNKDMLQHIS LLVKQVQELE LKLSGQNAMG SQDSLLEITF RSGALPVLCD PTTPKPEDLH SPPLGAGLAD FAHPAGSPLG RRDCLVKLEC FRFLPPEDTP PPAQGEALLG GLELIKFRES GIASEYESNT DESEERDSWS QEELPRLLNV LQRQELGDGL DDEIAV