Gene DCTD - ENSG00000129187 | NCBI Gene ID: 1635

Details for: DCTD

Gene ID: 1635

Symbol: DCTD

Ensembl ID: ENSG00000129187

Description: dCMP deaminase

Associated with

Interconversion of nucleotide di- and triphosphates
(R-HSA-499943)
Metabolism
(R-HSA-1430728)
Metabolism of nucleotides
(R-HSA-15869)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dcmp deaminase activity
(GO:0004132)
Deoxyribonucleoside 5'-monophosphate n-glycosidase activity
(GO:0070694)
Identical protein binding
(GO:0042802)
Nucleoside salvage
(GO:0043174)
Nucleotide biosynthetic process
(GO:0009165)
Protein binding
(GO:0005515)
Pyrimidine nucleotide metabolic process
(GO:0006220)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.49
Marker Score: 19645
Cell Name: decidual cell (CL2000002)
Fold Change: 1.47
Marker Score: 6318
Cell Name: preosteoblast (CL0007010)
Fold Change: 1.44
Marker Score: 407
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.43
Marker Score: 9297
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.3
Marker Score: 1386.5
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.23
Marker Score: 679
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.19
Marker Score: 1120
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.17
Marker Score: 1914
Cell Name: kidney cell (CL1000497)
Fold Change: 1.16
Marker Score: 774
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.16
Marker Score: 1223
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.16
Marker Score: 3145
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.14
Marker Score: 12829
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.12
Marker Score: 1651
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.11
Marker Score: 1121
Cell Name: Unknown (CL0002371)
Fold Change: 1.1
Marker Score: 1167
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.07
Marker Score: 980
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.07
Marker Score: 1336
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.06
Marker Score: 672
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.05
Marker Score: 18708
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.05
Marker Score: 2472
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.05
Marker Score: 16418
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.05
Marker Score: 3879
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.05
Marker Score: 710
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.05
Marker Score: 657
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.01
Marker Score: 238
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.01
Marker Score: 8702
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.01
Marker Score: 7875.5
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.01
Marker Score: 2106
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 1.01
Marker Score: 1552
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1
Marker Score: 1666
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71646
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47871
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.99
Marker Score: 33728
Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.98
Marker Score: 2226
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30380
Cell Name: peptic cell (CL0000155)
Fold Change: 0.96
Marker Score: 404
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.96
Marker Score: 906
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.96
Marker Score: 3913
Cell Name: osteoclast (CL0000092)
Fold Change: 0.96
Marker Score: 476
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.95
Marker Score: 332
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2387
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.94
Marker Score: 975
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 0.92
Marker Score: 320
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.92
Marker Score: 9258
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.92
Marker Score: 474
Cell Name: pneumocyte (CL0000322)
Fold Change: 0.92
Marker Score: 1476
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 0.92
Marker Score: 294
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.92
Marker Score: 522
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.91
Marker Score: 1295
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.91
Marker Score: 431
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.91
Marker Score: 23283
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.9
Marker Score: 496
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.9
Marker Score: 1894
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.9
Marker Score: 5112
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.9
Marker Score: 2344
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2681
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 0.89
Marker Score: 698
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.89
Marker Score: 1095
Cell Name: stem cell (CL0000034)
Fold Change: 0.89
Marker Score: 2103
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 0.88
Marker Score: 637
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.88
Marker Score: 452
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5287
Cell Name: osteoblast (CL0000062)
Fold Change: 0.87
Marker Score: 467
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.87
Marker Score: 5554
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 0.86
Marker Score: 2376
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.86
Marker Score: 1456
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.85
Marker Score: 306
Cell Name: plasmablast (CL0000980)
Fold Change: 0.85
Marker Score: 1126
Cell Name: stromal cell (CL0000499)
Fold Change: 0.85
Marker Score: 992
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.85
Marker Score: 1926
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.84
Marker Score: 208
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.84
Marker Score: 904
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.84
Marker Score: 504
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.84
Marker Score: 847
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 0.83
Marker Score: 1147
Cell Name: Unknown (CL0000548)
Fold Change: 0.83
Marker Score: 608
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.83
Marker Score: 6193
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.82
Marker Score: 210
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.82
Marker Score: 561
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.82
Marker Score: 873
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.82
Marker Score: 28280
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.82
Marker Score: 517
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.81
Marker Score: 2049
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.81
Marker Score: 674
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.81
Marker Score: 1244
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.8
Marker Score: 322
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.79
Marker Score: 1405
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.79
Marker Score: 386.5
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.79
Marker Score: 189
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.79
Marker Score: 850
Cell Name: keratocyte (CL0002363)
Fold Change: 0.79
Marker Score: 181
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.78
Marker Score: 4699
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.78
Marker Score: 175
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1263
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.78
Marker Score: 593
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.77
Marker Score: 2986
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.77
Marker Score: 1533
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.77
Marker Score: 512
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.76
Marker Score: 348
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.75
Marker Score: 242

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**Key characteristics** * The DCTD gene is located on chromosome 17q21.1. * It is a single-exon gene with a size of approximately 2.6 kb. * It encodes a protein of 137 amino acids. * The protein is a deaminase that catalyzes the deamination of dCMP to dGMP. **Pathways and functions** * DCTD is involved in several pathways, including the metabolism of deoxyribonucleoside 5-phosphate (dCMP), the deamination of dCMP to dGMP, and the interconversion of nucleotide di- and triphosphates. * It is also involved in the regulation of cell proliferation, differentiation, and apoptosis. * In cancer, mutations in the DCTD gene have been linked to the development of several types of cancer, including breast cancer, lung cancer, and colon cancer. **Clinical significance** * Mutations in the DCTD gene have been implicated in the development of several human diseases, including cancer, developmental disorders, and neurodegenerative diseases. * Targeting DCTD has been explored as a potential therapeutic strategy for cancer and other diseases that are characterized by defects in dCMP metabolism. * However, clinical trials of DCTD inhibitors have shown limited success, likely due to the tissue- and cell type-specificity of the protein. **Additional information** * The name DCTD is derived from the initials of the first three amino acids of the protein: D, C, and T. * The protein is a member of the deaminase superfamily of enzymes. * It is a highly conserved protein with sequences found in other vertebrates.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

DCTD_HUMAN

Genular Protein ID: 729643614

Symbol: DCTD_HUMAN

Name: N/A

UniProtKB Accession Codes:

P32321 B2R836 D3DP49 D3DP50 Q5M7Z8 Q9BVD8

Database IDs:

Citations:

PubMed ID: 7685356

Title: Primary structure of human deoxycytidylate deaminase and overexpression of its functional protein in Escherichia coli.

PubMed ID: 7685356

DOI: 10.1016/s0021-9258(18)31483-2

PubMed ID: 7642519

Title: Chromosomal location and structural organization of the human deoxycytidylate deaminase gene.

PubMed ID: 7642519

DOI: 10.1074/jbc.270.32.18727

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 33833118

Title: Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors.

PubMed ID: 33833118

DOI: 10.1126/science.abb4542

Sequence Information:

Length: 178
Mass: 20016
Checksum: 2B8DA5EAC85F3666
Sequence:

MSEVSCKKRD DYLEWPEYFM AVAFLSAQRS KDPNSQVGAC IVNSENKIVG IGYNGMPNGC 
SDDVLPWRRT AENKLDTKYP YVCHAELNAI MNKNSTDVKG CSMYVALFPC NECAKLIIQA 
GIKEVIFMSD KYHDSDEATA ARLLFNMAGV TFRKFIPKCS KIVIDFDSIN SRPSQKLQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: DCTD

Associated with

Cells (max top 100)

Other Information

Primary structure of human deoxycytidylate deaminase and overexpression of its functional protein in Escherichia coli. PubMed ID: 7685356

Chromosomal location and structural organization of the human deoxycytidylate deaminase gene. PubMed ID: 7642519

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors. PubMed ID: 33833118