Details for: NOS1AP

Gene ID: 9722

Symbol: NOS1AP

Ensembl ID: ENSG00000198929

Description: nitric oxide synthase 1 adaptor protein

Associated with

  • Anchoring junction
    (GO:0070161)
  • Caveola
    (GO:0005901)
  • Cytosol
    (GO:0005829)
  • Filopodium
    (GO:0030175)
  • Glutamatergic synapse
    (GO:0098978)
  • Mitochondrion
    (GO:0005739)
  • Nitric-oxide synthase binding
    (GO:0050998)
  • Nuclear membrane
    (GO:0031965)
  • Nucleus
    (GO:0005634)
  • Perinuclear region of cytoplasm
    (GO:0048471)
  • Podosome
    (GO:0002102)
  • Positive regulation of delayed rectifier potassium channel activity
    (GO:1902261)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of nitric-oxide synthase activity
    (GO:0051000)
  • Positive regulation of nitric oxide biosynthetic process
    (GO:0045429)
  • Positive regulation of nitric oxide mediated signal transduction
    (GO:0010750)
  • Positive regulation of peptidyl-cysteine s-nitrosylation
    (GO:2000170)
  • Positive regulation of potassium ion transmembrane transport
    (GO:1901381)
  • Positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
    (GO:1903762)
  • Postsynaptic actin cytoskeleton organization
    (GO:0098974)
  • Protein binding
    (GO:0005515)
  • Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
    (GO:1902514)
  • Regulation of cardiac muscle cell action potential
    (GO:0098901)
  • Regulation of heart rate by chemical signal
    (GO:0003062)
  • Regulation of high voltage-gated calcium channel activity
    (GO:1901841)
  • Regulation of nitric-oxide synthase activity
    (GO:0050999)
  • Regulation of nitric oxide biosynthetic process
    (GO:0045428)
  • Regulation of ventricular cardiac muscle cell membrane repolarization
    (GO:0060307)
  • Sarcolemma
    (GO:0042383)
  • Sarcoplasmic reticulum membrane
    (GO:0033017)
  • Signaling adaptor activity
    (GO:0035591)
  • T-tubule
    (GO:0030315)
  • Z disc
    (GO:0030018)

Other Information

Genular Protein ID: 1230917810

Symbol: CAPON_HUMAN

Name: C-terminal PDZ ligand of neuronal nitric oxide synthase protein

UniProtKB Accession Codes:

O75052 B7ZLF5 O43564 Q3T551 Q5VU95

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 31 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 3 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9455484

Title: Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.

PubMed ID: 9455484

DOI: 10.1093/dnares/4.5.345

PubMed ID: 16146415

Title: Increased expression in dorsolateral prefrontal cortex of CAPON in schizophrenia and bipolar disorder.

PubMed ID: 16146415

DOI: 10.1371/journal.pmed.0020263

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9459447

Title: CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95.

PubMed ID: 9459447

DOI: 10.1016/s0896-6273(00)80439-0

PubMed ID: 16648850

Title: A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization.

PubMed ID: 16648850

DOI: 10.1038/ng1790

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 33523862

Title: Recessive NOS1AP variants impair actin remodeling and cause glomerulopathy in humans and mice.

PubMed ID: 33523862

DOI: 10.1126/sciadv.abe1386

Sequence Information:

  • Length: 506
  • Mass: 56150
  • Checksum: D969C65E87684A7C
  • Sequence:
    • MPSKTKYNLV DDGHDLRIPL HNEDAFQHGI CFEAKYVGSL DVPRPNSRVE IVAAMRRIRY 
EFKAKNIKKK KVSIMVSVDG VKVILKKKKK LLLLQKKEWT WDESKMLVMQ DPIYRIFYVS 
HDSQDLKIFS YIARDGASNI FRCNVFKSKK KSQAMRIVRT VGQAFEVCHK LSLQHTQQNA 
DGQEDGESER NSNSSGDPGR QLTGAERAST ATAEETDIDA VEVPLPGNDV LEFSRGVTDL 
DAVGKEGGSH TGSKVSHPQE PMLTASPRML LPSSSSKPPG LGTETPLSTH HQMQLLQQLL 
QQQQQQTQVA VAQVHLLKDQ LAAEAAARLE AQARVHQLLL QNKDMLQHIS LLVKQVQELE 
LKLSGQNAMG SQDSLLEITF RSGALPVLCD PTTPKPEDLH SPPLGAGLAD FAHPAGSPLG 
RRDCLVKLEC FRFLPPEDTP PPAQGEALLG GLELIKFRES GIASEYESNT DESEERDSWS 
QEELPRLLNV LQRQELGDGL DDEIAV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.